The effect of somatostatin analog octreotide on diethylstilbestrol-induced prolactin secretion, cell proliferation and vascular changes in the rat anterior pituitary gland.

Abstract:

:The effects of diethylstilbestrol (DES) and of long-acting somatostatin analog, octreotide (SMS) on the rat anterior pituitary microvasculature have been studied by means of computer-assisted image analysis. Additionally, the effects of DES and SMS on prolactin secretion and anterior pituitary cell proliferation have been studied, as well. The vascularization was visualized using Selye's method modified by Poely et al. (1964). The prolactin serum levels were estimated by radio-immunoassay. The proliferation indices were assessed using bromodeoxyuridine incorporation assay. As expected, it was found that DES sharply increased serum prolactin levels and enhanced cell proliferation in the anterior pituitary gland. DES also induced changes in parameters of vascularization. Simultaneous treatment of rats with SMS inhibited the DES-induced elevation of prolactin levels and pituitary cell proliferation. It also suppressed some but not all DES-induced changes in the anterior pituitary vascularization. These data suggest that the angio-inhibitory activity of SMS might be involved in its anti-tumor action on pituitary adenomas, but not as a sole or principal mechanism.

journal_name

Histol Histopathol

authors

Pawlikowski M,Kunert-Radek J,Grochal M,Zieliński K,Kulig A

subject

Has Abstract

pub_date

1997-10-01 00:00:00

pages

991-4

issue

4

eissn

0213-3911

issn

1699-5848

journal_volume

12

pub_type

杂志文章
  • Effects of sex steroids on the Syrian hamster liver.

    abstract::The primary objective of this research project was to study the role of sex steroids in the pathogenesis of cholelithiasis using the Syrian hamster as a model. In addition to the morphological examination of the gallbladder epithelium, we thought it imperative to observe the changes induced in the biliary tract in res...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Karkare S,Adamiec-Beyga E,Gilloteaux J

    更新日期:1995-07-01 00:00:00

  • Cisplatin treatment of NIH/3T3 cultures induces a form of autophagic death in polyploid cells.

    abstract::The effects induced by different concentrations (50, 75, 100 microM) of the cytostatic drug cisplatin (cDDP) in NIH/3T3 cells were analyzed. Sub-confluent cultures of this mouse fibroblast line, obtained after serum deprivation, showed the presence of aneuploid/polyploid cells with ploidy values ranging from 4c to 24c...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-23.717

    authors: Spano A,Monaco G,Barni S,Sciola L

    更新日期:2008-06-01 00:00:00

  • Retinal afferents on Golgi-identified vertical neurons in the superior colliculus of the rabbit. A Golgi-EM, degenerative and autoradiographic study.

    abstract::The characteristics and distribution pattern of retinal afferent terminals making synaptic contacts on narrow field vertical neurons in the stratum griseum superficiale of the rabbit superior colliculus were studied using the Golgi-gold substitution technique in combination with either autoradiographic or degenerative...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Ortega F,Doñate-Oliver F,Grandes P

    更新日期:1993-01-01 00:00:00

  • Metalloproteinase expression by control and telomerase immortalized human endometrial endothelial cells.

    abstract::Vascular endothelial cells play a critical role in the maintenance of endometrial homeostasis. Indeed many pathological conditions causing abnormal endometrial bleeding including progestin only contraception, hormone replacement therapy, endometrial polyps, myomas, hyperplasia and cancer are associated with aberrant a...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-20.719

    authors: Krikun G,Mor G,Huang J,Schatz F,Lockwood CJ

    更新日期:2005-07-01 00:00:00

  • Ultrastructural study of the clearance of intracerebrally infused native and modified albumin-gold complexes.

    abstract::The main objective of this ultrastructural study was to gain a better understanding of the involvement of brain vasculature in clearance of proteins from edematous fluid. For this purpose, both native and modified (cationized, glucosylated, and mannosylated) bovine serum albumin-gold complexes (BSA-G, catBSA-G, glucBS...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-13.647

    authors: Dobrogowska DH,Lossinsky AS,Vorbrodt AW

    更新日期:1998-07-01 00:00:00

  • Localization of thrombospondin-1 and its cysteine-serine-valine-threonine-cysteine-glycine receptor in colonic anastomotic healing tissue.

    abstract::Thrombospondin-1 (TSP-1) is a matrix protein implicated in mechanisms of wound healing. TSP-1 contains the sequence cysteine-serine-valine-threonine-cysteine-glycine (CSVTCG) that has been shown to function primarily as a cell adhesion domain. Our laboratory has isolated a novel receptor specific for the CSVTCG adhesi...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-13.967

    authors: Roth JJ,Buckmire MA,Rolandelli RH,Granick MS,Tuszynski GP

    更新日期:1998-10-01 00:00:00

  • A truncated isoform of the PP2A B56gamma regulatory subunit reduces irradiation-induced Mdm2 phosphorylation and could contribute to metastatic melanoma cell radioresistance.

    abstract::F10, a subline of the B16 mouse melanoma cell line, is itself the parent of the more metastatic BL6 line. BL6 cells differ from F10 cells by an alteration of the gene encoding the B56gamma regulatory subunit of protein phosphatase 2A (PP2A), which results in mRNA encoding a truncated variant of the subunit (deltagamma...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-19.391

    authors: Koma YI,Ito A,Watabe K,Kimura SH,Kitamura Y

    更新日期:2004-04-01 00:00:00

  • Histochemical study of skin and gills of Senegal sole, Solea senegalensis larvae and adults.

    abstract::A battery of horseradish peroxidase-conjugated lectins (Con A, WGA and DBA), as well as conventional histochemical techniques (PAS, saponification, Alcian Blue pH 0.1, 1, 2.5, chlorhydric hydrolisis, neuraminidase, Bromophenol blue, Tioglycollate reduction and Ferric-ferricyanide-FeIII) were used to study the content ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-13.727

    authors: Sarasquete C,González de Canales ML,Arellano J,Muñoz Cueto JA,Ribeiro L,Dinis MT

    更新日期:1998-07-01 00:00:00

  • Localization of androgen and estrogen receptors in rat and primate tissues.

    abstract::There is now evidence that estrogens and androgens are exerting their effects in different tissues throughout the body. In order to determine the sites of action of these steroids, studies have been performed to identify at the cellular level the localization of androgen receptor (AR) and the two estrogen receptor (ER...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-15.1261

    authors: Pelletier G

    更新日期:2000-10-01 00:00:00

  • Chaperone-mediated autophagy in cancer: Advances from bench to bedside.

    abstract::Chaperone-mediated autophagy (CMA), a selective form of autophagy, where cellular proteins with KFERQ-like motif are targeted to the lysosome for degradation, is necessary to maintain cellular homeostasis. The role of CMA in neurodegenerative diseases has been extensively studied in the past decades, with defects in t...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-18-202

    authors: Hou T,Fan Y,Dan W,Liu B,Wang Z,Zeng J,Li L

    更新日期:2020-07-01 00:00:00

  • Fhit protein is preferentially expressed in the nucleus of monocyte-derived cells and its possible biological significance.

    abstract::The FHIT gene encompassing the most active common human fragile region, FRA3B, has been proposed as a tumour suppressor gene for important common human carcinomas. The mechanism in which Fhit protein exerts its tumour suppressor activity is still obscure. To further understand the Fhit function associated with its int...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-21.915

    authors: Zhao P,Hou N,Lu Y

    更新日期:2006-09-01 00:00:00

  • Beta-catenin expression pattern in small cell lung cancer: correlation with clinical and evolutive features.

    abstract::Beta-catenin expression in small cell lung carcinomas (SCLC) was investigated by immunohistochemical method using antibodies against beta-catenin. 50 pre-treatment biopsies were examined and the relationship between beta-catenin expression and the patients' relevant clinical characteristics, response to chemotherapy, ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-16.353

    authors: Rodríguez-Salas N,Palacios J,de Castro J,Moreno G,González-Barón M,Gamallo C

    更新日期:2001-04-01 00:00:00

  • Immunohistological signposts in central nervous system tumours with neuronal differentiation.

    abstract::25 neuronal tumours with a panel of antibodies were studied and it was found that vimentin was present in 15 tumours. It was also found in a few cells within rosettes. PGP 9.5 showed a somatic pattern of staining with nuclear and perinuclear positivity in 23. Neurofilament reactivity was found in 14. Retinal S-antigen...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Cruz-Sánchez FF,Rossi ML,Rodríguez-Prados S,Cusi V,Coakham HB

    更新日期:1991-10-01 00:00:00

  • Reduced expression of the membrane skeleton protein beta1-spectrin (SPTBN1) is associated with worsened prognosis in pancreatic cancer.

    abstract::Spectrins are members of the superfamily of F-actin cross linking proteins that are important as scaffolding proteins for protein sorting, cell adhesion, and migration. In addition, spectrins have been implicated in TGF-beta signaling. The aim of the present study was to analyze the expression and localization of beta...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-25.1497

    authors: Jiang X,Gillen S,Esposito I,Giese NA,Michalski CW,Friess H,Kleeff J

    更新日期:2010-12-01 00:00:00

  • Control of the cell cycle by neurotrophins: lessons from the p75 neurotrophin receptor.

    abstract::Although traditionally little attention has been paid to the interplay between neurotrophins and the cell cycle, a number of recent findings suggest an important role for these growth factors in the regulation of this aspect of the cellular physiology. In this article, we review the evidence from a number of studies t...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-17.1227

    authors: López-Sánchez N,Frade JM

    更新日期:2002-10-01 00:00:00

  • BDNF function and intracellular signaling in neurons.

    abstract::Brain-derived neurotrophic factor (BDNF) and its receptor, TrkB, are broadly expressed in the developing and adult mammalian brain. BDNF/TrkB-stimulated intracellular signaling is critical for neuronal survival, morphogenesis, and plasticity. It is well known that binding of BDNF to TrkB elicits various intracellular ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-25.237

    authors: Numakawa T,Suzuki S,Kumamaru E,Adachi N,Richards M,Kunugi H

    更新日期:2010-02-01 00:00:00

  • Insights into iron and nuclear factor-kappa B (NF-kappaB) involvement in chronic inflammatory processes in peritoneal endometriosis.

    abstract::Endometriosis is a chronic pelvic inflammatory process. Local inflammation is known to play a role in pain and infertility associated with the disease, and may be extensively involved in molecular and cellular processes leading to endometriosis development. In this review, we focus on two inflammatory mediators clearl...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-26.1083

    authors: Defrère S,González-Ramos R,Lousse JC,Colette S,Donnez O,Donnez J,Van Langendonckt A

    更新日期:2011-08-01 00:00:00

  • The contribution of cavernous body biopsy in the diagnosis and treatment of male impotence.

    abstract::This study concerns the results of penile biopsies in 50 patients aged 27 to 80, with secondary impotence removed with a biopty gun or during penile surgery. The biopty gun specimens were equally representative as the open biopsy ones. The cause and the degree of erectile dysfunction were determined by clinical and la...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Malovrouvas D,Petraki C,Constantinidis E,Petraki K,Antoniadis G,Constantinidis C,Kranidis A

    更新日期:1994-07-01 00:00:00

  • Atrial natriuretic peptide in the heart and pancreas.

    abstract::We used antisera to pure atrial natriuretic peptide to localise this peptide by immunocytochemistry in rat and human tissue. We showed that both rat and human atrial cardiocytes gave a positive reaction while ventricular cardiocytes were consistently negative. Peripheral islet cells in rat but not in human pancreas al...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Lindop GB,Mallon EA,MacIntyre G

    更新日期:1986-04-01 00:00:00

  • Antigen retrieval on epoxy sections based on tissue infiltration with a moderately increased amount of accelerator to detect immune complex deposits in glomerular tissue.

    abstract::We wanted to examine the effect of antigen retrieval on epoxy sections where the tissue had been infiltrated by resin containing moderately increased amounts of accelerator. The concentration of accelerator DMP-30 (Tri(Dimethyl Amino Methyl) Phenol) was varied in the range of 0% to 4% in the infiltration step of the t...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-14.151

    authors: Brorson SH,Andersen T,Haug S,Kristiansen I,Risstubben A,Tchou H,Ulstein J

    更新日期:1999-01-01 00:00:00

  • Studies with the Golgi method in central gangliogliomas and dysplastic gangliocytoma of the cerebellum (Lhermitte-Duclos disease).

    abstract::The rapid Golgi method, combined with current optical and electronmicroscopical techniques, was used in three central gangliogliomas and in one dysplastic gangliocytoma of the cerebellum to study the morphology of ganglionic cells. Gangliogliomas were composed of bipolar, fusiform and radiate cells with dense core and...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Ferrer I,Martí E,Guionnet N,Bella R,Serrano T,Towse J,Conesa G,Isamat F

    更新日期:1990-07-01 00:00:00

  • Immunocytohistochemical characterization of pituitary cells of the bluefin tuna, Thunnus thynnus L.

    abstract::In this paper we report the first complete mapping of the pituitary in a tuna species. The various different adenohypophysis cell types of the bluefin tuna, Thunnus thynnus L. have been identified and located using different antisera against mammalian and piscine hormones and various histochemical techniques: PAS, Alc...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-16.443

    authors: Rodríguez-Gómez FJ,Rendón-Unceta MC,Piñuela C,Muñoz-Cueto JA,Jiménez-Tenorio N,Sarasquete C

    更新日期:2001-04-01 00:00:00

  • Distribution and pathophysiologic role of molybdenum-containing enzymes.

    abstract::The importance of molybdenum-containing enzymes in the pathophysiology of a number of clinical disorders necessitates a comprehensive understanding of their histological localization and expression. The objectives of this review are to cover such enzymes so far reported and their enzyme- and immunohistochemical locali...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:

    authors: Moriwaki Y,Yamamoto T,Higashino K

    更新日期:1997-04-01 00:00:00

  • Advances in translational orthopaedic research with species-specific multipotent mesenchymal stromal cells derived from the umbilical cord.

    abstract::Compliance with current regulations for the development of innovative medicines require the testing of candidate therapies in relevant translational animal models prior to human use. This poses a great challenge when the drug is composed of cells, not only because of the living nature of the active ingredient but also...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-18-249

    authors: Ramallo M,Carreras-Sánchez I,López-Fernández A,Vélez R,Aguirre M,Feldman S,Vives J

    更新日期:2020-09-11 00:00:00

  • Potential therapeutic effect of SO₂ on fibrosis.

    abstract::Fibrosis is a pathological feature of most chronic diseases and leads to the dysfunction of various organs. However, there is currently no effective method for treating fibrosis. In recent years, a small gas, sulfur dioxide (SO₂), which can be generated endogenously in mammals, has been found to have vasorelaxation ac...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-18-169

    authors: Wang XB,Cui H,Du JB

    更新日期:2019-12-01 00:00:00

  • Expression of cyclooxygenase-2 in invasive breast carcinomas and its prognostic impact.

    abstract::Representative tumour sections from 468 patients with invasive breast cancer were immunostained for cyclooxygenase-2 (COX-2) and evaluated. The relationships between COX-2 expression, clinical outcome and various clinicopathological variables, including tumour vascularity and disseminated tumour cells (DTC) in the bon...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-27.1315

    authors: Dhakal HP,Naume B,Synnestvedt M,Borgen E,Kaaresen R,Schlichting E,Wiedswang G,Bassarova A,Holm R,Giercksky KE,Nesland JM

    更新日期:2012-10-01 00:00:00

  • Cape Town solution in prolonged myocardial preservation: structural and ultrastructural study.

    abstract::This study deals with myocardial preservation after 24 hours of continuous, hypothermic and oxygenated perfusion with Cape Town (CT) solution, focusing on the morphological changes produced by preservation and reperfusion, and their possible relationship to the composition of the solution and the immediate hemodynamic...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-13.21

    authors: García-Poblete E,Alvarez L,Fernández H,Escudero C,Torralba A

    更新日期:1998-01-01 00:00:00

  • Localization of serotonin, cholecystokinin and somatostatin immunoreactivity in the lower respiratory tract of embryonic, foetal and postnatal sheep.

    abstract::The lower respiratory tract of the sheep was studied by light-microscopical immunocytochemistry for serotonin, cholecystokinin, somatostatin, bombesin and calcitonin during different periods of lung development; embryonic, foetal and postnatal. At embryonic period only intraepithelial serotonin-containing cells as sol...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Balaguer L,Romano J,Ruiz-Pesini P

    更新日期:1992-10-01 00:00:00

  • Recombinant generation of two fragments of the rat complement inhibitory factor H [FH(SCR1-7) and FH(SCR1-4)] and their structural and functional characterization in comparison to FH isolated from rat serum.

    abstract::Factor H (FH) is the predominant soluble inhibitor of the complement system. With a concentration of 200-800 microg/ml in human and rat plasma it acts as a cofactor for the soluble factor I (FI)-mediated cleavage of the component C3b to iC3b. Furthermore it competes with factor B for binding to C3b and C3(H2O) and pro...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-21.93

    authors: Demberg T,Heine I,Götze O,Altermann WW,Seliger B,Schlaf G

    更新日期:2006-01-01 00:00:00

  • Induction system of neural and muscle lineage cells from bone marrow stromal cells; a new strategy for tissue reconstruction in degenerative diseases.

    abstract::Since bone marrow stromal cells (MSCs) are easily accessible both from healthy donors and patients, and can be expanded on a therapeutic scale, they have attracted attention for cell-based therapy. MSCs contribute to the protection of host tissue after transplantation by Immune modulation and trophic effect. They also...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-24.631

    authors: Kitada M,Dezawa M

    更新日期:2009-05-01 00:00:00