Abstract：
:Patients with schizophrenia are affected more adversely than healthy controls by distracting conditions, due to their inability to adequately apportion attentional resources to targets or distractors. We attempted to re-evaluate the effects of distractors in 25 patients with chronic schizophrenia and in 12 controls. They performed an auditory target-detection task with 1500 Hz tone distractors and an additional control condition where a 1500-Hz tone was used as the target. The rate of target misses for patients with schizophrenia was 3.79% in non-distractor conditions and 14.79% in distractor conditions. Significantly reduced N100 responses to distractors and distractor condition targets were found. P300 responses to all target stimulus categories were reduced, but P300 responses to distractors were equal to those in the control group. There was a reduction of P300 amplitudes to distractors in both groups; however, only the control group showed significant enlargement of P300 amplitude when the distractors became the target stimuli. There is evidence that patients with schizophrenia tend to be less able to allocate their attentional resources adequately to target vs. distractor stimuli. When the distractors became the target stimuli, their responses remained unchanged, which suggests their inability to appropriately integrate stimulus information with contextual information.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Kogoj A,Pirtosek Z,Tomori M,Vodusek DBdoi
10.1016/j.psychres.2005.07.017subject
Has Abstractpub_date
2005-11-15 00:00:00pages
49-59issue
1-2eissn
0165-1781issn
1872-7123pii
S0165-1781(05)00225-8journal_volume
137pub_type
杂志文章abstract：:Behavioural interventions show promising results among patients with mild- to moderate depression. However, whether tobacco use moderates the effects of these interventions is not known. In the present study, we examined whether patients suffering from mild-to-moderate depression differed in their response to prescrib...
journal_title：Psychiatry research
pub_type： 杂志文章,多中心研究,随机对照试验
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更新日期：2018-03-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章,随机对照试验
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pub_type： 临床试验,杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2015-06-30 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
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