Localization of thrombospondin-1 and its cysteine-serine-valine-threonine-cysteine-glycine receptor in colonic anastomotic healing tissue.


:Thrombospondin-1 (TSP-1) is a matrix protein implicated in mechanisms of wound healing. TSP-1 contains the sequence cysteine-serine-valine-threonine-cysteine-glycine (CSVTCG) that has been shown to function primarily as a cell adhesion domain. Our laboratory has isolated a novel receptor specific for the CSVTCG adhesive domain of TSP-1. Immunohistochemical staining techniques and computerized image analysis were used to identify and quantitate TSP-1 and its CSVTCG receptor in surgically created colon anastomotic wounds. Histopathologic and quantitative examination demonstrated increased expression of TSP-1 and its CSVTCG receptor in areas of wound healing. These findings suggest a role for TSP-1 and its CSVTCG receptor in wound healing. The control of expression and activity of these molecules may eventually be the basis for the development of wound healing agents that could significantly reduce the morbidity from surgical intervention.


Histol Histopathol


Roth JJ,Buckmire MA,Rolandelli RH,Granick MS,Tuszynski GP




Has Abstract


1998-10-01 00:00:00












  • Morphogenesis of normal human salivary gland cells in vitro.

    abstract::Primary cultured human salivary gland cells were transfected with ori-defective mutant DNA of SV40. Following 2-3 weeks of transfection, slowly expanding colonies consisting of small compact cells emerged, while mock-transfected cells did not grow any more and eventually entered crisis, followed by cell death. Using l...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Azuma M,Sato M

    更新日期:1994-10-01 00:00:00

  • Muscle fiber types in tetrapods. A comparative histochemical and morphometric study.

    abstract::A comparative histochemical and morphometric study in two groups of homologous muscles from different tetrapods (rat, pigeon, lizard and frog) was performed. On the basis of their fiber diameters and oxidative enzyme activities, an initial correlation between fiber types of all animals is observed, although in the liz...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Burgos Bretones JJ,Razquin Peralta B,Aguirre Urizar J,Rivera Pomar JM

    更新日期:1987-01-01 00:00:00

  • Synaptophysin immunoreactivity in the cat cochlear nuclei.

    abstract::The presence of synaptophysin, a presynaptic Ca2+ binding glycoprotein, has been analyzed in the cochlear nucleus complex of the adult cat using an antisynaptophysin monoclonal antibody. Synaptophysin immunoreactivity was differently distributed between regions of cochlear nuclei. Terminal boutons contacting directly ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Gil-Loyzaga P,Bartolomé MV,Ibáñez A

    更新日期:1998-04-01 00:00:00

  • Morphological characteristics and peptidergic innervation in the carotid body of spontaneously hypertensive rats.

    abstract::We examined morphological characteristics of the carotid body of spontaneously hypertensive rats (SHR), those of age-matched normotensive Wistar rats (NWR), and age-matched genetically comparable Wistar Kyoto rats (WKY). We examined the distribution and abundance of four different regulatory neuropeptides: substance P...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Takahashi M,Matsuda H,Hayashida Y,Yamamoto Y,Tsukuda M,Kusakabe T

    更新日期:2011-03-01 00:00:00

  • Effects of sex steroids on the Syrian hamster liver.

    abstract::The primary objective of this research project was to study the role of sex steroids in the pathogenesis of cholelithiasis using the Syrian hamster as a model. In addition to the morphological examination of the gallbladder epithelium, we thought it imperative to observe the changes induced in the biliary tract in res...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Karkare S,Adamiec-Beyga E,Gilloteaux J

    更新日期:1995-07-01 00:00:00

  • Domestic microwave processing for rapid immunohistochemical diagnosis of bovine rabies.

    abstract::The present study describes the use of a microwave processing protocol for the rapid histopathological and immunohistochemical diagnosis of bovine rabies. Immunohistochemistry has been used for rabies diagnosis in formalin-fixed tissue with satisfactory results, although the time to diagnosis is considerably longer th...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Abreu CC,Nakayama PA,Nogueira CI,Mesquita LP,Lopes PF,Varaschin MS,Seixas Jdo N,Ferreira E,Bezerra PS Jr

    更新日期:2012-09-01 00:00:00

  • Role of angiogenesis on bone formation.

    abstract::Angiogenesis and bone formation are coupled during skeletal development and fracture healing. This relationship, although known for some time, has not been properly explored. Advances in the discovery of how angiogenesis is regulated in physiological processes like embryogenesis, endometrial regeneration and wound hea...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Portal-Núñez S,Lozano D,Esbrit P

    更新日期:2012-05-01 00:00:00

  • Chaperone-mediated autophagy in cancer: Advances from bench to bedside.

    abstract::Chaperone-mediated autophagy (CMA), a selective form of autophagy, where cellular proteins with KFERQ-like motif are targeted to the lysosome for degradation, is necessary to maintain cellular homeostasis. The role of CMA in neurodegenerative diseases has been extensively studied in the past decades, with defects in t...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Hou T,Fan Y,Dan W,Liu B,Wang Z,Zeng J,Li L

    更新日期:2020-07-01 00:00:00

  • MgSO4 treatment preserves the ischemia-induced reduction in S-100 protein without modification of the expression of endothelial tight junction molecules.

    abstract:UNLABELLED:The aim of this work was to evaluate the effect of magnesium sulphate (MgSO4) administration on blood-brain barrier (BBB) permeabilization after cerebral hypoxia-ischemia (HI) induced by partial occlusion of the umbilical cord of premature fetal lambs. We also characterized BBB dysfunction in terms of the le...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Goñi-de-Cerio F,Alvarez A,Alvarez FJ,Rey-Santano MC,Alonso-Alconada D,Mielgo VE,Gastiasoro E,Hilario E

    更新日期:2009-09-01 00:00:00

  • Multilocular cystic renal cell carcinoma with focus on clinical and pathobiological aspects.

    abstract::Multilocular cystic renal cell carcinoma (MCRCC) accounts for approximately 1 to 2% of all renal tumors. This tumor is currently classified as a subtype of clear cell RCC. Clinically, the majority of these tumors are incidentally found. Macroscopically, the tumor is well demarcated and consists of various-sized cysts....

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Kuroda N,Ohe C,Mikami S,Inoue K,Nagashima Y,Cohen RJ,Pan CC,Michal M,Hes O

    更新日期:2012-08-01 00:00:00

  • An ultrastructural stereologic study of aldosterone secreting adrenal adenomas and of adjacent zona glomerulosa.

    abstract::The ultrastructure of four aldosterone secreting adenomas and of the adjacent zona glomerulosa has been described by the use of stereological techniques. Adenomatous cells (about 2800 microns 3 in volume) invariably displayed a striking abundance of lipid droplets, which occupied about 30% of the cytoplasm. Mitochondr...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Belloni AS,Mantero F,Rocco S,Gottardo G,Mazzocchi G,Nussdorfer GG

    更新日期:1988-07-01 00:00:00

  • Pathological changes of human unmyelinated nerve fibers: a review.

    abstract::In the cutaneous nerves, unmyelinated nerve fibers outnumber the myelinated ones but are scarcely analyzed, especially at autopsy. This indifference toward the pathology of unmyelinated nerve fibers may be due to the necessity of electron microscopic analyses and, more importantly, the obscurity of pathological altera...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Kanda T

    更新日期:2000-01-01 00:00:00

  • The S100 proteins for screening and prognostic grading of bladder cancer.

    abstract::The S100 gene family, which is composed of at least 24 members carrying the Ca2+ binding EF-hand motif, has been implicated in both intracellular and extracellular functions, including enzyme activities, immune responses, cytoskeleton dynamics, Ca2+ homeostasis, cell growth and cell differentiation. Altered S100 prote...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Yao R,Davidson DD,Lopez-Beltran A,MacLennan GT,Montironi R,Cheng L

    更新日期:2007-09-01 00:00:00

  • The prognostic significance of thymidine phosphorylase, thymidylate synthase and dihydropyrimidine dehydrogenase mRNA expressions in breast carcinomas.

    abstract::Thymidine phosphorylase (TP), thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) have been indicated as possible predictive markers for epithelial malignancies. All these three enzymes are actively involved in 5-FU metabolism. In this report, we investigated mRNA expression of these factors with real-...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Li H,Suo Z,Zhang Y,Risberg B,Karlsson MG,Villman K,Nesland JM

    更新日期:2004-01-01 00:00:00

  • Differential severity of LPS-induced lung injury in CD26/DPP4 positive and deficient F344 rats.

    abstract:BACKGROUND:Lipopolysaccharide (LPS) induced inflammation often leads to lung injury, in which pulmonary recruitment of neutrophils plays a pivotal role. Inflammatory processes are influenced by CD26/DPP4, highly expressed in lungs. Asthma induced CD26/DPP4 deficient (CD26/DPP4⁻) Fischer (F) 344 rats suffering from a tr...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Zientara A,Stephan M,von Hörsten S,Schmiedl A

    更新日期:2019-10-01 00:00:00

  • The combination of strong immunohistochemical mtTFA expression and a high survivin index predicts a shorter disease-specific survival in pancreatic ductal adenocarcinoma.

    abstract::Mitochondrial transcription factor A (mtTFA) plays a crucial role in both the transcription and maintenance of mitochondrial DNA. A high expression of mtTFA has been demonstrated in several solid tumors, and is closely associated with cancer cell survival/apoptosis and growth. However, its expression pattern in pancre...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Kimura T,Kitada S,Uramoto H,Zhi L,Kawatsu Y,Takeda T,Horie S,Nabeshima A,Noguchi H,Sasaguri Y,Izumi H,Kohno K,Yamada S

    更新日期:2015-02-01 00:00:00

  • Microglia and prion disease: a review.

    abstract::Prion diseases are characterized by the accumulation of PrPSc, an altered isoform of a normal cellular protein, PrPc. The prion hypothesis holds that the process of conformational change from PrPc to PrPSc under the influence of PrPSc constitutes the basic infectious mechanism in prion diseases. It is still unknown wh...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Brown DR,Kretzschmar HA

    更新日期:1997-07-01 00:00:00

  • Telocytes and lung disease.

    abstract::Telocytes (TCs) represent a new distinct type of interstitial cells found in many organs, including lungs. TCs are mainly defined by a small cellular body from which arise very long (hundreds of micrometers) extensions named telopodes. During the last years, TCs were characterized in respect with their microRNA profil...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Song D,Cretoiu D,Cretoiu SM,Wang X

    更新日期:2016-12-01 00:00:00

  • Down-regulation of TSG101 by small interfering RNA inhibits the proliferation of breast cancer cells through the MAPK/ERK signal pathway.

    abstract::We designed to investigate the effects of down-regulating the tumor susceptibility gene 101 (TSG101) on the proliferation and apoptosis of the human breast cancer MCF-7 cell line, and the role of the MAPK/ERK signal pathway in this process. The siRNA against TSG101 was transfected into the breast cancer MCF-7 cell lin...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Zhang Y,Song M,Cui ZS,Li CY,Xue XX,Yu M,Lu Y,Zhang SY,Wang EH,Wen YY

    更新日期:2011-01-01 00:00:00

  • Gastric intestinal metaplasia eleven years after randomized selective proximal vagotomy for peptic ulcer.

    abstract::The presence of intestinal metaplasia (IM) 11 years after selective proximal vagotomy (SPV), selective proximal vagotomy with pyloroplasty (SPV + PP) and selective vagotomy with pyloroplasty (SV + PP) was investigated in 38 consecutive patients. IM was significantly more frequent in SPV than in SV + PP, SPV + PP or in...

    journal_title:Histology and histopathology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Rubio CA,Emås S,Slezak P,Nakano H,Kalin B

    更新日期:1993-04-01 00:00:00

  • Ultrastructural substrates for increased lung water content in experimental pulmonary edema.

    abstract::We examined the relationship between the incidence of ultrastructural changes in the alveolar septum and the extravascular lung water content. Pulmonary edema was induced in 18 mongrel dogs by either dextran (n = 12) or alloxan (n = 6) administration. Six other dogs served as controls. Extravascular lung water content...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Oda H,Arakawa M,Kambara K,Nakahara K,Segawa T,Ando F,Kawada T,Hirakawa S,Shoumura S,Isono H

    更新日期:1993-01-01 00:00:00

  • Ontogenic attendance of neuropeptides in the embryo chicken retina.

    abstract::We have examined the ontogeny of somatostatin-, Glucagon-, Vasoactive Intestinal Polypeptide-, Substance P-, Neuropeptide Y, and Calcitonin gene-related peptide-Iike structures in the chicken retina by immunocytochemistry. Neuroblastic cells containing Substance P-Iike immunoreactivity (IR) first appeared at embryonic...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Prada Oliveira JA,Verástegui Escolano C,Gómez Luy C,Collantes Ruiz J

    更新日期:2003-10-01 00:00:00

  • Effects of Helicobacter pylori on biological characteristics of gastric epithelial cells.

    abstract::Infection with Helicobacter pylori (H. pylori) strains is linked to an increased risk of inflammation and gastric cancer. To investigate the effects of H. pylori on biological characteristics of gastric epithelial cells SGC-7901, derived from human adenocarcinoma, morphological appearances of both the pathogen and the...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Wang P,Mei J,Tao J,Zhang N,Tian H,Fu GH

    更新日期:2012-08-01 00:00:00

  • The role of apoptosis in pulmonary fibrosis.

    abstract::Pulmonary fibrosis is a common response to various injuries to the lung. The resolution of a fibroproliferative response after lung injury is key to survival. Although there are various initiating factors or causes, the terminal stages are characterized by proliferation and progressive accumulation of connective tissu...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Kuwano K,Hagimoto N,Nakanishi Y

    更新日期:2004-07-01 00:00:00

  • Pancreas is a preeminent source of ghrelin after sleeve gastrectomy in Wistar rats.

    abstract::Many surgical techniques are employed in the treatment of severe obesity. A main consequence of these techniques is the improvement of type 2 Diabetes mellitus. Ghrelin is a gut hormone released in the gastric fundus and corpus, which has been related to diabetic improvement as mentioned in these papers. Sleeve gastre...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Camacho-Ramírez A,Mayo-Ossorio MÁ,Pacheco-García JM,Almorza-Gomar D,Ribelles-García A,Belmonte-Núñez A,Prada-Oliveira JA,Pérez-Arana GM

    更新日期:2020-08-01 00:00:00

  • Duodenal microanatomy of the domestic cat (Felis catus).

    abstract::Duodenal samples were taken from similar locations in six cats, processed, stained, and examined via light microscope. There were no prominent circular folds (plicae circulares) or stratum compactum (lamina subglandularis). The 1072 microns x 201 microns villi were covered by 46 microns high columnar epitheliocytes pr...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Henry RW,al-Bagdadi FK

    更新日期:1986-10-01 00:00:00

  • Insights into iron and nuclear factor-kappa B (NF-kappaB) involvement in chronic inflammatory processes in peritoneal endometriosis.

    abstract::Endometriosis is a chronic pelvic inflammatory process. Local inflammation is known to play a role in pain and infertility associated with the disease, and may be extensively involved in molecular and cellular processes leading to endometriosis development. In this review, we focus on two inflammatory mediators clearl...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Defrère S,González-Ramos R,Lousse JC,Colette S,Donnez O,Donnez J,Van Langendonckt A

    更新日期:2011-08-01 00:00:00

  • Glucose transporter expression in developing fetal lungs and lung neoplasms.

    abstract::Glucose uptake and metabolism are essential for proliferation and survival of cells, and are supposed to be enhanced in actively proliferating cell systems such as embryonic and cancer tissues. Glucose uptake is usually carried out through glucose transporters. In the developing fetal lung, metabolism of glucose is th...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Ito T,Noguchi Y,Udaka N,Kitamura H,Satoh S

    更新日期:1999-07-01 00:00:00

  • Studies with the Golgi method in central gangliogliomas and dysplastic gangliocytoma of the cerebellum (Lhermitte-Duclos disease).

    abstract::The rapid Golgi method, combined with current optical and electronmicroscopical techniques, was used in three central gangliogliomas and in one dysplastic gangliocytoma of the cerebellum to study the morphology of ganglionic cells. Gangliogliomas were composed of bipolar, fusiform and radiate cells with dense core and...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Ferrer I,Martí E,Guionnet N,Bella R,Serrano T,Towse J,Conesa G,Isamat F

    更新日期:1990-07-01 00:00:00

  • The relationship between mucin phenotype and clinicopathological factors, proliferative activity and p53 expression in gastric hyperplastic polyps.

    abstract:AIMS:Gastric hyperplastic polyps (GHPs) are the most common polypoid lesion of the stomach, and their malignant potential has been demonstrated. In the present study, we evaluated the mucin phenotypes of GHPs and investigated the relationships among mucin phenotypes and clinical-pathological factors, proliferative acti...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Li J,Wu LH,Shi Y,Li HM,Song MY,Jiao YF

    更新日期:2014-03-01 00:00:00