Abstract：
:Increased Reaction Time (RT) studies intra-subject variability is an emerging and consistent finding in RT studies of schizophrenia. A group of 23 patients suffering from DSM-IV schizophrenia and a group of 23 age-matched control subjects performed two RT tasks requiring basic sensorimotor processing and engaging two different motor systems: the Finger Lift Reaction Time task and the Voluntary Saccade Reaction Time task. The Ex-Gaussian model was applied to the RT distributions measuring the mean (mu), and standard deviation (sigma) of a Gaussian component thought to reflect sensorimotor processing and an exponential component (tau), thought to reflect an intermediate decision process. In both tasks, a significantly larger RT intra-subject variability effectively dissociated patients from controls. RT intra-subject variability in the two tasks was highly correlated only for patients. Both sigma and tau were significantly higher in the patient group with tau being the best predictor of schizophrenia. Furthermore, only in the patient group were sigma and tau highly correlated between the two tasks. The results reflect a deficit in information processing that may not be confined to decision processes related to the frontal cortex; rather, they may indicate dysfunction in distributed neural networks modulating adaptive regulation of performance.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Karantinos T,Tsoukas E,Mantas A,Kattoulas E,Stefanis NC,Evdokimidis I,Smyrnis Ndoi
10.1016/j.psychres.2013.10.031subject
Has Abstractpub_date
2014-01-30 00:00:00pages
26-32issue
1eissn
0165-1781issn
1872-7123pii
S0165-1781(13)00682-3journal_volume
215pub_type
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