Defect of the cerebellar vermis induced by prenatal gamma-ray irradiation in radiosensitive BALB/c mice.

Abstract:

:The developing fetal brain is one of the most susceptible organs to irradiation insult. Prenatal irradiation-induced abnormalities in the cerebrum have been well examined in mouse fetuses. However, little information on abnormalities in the cerebellum caused by irradiation is available. Moreover, few reports have examined the chronological changes of the brain from the prenatal to the postnatal period. To analyze the chronological changes induced by irradiation, we exposed pregnant mice to gamma-ray irradiation on embryonic day 13.5 (E13.5) and investigated the histopathology of the cerebellum at several time points from E14.5 to postnatal day 28. BALB/cA mice were used, which is a radiosensitive strain, and C57BL/6J, which is a radioresistant strain. The irradiated BALB/c showed a remarkable vermis deficit after birth, and histological analysis demonstrated that there were severe losses of the external germinal layer (EGL) and Purkinke cell layer. TUNEL analysis shoed that apoptosis was strongly induce in the cerebellar anlage of the irradiated BALB/c compared to the C57BL/6J at E14.5. Immunohistochemical analysis revealed a significant decrease of phospho-histone H3 positive EGL cells in the irradiated BALB/c at E18.5 and E0, indicating that irradiation causes a decrease in the number of mitotic cells. The results suggest that the strong induction of apoptosis in radiosensitive BALB/c led to a decrease of proliferation activity in the cerebellar anlage during embryonic development, and consequently, severe cerebellar abnormality was evoked.

journal_name

Histol Histopathol

authors

Saito A,Yamauchi H,Ishida Y,Ohmachi Y,Nakayama H

doi

10.14670/HH-23.953

subject

Has Abstract

pub_date

2008-08-01 00:00:00

pages

953-64

issue

8

eissn

0213-3911

issn

1699-5848

journal_volume

23

pub_type

杂志文章
  • Time-dependent effects of maternal continuous propranolol on fetal lung development in rats.

    abstract::Previous studies have demonstrated a role for the beta-adrenergic system in the maturation of the fetal alveolar epithelium. Chronic blockade of beta-adrenergic binding sites has been shown to adversely effect physiologic and biochemical indices of fetal lung maturation. In the present study timed-pregnant female Spra...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-17.365

    authors: Smith DM,Sommers SS

    更新日期:2002-04-01 00:00:00

  • DEC1 expression in 1p-aberrant oligodendroglial neoplasms.

    abstract:BACKGROUND:Expression of hypoxia-related tissue factors in 1p-aberrant oligodendroglial neoplasms diminishes patient outcome. Differentiated embryo-chondrocyte expressed gene 1 (DEC1) has been described as novel hypoxia-related tissue factor. In our study, we assessed the expression of DEC1 in 1p aberrant oligodendrogl...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-20.1173

    authors: Preusser M,Birner P,Ambros IM,Ambros PF,Budka H,Harris AL,Hainfellner JA

    更新日期:2005-10-01 00:00:00

  • Muscle fiber types in tetrapods. A comparative histochemical and morphometric study.

    abstract::A comparative histochemical and morphometric study in two groups of homologous muscles from different tetrapods (rat, pigeon, lizard and frog) was performed. On the basis of their fiber diameters and oxidative enzyme activities, an initial correlation between fiber types of all animals is observed, although in the liz...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Burgos Bretones JJ,Razquin Peralta B,Aguirre Urizar J,Rivera Pomar JM

    更新日期:1987-01-01 00:00:00

  • Adhesion-dependent signalling and the initiation of haemostasis and thrombosis.

    abstract::Cell-cell and cell-extracellular matrix adhesion are critical aspects of platelet function, regulating interactions between circulating platelets in the bloodstream with the blood vessel wall. In haemostasis, platelets adhere to the subendothelial matrix of a damaged vessel, spread over the surface and recruit additio...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-13.837

    authors: Andrews RK,Berndt MC

    更新日期:1998-07-01 00:00:00

  • Comparison of the dysadherin and E-cadherin expression in primary lung cancer and metastatic sites.

    abstract::Dysadherin, a cancer associated cell membrane glycoprotein, has been reported to downregulate E-cadherin. Aberrant expression of E-cadherin has been associated with the development of metastases in patients with cancer. Even though the expression of dysadherin and E-cadherin has been studied in primary non-small cell ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-25.1257

    authors: Mitselou A,Batistatou A,Nakanishi Y,Hirohashi S,Vougiouklakis T,Charalabopoulos K

    更新日期:2010-10-01 00:00:00

  • Retinal afferents on Golgi-identified vertical neurons in the superior colliculus of the rabbit. A Golgi-EM, degenerative and autoradiographic study.

    abstract::The characteristics and distribution pattern of retinal afferent terminals making synaptic contacts on narrow field vertical neurons in the stratum griseum superficiale of the rabbit superior colliculus were studied using the Golgi-gold substitution technique in combination with either autoradiographic or degenerative...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Ortega F,Doñate-Oliver F,Grandes P

    更新日期:1993-01-01 00:00:00

  • Histochemical aspects of the yolk-sac and digestive tract of larvae of the Senegal sole, Solea senegalensis (Kaup, 1858).

    abstract::Histochemical distribution of glycoproteins, carbohydrates and proteins rich in different amino acids were studied using histological and histochemical procedures, in Senegal sole, Solea senegalensis (Kaup, 1858) larvae from hatching until day 15. Glycogen, proteins and glycoproteins were detected in the yolk-sac of t...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Sarasquete C,González de Canales ML,Arellano JM,Muñoz-Cueto JA,Ribeiro L,Dinis MT

    更新日期:1996-10-01 00:00:00

  • Fine structure of the retinal photoreceptors of the barred owl (Strix varia).

    abstract::The photoreceptors of the barred owl (Strix varia) consist of rods, single cones and unequal double cones present in a ratio of about 35:1:3. In the light-adapted condition the rods are of uniform diameter along their entire length and are therefore not felt to undergo photomechanical changes. The rod outer segment co...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Braekevelt CR,Smith SA,Smith BJ

    更新日期:1996-01-01 00:00:00

  • Apocrine secretory mechanism: recent findings and unresolved problems.

    abstract::Cell secretion is an important physiological process that ensures smooth metabolic activities, tissue repair and growth and immunological functions in the body. It occurs when the intracellular secretory materials are released to the exterior; these may be in the form of lipids, protein or mucous and may travel throug...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-18.597

    authors: Gesase AP,Satoh Y

    更新日期:2003-04-01 00:00:00

  • Immunoexpression of gelatinase (MMP-2 and MMP-9) in the seminal vesicles and ventral prostate of Libyan jird (Meriones libycus) during the seasonal cycle of reproduction.

    abstract::An immunohistochemical study of matrix metalloproteinases (MMP-2 and MMP-9) or gelatinase (gelatinase A and gelatinase B) was performed on the seminal vesicles and ventral prostate of the Libyan jird (Meriones libycus) collected in the Beni-Abbes area during breeding period (spring and early summer), during resting ph...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-25.619

    authors: Belhocine M,Gernigon-Spychalowicz T,Jacob MP,Benazzoug Y,Exbrayat JM

    更新日期:2010-05-01 00:00:00

  • The distribution of corticotropin-releasing factor immunoreactive neurons and nerve fibres in the brain of Gambusia affinis and Salmo trutta.

    abstract::The study was carried out on the distribution of neurons and fibres which contain the Corticotropin releasing factor-like (CRF) immunoreactivity in the encephalon of two species of teleosts, Gambusia affinis and Salmo trutta. The peroxidase-antiperoxidase (PAP) immunocytochemical technique was employed. The present st...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Coto-Montes A,García-Fernández JM,del Brío MA,Riera P

    更新日期:1994-04-01 00:00:00

  • Hepatic response to chronic hypoxia in experimental rat model through HIF-1 alpha, activator protein-1 and NF-kappa B.

    abstract::Chronic liver diseases are commonly associated with tissue hypoxia that may cause inflammation, oxidative stress, liver cell injury and increased nuclear transcriptional regulation. The hepatic response to chronic hypoxia at the molecular level has not yet been clearly understood until now. The aim of this study is to...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Lau TY,Xiao J,Liong EC,Liao L,Leung TM,Nanji AA,Fung ML,Tipoe GL

    更新日期:2013-04-01 00:00:00

  • Prognostic significance of metallothionein expression in correlation with Ki-67 expression in adenocarcinomas of large intestine.

    abstract::The study aimed at determining levels of metallothionein (MT) and Ki-67 antigen expression in adenocarcinomas of large intestine and examining relation of the expression levels with various clinical and pathological variables. The studies were performed on 81 cases of large intestine adenocarcinoma. Using immunocytoch...

    journal_title:Histology and histopathology

    pub_type: 临床试验,杂志文章

    doi:10.14670/HH-18.401

    authors: Dziegiel P,Forgacz J,Suder E,Surowiak P,Kornafel J,Zabel M

    更新日期:2003-04-01 00:00:00

  • Daunorubicin does not induce immunohistochemically detectable endothelial dysfunction in rabbit aorta and femoral artery.

    abstract::Anthracyclines are one of the most effective anticancer drugs ever developed, but their clinical use has been hampered by the risk of severe cardiotoxicity. In this study, we investigated whether rabbits exposed to a different cumulative dose of anthracycline suffer from immunohistochemically detectable vascular toxic...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-26.551

    authors: Nachtigal P,Sterba M,Popelová O,Večeřová L,Kudláčková Z,Jirkovský E,Geršl V

    更新日期:2011-05-01 00:00:00

  • Histopathological changes in the eyes in systemic lupus erythematosus: an electron microscope and immunohistochemical study.

    abstract::This paper reports the histopathological findings in the eyes of a 26-year-old female patient diagnosed with systemic lupus erythematosus (SLE) with peripheral neuropathy. The patient had no significant ocular problems. She died of pneumonia after two years of suffering. The eyeballs were procured at autopsy and the r...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-20.373

    authors: Nag TC,Wadhwa S

    更新日期:2005-04-01 00:00:00

  • Expression of mitotic kinases phospho-aurora A and aurora B correlates with clinical and pathological parameters in bladder neoplasms.

    abstract::Aurora A and Aurora B are serine-threonine kinase proteins which have both been implicated in human carcinogenesis through development of aneuploidy and chromosomal instability. The aim of the study is to assess the correlation of both markers with clinical and pathological parameters in patients with bladder cancer o...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-25.1371

    authors: Bufo P,Sanguedolce F,Tortorella S,Cormio L,Carrieri G,Pannone G

    更新日期:2010-11-01 00:00:00

  • Liver growth factor antifibrotic activity in vivo is associated with a decrease in activation of hepatic stellate cells.

    abstract::The antifibrotic activity of Liver Growth Factor (LGF), a liver mitogen, was previously demonstrated in several models of rat liver fibrosis and even in extrahepatic sites, such as carotid artery in hypertensive rats and rat CdCl2-induced lung fibrosis. In the present study, we have attempted to examine in depth its m...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-24.473

    authors: Díaz-Gil JJ,García-Monzón C,Rúa C,Martín-Sanz P,Cereceda RM,Miquilena-Colina ME,Machín C,Fernández-Martínez A,García-Cañero R

    更新日期:2009-04-01 00:00:00

  • Immunohistochemical demonstration of metallothionein in benign and malignant canine mammary tumours.

    abstract::Immunocytochemical demonstration of metallothionein (MT) has been reported as a useful prognostic tool in human breast cancer. The aim of this study was to determine the immunohistochemical location of MT in canine mammary tumours and its possible correlation with the morphologic characteristics of these tumours. Surg...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-14.51

    authors: Fuentealba IC,Mullins JE

    更新日期:1999-01-01 00:00:00

  • The induction of gut hyperplasia by phytohaemagglutinin in the diet and limitation of tumour growth.

    abstract::The growth of a transplantable murine non-Hodgkin lymphoma tumour, developing either intraperitoneally as an ascites tumour or subcutaneously as a solid tumour, has been shown to be markedly diminished by including phytohaemagglutinin (PHA), a lectin present in raw kidney bean (Phaseolus vulgaris) in the diet. In NMRI...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-13.575

    authors: Pryme IF,Pusztai A,Bardocz S,Ewen SW

    更新日期:1998-04-01 00:00:00

  • Sulfur dioxide: foe or friend for life?

    abstract::Sulfur dioxide (SO₂) is a toxic gas and air pollutant. The toxic effects of SO₂ have been extensively studied. Oxidative damage due to SO₂ can occur in multiple organs. Inhaled SO₂ can also cause chromosomal aberrations, DNA damage and gene mutations in mammals. However, SO₂ can also be generated from the sulfur-conta...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-11-904

    authors: Wang XB,Cui H,Liu X,Du JB

    更新日期:2017-12-01 00:00:00

  • STAT and SMAD signaling in cancer.

    abstract::STAT and SMAD often exert opposite biological effects on diverse cellular functions. Recent studies have shown that STAT can interface with SMAD at molecular level and that some novel molecules, such as SOCS (also called CIS) and APRO6 (also called TOB), modulate this signaling. A cofactor p300/CBP might act as a brid...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-17.887

    authors: Iwamoto T,Oshima K,Seng T,Feng X,Oo ML,Hamaguchi M,Matsuda S

    更新日期:2002-01-01 00:00:00

  • The effects of low laser irradiation on angiogenesis in injured rat tibiae.

    abstract::The influence of He-Ne laser radiation on the formation of new blood vessels in the bone marrow compartment of a regenerating area of the mid-cortical diaphysis of the tibiae of young adult rats was studied. A small hole was surgically made with a dentistry burr in the tibia and the injured area received a daily laser...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-19.43

    authors: Garavello I,Baranauskas V,da Cruz-Höfling MA

    更新日期:2004-01-01 00:00:00

  • Neonatal thymulin gene therapy in nude mice: Effects on the morphology of the pituitary corticotrope population.

    abstract::The integrity of the thymus during early life is necessary for a proper maturation of the neuroendocrine system, including the adrenal axis. The thymic metallopeptide thymulin seems to be a central physiologic mediator of thymus-pituitary communication. Furthermore, neonatal thymulin gene therapy has been shown to pre...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-26.471

    authors: Martines E,Reggiani PC,Schwerdt JI,Goya RG,Cónsole G

    更新日期:2011-04-01 00:00:00

  • Advances in the knowledge of breast cancer stem cells. A review.

    abstract::Much effort has been made by researchers to elucidate the complex biology of breast cancer stem cells (BCSCs), a small subset of breast tumor cells that display stem cell properties, drive tumor initiation, and growth. In recent years, it has been suggested that BCSCs could be responsible for the process of metastasis...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-11-718

    authors: Schwarz-Cruz Y Celis A,Espinosa M,Maldonado V,Melendez-Zajgla J

    更新日期:2016-06-01 00:00:00

  • Immunohistochemical characterisation of dorsal root ganglia neurons supplying the porcine mammary gland.

    abstract::The present study investigated the chemical coding of mammary gland-projecting dorsal root ganglia (DRG) neurons using double-labelling immunohistochemistry. Earlier investigations revealed the presence of Fast blue - positive (FB+) neurons in Th9-Th12 DRG after injection of the tracer into the second, right thoracic ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-26.1509

    authors: Franke-Radowiecka A

    更新日期:2011-12-01 00:00:00

  • Physiological and pathological significance of the molecular cross-talk between autophagy and apoptosis.

    abstract::Autophagy and apoptosis are two important molecular mechanisms that maintain cellular homeostasis under stress conditions. Autophagy represents an intracellular mechanism responsible for turnover of organelles and long-lived proteins through a lysosome-dependent degradation pathway. Cell death signals or sustained str...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-11-714

    authors: Oral O,Akkoc Y,Bayraktar O,Gozuacik D

    更新日期:2016-05-01 00:00:00

  • Fluoxetine may worsen hyperoxia-induced lung damage in neonatal rats.

    abstract::Fluoxetine shows controversial lung effects as it prevents pulmonary hypertension in adult rats but exposure during gestation causes pulmonary hypertension in neonatal rats. In the present study, we tested the null hypothesis that the antidepressant drug fluoxetine does not modify the development of bronchopulmonary d...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-27.1599

    authors: Porzionato A,Zaramella P,Macchi V,Grisafi D,Salmaso R,Baraldi M,Fornaro E,Tassone E,Masola V,Onisto M,Chiandetti L,De Caro R

    更新日期:2012-12-01 00:00:00

  • Domestic microwave processing for rapid immunohistochemical diagnosis of bovine rabies.

    abstract::The present study describes the use of a microwave processing protocol for the rapid histopathological and immunohistochemical diagnosis of bovine rabies. Immunohistochemistry has been used for rabies diagnosis in formalin-fixed tissue with satisfactory results, although the time to diagnosis is considerably longer th...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-27.1227

    authors: Abreu CC,Nakayama PA,Nogueira CI,Mesquita LP,Lopes PF,Varaschin MS,Seixas Jdo N,Ferreira E,Bezerra PS Jr

    更新日期:2012-09-01 00:00:00

  • Influence of age on the production of rat spermatozoa, on their concentration in the cauda epididymidis, and on FSH, LH and testosterone plasma levels.

    abstract::Testis samples were taken from young (3 months), middle-aged (12 months) and aged (24 months) male rats, processed, stained and examined via a light microscope. There were no prominent abnormal germinal epithelium and interstitial tissue. However, the aging process promoted a significant decrease in the mean amount of...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Carvalho TL,Favaretto AL,Komesu MC,Lopes RA,Petenusci SO,Silva-Netto CR

    更新日期:1988-10-01 00:00:00

  • Keratins in the human trophoblast.

    abstract::Besides microfilaments and microtubules, intermediate filaments are major components of the cytoskeleton. In epithelial cells intermediate filaments are formed by heterodimers of specific keratins, whose expression pattern highly depends on the type of epithelium and differentiation degree of the cell. During the proc...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-28.817

    authors: Gauster M,Blaschitz A,Siwetz M,Huppertz B

    更新日期:2013-07-01 00:00:00