Defect of the cerebellar vermis induced by prenatal gamma-ray irradiation in radiosensitive BALB/c mice.


:The developing fetal brain is one of the most susceptible organs to irradiation insult. Prenatal irradiation-induced abnormalities in the cerebrum have been well examined in mouse fetuses. However, little information on abnormalities in the cerebellum caused by irradiation is available. Moreover, few reports have examined the chronological changes of the brain from the prenatal to the postnatal period. To analyze the chronological changes induced by irradiation, we exposed pregnant mice to gamma-ray irradiation on embryonic day 13.5 (E13.5) and investigated the histopathology of the cerebellum at several time points from E14.5 to postnatal day 28. BALB/cA mice were used, which is a radiosensitive strain, and C57BL/6J, which is a radioresistant strain. The irradiated BALB/c showed a remarkable vermis deficit after birth, and histological analysis demonstrated that there were severe losses of the external germinal layer (EGL) and Purkinke cell layer. TUNEL analysis shoed that apoptosis was strongly induce in the cerebellar anlage of the irradiated BALB/c compared to the C57BL/6J at E14.5. Immunohistochemical analysis revealed a significant decrease of phospho-histone H3 positive EGL cells in the irradiated BALB/c at E18.5 and E0, indicating that irradiation causes a decrease in the number of mitotic cells. The results suggest that the strong induction of apoptosis in radiosensitive BALB/c led to a decrease of proliferation activity in the cerebellar anlage during embryonic development, and consequently, severe cerebellar abnormality was evoked.


Histol Histopathol


Saito A,Yamauchi H,Ishida Y,Ohmachi Y,Nakayama H




Has Abstract


2008-08-01 00:00:00












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    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Isasa Chueca JA,Lahoz Gimeno M,Redondo Marco JA

    更新日期:1992-07-01 00:00:00

  • High prevalence of human papillomavirus 16 in penile carcinoma.

    abstract::In order to analyze the incidence and prevalence of Human Papillomavirus (HPV) in penile carcinoma, we studied 49 patients with penile carcinoma. Formalin-fixed, paraffin-embedded tissue samples were collected from 64 samples of penile carcinoma from the Hospital General Universitario (Albacete, Spain). Cases were his...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Pascual A,Pariente M,Godínez JM,Sánchez-Prieto R,Atienzar M,Segura M,Poblet E

    更新日期:2007-02-01 00:00:00

  • Elastin variations implicating in vascular smooth muscle cells phenotype in human tortuous arteries.

    abstract::The aim of the present work was to study the morphological implications between the elastin and the phenotypic expression of the vascular smooth muscle cells. For this purpose, sixty human tortuous arteries from different territories have been studied. We have measured the morphometric indexes Intimal Thickening Index...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Ortiz PP,Sarrat R,Daret D,Whyte J,Torres A,Lamazière JM

    更新日期:2000-01-01 00:00:00

  • Short term regulation of hepatocyte glutathione content by hepatic sinusoidal cells in co-culture.

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    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Catalá M,Pagani R,Portolés MT

    更新日期:2007-04-01 00:00:00

  • Comparative in vivo and in vitro models to approach the cellular basis of endotoxic shock. The role of sinusoidal liver cells.

    abstract::During endotoxic shock, the liver exerts a lipopolysaccharide (LPS) clearance function with the participation of both parenchymal and sinusoidal cells. Liver damage could be caused by LPS direct action, hypoxia and/or inflammatory mediators released by Kupffer cells. The aim of this study is to establish an experiment...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Pagani R,Portolés MT,Arahuetes R,Ainaga MJ,Machín C,Rua C

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    abstract::Nitric oxide (NO) is a biological messenger molecule produced by one of the essential amino acids L-arginine by the catalytic action of the enzyme NO synthase (NOS). The dual role of NO as a protective or toxic molecule is due to several factors, such as; the isoform of NOS involved, concentration of NO and the type o...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Thippeswamy T,McKay JS,Quinn JP,Morris R

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    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Mayhew TM,Myklebust R,Whybrow A,Jenkins R

    更新日期:1999-01-01 00:00:00

  • Anti-apoptotic activity in deep pelvic endometriosis.

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    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Abdalla Ribeiro HS,Galvāo MA,Aoki T,Aldrighi JM,Ribeiro PA

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    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Salas Valién JS,Ribas Ariño MT,Egido Romo M,Palau Benavides MT

    更新日期:1990-01-01 00:00:00

  • Comparison of the dysadherin and E-cadherin expression in primary lung cancer and metastatic sites.

    abstract::Dysadherin, a cancer associated cell membrane glycoprotein, has been reported to downregulate E-cadherin. Aberrant expression of E-cadherin has been associated with the development of metastases in patients with cancer. Even though the expression of dysadherin and E-cadherin has been studied in primary non-small cell ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Mitselou A,Batistatou A,Nakanishi Y,Hirohashi S,Vougiouklakis T,Charalabopoulos K

    更新日期:2010-10-01 00:00:00

  • Expression pattern of the endoplasmic reticulum stress protein gp96 in monophasic and chronic relapsing form of experimental autoimmune encephalomyelitis in rats.

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    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Jakovac H,Grebic D,Barac-Latas V,Mrakovcic I,Radosevic-Stasic B

    更新日期:2013-01-01 00:00:00

  • Clinical significance of Src expression and activity in human neoplasia.

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    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Chatzizacharias NA,Kouraklis GP,Giaginis CT,Theocharis SE

    更新日期:2012-06-01 00:00:00

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    pub_type: 临床试验,杂志文章


    authors: Dziegiel P,Forgacz J,Suder E,Surowiak P,Kornafel J,Zabel M

    更新日期:2003-04-01 00:00:00

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    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Gabrielli MG,Bondi AM,Materazzi G,Menghi G

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    authors: Carvalho TL,Favaretto AL,Komesu MC,Lopes RA,Petenusci SO,Silva-Netto CR

    更新日期:1988-10-01 00:00:00

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    authors: de Luaces CP,Peral JI,García Tejeiro M,Aguirre C

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  • Expression of cell-cycle regulatory proteins BUBR1, MAD2, Aurora A, cyclin A and cyclin E in invasive ductal breast carcinomas.

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    journal_title:Histology and histopathology

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    authors: Du J,Du Q,Zhang Y,Sajdik C,Ruan Y,Tian XX,Fang WG

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    journal_title:Histology and histopathology

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    authors: Prada Oliveira JA,Verástegui Escolano C,Gómez Luy C,Collantes Ruiz J

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  • Airway and lung parenchyma morphology during the respiratory cycle.

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    journal_title:Histology and histopathology

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    authors: Escolar JD,Escolar MA,Blasco J,Ros LH

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    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Takahashi M,Matsuda H,Hayashida Y,Yamamoto Y,Tsukuda M,Kusakabe T

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  • An up-date on newly discovered immunohistochemical biomarkers for the diagnosis of human testicular germ cell tumors.

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    authors: Chieffi P,Chieffi S

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    journal_title:Histology and histopathology

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    authors: Numakawa T,Suzuki S,Kumamaru E,Adachi N,Richards M,Kunugi H

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    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Hou T,Fan Y,Dan W,Liu B,Wang Z,Zeng J,Li L

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    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Regauer S,Beham-Schmid C

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    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Schwarz-Cruz Y Celis A,Espinosa M,Maldonado V,Melendez-Zajgla J

    更新日期:2016-06-01 00:00:00

  • Chronic retinal effects by ultraviolet irradiation, with special reference to superoxide dismutases.

    abstract::Recently ultraviolet light (UV) reaching the Earth's surface has been gradually increasing in amounts by the destruction of the ozone layers. Large parts of UV are absorbed in the cornea and lens, and only a few amounts reached the retina; however, the effect on the retina is not fully elucidated. 38 rats were irradia...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Oguni M,Tamura H,Kato K,Setogawa T

    更新日期:1996-07-01 00:00:00

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    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Penzo M,Casoli L,Ceccarelli C,Treré D,Ludovini V,Crinò L,Montanaro L

    更新日期:2013-03-01 00:00:00

  • Pathophysiology of stem cells in restenosis.

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    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Forte A,Cipollaro M,Cascino A,Galderisi U

    更新日期:2007-05-01 00:00:00

  • Molecular actions of nitric oxide in mesangial cells.

    abstract::Nitric oxide (NO) is a widely recognized mediator of physiological and pathophysiological signal transmission. Its generation through L-arginine metabolism is relevant in the mesangium of the kidney where NO is produced by constitutive and inducible NO-synthase isoenzymes. Signaling is achieved through target interact...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Sandau KB,Brüne B

    更新日期:2000-10-01 00:00:00

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    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Mazzocchi G,Gottardo G,Nussdorfer GG

    更新日期:1998-01-01 00:00:00