Abstract：
:Neuroendocrine studies that examine the changes in serum prolactin levels following intramuscular (im) neuroleptics have usually monitored prolactin levels before and for 90 minutes to 3 hours after neuroleptic injection. Recent studies have suggested that this may be an inadequate period of time. In the present study, six male and four female psychiatric inpatients, who had not received neuroleptic medication for at least 1 week before the study began, received an injection of chlorpromazine (CPZ) 25 mg im; serum prolactin levels were monitored for 6 hours after injection. Peak serum prolactin levels occurred at 60 minutes in one subject, 90 minutes in three subjects, 120 minutes in two subjects, 180 minutes in three subjects, and 240 minutes in one subject. Area under the serum prolactin curve at 2 hours and area under the curve at 3 hours after CPZ injection were found to be good predictors (r = 0.86; r = 0.95, respectively) of 6-hour area under the curve. Two-hour studies should therefore not be considered inadequate; however, a 3-hour study length results in more precise characterization of prolactin response to im CPZ.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Busch DA,Fang VS,Meltzer HYdoi
10.1016/0165-1781(79)90056-8subject
Has Abstractpub_date
1979-10-01 00:00:00pages
153-9issue
2eissn
0165-1781issn
1872-7123pii
0165-1781(79)90056-8journal_volume
1pub_type
杂志文章abstract：:Neurobiological mechanisms underlying the development of major depressive disorder (MDD) may differ depending on age-of-onset. Our aim was to compare patients who differ in age-of-onset, while controlling for illness duration, and number of depressive episodes. By directly comparing early-(EOD) and late-onset (LOD) pa...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2013.09.003
更新日期：2013-12-30 00:00:00
abstract：:It has been suggested that reversal learning deficits might be an endophenotype of OCD. To investigate this hypothesis, we administered a probabilistic reversal learning task (ProbRev) to OCD patients, their unaffected first-degree relatives, and healthy controls. Although the relatives had a performance in between OC...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.03.001
更新日期：2017-06-01 00:00:00
abstract：:Patients with bipolar mania often require re-hospitalization, which can be a social-economic burden. This study aimed to investigate the factors affecting time to re-hospitalization for inpatients with acute bipolar mania. In this 6-year naturalistic study we reviewed the charts of inpatients with acute bipolar mania....
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.10.073
更新日期：2018-12-01 00:00:00
abstract：:A comprehensive study was conducted 8 months after the 2010 Yushu earthquake to assess the prevalence of posttraumatic stress disorder (PTSD) among medical rescuers and the rescuers' quality of life. Additionally, the study examines differences between local and supporting forces, as well as the relationship between P...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2015.09.047
更新日期：2015-12-15 00:00:00
abstract：:Substance use disorder (SUD) is a worldwide concern that has its own particularities regarding age and sex. This study aims to assess the differences between old SUD women and men regarding socio-demographics, clinical factors and outcomes. A 6-months follow-up longitudinal study was conducted in an outpatient center,...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.10.041
更新日期：2018-12-01 00:00:00
abstract：:Semantic disturbances have been proposed as a possible cause of formal thought disorder in schizophrenia. Fluency tasks, in which volunteers are asked to produce as many exemplars as they can for a given category during one minute, are usually applied to the assessment of semantic processing. However, studies associat...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.11.074
更新日期：2019-01-01 00:00:00
abstract：:Depression is associated with attentional biases for emotional information that are proposed to reflect stable vulnerability factors for the development and recurrence of depression. A key question for researchers is whether those who have recovered from depression also exhibit attentional biases, and if so, how simil...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2015.09.036
更新日期：2015-12-15 00:00:00
abstract：:Evidence from in vitro and in vivo studies suggests that the therapeutic and prophylactic effects of lithium in recurrent affective disorders are due to an attenuation of the inositol-phospholipid (IPL) second messenger system. An increased sensitivity of this signal transduction system might therefore constitute a ri...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(96)02913-7
更新日期：1996-11-01 00:00:00
abstract：:We examined the impact of substance use disorder (SUD) history among patients with bipolar I disorder (BD) in regards to medication-taking behaviors and attitudes. Interviews were conducted with inpatients hospitalized for BD, which included diagnostic instruments and measures of attitudes concerning psychiatric medic...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2011.05.042
更新日期：2011-12-30 00:00:00
abstract：:Specific patterns of cortical glucose metabolism disturbances and increased CSF phospho-tau (p-tau(181)) concentrations could be demonstrated to predict cognitive decline and shift to dementia in amnestic mild cognitive impairment (MCI). But comparisons of both diagnostic tools have not been undertaken so far. The aim...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2006.12.002
更新日期：2007-07-15 00:00:00
abstract：:Childhood physical abuse (CPA) has numerous short and long-term negative effects. One of the most serious consequences of CPA is an increased risk for suicide attempts. Clarifying the mechanisms by which CPA increases risk for suicidal behavior may enhance preventive interventions. One potential mechanism is a tendenc...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2010.07.036
更新日期：2011-02-28 00:00:00
abstract：:Schizophrenia is a chronic disorder that is usually characterized by relapses alternating with periods of full or partial remission. We examined whether combined therapy with a psychosocial intervention for relapse prevention (PIRP) and risperidone administered by long-acting injection (RLAI) would be more effective i...
journal_title：Psychiatry research
pub_type： 临床试验,杂志文章
doi：10.1016/j.psychres.2008.06.043
更新日期：2010-02-28 00:00:00
abstract：:Twenty-one unmedicated, sequentially admitted psychiatric patients of either sex and four male healthy volunteers were given an intravenous injection of 2.5 mg morphine. Blood samples were drawn immediately before and at 30-minute intervals for 3 hours after the injection and assayed for cortisol. Morphine suppressed ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(85)90044-7
更新日期：1985-06-01 00:00:00
abstract：:It has been shown that the dysfunction of N-methyl-d-asparate (NMDA) receptors-mediated neurotransmission plays a role in the pathophysiology of schizophrenia. Especially, GluN2B, a subunit of NMDA receptors, associated trafficking complex is altered in the prefrontal cortex of schizophrenia. The kinesin superfamily m...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2015.09.031
更新日期：2015-12-15 00:00:00
abstract：:The purpose of this study was to investigate the influence of clozapine on plasma serotonin, platelet serotonin and monoamine oxidase (MAO) levels in schizophrenic patients and to compare their results with those of unmedicated healthy controls. Groups of 20 outpatients with schizophrenia and 20 healthy controls match...
journal_title：Psychiatry research
pub_type： 临床试验,杂志文章
doi：10.1016/j.psychres.2005.12.009
更新日期：2007-01-15 00:00:00
abstract：:Clearer understanding of psychological processes and mechanisms such as cognitive style inform more targeted psychological treatments for mood disorders. Studies to date have focused on bipolar I disorder or combined bipolar sub-types, precluding identification of any distinctive cognitive style profiles. We examined ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2012.11.036
更新日期：2013-04-30 00:00:00
abstract：:Psychiatric symptoms have been reported for individuals who experience chronic exposure to low levels of organic solvents. However, it is not known what proportion of such individuals experience psychiatric disorder; which specific disorders may be characteristic of this population; or whether bioaccumulation of lead ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0165-1781(00)00217-1
更新日期：2000-12-27 00:00:00
abstract：:Because estrogen may influence brain blood flow and metabolism in older adults, we used positron emission tomography to evaluate cerebral glucose metabolic change in post-menopausal women and men. Women estrogen users (n=4), women non-users (n=8) and men (n=10) were scanned at baseline and two years later. Analyses fo...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0925-4927(01)00084-1
更新日期：2001-07-01 00:00:00
abstract：:Limited research has examined differences in well-established suicide correlates between individuals with various histories of suicidality within the ideation to action framework. We hypothesized that individuals without a history of elevated suicidality would exhibit lowest levels of suicide correlates (perceived bur...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2016.08.038
更新日期：2016-11-30 00:00:00
abstract：:Joint effects of genotype and the environment have turned out to be significant in the development of psychotic disorders. The purpose of the present study was to assess the association of an adoptive child׳s thought and schizophrenia spectrum disorders with genetic and environmental risk indicators and their interact...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2014.12.036
更新日期：2015-04-30 00:00:00
abstract：:Concentrations of plasma norepinephrine (NE) and plasma-3-methoxy-4-hydroxyphenylglycol (MHPG), blood pressure, and heart rate were measured on 2 days in 25 depressed patients and 25 controls. Comparisons were made between patients and controls, and also between days for both groups, to determine the short-term stabil...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(86)90093-4
更新日期：1986-09-01 00:00:00
abstract：:Growing evidence supports a continuum model of psychosis, with mild psychotic symptoms being frequently experienced by the general population. Moreover, believing in the continuum model correlates with less stigmatization of schizophrenia. This study explores whether continuum beliefs are a valid construct and develop...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2016.04.085
更新日期：2016-07-30 00:00:00
abstract：:Functional magnetic resonance imaging was used to compare cortical activation patterns in healthy volunteers with those in patients with schizophrenia during a modified verbal Stroop task. Healthy subjects (n=13) and patients with schizophrenia (n=13) on stable antipsychotic treatment, matched on demographic variables...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0925-4927(03)00019-2
更新日期：2003-05-01 00:00:00
abstract：:The goals of the present study were to determine the prevalence of depression in the adult population of Sao Paulo, Brazil and to explore the relationship among sociodemographic, physical and psychological factors, sleep-related symptoms and polysomnography parameters. Participants of a cross-sectional study (N = 1101...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2013.08.036
更新日期：2013-12-30 00:00:00
abstract：:As a well-known bile acid receptor, the role of Farnesoid X receptor (FXR) in the digestive system and cardiovascular system has been widely explored. However, there are very few studies involving FXR in the central nervous system. In this study, we explored the role of FXR in the pathogenesis of depression, a serious...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.04.025
更新日期：2018-06-01 00:00:00
abstract：:Destination memory refers to the ability to remember to whom a piece of information was previously transmitted. Our paper assessed this ability in schizophrenia. Twenty-five patients with schizophrenia and 25 control participants told proverbs (e.g., "send a thief to catch a thief") to pictures of celebrities (e.g., E...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2016.12.023
更新日期：2017-02-01 00:00:00
abstract：:In this study, we evaluated the efficacy of mindfulness-based stress reduction (MBSR) for young people with anxiety symptoms. We used many databases, including PubMed, PsycINFO, Web of Science, EMBASE, CINAHL and Cochrane Library (from inception to May 2019). We included randomized controlled trials (RCTs) comparing M...
journal_title：Psychiatry research
pub_type： 杂志文章,评审
doi：10.1016/j.psychres.2020.113002
更新日期：2020-07-01 00:00:00
abstract：:We assess the health and wellbeing of normal adults living and working after one month of confinement to contain the COVID-19 outbreak in China. On Feb 20-21, 2020, we surveyed 369 adults in 64 cities in China that varied in their rates of confirmed coronavirus cases on their health conditions, distress and life satis...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2020.112958
更新日期：2020-06-01 00:00:00
abstract：:Posttraumatic Stress Disorder (PTSD) is an anxiety disorder which occurs after a traumatic event. The NR3C1 gene codes for the Glucocorticoid Receptor, which participate in the Hypothalamic-Pituitary-Adrenal (HPA) axis and is altered in PTSD patients. To evaluate whether the NR3C1 gene expression in peripheral blood c...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2020.112797
更新日期：2020-02-01 00:00:00
abstract：:There is limited evidence on the association between socioeconomic status (SES) and autism in developing nations. The aim of this study was to examine this association among children aged 0-17 years in China. We obtained data from the Second National Sample Survey on Disability, and selected 616,940 children for analy...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.08.046
更新日期：2018-01-01 00:00:00
