Abstract:
:Thrombospondin-1 (TSP-1) is a matrix protein implicated in mechanisms of wound healing. TSP-1 contains the sequence cysteine-serine-valine-threonine-cysteine-glycine (CSVTCG) that has been shown to function primarily as a cell adhesion domain. Our laboratory has isolated a novel receptor specific for the CSVTCG adhesive domain of TSP-1. Immunohistochemical staining techniques and computerized image analysis were used to identify and quantitate TSP-1 and its CSVTCG receptor in surgically created colon anastomotic wounds. Histopathologic and quantitative examination demonstrated increased expression of TSP-1 and its CSVTCG receptor in areas of wound healing. These findings suggest a role for TSP-1 and its CSVTCG receptor in wound healing. The control of expression and activity of these molecules may eventually be the basis for the development of wound healing agents that could significantly reduce the morbidity from surgical intervention.
journal_name
Histol Histopatholjournal_title
Histology and histopathologyauthors
Roth JJ,Buckmire MA,Rolandelli RH,Granick MS,Tuszynski GPdoi
10.14670/HH-13.967subject
Has Abstractpub_date
1998-10-01 00:00:00pages
967-71issue
4eissn
0213-3911issn
1699-5848journal_volume
13pub_type
杂志文章abstract::Chronic lung allograft dysfunction (CLAD) still remains a major drawback in the outcome following lung transplantation (LTx). New therapeutic strategies are warranted. Growth factors and their receptors like platelet-derived growth factor-receptor (PDGFR) and vascular endothelial growth factor-receptor (VEGFR), may pl...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-18-088
更新日期:2019-07-01 00:00:00
abstract::Mesothelial cells (MC) obtained from the human omentum are a good alternative to the use of endothelial cells (EC) as a covering for vascular prostheses of polytetrafluoroethylene (PTFE), given the antithrombogenic properties and good behavior in vitro of mesothelial cells. We studied the behaviour of mesothelial cell...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1995-10-01 00:00:00
abstract::The low density lipoprotein receptor-related protein (LRP) 1 is a ubiquitously expressed, versatile cell surface transmembrane receptor involved in embryonic development and adult tissue homeostasis. LRP1 binds and endocytoses a broad spectrum of over 40 ligands identified thus far, including lipoproteins, extracellul...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-11-746
更新日期:2016-07-01 00:00:00
abstract::The distribution of peptidergic nerves in canine mammary tissues was studied by immunohistochemical techniques. In addition, the general and the noradrenergic innervations were demonstrated using protein gene product 9.5 and tyrosine hydroxylase immunoreactivities as markers, respectively. Tissue specimens from the ca...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-22.1175
更新日期:2007-11-01 00:00:00
abstract::The coexistence of serotonin and cholecystokinin was studied in foetal sheep lungs at pseudoglandular stage of development by light microscopic immunohistochemistry. The coexistence was examined by staining consecutive sections with the different antibodies. Serotonin and cholecystokinin immunoreactivity was found wit...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
abstract::Spinal cord injury (SCI) is one of the most destructive traumatic diseases in human beings. The balance of inflammation in the microenvironment is crucial to the repair process of spinal cord injury. Inflammatory cytokines are direct mediators of local lesion inflammation and affect the prognosis of spinal cord injury...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-18-262
更新日期:2020-10-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1988-04-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1997-10-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1994-07-01 00:00:00
abstract::The study aimed at determining levels of metallothionein (MT) and Ki-67 antigen expression in adenocarcinomas of large intestine and examining relation of the expression levels with various clinical and pathological variables. The studies were performed on 81 cases of large intestine adenocarcinoma. Using immunocytoch...
journal_title:Histology and histopathology
pub_type: 临床试验,杂志文章
doi:10.14670/HH-18.401
更新日期:2003-04-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-18-169
更新日期:2019-12-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-21.93
更新日期:2006-01-01 00:00:00
abstract::Cyclin A, cyclin E, BUBR1, MAD2 and Aurora A are all cell-cycle regulatory proteins and have been proven to play crucial roles in carcinogenesis. However, their expression patterns in invasive ductal breast carcinoma (IDBC) are controversial and unclear. In this study, we examined the expression status of these candid...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-26.761
更新日期:2011-06-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-11-951
更新日期:2018-07-01 00:00:00
abstract::The study was carried out on the distribution of neurons and fibres which contain the Corticotropin releasing factor-like (CRF) immunoreactivity in the encephalon of two species of teleosts, Gambusia affinis and Salmo trutta. The peroxidase-antiperoxidase (PAP) immunocytochemical technique was employed. The present st...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1994-04-01 00:00:00
abstract::We review here the 14 members of the Monocarboxylate transporter family (MCTs), their relationship based on sequence homology. The range of substrates transported by different members of this family extends from the standard monocarboxylate metabolites, lactic and pyruvic acids, to aromatic amino acids and thyroid hor...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-24.243
更新日期:2009-02-01 00:00:00
abstract::The main objective of this ultrastructural study was to gain a better understanding of the involvement of brain vasculature in clearance of proteins from edematous fluid. For this purpose, both native and modified (cationized, glucosylated, and mannosylated) bovine serum albumin-gold complexes (BSA-G, catBSA-G, glucBS...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-13.647
更新日期:1998-07-01 00:00:00
abstract::Peritumoral brain edema (PTBE) is considered to be one of the main biological behaviors of brain glioma. However, the histopathological features of PTBE remain imprecisely defined. We analyzed the histopathological characteristics in the PTBE area of 22 cases of glioma. Microscopically, the pre-existing basic structur...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-11-607
更新日期:2015-09-01 00:00:00
abstract::A large number of biologically active substances have been identified and characterised in the respiratory tract of several mammals. These substances (amines and peptides) exert important regulatory influences on respiratory functions, and they act as neurotransmitters/neuromodulators, both being released from nerve t...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1997-10-01 00:00:00
abstract::Bone morphogenetic proteins (BMPs) belong to the TGF-Beta superfamily and are vital bone inductive factors. BMPs also play important roles during embryonic development and the postnatal homeostasis of various organs and tissues, by controlling cellular differentiation, proliferation and apoptosis. Prostate cancer is t...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-22.1129
更新日期:2007-10-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-15.95
更新日期:2000-01-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-20.719
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-24.717
更新日期:2009-06-01 00:00:00
abstract::Differentiating nonspecific interstitial pneumonia (NSIP) from usual interstitial pneumonia (UIP) is important for the determination of both treatment and prognosis. Using two-dimensional fluorescence difference gel electrophoresis (2D-DIGE), we examined 8 UIPs, 8 NSIPs, and 30 normal lung tissues. Comparisons with co...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-29.377
更新日期:2014-03-01 00:00:00
abstract::This study concerns the results of penile biopsies in 50 patients aged 27 to 80, with secondary impotence removed with a biopty gun or during penile surgery. The biopty gun specimens were equally representative as the open biopsy ones. The cause and the degree of erectile dysfunction were determined by clinical and la...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1994-07-01 00:00:00
abstract::Prion diseases are characterized by the accumulation of PrPSc, an altered isoform of a normal cellular protein, PrPc. The prion hypothesis holds that the process of conformational change from PrPc to PrPSc under the influence of PrPSc constitutes the basic infectious mechanism in prion diseases. It is still unknown wh...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:
更新日期:1997-07-01 00:00:00
abstract::Sixty male Wistar rats were used for this experiment and assigned at random to the control group or to the stimulation method. Control rats show cerebral asymmetry with right bias at the frontal and occipital lobes. In the case of stimulated rats the differences from the occipital zone increase while those from the fr...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1992-07-01 00:00:00
abstract::Much effort has been made by researchers to elucidate the complex biology of breast cancer stem cells (BCSCs), a small subset of breast tumor cells that display stem cell properties, drive tumor initiation, and growth. In recent years, it has been suggested that BCSCs could be responsible for the process of metastasis...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-11-718
更新日期:2016-06-01 00:00:00
abstract::There is now evidence that estrogens and androgens are exerting their effects in different tissues throughout the body. In order to determine the sites of action of these steroids, studies have been performed to identify at the cellular level the localization of androgen receptor (AR) and the two estrogen receptor (ER...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-15.1261
更新日期:2000-10-01 00:00:00
abstract::Griffonia simplicifolia agglutinin I-B4 (GSAI-B4) has broader specificity for B antigen variants and can recognize the antigens in a wide variety of human tissues. Thus, the concentration range of GSAI-B4 required for staining and the susceptibility of staining to alpha-galactosidase digestion is presumed to correlate...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1997-04-01 00:00:00