An ultrastructural and immunohistochemical study of extracellular matrix in meningiomas.


:Extracellular matrix of meningiomas was studied by light and electron microscopy with the aid of immunohistochemical techniques. Special attention was paid to the distribution of type I, III, IV, V collagens and laminin with a comparison between meningothelial and fibroblastic types. Connective tissue fibers and basement membrane were not found among the tumor cells in the meningothelial type, but were found in the fibroblastic type. The immunolocalizations were consistently demonstrated extracellularly, but were not within the cytoplasm. Type I, III and V collagens were usually demonstrated in the fibrous septum in the meningothelial type, while they were localized among the tumor cells in the fibroblastic type. Furthermore, type IV collagen and laminin were demonstrated within the vascular walls or around the syncytium in the meningothelial type, while they were localized among the tumor cells in the fibroblastic type. In both types the expression of type IV collagen and laminin was closely related to the distribution of basement membrane. Although meningothelial and fibroblastic meningiomas showed quite different distribution of extracellular matrices, the profile of collagen types expressed by these two basic types was essentially the same. The cellular derivation of meningiomas was discussed with particular attention to the structure of human arachnoid villi and meninges.


Histol Histopathol


Nitta H,Yamashima T,Yamashita J,Kubota T


Has Abstract


1990-07-01 00:00:00












  • Effects of Helicobacter pylori on biological characteristics of gastric epithelial cells.

    abstract::Infection with Helicobacter pylori (H. pylori) strains is linked to an increased risk of inflammation and gastric cancer. To investigate the effects of H. pylori on biological characteristics of gastric epithelial cells SGC-7901, derived from human adenocarcinoma, morphological appearances of both the pathogen and the...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Wang P,Mei J,Tao J,Zhang N,Tian H,Fu GH

    更新日期:2012-08-01 00:00:00

  • In vivo toxicity of the ribosome-inactivating lectin ebulin f in elderly mice.

    abstract::Ebulin f is a ribosome-inactivating protein (RIP) present in green fruits of the dwarf elder (Sambucus ebulus L). Since dwarf elder fruits are used for food and as a medicine, we assessed the study of toxicological effects and safety of ebulin f in elderly mice, comparing these results with those reported in young ani...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Garrosa M,Jiménez P,Córdoba-Díaz D,García-Recio V,Gayoso S,Rojo MÁ,Gayoso MJ,Girbés T

    更新日期:2018-09-01 00:00:00

  • DEC1 expression in 1p-aberrant oligodendroglial neoplasms.

    abstract:BACKGROUND:Expression of hypoxia-related tissue factors in 1p-aberrant oligodendroglial neoplasms diminishes patient outcome. Differentiated embryo-chondrocyte expressed gene 1 (DEC1) has been described as novel hypoxia-related tissue factor. In our study, we assessed the expression of DEC1 in 1p aberrant oligodendrogl...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Preusser M,Birner P,Ambros IM,Ambros PF,Budka H,Harris AL,Hainfellner JA

    更新日期:2005-10-01 00:00:00

  • Epidemiology and molecular biology of gastrointestinal stromal tumors (GISTs): a population-based study in the South of Switzerland, 1999-2005.

    abstract::Introduction. Gastrointestinal stromal tumors (GISTs) are characterized at the molecular level by c-kit or PDGFRA oncogene mutations. Although GISTs raised major interest in past decades, population-based studies are still rare. Materials and Methods. All GISTs diagnosed in Southern Switzerland (1999-2005) were identi...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Mazzola P,Spitale A,Banfi S,Mazzucchelli L,Frattini M,Bordoni A

    更新日期:2008-11-01 00:00:00

  • New models towards assessing anti-cancer therapeutics.

    abstract::Cancer is the subject of intense research around the world, but many questions about how the disease works remain unanswered. How exactly does cancer start and how do tumours grow? In fact, at present there are ten times more anticancer drugs being tested in clinical trials than there were 15 years ago. However, many ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Romero-Camarero I,Barajas-Diego M,Castellanos-Martín A,García-Martín Á,Varela G,Abad M,Ludeña MD,Pérez-Losada J,Sánchez-García I

    更新日期:2012-02-01 00:00:00

  • Expression of mitotic kinases phospho-aurora A and aurora B correlates with clinical and pathological parameters in bladder neoplasms.

    abstract::Aurora A and Aurora B are serine-threonine kinase proteins which have both been implicated in human carcinogenesis through development of aneuploidy and chromosomal instability. The aim of the study is to assess the correlation of both markers with clinical and pathological parameters in patients with bladder cancer o...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Bufo P,Sanguedolce F,Tortorella S,Cormio L,Carrieri G,Pannone G

    更新日期:2010-11-01 00:00:00

  • Localization of blood coagulation factors in the germinal centers of human Peyer's patches.

    abstract::The immunohistochemical distribution of 15 blood coagulation factors in the germinal centers (GCs) of human Peyer's patches (PPs) was studied. Although factor VIII, active alpha-thrombin, and fibrinogen were hardly evident in the GCs, the majority of coagulation factors, such as kallikrein, high-molecular-weight kinin...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Kudo S,Yamakawa M,Imai Y,Tsukamoto M

    更新日期:1992-04-01 00:00:00

  • Histochemical aspects of the yolk-sac and digestive tract of larvae of the Senegal sole, Solea senegalensis (Kaup, 1858).

    abstract::Histochemical distribution of glycoproteins, carbohydrates and proteins rich in different amino acids were studied using histological and histochemical procedures, in Senegal sole, Solea senegalensis (Kaup, 1858) larvae from hatching until day 15. Glycogen, proteins and glycoproteins were detected in the yolk-sac of t...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Sarasquete C,González de Canales ML,Arellano JM,Muñoz-Cueto JA,Ribeiro L,Dinis MT

    更新日期:1996-10-01 00:00:00

  • Pathophysiology of stem cells in restenosis.

    abstract::Recent evidence has shown that vascular function depends not only on cells within the vessels, but is also significantly modulated by circulating cells derived from the bone marrow. A number of studies indicate that an early reendothelialization by circulating endothelial precursors after vascular injury prevents exce...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Forte A,Cipollaro M,Cascino A,Galderisi U

    更新日期:2007-05-01 00:00:00

  • Oxidative damage in age-related macular degeneration.

    abstract::Epidemiologic studies have suggested that elderly patients who consumed diets rich in antioxidants throughout their lives are less likely to be afflicted with age-related macular degeneration (AMD). This led to the Age-Related Eye Disease Study, which showed that supplements containing antioxidant vitamins and zinc re...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Shen JK,Dong A,Hackett SF,Bell WR,Green WR,Campochiaro PA

    更新日期:2007-12-01 00:00:00

  • Physiopathologic dynamics of vesicle traffic in astrocytes.

    abstract::The view of how astrocytes, a type of glial cells, contribute to the functioning of the central nervous system (CNS) has changed greatly in the last decade. Although glial cells outnumber neurons in the mammalian brain, it was considered for over a century that they played a subservient role to neurons. This view chan...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Potokar M,Stenovec M,Kreft M,Gabrijel M,Zorec R

    更新日期:2011-02-01 00:00:00

  • Myofibroblasts and myoepithelial cells in the chicken harderian gland.

    abstract::An electron microscopic study of the myoepithelial cells in the chicken Harderian gland provides evidence that these cells can be transformed into myofibroblasts. After the application of a Brucella ovis suspension in sterile saline onto the eyeball, every 5 minutes for half an hour, myoepithelial cells gradually deve...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: del Cacho E,Gallego M,Felices C,Bascuas JA

    更新日期:1991-07-01 00:00:00

  • Transcriptional mRNA of BMP-2, 3, 4 and 5 in trigeminal nerve, benign and malignant peripheral nerve sheath tumors.

    abstract::The aim of our study was to document whether relationships existed among bone morphogenetic proteins (BMPs), peripheral nerve and neoplastic lesions of nerve sheath tumors. The mRNA transcriptions of BMP-2, 3, 4 and 5 in 10 cases of schwannoma, three cases of malignant schwannoma and two cases of trigeminal neuralgia ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Jin Y,Lu HB,Liong E,Lau TY,Tipoe GL

    更新日期:2001-10-01 00:00:00

  • Domestic microwave processing for rapid immunohistochemical diagnosis of bovine rabies.

    abstract::The present study describes the use of a microwave processing protocol for the rapid histopathological and immunohistochemical diagnosis of bovine rabies. Immunohistochemistry has been used for rabies diagnosis in formalin-fixed tissue with satisfactory results, although the time to diagnosis is considerably longer th...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Abreu CC,Nakayama PA,Nogueira CI,Mesquita LP,Lopes PF,Varaschin MS,Seixas Jdo N,Ferreira E,Bezerra PS Jr

    更新日期:2012-09-01 00:00:00

  • Neutrophil gelatinase-associated lipocalin (NGAL) immunohistochemical expression in follicular cell-derived thyroid tumors: a novel diagnostic tool?

    abstract::Discrimination of follicular cell-derived benign and malignant tumors of the thyroid is one of the major problems encountered in surgical pathology. In the present study, we evaluated the immunohistochemical expression of NGAL, an iron-binding protein involved in the infiltrative potential of cancer cells, in a cohort...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Barresi V,Leni A,Tuccari G,Barresi G

    更新日期:2012-03-01 00:00:00

  • Tissue and molecular events in human conjunctival scarring in ocular cicatricial pemphigoid.

    abstract::Detailed histomorphometric analysis of human conjunctival biopsy specimens has convincingly demonstrated that tissue remodeling of the extracellular matrix (ECM) is an essential and dynamic process associated with conjunctival scarring in ocular cicatricial pemphigoid (OCP). The conjunctival scarring often eventually ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Razzaque MS,Foster CS,Ahmed AR

    更新日期:2001-10-01 00:00:00

  • Current knowledge of dystrophin and dystrophin-associated proteins in the retina.

    abstract::Dramatical development of molecular genetics has been disclosing the molecular mechanism of Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD). DMD gene product, dystrophin, is a submembranous cytoskeletal protein and many dystrophin-associated proteins (DAPs) have been identified, such as utrophin,...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Ueda H,Baba T,Ohno S

    更新日期:2000-07-01 00:00:00

  • Effects of orexins A and B on the secretory and proliferative activity of immature and regenerating rat adrenal glands.

    abstract::Orexins A and B are two hypothalamic peptides, involved in the central regulation of feeding, which act through two receptor subtypes, named OX1R and OX2R. OX1R is selective for orexin-A, and OX2R binds both orexins. We have investigated the effects of three subcutaneous injections of 10 nmol/kg body weight of orexins...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Malendowicz LK,Jedrzejczak N,Belloni AS,Trejter M,Hochól A,Nussdorfer GG

    更新日期:2001-07-01 00:00:00

  • Chaperone-mediated autophagy in cancer: Advances from bench to bedside.

    abstract::Chaperone-mediated autophagy (CMA), a selective form of autophagy, where cellular proteins with KFERQ-like motif are targeted to the lysosome for degradation, is necessary to maintain cellular homeostasis. The role of CMA in neurodegenerative diseases has been extensively studied in the past decades, with defects in t...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Hou T,Fan Y,Dan W,Liu B,Wang Z,Zeng J,Li L

    更新日期:2020-07-01 00:00:00

  • An immunohistochemical study of NFE2L2, KEAP1 and 8-hydroxy-2'-deoxyguanosine and the EMT markers SNAI2, ZEB1 and TWIST1 in metastatic melanoma.

    abstract:BACKGROUND:Little is known regarding the role of redox balance regulators in metastatic melanomas, but there is some evidence for a link between epithelial-to-mesenchymal transition (EMT) and cellular redox status. METHODS:We compared the immunohistochemical expression of nuclear factor erythroid-2-related factor 2 (N...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Hintsala HR,Haapasaari KM,Soini Y,Karihtala P

    更新日期:2017-02-01 00:00:00

  • Multilocular cystic renal cell carcinoma with focus on clinical and pathobiological aspects.

    abstract::Multilocular cystic renal cell carcinoma (MCRCC) accounts for approximately 1 to 2% of all renal tumors. This tumor is currently classified as a subtype of clear cell RCC. Clinically, the majority of these tumors are incidentally found. Macroscopically, the tumor is well demarcated and consists of various-sized cysts....

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Kuroda N,Ohe C,Mikami S,Inoue K,Nagashima Y,Cohen RJ,Pan CC,Michal M,Hes O

    更新日期:2012-08-01 00:00:00

  • The role of TET family proteins and 5-hydroxymethylcytosine in human tumors.

    abstract::Tumorigenesis correlates with hypermethylation of tumor suppressors and hypomethylation of oncogenes. DNA methyltransferases (DNMTs) catalyze DNA methylation, and mutations and aberrant expression in DNMT genes are found in multiple human tumors. The discovery of the DNA demethylation function of TET proteins has open...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Wu YC,Ling ZQ

    更新日期:2014-08-01 00:00:00

  • Morphological hysteresis of the small airways.

    abstract::The resistance to airflow that develops in most obstructive processes takes place in the small airways. The aim of the present paper is to describe bronchial hysteresis morphometrically in a respiratory cycle model. As a working hypothesis, it is proposed that the changes that take place in the respiratory tract durin...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Escolar JD,Escolar MA,Guzmán J,Roqués M

    更新日期:2003-01-01 00:00:00

  • Physical forces and non linear dynamics mould fractal cell shape: quantitative morphological parameters and cell phenotype.

    abstract::Cell shape is mainly determined by biophysical constraints, interacting according to non-linear dynamics upon the basic units provided by the genome. In turn, the specific configuration a cell acquires plays a fundamental, permissive role in modulating gene expression and many other complex biological functions. Cell ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Bizzarri M,Pasqualato A,Cucina A,Pasta V

    更新日期:2013-02-01 00:00:00

  • Dental stem cells--characteristics and potential.

    abstract::Soft dental tissues have been identified as easily accessible sources of multipotent postnatal stem cells. Dental stem cells are mesenchymal stem cells (MSC) capable of differentiating into at least three distinct cell lineages: osteo/odontogenic, adipogenic and neurogenic. They express various markers including those...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Bojic S,Volarevic V,Ljujic B,Stojkovic M

    更新日期:2014-06-01 00:00:00

  • Morphological changes in the rat exocrine pancreas after pancreatic duct ligation.

    abstract::In the present study, morphological changes of the exocrine pancreas in rats after pancreatic duct ligation were examined with light microscopy (hematoxylin-eosin, TUNEL, and PCNA staining) and scanning electron microscopy in order to elucidate the effects of increased pancreatic duct pressure. On the fifth day after ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Hamamoto N,Ashizawa N,Niigaki M,Kaji T,Katsube T,Endoh H,Watanabe M,Sumi S,Kinoshita Y

    更新日期:2002-10-01 00:00:00

  • New insights into the cytoplasmic function of PML.

    abstract::PML is a tumour suppressor inactivated in Acute Promyelocytic Leukaemia (APL). PML is the essential component of a subnuclear structure called the PML nuclear body (PML-NB), which is disrupted in APL. By targeting different cellular proteins to this structure, PML can either hamper or potentiate their functions. The P...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Salomoni P,Bellodi C

    更新日期:2007-08-01 00:00:00

  • Markers of squamocolumnar junction cells in normal tonsils and oropharyngeal cancer with and without HPV infection.

    abstract::HPV infection has been identified recently as the causative agent of a subset of squamous cell carcinomas arising in oropharyngeal tonsils. Factors influencing the susceptibility of tonsillar epithelium to HPV-induced oncogenesis are far from being elucidated. A 5-protein signature including cytokeratin (CK)7, anterio...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Morbini P,Capello GL,Alberizzi P,Benazzo M,Paglino C,Comoli P,Pedrazzoli P

    更新日期:2015-07-01 00:00:00

  • Time-dependent effects of maternal continuous propranolol on fetal lung development in rats.

    abstract::Previous studies have demonstrated a role for the beta-adrenergic system in the maturation of the fetal alveolar epithelium. Chronic blockade of beta-adrenergic binding sites has been shown to adversely effect physiologic and biochemical indices of fetal lung maturation. In the present study timed-pregnant female Spra...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Smith DM,Sommers SS

    更新日期:2002-04-01 00:00:00

  • Nitric oxide, a biological double-faced janus--is this good or bad?

    abstract::Nitric oxide (NO) is a biological messenger molecule produced by one of the essential amino acids L-arginine by the catalytic action of the enzyme NO synthase (NOS). The dual role of NO as a protective or toxic molecule is due to several factors, such as; the isoform of NOS involved, concentration of NO and the type o...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Thippeswamy T,McKay JS,Quinn JP,Morris R

    更新日期:2006-04-01 00:00:00