Abstract：
:Cyclin A, cyclin E, BUBR1, MAD2 and Aurora A are all cell-cycle regulatory proteins and have been proven to play crucial roles in carcinogenesis. However, their expression patterns in invasive ductal breast carcinoma (IDBC) are controversial and unclear. In this study, we examined the expression status of these candidate proteins in a set of 117 invasive ductal carcinomas, and evaluated their associations with known clinicopathological parameters and the expressions of estrogen receptor, progesterone receptor, Ki-67 and Her-2. Univariate and multivariate data analyses both displayed that positive BUBR1 expression was associated with a high Ki-67 labeling index, and negative MAD2 expression was associated with Her-2 overexpression. Positive BUBR1 expression was also associated with a high histological tumor grade in univariate analysis, but not in multivariate analysis. In addition, high Aurora A expression was weakly associated with lymph node metastasis, and cyclin A was strongly associated with the expression of cyclin E in both univariate and multivariate models. In conclusion, this study suggests that evaluation of BUBR1, MAD2 and Aurora A expression levels is likely to improve accuracy of prognostic predictions in IDBC.
journal_name
Histol Histopatholjournal_title
Histology and histopathologyauthors
Du J,Du Q,Zhang Y,Sajdik C,Ruan Y,Tian XX,Fang WGdoi
10.14670/HH-26.761subject
Has Abstractpub_date
2011-06-01 00:00:00pages
761-8issue
6eissn
0213-3911issn
1699-5848journal_volume
26pub_type
杂志文章abstract：:In the present work we analyze the cerebellum of chronic parkinsonian monkeys in order to clarify whether chronic mesencephalic depletion is associated with long term activation of the cerebellar neurons in chronic Parkinsonism. In our study, we observed a persistent activation of Purkinje cells in the cerebellum of c...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-27.89
更新日期：2012-01-01 00:00:00
abstract：:Cell shape is mainly determined by biophysical constraints, interacting according to non-linear dynamics upon the basic units provided by the genome. In turn, the specific configuration a cell acquires plays a fundamental, permissive role in modulating gene expression and many other complex biological functions. Cell ...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-28.155
更新日期：2013-02-01 00:00:00
abstract：:This study evidences the presence of primordial germ cells, in tissue squash preparations and sections from hematological malignancies. Primordial germ cells were identified by their morphology, the intense PAS, PAS-D reaction and presence of calcium-activated neutral proteinase. Primordial germ cells gave rise to nuc...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1996-10-01 00:00:00
abstract：:Griffonia simplicifolia agglutinin I-B4 (GSAI-B4) has broader specificity for B antigen variants and can recognize the antigens in a wide variety of human tissues. Thus, the concentration range of GSAI-B4 required for staining and the susceptibility of staining to alpha-galactosidase digestion is presumed to correlate...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1997-04-01 00:00:00
abstract：:Soft dental tissues have been identified as easily accessible sources of multipotent postnatal stem cells. Dental stem cells are mesenchymal stem cells (MSC) capable of differentiating into at least three distinct cell lineages: osteo/odontogenic, adipogenic and neurogenic. They express various markers including those...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-29.699
更新日期：2014-06-01 00:00:00
abstract：:We compared characteristic lesions occurring in chickens and domestic ducks naturally infected with H5N1 HPAI virus in April and May 2008. Infected chickens generally exhibited pale-green, watery diarrhoea, depression, neurological signs and cyanosis of wattles and combs, and infected ducks generally exhibited neurolo...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-26.167
更新日期：2011-02-01 00:00:00
abstract：:Nitric oxide (NO) has opened a new and vigorous field of biological and clinical experimentation as evidenced presently by about one hundred original publications every week. Being a biological signal under physiological conditions, NO may be
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：
更新日期：1997-01-01 00:00:00
abstract：:Our study aimed to investigate the association of Pyruvate Kinase isozyme type M2 (PKM2) with radiation resistance in locally advanced cervical squamous cell carcinoma (LACSCC). We retrospectively reviewed 132 female patients who received primary radiation therapy to treat LACSCC at Federation Internationale of Gyneco...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-11-627
更新日期：2015-11-01 00:00:00
abstract：:Many surgical techniques are employed in the treatment of severe obesity. A main consequence of these techniques is the improvement of type 2 Diabetes mellitus. Ghrelin is a gut hormone released in the gastric fundus and corpus, which has been related to diabetic improvement as mentioned in these papers. Sleeve gastre...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-18-200
更新日期：2020-08-01 00:00:00
abstract：:In order to analyze the incidence and prevalence of Human Papillomavirus (HPV) in penile carcinoma, we studied 49 patients with penile carcinoma. Formalin-fixed, paraffin-embedded tissue samples were collected from 64 samples of penile carcinoma from the Hospital General Universitario (Albacete, Spain). Cases were his...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-22.177
更新日期：2007-02-01 00:00:00
abstract：:The renin-angiotensin system (RAS) and tubuloglomerular feedback (TGF) are central to the maintenance of blood pressure and body fluid composition. Renin, NO synthase-1 (NOS-1), and cyclooxygenase-2 (COX-2) are key regulators of the RAS and TGF. In the present study, to investigate species-specific differences in the ...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-23.143
更新日期：2008-02-01 00:00:00
abstract：:Cocaine- and amphetamine-regulated transcript peptide (CART) is a neuromediator and/or neuromodulator in nerve structures within the gastrointestinal tract, but knowledge about its distribution, functions and co-localisation with other neuronal factors, especially in humans, is very scarce. During the present investig...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-28.851
更新日期：2013-07-01 00:00:00
abstract：:The repair of articular cartilage defects is increasingly moving into the focus of experimental and clinical investigations. Histological analysis is the gold standard for a valid and objective evaluation of cartilaginous repair tissue and predominantly relies on the use of established scoring systems. In the past thr...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-11-620
更新日期：2015-08-01 00:00:00
abstract：:Osteoclasts are physiological polykaryons specialized in the resorption of calcified tissue. In the context of the clinical use of calcium-phosphate (CaP) ceramics as bone substitutes, this study used transmission electron microscopy to investigate the in vitro mechanisms of CaP ceramic degradation by osteoclastic cel...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-16.37
更新日期：2001-01-01 00:00:00
abstract：:Macrophages play important roles in host defense mechanisms. In the brain, besides microglial cells, meningeal macrophages are present. However, the pathobiological characteristics of meningeal macrophages in rats remain to be investigated. In normal meninx, immunohistochemically, macrophages reacting to CD163 (macrop...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-24.13
更新日期：2009-01-01 00:00:00
abstract：:Extracellular matrix of meningiomas was studied by light and electron microscopy with the aid of immunohistochemical techniques. Special attention was paid to the distribution of type I, III, IV, V collagens and laminin with a comparison between meningothelial and fibroblastic types. Connective tissue fibers and basem...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1990-07-01 00:00:00
abstract：:Prion diseases are characterized by the accumulation of PrPSc, an altered isoform of a normal cellular protein, PrPc. The prion hypothesis holds that the process of conformational change from PrPc to PrPSc under the influence of PrPSc constitutes the basic infectious mechanism in prion diseases. It is still unknown wh...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：
更新日期：1997-07-01 00:00:00
abstract：:The corneas of nine pipefish, Corythoichthyes paxtoni (Syngnathidae, Teleostei), five freshly fixed and four museum specimens, were examined using light and electron microscopy. In transverse section, the surface of the corneal epithelium is covered by a complex series of ridges or microplicae which extends over the c...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1995-04-01 00:00:00
abstract：:This study concerns the results of penile biopsies in 50 patients aged 27 to 80, with secondary impotence removed with a biopty gun or during penile surgery. The biopty gun specimens were equally representative as the open biopsy ones. The cause and the degree of erectile dysfunction were determined by clinical and la...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1994-07-01 00:00:00
abstract：:During endotoxic shock, the liver exerts a lipopolysaccharide (LPS) clearance function with the participation of both parenchymal and sinusoidal cells. Liver damage could be caused by LPS direct action, hypoxia and/or inflammatory mediators released by Kupffer cells. The aim of this study is to establish an experiment...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1996-07-01 00:00:00
abstract：:The growth of a transplantable murine non-Hodgkin lymphoma tumour, developing either intraperitoneally as an ascites tumour or subcutaneously as a solid tumour, has been shown to be markedly diminished by including phytohaemagglutinin (PHA), a lectin present in raw kidney bean (Phaseolus vulgaris) in the diet. In NMRI...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-13.575
更新日期：1998-04-01 00:00:00
abstract：:The effect of chronic alcoholism on the human hippocampus was studied in 21 patients, divided in 4 groups: Group A under 45 years, group B 46-59 years, group C 60-69, and Group D over 70 years; and compared with age-matched control patients who died without neurological complications. The gyrus dentatus and the ammoni...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1990-07-01 00:00:00
abstract：:The effects of the administration of cyclophosphamide to male rats at doses of 400 mg/m2 for a period of 5 days and of 200 mg/m2 over two five-day cycles interrupted by a 21-day break reveal differences in the ultrastructural morphology of gonadotrophic cells between treated animals and normal controls. The ultrastruc...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1990-04-01 00:00:00
abstract：:Pulmonary fibrosis is a common response to various injuries to the lung. The resolution of a fibroproliferative response after lung injury is key to survival. Although there are various initiating factors or causes, the terminal stages are characterized by proliferation and progressive accumulation of connective tissu...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-19.867
更新日期：2004-07-01 00:00:00
abstract：:Processing adult human trabecular bone to obtain tissue sections suitable for research or diagnostic purposes has always been challenging, particularly in the preparation of adult bone specimens for advanced immunohistochemistry applications. In contrast to the majority of soft tissues, decalcified bone samples perfor...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-28.1605
更新日期：2013-12-01 00:00:00
abstract：:The developing fetal brain is one of the most susceptible organs to irradiation insult. Prenatal irradiation-induced abnormalities in the cerebrum have been well examined in mouse fetuses. However, little information on abnormalities in the cerebellum caused by irradiation is available. Moreover, few reports have exam...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-23.953
更新日期：2008-08-01 00:00:00
abstract：:The influence of He-Ne laser radiation on the formation of new blood vessels in the bone marrow compartment of a regenerating area of the mid-cortical diaphysis of the tibiae of young adult rats was studied. A small hole was surgically made with a dentistry burr in the tibia and the injured area received a daily laser...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-19.43
更新日期：2004-01-01 00:00:00
abstract：:STAT and SMAD often exert opposite biological effects on diverse cellular functions. Recent studies have shown that STAT can interface with SMAD at molecular level and that some novel molecules, such as SOCS (also called CIS) and APRO6 (also called TOB), modulate this signaling. A cofactor p300/CBP might act as a brid...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-17.887
更新日期：2002-01-01 00:00:00
abstract：:The liver represents a site of expression of neurotrophins and their receptors. We have characterized the expression and intracellular localization of the nerve growth factor (NGF) receptor, Trk-A, in liver cells in vivo and in vitro. In both normal and fibrotic liver tissue, Trk-A immunostaining was present in differ...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-23.327
更新日期：2008-03-01 00:00:00
abstract：:Smads are signal transducers for the members of the TGF-beta superfamily. Of these Smads, Smad4 is essential for TGF-beta signaling. The purpose of this study was to elucidate Smad4 expression and localization in 65 gastric adenomas, 49 intestinal-type and 39 diffuse type of gastric adenocarcinomas (including 12 cases...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-20.543
更新日期：2005-04-01 00:00:00
