Abstract:
:Fibrosis is a pathological feature of most chronic diseases and leads to the dysfunction of various organs. However, there is currently no effective method for treating fibrosis. In recent years, a small gas, sulfur dioxide (SO₂), which can be generated endogenously in mammals, has been found to have vasorelaxation activity, improve cardiac function and decrease myocardial injury. Endogenous SO₂ also mediates the process of fibrosis. Inhibition of endogenous SO₂ can aggravate small pulmonary artery remodeling and abnormal collagen accumulation. SO₂ treatment significantly improves pulmonary fibrosis and pulmonary arterial remodeling. Overexpression of the key enzymes associated with endogenous SO₂ generation, aspartate aminotransferase (AAT) 1 and AAT2, mimics the effect of SO₂ on the down-regulation of collagen synthesis, while AAT1 or AAT2 knockdown aggravates abnormal collagen accumulation in vascular smooth muscle cells (VSMCs). SO₂ also improves myocardial fibrosis induced by myocardial infarction or diabetes in rats, and inhibits myocardial fibroblast proliferation and migration by the extracellular signal-regulated protein kinase pathway. The mechanisms underlying the inhibition of fibrosis by SO₂ are related to its antioxidant effect, anti-inflammation effect, improvement in cardiac function, and cell proliferation inhibition. Therefore, SO₂ has a potential therapeutic effect on fibrosis.
journal_name
Histol Histopatholjournal_title
Histology and histopathologyauthors
Wang XB,Cui H,Du JBdoi
10.14670/HH-18-169subject
Has Abstractpub_date
2019-12-01 00:00:00pages
1289-1297issue
12eissn
0213-3911issn
1699-5848pii
HH-18-169journal_volume
34pub_type
杂志文章,评审abstract::Chorioamnionitis and preeclampsia account for the majority of preterm births worldwide. Thus far, adequate methods for early detection or prevention of these diseases are lacking. In preeclampsia, accelerated villous maturation is believed to compensate placental insufficiency. However, little is known about the effec...
journal_title:Histology and histopathology
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journal_title:Histology and histopathology
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journal_title:Histology and histopathology
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journal_title:Histology and histopathology
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journal_title:Histology and histopathology
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journal_title:Histology and histopathology
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journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:
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journal_title:Histology and histopathology
pub_type: 杂志文章
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journal_title:Histology and histopathology
pub_type: 杂志文章
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journal_title:Histology and histopathology
pub_type: 杂志文章,评审
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更新日期:2000-07-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
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journal_title:Histology and histopathology
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journal_title:Histology and histopathology
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更新日期:2010-02-01 00:00:00
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更新日期:2000-04-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1989-04-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-14.1145
更新日期:1999-10-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1992-04-01 00:00:00
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journal_title:Histology and histopathology
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doi:
更新日期:1991-01-01 00:00:00
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journal_title:Histology and histopathology
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doi:
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journal_title:Histology and histopathology
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journal_title:Histology and histopathology
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journal_title:Histology and histopathology
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journal_title:Histology and histopathology
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
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更新日期:2003-07-01 00:00:00