Abstract:
:Melanopsin-expressing retinal ganglion cells (mRGCs) constitute a system in the mammalian retina used for irradiance detection, regulating non-image forming functions, such as photoentrainment of circadian rhythms, control of the pupillary light reflex, masking response, light-regulated melatonin secretion, and modulation of the sleep/wake cycle. There are five subtypes of mRGCs differentiated by morphology and function. Recent years of research on mRGCs have identified a broad number of neurodegenerative diseases in the eye and the brain with altered physiologic light responses, leading to disturbances of non-image forming light response(s). In this review, we briefly summarise the melanopsin system in the normal retina and discuss its role in connection to human aging (sleep/wake problems) and retinal pathology in Alzheimer and Parkinson diseases, diabetic retinopathy, mitochondrial optic neuropathies, glaucoma, retinitis pigmentosa, and in photophobia during migraine and in seasonal affective disorder (SAD). Finally, we discuss the diagnostic tools that are being used to differentiate retinal diseases involving the melanopsin system in the rods and cones from the inner versus the outer retina.
journal_name
Histol Histopatholjournal_title
Histology and histopathologyauthors
Esquiva G,Hannibal Jdoi
10.14670/HH-18-138subject
Has Abstractpub_date
2019-12-01 00:00:00pages
1299-1311issue
12eissn
0213-3911issn
1699-5848pii
HH-18-138journal_volume
34pub_type
杂志文章,评审abstract::The FHIT gene encompassing the most active common human fragile region, FRA3B, has been proposed as a tumour suppressor gene for important common human carcinomas. The mechanism in which Fhit protein exerts its tumour suppressor activity is still obscure. To further understand the Fhit function associated with its int...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-21.915
更新日期:2006-09-01 00:00:00
abstract::One hundred and eleven pituitary glands of patients (93 males, 18 females; mean age 32 years, 5 months) who died of fully developed AIDS or ARC were examined under light microscopy with the aid of immunohistochemistry. On post mortem (p.m.) examination a wide series of multiorgan alterations was noticed. Microscopical...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1992-04-01 00:00:00
abstract::A large number of biologically active substances have been identified and characterised in the respiratory tract of several mammals. These substances (amines and peptides) exert important regulatory influences on respiratory functions, and they act as neurotransmitters/neuromodulators, both being released from nerve t...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1997-10-01 00:00:00
abstract::The resistance to airflow that develops in most obstructive processes takes place in the small airways. The aim of the present paper is to describe bronchial hysteresis morphometrically in a respiratory cycle model. As a working hypothesis, it is proposed that the changes that take place in the respiratory tract durin...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-18.19
更新日期:2003-01-01 00:00:00
abstract::In order to reveal modulation of the number of pulmonary neuroendocrine cells (PNEC) in interstitial lung diseases and to clarify significance of cell proliferation activity in occurrence of PNEC, we counted airway PNEC of the patients of idiopathic interstitial pneumonia, secondary interstitial pneumonia and control ...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-17.1121
更新日期:2002-10-01 00:00:00
abstract::Extracellular matrix of meningiomas was studied by light and electron microscopy with the aid of immunohistochemical techniques. Special attention was paid to the distribution of type I, III, IV, V collagens and laminin with a comparison between meningothelial and fibroblastic types. Connective tissue fibers and basem...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1990-07-01 00:00:00
abstract::Recently, the characterization of mucinous tubular and spindle-cell carcinoma (MTSCC) has been established. MTSCC predominantly occurs in females. This tumor is histologically characterized by eosinophilic cytoplasm, elongated and anastomosing tubules, myxomatous stroma and low-grade nuclear cytology. Proliferation of...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-20.221
更新日期:2005-01-01 00:00:00
abstract::Close contacts between endocrine insular cells and exocrine acinar, centroacinar and ductular cells occur frequently in the rat pancreas as seen by both light and electron microscopy. Islets of Langerhans are surrounded incompletely by a thin connective tissue capsule or mantle but numerous exocrine-endocrine cell con...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1986-01-01 00:00:00
abstract::Bacillary angiomatosis (BA) is a reactive vasoproliferative lesion occurring almost exclusively in immunocompromised individuals in response to infection by a bacillus closely related to Rochalimaea quintana. The commonest site of involvement is the skin, in the form of multiple erythematous nodules, but bacillary ang...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:
更新日期:1992-01-01 00:00:00
abstract::CD45RO+ T cells are referred to as memory or helper-inducer while CD45RA+ T cells are regarded as naive or suppressor-inducer T cells. The former population predominates in the peripheral blood and even more in the synovial fluid of patients with rheumatoid arthritis, to the expense of the latter population. Within th...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-15.587
更新日期:2000-04-01 00:00:00
abstract::"Classically activated macrophages (M1)" and "alternatively activated macrophages (M2)", which appear in injured tissues, control either inflammation or remodeling. The mechanism remains unclear. To clarify the M1-/M2-macrophage polarization in acute liver injury, M1- and M2-related factors were analysed in F344 rats ...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-29.10.497
更新日期:2014-04-01 00:00:00
abstract::Recent evidence has shown that vascular function depends not only on cells within the vessels, but is also significantly modulated by circulating cells derived from the bone marrow. A number of studies indicate that an early reendothelialization by circulating endothelial precursors after vascular injury prevents exce...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-22.547
更新日期:2007-05-01 00:00:00
abstract::Thyroid glands from 7 marmosets (Callithrix jacchus) of different age groups (newborn, 2 weeks, 2, 7, 8 and 11 months, and 8 years) were grown as organ culture according to Trowell at the medium/air interphase for 3 to 30 days. The morphology of thyroid tissue was well preserved until the end of the culture period. Ne...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1995-10-01 00:00:00
abstract::The pineal organs of 14-week-old domestic geese were investigated with light and electron microscopy. The pineals consisted of a wide distal part and a narrow middle-proximal one. The glands were attached to the intercommissural region via the choroid plexus. The pineal parenchyma was formed by round or elongated foll...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-21.1075
更新日期:2006-10-01 00:00:00
abstract::Earlier we reported that atherosclerotic lesions of apoE-deficient mice contained cells which stained positively with anti-S-100 antibody and that cells exhibiting the ultrastructural features of dendritic cells were present in the aortic lesions. These observations suggested that dendritic cells might be involved in ...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-16.801
更新日期:2001-07-01 00:00:00
abstract::Multilocular cystic renal cell carcinoma (MCRCC) accounts for approximately 1 to 2% of all renal tumors. This tumor is currently classified as a subtype of clear cell RCC. Clinically, the majority of these tumors are incidentally found. Macroscopically, the tumor is well demarcated and consists of various-sized cysts....
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-27.969
更新日期:2012-08-01 00:00:00
abstract:UNLABELLED:The aim of this work was to evaluate the effect of magnesium sulphate (MgSO4) administration on blood-brain barrier (BBB) permeabilization after cerebral hypoxia-ischemia (HI) induced by partial occlusion of the umbilical cord of premature fetal lambs. We also characterized BBB dysfunction in terms of the le...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-24.1129
更新日期:2009-09-01 00:00:00
abstract::A battery of horseradish peroxidase-conjugated lectins (Con A, WGA and DBA), as well as conventional histochemical techniques (PAS, saponification, Alcian Blue pH 0.1, 1, 2.5, chlorhydric hydrolisis, neuraminidase, Bromophenol blue, Tioglycollate reduction and Ferric-ferricyanide-FeIII) were used to study the content ...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-13.727
更新日期:1998-07-01 00:00:00
abstract::Recent studies have shown that papillary renal cell carcinoma (RCC) is clinically and genotypically a distinct entity. Papillary RCCs account for about 10-15% of renal parenchymal neoplasms. Macroscopically, the cut surface is yellow or brown in color and large tumors frequently show cystic change. Hemorrhage and necr...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-18.487
更新日期:2003-04-01 00:00:00
abstract::It has been commonly supposed that adult stem cells co-localize with supporting cells within specific regions or specialized microenvironment in each tissue/organ, called stem cell niche. This concept was based on the assumption that stem cells are intrinsically hierarchical in nature. However, recent data indicate th...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-25.397
更新日期:2010-03-01 00:00:00
abstract::Terminal dendrites of cone horizontal cells (HCs) in teleost retinas show numerous spine-like protrusions named spinules, which are invaginated into the cone pedicles during light-adaptation, but retracted during dark-adaptation. Somata of HC show nematosomes whose size decreases as the number of spinules increases. M...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-17.721
更新日期:2002-01-01 00:00:00
abstract::HtrA1 is a secreted protein which behaves as a molecular chaperone at low temperatures and as a serine protease at high temperatures. When the placenta escapes the normal growth control mechanisms, which are present during normal pregnancy, it may develop trophoblastic diseases, such as hydatidiform mole and choriocar...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-24.1213
更新日期:2009-10-01 00:00:00
abstract::Gliomas are the most common intracranial malignant tumors in humans, and high-grade gliomas in particular pose a unique challenge due to their propensity for proliferation and tissue invasion. Our understanding of glioma oncogenesis, proliferation, and invasion has been greatly advanced in the past 10 years as researc...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-18.207
更新日期:2003-01-01 00:00:00
abstract:INTRODUCTION:It is difficult to prevent and treat intra- and peri-neural fibrosis after peripheral nerve surgery. Many authors have attempted to develop and verify the effectiveness of substances to decrease the formation of adherences in different tissues. MATERIAL AND METHODS:this study aimed to assess the effective...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-25.741
更新日期:2010-06-01 00:00:00
abstract::Thyroid hormones (TH) stimulate oxidative metabolism in many tissues in the body, but testis is not one of them. Therefore, in this sense, testis is not considered as a target organ for TH. However, recent findings clearly show that TH have significant functions on the testis in general, and Leydig cells in particular...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-19.985
更新日期:2004-07-01 00:00:00
abstract::Androgen receptor (AR) interact with many pathways involved in bladder cancer development and progression. FUS (fused in liposarcoma), a multifunctional protein essential for different cellular processes, has been demonstrated as a key link between androgen receptor signaling and cell-cycle progression in prostate can...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-18-295
更新日期:2020-12-23 00:00:00
abstract:BACKGROUND:The Shwachman-Bodian-Diamond syndrome (SBDS) protein is a member of a highly conserved family which influences RNA activation and is associated with pancreatic, skeletal and bone marrow deficiencies, as well as hematological malignancies. METHODS:In this study, the expression and localization of SBDS were i...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-23.819
更新日期:2008-07-01 00:00:00
abstract:BACKGROUND:Little is known regarding the role of redox balance regulators in metastatic melanomas, but there is some evidence for a link between epithelial-to-mesenchymal transition (EMT) and cellular redox status. METHODS:We compared the immunohistochemical expression of nuclear factor erythroid-2-related factor 2 (N...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-11-778
更新日期:2017-02-01 00:00:00
abstract::Actin microfilaments and microtubules are important cytoskeletal proteins that regulate endothelial repair through alterations in cell shape and through regulation of cell migration following wounding of the endothelium. Upstream pathways have been identified in the regulation of actin and microtubule organization, es...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-18.879
更新日期:2003-07-01 00:00:00
abstract::Detailed histomorphometric analysis of human conjunctival biopsy specimens has convincingly demonstrated that tissue remodeling of the extracellular matrix (ECM) is an essential and dynamic process associated with conjunctival scarring in ocular cicatricial pemphigoid (OCP). The conjunctival scarring often eventually ...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-16.1203
更新日期:2001-10-01 00:00:00