Abstract：
:The human opposite paired-containing (HOPA) gene is believed to be a co-activator of the thyroid hormone receptor and involved in thyroid hormone signal transduction. The gene consists of 45 exons and includes a dodecamer duplication in exon 43, which has been reported to be associated with mental retardation, autism, psychiatric disorders and hypothyroidism. We were interested to know if the 12-bp duplication variant of the HOPA gene is a risk factor for mental retardation and schizophrenia in the Chinese population. We investigated the prevalence of the 12-bp variant in a sample of Chinese mental retardation and schizophrenic patients from Taiwan by PCR-based genotyping. None of the mentally retarded and schizophrenic patients were found to have this dodecamer duplication variant. Our results indicate that the HOPA polymorphism might be very rare in our population and is unlikely to be a major risk factor for mental retardation and schizophrenia in the Chinese population.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Hung CC,Yeh JI,Fang JS,Chen CHdoi
10.1016/s0165-1781(03)00135-5subject
Has Abstractpub_date
2003-07-15 00:00:00pages
163-6issue
1-2eissn
0165-1781issn
1872-7123pii
S0165178103001355journal_volume
119pub_type
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