Abstract：
:In view of the limitations of conventional prognostic factors such as differentiation degree, metastatic lymph nodes, hormonal receptors and others, especially when early lesions are found, additional new markers have been studied, such as gene amplification and cell proliferation index, in order to choose the appropriate treatment. Primary breast carcinoma tumors from 97 patients were examined for differentiation degree, metastatic lymph nodes, hormonal receptors, c-erbB-2 amplification and cell proliferation index (Ki-67). A negative relationship with hormonal receptors and c-erbB-2 amplification, Ki-67 and differentiation degree was found, whereas the relationship between c-erbB-2, Ki-67 and differentiation degree was positive. No relationship was found between these factors and metastatic lymph nodes. The concurrence of high cell proliferation index, c-erbB-2 amplification and negative hormonal receptor presence would indicate a subpopulation with a high risk of recurrence. But a larger survival study is necessary to correlate these factors with clinical outcome.
journal_name
Histol Histopatholjournal_title
Histology and histopathologyauthors
Sirvent JJ,Santafé M,Salvadó MT,Alvaro T,Raventós A,Palacios Jsubject
Has Abstractpub_date
1994-07-01 00:00:00pages
563-70issue
3eissn
0213-3911issn
1699-5848journal_volume
9pub_type
杂志文章abstract：:Little is known about the morphological response of muscle after long term traction. The purpose of this study was to investigate the morphological changes of skeletal muscle during limb lengthening. After application of mini-extraskeletal fixator, the hindlimb of New Zealand white rabbit was osteotomized and then slo...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1996-04-01 00:00:00
abstract：:In the present work we analyze the cerebellum of chronic parkinsonian monkeys in order to clarify whether chronic mesencephalic depletion is associated with long term activation of the cerebellar neurons in chronic Parkinsonism. In our study, we observed a persistent activation of Purkinje cells in the cerebellum of c...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-27.89
更新日期：2012-01-01 00:00:00
abstract：:The purpose of this investigation was to clarify the mechanisms of amyloid fibril formation in human lymph nodes. In our present study, amyloid deposition was observed diffusely in all compartments of the lymph nodes. The deposition form showed extremely characteristic findings in its morphological features. Namely, a...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1986-07-01 00:00:00
abstract：:A technique for staining the nucleolar organizer regions (NORs) in tumor cells applied to smears from brain tumor biopsy specimens is described. This technique provides a rapid intraoperative evaluation of the proliferative activity in cerebral neoplasms and is a valuable complement to hematoxylineosin stained smears,...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1991-10-01 00:00:00
abstract：:The rapid Golgi method, combined with current optical and electronmicroscopical techniques, was used in three central gangliogliomas and in one dysplastic gangliocytoma of the cerebellum to study the morphology of ganglionic cells. Gangliogliomas were composed of bipolar, fusiform and radiate cells with dense core and...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1990-07-01 00:00:00
abstract：:The study aimed at determining levels of metallothionein (MT) and Ki-67 antigen expression in adenocarcinomas of large intestine and examining relation of the expression levels with various clinical and pathological variables. The studies were performed on 81 cases of large intestine adenocarcinoma. Using immunocytoch...
journal_title：Histology and histopathology
pub_type： 临床试验,杂志文章
doi：10.14670/HH-18.401
更新日期：2003-04-01 00:00:00
abstract：:Bone morphogenetic proteins (BMPs) belong to the TGF-Beta superfamily and are vital bone inductive factors. BMPs also play important roles during embryonic development and the postnatal homeostasis of various organs and tissues, by controlling cellular differentiation, proliferation and apoptosis. Prostate cancer is t...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-22.1129
更新日期：2007-10-01 00:00:00
abstract：AIMS:Gastric hyperplastic polyps (GHPs) are the most common polypoid lesion of the stomach, and their malignant potential has been demonstrated. In the present study, we evaluated the mucin phenotypes of GHPs and investigated the relationships among mucin phenotypes and clinical-pathological factors, proliferative acti...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-29.343
更新日期：2014-03-01 00:00:00
abstract：:Experimental Doxorubicin-exposure in utero is correlated with foetal oesophageal atresia, tracheo-oesophageal fistula, axial alterations. While gastrointestinal and respiratory defects have been largely investigated, only sporadic data have been published to date on notochordal and vertebral defects. The aim of this w...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-17.31
更新日期：2002-01-01 00:00:00
abstract：:Nitric oxide (NO) has opened a new and vigorous field of biological and clinical experimentation as evidenced presently by about one hundred original publications every week. Being a biological signal under physiological conditions, NO may be
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：
更新日期：1997-01-01 00:00:00
abstract：:The aim of our study was to document whether relationships existed among bone morphogenetic proteins (BMPs), peripheral nerve and neoplastic lesions of nerve sheath tumors. The mRNA transcriptions of BMP-2, 3, 4 and 5 in 10 cases of schwannoma, three cases of malignant schwannoma and two cases of trigeminal neuralgia ...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-16.1013
更新日期：2001-10-01 00:00:00
abstract：UNLABELLED:The aim of this work was to evaluate the effect of magnesium sulphate (MgSO4) administration on blood-brain barrier (BBB) permeabilization after cerebral hypoxia-ischemia (HI) induced by partial occlusion of the umbilical cord of premature fetal lambs. We also characterized BBB dysfunction in terms of the le...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-24.1129
更新日期：2009-09-01 00:00:00
abstract：:We designed to investigate the effects of down-regulating the tumor susceptibility gene 101 (TSG101) on the proliferation and apoptosis of the human breast cancer MCF-7 cell line, and the role of the MAPK/ERK signal pathway in this process. The siRNA against TSG101 was transfected into the breast cancer MCF-7 cell lin...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-26.87
更新日期：2011-01-01 00:00:00
abstract：:Our study aimed to investigate the association of Pyruvate Kinase isozyme type M2 (PKM2) with radiation resistance in locally advanced cervical squamous cell carcinoma (LACSCC). We retrospectively reviewed 132 female patients who received primary radiation therapy to treat LACSCC at Federation Internationale of Gyneco...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-11-627
更新日期：2015-11-01 00:00:00
abstract：:Serotonin-producing pancreatic endocrine tumours are rare neoplasms which in most cases exhibit malignant biological behaviour. These tumours, in the majority of the well-documented cases, are composed of argyrophil- and argentaffin-positive cells which contain large pleomorphic neurosecretory granules. In contrast, a...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1990-07-01 00:00:00
abstract：:Osteoclasts are physiological polykaryons specialized in the resorption of calcified tissue. In the context of the clinical use of calcium-phosphate (CaP) ceramics as bone substitutes, this study used transmission electron microscopy to investigate the in vitro mechanisms of CaP ceramic degradation by osteoclastic cel...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-16.37
更新日期：2001-01-01 00:00:00
abstract：:Cell secretion is an important physiological process that ensures smooth metabolic activities, tissue repair and growth and immunological functions in the body. It occurs when the intracellular secretory materials are released to the exterior; these may be in the form of lipids, protein or mucous and may travel throug...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-18.597
更新日期：2003-04-01 00:00:00
abstract：:The purpose of this study was to determine the histological characteristics of a skeletal muscle reconstructed by means of the implantation of autologous adipose tissue following an experimentally-induced volumetric muscle loss. A cylindrical piece in the belly of the rat anterior tibial muscle was removed. In the hol...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-18-163
更新日期：2020-05-01 00:00:00
abstract：:Ductular hepatocytes are observed in the livers of both experimental animals and man under various conditions of severe toxin-, carcinogen- or viral-induced hepatic injury with prominent loss of parenchymal hepatocytes. These unique hepatic epithelial cells are characterized by phenotypic traits that are intermediate ...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：
更新日期：1995-04-01 00:00:00
abstract：:The terms construct or tissue equivalent refer to neotissue produced by tissue engineering techniques. The elements forming the construct are scaffolds on which cells are "recreated" to form an engineered-tissue sensitive to certain cell signals. The ability of the cells to expand and differentiate on the scaffold is ...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-20.891
更新日期：2005-07-01 00:00:00
abstract：:Renal oncocytosis is a recently established disease entity characterized by numerous oncocytic tumors and diffuse involvement of oncocytic changes in renal parenchymal epithelia. In this article, we review this disease with a focus on its clinical and pathobiological aspects. Clinically, renal oncocytosis may occur in...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-27.1407
更新日期：2012-11-01 00:00:00
abstract：:Cancer is the subject of intense research around the world, but many questions about how the disease works remain unanswered. How exactly does cancer start and how do tumours grow? In fact, at present there are ten times more anticancer drugs being tested in clinical trials than there were 15 years ago. However, many ...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-27.157
更新日期：2012-02-01 00:00:00
abstract：:STAT and SMAD often exert opposite biological effects on diverse cellular functions. Recent studies have shown that STAT can interface with SMAD at molecular level and that some novel molecules, such as SOCS (also called CIS) and APRO6 (also called TOB), modulate this signaling. A cofactor p300/CBP might act as a brid...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-17.887
更新日期：2002-01-01 00:00:00
abstract：:Src, a 60 kDa non-receptor tyrosine kinase, is the product of normal c-src of the human genome and member of the Src protein tyrosine kinases family (SFK). As described by Martin and Rous, a genetic recombination between c-src and the RSV oncogene of Rous sarcoma virus results in a modified Src protein, with increased...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-27.677
更新日期：2012-06-01 00:00:00
abstract：:Although testicular germ cell tumors (TGCTs) are relatively uncommon, they are particularly important, as they tend to affect children and young men, the most common tumor being in males aged from 20 to 40 years, and the incidence has been increasing in the last years. TGCTs comprise two major histologic groups: semin...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-29.999
更新日期：2014-08-01 00:00:00
abstract：:Hexachlorobenzene (HCB) is a fungicide and a pollutant of increasing concern in industrialized regions of the world. Reproductive failure is one of the effects of HCB upon mammals. Alteration of cell shape in the ovary surface epithelium (OSE) of Cynomolgus monkeys following oral administration of HCB was observed in ...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1991-10-01 00:00:00
abstract：:Duodenal samples were taken from similar locations in six cats, processed, stained, and examined via light microscope. There were no prominent circular folds (plicae circulares) or stratum compactum (lamina subglandularis). The 1072 microns x 201 microns villi were covered by 46 microns high columnar epitheliocytes pr...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1986-10-01 00:00:00
abstract：:Bone marrow features in stable-phase chronic myelogenous leukemia (CML) are characterized by a striking heterogeneity which is determinable by appropriate means including representative pre-treatment trephine biopsies, immunohistochemistry and morphometry. Cell lineages involved to a variable extent consist not only o...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-14.1241
更新日期：1999-10-01 00:00:00
abstract：:Aurora A and Aurora B are serine-threonine kinase proteins which have both been implicated in human carcinogenesis through development of aneuploidy and chromosomal instability. The aim of the study is to assess the correlation of both markers with clinical and pathological parameters in patients with bladder cancer o...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-25.1371
更新日期：2010-11-01 00:00:00
abstract：:The integrity of the thymus during early life is necessary for a proper maturation of the neuroendocrine system, including the adrenal axis. The thymic metallopeptide thymulin seems to be a central physiologic mediator of thymus-pituitary communication. Furthermore, neonatal thymulin gene therapy has been shown to pre...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-26.471
更新日期：2011-04-01 00:00:00
