Defect of the cerebellar vermis induced by prenatal gamma-ray irradiation in radiosensitive BALB/c mice.

Abstract:

:The developing fetal brain is one of the most susceptible organs to irradiation insult. Prenatal irradiation-induced abnormalities in the cerebrum have been well examined in mouse fetuses. However, little information on abnormalities in the cerebellum caused by irradiation is available. Moreover, few reports have examined the chronological changes of the brain from the prenatal to the postnatal period. To analyze the chronological changes induced by irradiation, we exposed pregnant mice to gamma-ray irradiation on embryonic day 13.5 (E13.5) and investigated the histopathology of the cerebellum at several time points from E14.5 to postnatal day 28. BALB/cA mice were used, which is a radiosensitive strain, and C57BL/6J, which is a radioresistant strain. The irradiated BALB/c showed a remarkable vermis deficit after birth, and histological analysis demonstrated that there were severe losses of the external germinal layer (EGL) and Purkinke cell layer. TUNEL analysis shoed that apoptosis was strongly induce in the cerebellar anlage of the irradiated BALB/c compared to the C57BL/6J at E14.5. Immunohistochemical analysis revealed a significant decrease of phospho-histone H3 positive EGL cells in the irradiated BALB/c at E18.5 and E0, indicating that irradiation causes a decrease in the number of mitotic cells. The results suggest that the strong induction of apoptosis in radiosensitive BALB/c led to a decrease of proliferation activity in the cerebellar anlage during embryonic development, and consequently, severe cerebellar abnormality was evoked.

journal_name

Histol Histopathol

authors

Saito A,Yamauchi H,Ishida Y,Ohmachi Y,Nakayama H

doi

10.14670/HH-23.953

subject

Has Abstract

pub_date

2008-08-01 00:00:00

pages

953-64

issue

8

eissn

0213-3911

issn

1699-5848

journal_volume

23

pub_type

杂志文章
  • Alveolar cells in cyclophosphamide-induced lung injury. II. Pathogenesis of experimental endogenous lipid pneumonia.

    abstract::An ultrastructural and histological study was made to analyse the structural and cellular features of the pulmonary lesions produced in Wistar rats by intraperitoneal (i.p.) administration of cyclophosphamide (two i.p. doses of 150 mg CP/1 kg bw/1 ml PBS). Rats exposed to cyclophosphamide (CP) developed a condition wh...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-14.1145

    authors: Sulkowski S,Sulkowska M

    更新日期:1999-10-01 00:00:00

  • Influence of age on the production of rat spermatozoa, on their concentration in the cauda epididymidis, and on FSH, LH and testosterone plasma levels.

    abstract::Testis samples were taken from young (3 months), middle-aged (12 months) and aged (24 months) male rats, processed, stained and examined via a light microscope. There were no prominent abnormal germinal epithelium and interstitial tissue. However, the aging process promoted a significant decrease in the mean amount of...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Carvalho TL,Favaretto AL,Komesu MC,Lopes RA,Petenusci SO,Silva-Netto CR

    更新日期:1988-10-01 00:00:00

  • Renal clear-cell carcinoma: an ultrastructural study on the junctional complexes.

    abstract::Junctional complexes such as tight junctions, adherens junctions, and desmosomes play crucial roles in the structure and function of epithelial cells. These junctions are involved in increasing cell-cell contact and as well serve as signaling centers regulating multiple functions in epithelial cells. Carcinoma cell li...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-20.35

    authors: Kim G,Rajasekaran SA,Thomas G,Rosen EA,Landaw EM,Shintaku P,Lassman C,Said J,Rajasekaran AK

    更新日期:2005-01-01 00:00:00

  • Review of mucinous tubular and spindle-cell carcinoma of the kidney with a focus on clinical and pathobiological aspects.

    abstract::Recently, the characterization of mucinous tubular and spindle-cell carcinoma (MTSCC) has been established. MTSCC predominantly occurs in females. This tumor is histologically characterized by eosinophilic cytoplasm, elongated and anastomosing tubules, myxomatous stroma and low-grade nuclear cytology. Proliferation of...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-20.221

    authors: Kuroda N,Toi M,Hiroi M,Shuin T,Enzan H

    更新日期:2005-01-01 00:00:00

  • Interocular effect of intravitreal injection of 6-hydroxydopamine and dopamine on spinule formation in teleost retina.

    abstract::Terminal dendrites of cone horizontal cells (HCs) in teleost retinas show numerous spine-like protrusions named spinules, which are invaginated into the cone pedicles during light-adaptation, but retracted during dark-adaptation. Somata of HC show nematosomes whose size decreases as the number of spinules increases. M...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-17.721

    authors: García M,Grzywacz NM,De Juan J

    更新日期:2002-01-01 00:00:00

  • Toxicity of non-steroidal anti-inflammatory drugs: a review of melatonin and diclofenac sodium association.

    abstract::Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for the purpose of anti-inflammation, antipyretic, and analgesia. For this aim, they are used for the alleviation of pain, fever, and inflammation associated with rheumatoid arthritis, sports injuries, and temporary pain. However, treatment with NSAIDs may ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-27.417

    authors: Aygün D,Kaplan S,Odaci E,Onger ME,Altunkaynak ME

    更新日期:2012-04-01 00:00:00

  • Transcriptional mRNA of BMP-2, 3, 4 and 5 in trigeminal nerve, benign and malignant peripheral nerve sheath tumors.

    abstract::The aim of our study was to document whether relationships existed among bone morphogenetic proteins (BMPs), peripheral nerve and neoplastic lesions of nerve sheath tumors. The mRNA transcriptions of BMP-2, 3, 4 and 5 in 10 cases of schwannoma, three cases of malignant schwannoma and two cases of trigeminal neuralgia ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-16.1013

    authors: Jin Y,Lu HB,Liong E,Lau TY,Tipoe GL

    更新日期:2001-10-01 00:00:00

  • Immunohistochemical determination of mTOR pathway molecules in ovaries and uterus in rat estrous cycle stages.

    abstract::mTOR is a member of the PI3K/Akt/mTOR signaling pathway that participates in cell growth, proliferation, protein synthesis, transcription, angiogenesis, apoptosis and autophagy. mTOR and MAPK pahways are two important key signal pathways which are related to each other. We investigated the role of mTOR and other signa...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-18-258

    authors: Ekizceli G,Inan S,Oktem G,Onur E,Ozbilgin K

    更新日期:2020-11-01 00:00:00

  • Keratins in the human trophoblast.

    abstract::Besides microfilaments and microtubules, intermediate filaments are major components of the cytoskeleton. In epithelial cells intermediate filaments are formed by heterodimers of specific keratins, whose expression pattern highly depends on the type of epithelium and differentiation degree of the cell. During the proc...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-28.817

    authors: Gauster M,Blaschitz A,Siwetz M,Huppertz B

    更新日期:2013-07-01 00:00:00

  • BDNF function and intracellular signaling in neurons.

    abstract::Brain-derived neurotrophic factor (BDNF) and its receptor, TrkB, are broadly expressed in the developing and adult mammalian brain. BDNF/TrkB-stimulated intracellular signaling is critical for neuronal survival, morphogenesis, and plasticity. It is well known that binding of BDNF to TrkB elicits various intracellular ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-25.237

    authors: Numakawa T,Suzuki S,Kumamaru E,Adachi N,Richards M,Kunugi H

    更新日期:2010-02-01 00:00:00

  • Molecular and morphological characterization of neural tube defects in embryos of diabetic Swiss Albino mice.

    abstract:BACKGROUND AND RESULTS:Embryos from diabetic mice exhibit several forms of neural tube defects, including non-closure of the neural tube. In the present study, embryos collected at embryonic day 11.5 from diabetic pregnancies displayed open neural tube with architectural disruption of the surrounding tissues. The perce...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-26.965

    authors: Loh WT,Dheen ST,Jiang B,Kumar SD,Tay SS

    更新日期:2011-08-01 00:00:00

  • Therapeutic perspectives for the treatment of Huntington's disease: treating the whole body.

    abstract::Huntington's disease (HD) is a tremendously debilitating disorder that strikes relatively young individuals and progresses rapidly over the next ten to fifteen years inducing a loss of cognitive and motor skills and eventually death occurs. The primary locus of the disorder is a polyglutamine expansion of the protein ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-23.237

    authors: Martin B,Golden E,Keselman A,Stone M,Mattson MP,Egan JM,Maudsley S

    更新日期:2008-02-01 00:00:00

  • Bacillary angiomatosis. A "new" disease with a broadening clinicopathologic spectrum.

    abstract::Bacillary angiomatosis (BA) is a reactive vasoproliferative lesion occurring almost exclusively in immunocompromised individuals in response to infection by a bacillus closely related to Rochalimaea quintana. The commonest site of involvement is the skin, in the form of multiple erythematous nodules, but bacillary ang...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:

    authors: Tsang WY,Chan JK

    更新日期:1992-01-01 00:00:00

  • Physiological and pathological significance of the molecular cross-talk between autophagy and apoptosis.

    abstract::Autophagy and apoptosis are two important molecular mechanisms that maintain cellular homeostasis under stress conditions. Autophagy represents an intracellular mechanism responsible for turnover of organelles and long-lived proteins through a lysosome-dependent degradation pathway. Cell death signals or sustained str...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-11-714

    authors: Oral O,Akkoc Y,Bayraktar O,Gozuacik D

    更新日期:2016-05-01 00:00:00

  • An up-date on newly discovered immunohistochemical biomarkers for the diagnosis of human testicular germ cell tumors.

    abstract::Although testicular germ cell tumors (TGCTs) are relatively uncommon, they are particularly important, as they tend to affect children and young men, the most common tumor being in males aged from 20 to 40 years, and the incidence has been increasing in the last years. TGCTs comprise two major histologic groups: semin...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-29.999

    authors: Chieffi P,Chieffi S

    更新日期:2014-08-01 00:00:00

  • Neutrophil gelatinase-associated lipocalin (NGAL) immunohistochemical expression in follicular cell-derived thyroid tumors: a novel diagnostic tool?

    abstract::Discrimination of follicular cell-derived benign and malignant tumors of the thyroid is one of the major problems encountered in surgical pathology. In the present study, we evaluated the immunohistochemical expression of NGAL, an iron-binding protein involved in the infiltrative potential of cancer cells, in a cohort...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-27.329

    authors: Barresi V,Leni A,Tuccari G,Barresi G

    更新日期:2012-03-01 00:00:00

  • Atrial natriuretic peptide in the heart and pancreas.

    abstract::We used antisera to pure atrial natriuretic peptide to localise this peptide by immunocytochemistry in rat and human tissue. We showed that both rat and human atrial cardiocytes gave a positive reaction while ventricular cardiocytes were consistently negative. Peripheral islet cells in rat but not in human pancreas al...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Lindop GB,Mallon EA,MacIntyre G

    更新日期:1986-04-01 00:00:00

  • Review of papillary renal cell carcinoma with focus on clinical and pathobiological aspects.

    abstract::Recent studies have shown that papillary renal cell carcinoma (RCC) is clinically and genotypically a distinct entity. Papillary RCCs account for about 10-15% of renal parenchymal neoplasms. Macroscopically, the cut surface is yellow or brown in color and large tumors frequently show cystic change. Hemorrhage and necr...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-18.487

    authors: Kuroda N,Toi M,Hiroi M,Enzan H

    更新日期:2003-04-01 00:00:00

  • High prevalence of human papillomavirus 16 in penile carcinoma.

    abstract::In order to analyze the incidence and prevalence of Human Papillomavirus (HPV) in penile carcinoma, we studied 49 patients with penile carcinoma. Formalin-fixed, paraffin-embedded tissue samples were collected from 64 samples of penile carcinoma from the Hospital General Universitario (Albacete, Spain). Cases were his...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-22.177

    authors: Pascual A,Pariente M,Godínez JM,Sánchez-Prieto R,Atienzar M,Segura M,Poblet E

    更新日期:2007-02-01 00:00:00

  • Microtubules regulate aortic endothelial cell actin microfilament reorganization in intact and repairing monolayers.

    abstract::To understand the role of microtubules and microfilaments in regulating endothelial monolayer integrity and repair, and since microtubules and microfilaments show some co-alignment in endothelial cells, we tested the hypothesis that microtubules organize microfilament distribution. Disruption of microtubules with colc...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-20.455

    authors: Lee JS,Gotlieb AI

    更新日期:2005-04-01 00:00:00

  • Muscle fiber types in tetrapods. A comparative histochemical and morphometric study.

    abstract::A comparative histochemical and morphometric study in two groups of homologous muscles from different tetrapods (rat, pigeon, lizard and frog) was performed. On the basis of their fiber diameters and oxidative enzyme activities, an initial correlation between fiber types of all animals is observed, although in the liz...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Burgos Bretones JJ,Razquin Peralta B,Aguirre Urizar J,Rivera Pomar JM

    更新日期:1987-01-01 00:00:00

  • Nigral degeneration correlates with persistent activation of cerebellar Purkinje cells in MPTP-treated monkeys.

    abstract::In the present work we analyze the cerebellum of chronic parkinsonian monkeys in order to clarify whether chronic mesencephalic depletion is associated with long term activation of the cerebellar neurons in chronic Parkinsonism. In our study, we observed a persistent activation of Purkinje cells in the cerebellum of c...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-27.89

    authors: Heman P,Barcia C,Gómez A,Ros CM,Ros-Bernal F,Yuste JE,de Pablos V,Fernandez-Villalba E,Toledo-Cárdenas MR,Herrero MT

    更新日期:2012-01-01 00:00:00

  • Microvascular changes in relation to inflammation and epidermal hyperplasia in chronic cutaneous lesions of psoriasis vulgaris.

    abstract::Epidermal proliferation, inflammatory changes and microvascular augmentation are prominent features of chronic cutaneous psoriatic lesions. The objective of this study was the investigation of blood and lymphatic microvascular changes in relation to epidermal changes and inflammatory infiltration in dermis. Immunohist...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-11-811

    authors: Výbohová D,Adamicová K,Mellová Y,Hešková G

    更新日期:2017-05-01 00:00:00

  • A truncated isoform of the PP2A B56gamma regulatory subunit reduces irradiation-induced Mdm2 phosphorylation and could contribute to metastatic melanoma cell radioresistance.

    abstract::F10, a subline of the B16 mouse melanoma cell line, is itself the parent of the more metastatic BL6 line. BL6 cells differ from F10 cells by an alteration of the gene encoding the B56gamma regulatory subunit of protein phosphatase 2A (PP2A), which results in mRNA encoding a truncated variant of the subunit (deltagamma...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-19.391

    authors: Koma YI,Ito A,Watabe K,Kimura SH,Kitamura Y

    更新日期:2004-04-01 00:00:00

  • Potential therapeutic effect of SO₂ on fibrosis.

    abstract::Fibrosis is a pathological feature of most chronic diseases and leads to the dysfunction of various organs. However, there is currently no effective method for treating fibrosis. In recent years, a small gas, sulfur dioxide (SO₂), which can be generated endogenously in mammals, has been found to have vasorelaxation ac...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-18-169

    authors: Wang XB,Cui H,Du JB

    更新日期:2019-12-01 00:00:00

  • Elastin variations implicating in vascular smooth muscle cells phenotype in human tortuous arteries.

    abstract::The aim of the present work was to study the morphological implications between the elastin and the phenotypic expression of the vascular smooth muscle cells. For this purpose, sixty human tortuous arteries from different territories have been studied. We have measured the morphometric indexes Intimal Thickening Index...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-15.95

    authors: Ortiz PP,Sarrat R,Daret D,Whyte J,Torres A,Lamazière JM

    更新日期:2000-01-01 00:00:00

  • Epithelial integrity, cell death and cell loss in mammalian small intestine.

    abstract::In recent years, the different mechanisms of epithelial cell loss which occur in mammalian and avian small intestine have been re-investigated. Information is now available for a variety of mammalian types and mechanisms can be divided into two major classes: [i] those preserving epithelial integrity by maintaining in...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-14.257

    authors: Mayhew TM,Myklebust R,Whybrow A,Jenkins R

    更新日期:1999-01-01 00:00:00

  • Melanopsin-expressing retinal ganglion cells in aging and disease.

    abstract::Melanopsin-expressing retinal ganglion cells (mRGCs) constitute a system in the mammalian retina used for irradiance detection, regulating non-image forming functions, such as photoentrainment of circadian rhythms, control of the pupillary light reflex, masking response, light-regulated melatonin secretion, and modula...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-18-138

    authors: Esquiva G,Hannibal J

    更新日期:2019-12-01 00:00:00

  • Ultrastructural study of the clearance of intracerebrally infused native and modified albumin-gold complexes.

    abstract::The main objective of this ultrastructural study was to gain a better understanding of the involvement of brain vasculature in clearance of proteins from edematous fluid. For this purpose, both native and modified (cationized, glucosylated, and mannosylated) bovine serum albumin-gold complexes (BSA-G, catBSA-G, glucBS...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-13.647

    authors: Dobrogowska DH,Lossinsky AS,Vorbrodt AW

    更新日期:1998-07-01 00:00:00

  • Primary papillary psammomatous adenocarcinoma of the umbilicus.

    abstract::The histological and ultrastructural features, as well as the immunoreactivity of one case of uncommon primary papillary and psammomatous adenocarcinoma of the umbilicus are studied in the present work. The observations have been undertaken in a nine-year follow-up, and have included the primitive tumour, two local re...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Hernández N,Medina V,Alvarez-Arguelles H,Gutiérrez R,Pérez-Palma J,Díaz-Flores L

    更新日期:1993-10-01 00:00:00