Liver growth factor antifibrotic activity in vivo is associated with a decrease in activation of hepatic stellate cells.

Abstract:

:The antifibrotic activity of Liver Growth Factor (LGF), a liver mitogen, was previously demonstrated in several models of rat liver fibrosis and even in extrahepatic sites, such as carotid artery in hypertensive rats and rat CdCl2-induced lung fibrosis. In the present study, we have attempted to examine in depth its mechanism of antifibrotic action in bile duct-ligated (BDL) rats, with special emphasis on its activity in fibrogenic liver cells. BDL rats received either LGF 9 microg/week for 2 or 3 weeks (BDL+LGF, n=20/group) or saline (BDL+S, n=20/group), at times 0, week 2, or week 5 after operation. Groups were compared in terms of liver alpha-smooth muscle actin (SMA) content (western blotting and immunohistochemistry), hepatic apoptosis, liver desmin content (western blotting), and serum endothelin-1 (ELISA). LGF produced a marked decrease in liver alpha-SMA content compared with saline-injected rats, especially evident at longer times (5w and 8w; p<0.05). Moreover, LGF did not seem to influence HSC proliferation, as shown by measuring liver desmin content. The antifibrotic activity exerted by LGF seems to be closely related to a modulation of the activation state of fibrogenic liver cells (activated HSC and myofibroblasts) in BDL rats.

journal_name

Histol Histopathol

authors

Díaz-Gil JJ,García-Monzón C,Rúa C,Martín-Sanz P,Cereceda RM,Miquilena-Colina ME,Machín C,Fernández-Martínez A,García-Cañero R

doi

10.14670/HH-24.473

subject

Has Abstract

pub_date

2009-04-01 00:00:00

pages

473-9

issue

4

eissn

0213-3911

issn

1699-5848

journal_volume

24

pub_type

杂志文章
  • Anti-apoptotic activity in deep pelvic endometriosis.

    abstract::Since endometriosis is a proliferative disease we evaluated the presence of anti-apoptotic factor (Bcl-2) and pro-apoptotic factor (Bax) in deep pelvic endometriosis. A Cross-sectional observational study was performed at Santa Casa de Misericórdia de São Paulo, São Paulo, Brazil. Forty women aged 26 to 46 years with ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-29.1129

    authors: Abdalla Ribeiro HS,Galvāo MA,Aoki T,Aldrighi JM,Ribeiro PA

    更新日期:2014-09-01 00:00:00

  • Ultrastructural analysis of HNK-1+ cells in human peripheral blood and lymph nodes.

    abstract::HNK-1 positive (HNK-1+) cells in human peripheral blood and lymph nodes were comparatively analysed by means of immunohistochemistry and immunoelectron microscopy. In peripheral blood, the HNK-1+ cells were grouped into large granular lymphocytes (LGLs), small lymphocytes and intermediate forms, all of which had many ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Yuda F,Terashima K,Dobashi M,Ishikawa M,Imai Y

    更新日期:1989-04-01 00:00:00

  • Muscle fiber types in tetrapods. A comparative histochemical and morphometric study.

    abstract::A comparative histochemical and morphometric study in two groups of homologous muscles from different tetrapods (rat, pigeon, lizard and frog) was performed. On the basis of their fiber diameters and oxidative enzyme activities, an initial correlation between fiber types of all animals is observed, although in the liz...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Burgos Bretones JJ,Razquin Peralta B,Aguirre Urizar J,Rivera Pomar JM

    更新日期:1987-01-01 00:00:00

  • Novel PD-L1 mAb HC16 reveals upregulation of PD-L1 in BAC subtype.

    abstract::Programmed death-ligand 1 (PD-L1) is an inhibitory transmembrane protein that can prevent autoimmune response. Upregulated PD-L1 serves as a predictive biomarker for patients who may respond well to immune checkpoint therapies. However, variable associations of PD-L1 level with prognoses have been reported. In this st...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-18-272

    authors: Su BC,Ting CH,Lee KY,Wu SM,Feng PH,Chan YF,Chen JY

    更新日期:2020-10-28 00:00:00

  • Histopathological features of endometritis eosinophilica in mares.

    abstract::Equine endometritis eosinophilica (EE) is rarely described and its diagnostic criteria are not defined. The aim of this study was to characterize histological features of EE. A data base (1995-2013) was searched for biopsies with increased eosinophils. This study included all biopsies with this diagnosis and represent...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-11-872

    authors: Grimm AL,Schoon HA,Schöniger S

    更新日期:2017-11-01 00:00:00

  • Nitric oxide and nitric oxide synthase: biology, pathology, localization.

    abstract::Nitric oxide (NO) has opened a new and vigorous field of biological and clinical experimentation as evidenced presently by about one hundred original publications every week. Being a biological signal under physiological conditions, NO may be to pathologically affected tissues. Major insights into the ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:

    authors: Wolf G

    更新日期:1997-01-01 00:00:00

  • Effects of orexins A and B on the secretory and proliferative activity of immature and regenerating rat adrenal glands.

    abstract::Orexins A and B are two hypothalamic peptides, involved in the central regulation of feeding, which act through two receptor subtypes, named OX1R and OX2R. OX1R is selective for orexin-A, and OX2R binds both orexins. We have investigated the effects of three subcutaneous injections of 10 nmol/kg body weight of orexins...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-16.713

    authors: Malendowicz LK,Jedrzejczak N,Belloni AS,Trejter M,Hochól A,Nussdorfer GG

    更新日期:2001-07-01 00:00:00

  • The combination of strong immunohistochemical mtTFA expression and a high survivin index predicts a shorter disease-specific survival in pancreatic ductal adenocarcinoma.

    abstract::Mitochondrial transcription factor A (mtTFA) plays a crucial role in both the transcription and maintenance of mitochondrial DNA. A high expression of mtTFA has been demonstrated in several solid tumors, and is closely associated with cancer cell survival/apoptosis and growth. However, its expression pattern in pancre...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-30.193

    authors: Kimura T,Kitada S,Uramoto H,Zhi L,Kawatsu Y,Takeda T,Horie S,Nabeshima A,Noguchi H,Sasaguri Y,Izumi H,Kohno K,Yamada S

    更新日期:2015-02-01 00:00:00

  • Pathological findings in a cat with cryptococcosis and feline immunodeficiency virus infection.

    abstract::This report describes the gross, histopathological, immunocytochemical and electron microscopic findings in a cat with systemic cryptococcosis and feline immunodeficiency virus (FIV) infection. Lymphadenopathy and cloudiness of leptomeninges were the major gross findings. Numerous cryptococcal yeasts were found in lym...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Ramos-Vara JA,Ferrer L,Visa J

    更新日期:1994-04-01 00:00:00

  • Regulation and function of sphingosine kinase 2 in diseases.

    abstract::Sphingosine kinase functions to phosphorylate sphingosine to sphingosine 1-phosphate (S1P) to keep balance in the metabolites of sphingolipids. There are two isoforms of sphingosine kinase, sphingosine kinase 1 (SphK1) and sphingosine kinase 2 (SphK2). Although SphK1 and SphK2 share high sequence similarity, SphK2 has...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-11-939

    authors: Song DD,Zhou JH,Sheng R

    更新日期:2018-05-01 00:00:00

  • Morphogenesis of normal human salivary gland cells in vitro.

    abstract::Primary cultured human salivary gland cells were transfected with ori-defective mutant DNA of SV40. Following 2-3 weeks of transfection, slowly expanding colonies consisting of small compact cells emerged, while mock-transfected cells did not grow any more and eventually entered crisis, followed by cell death. Using l...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:

    authors: Azuma M,Sato M

    更新日期:1994-10-01 00:00:00

  • DEC1 expression in 1p-aberrant oligodendroglial neoplasms.

    abstract:BACKGROUND:Expression of hypoxia-related tissue factors in 1p-aberrant oligodendroglial neoplasms diminishes patient outcome. Differentiated embryo-chondrocyte expressed gene 1 (DEC1) has been described as novel hypoxia-related tissue factor. In our study, we assessed the expression of DEC1 in 1p aberrant oligodendrogl...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-20.1173

    authors: Preusser M,Birner P,Ambros IM,Ambros PF,Budka H,Harris AL,Hainfellner JA

    更新日期:2005-10-01 00:00:00

  • Effect of unilateral nephrectomy on renal function of diabetic rats.

    abstract::Glomerular alterations of experimental diabetes mellitus are observed in animals submitted to a reduction in renal mass, suggesting that some mechanisms responsible for the progression of renal disease are common. The aim of this study was to investigate the effect of nephrectomy on the renal function and morphology o...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-19.1085

    authors: Lopes GS,Lemos CC,Mandarim-De-Lacerda CA,Bregman R

    更新日期:2004-10-01 00:00:00

  • Extrahepatic production of acute phase serum amyloid A.

    abstract::Amyloidosis is a group of diseases characterized by the extracellular deposition of protein that contains non-branching, straight fibrils on electron microscopy (amyloid fibrils) that have a high content of beta-pleated sheet conformation. Various biochemically distinct proteins can undergo transformation into amyloid...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-20.1295

    authors: Upragarin N,Landman WJ,Gaastra W,Gruys E

    更新日期:2005-10-01 00:00:00

  • Expression of the Shwachman-Bodian-Diamond syndrome (SBDS) protein in human pancreatic cancer and chronic pancreatitis.

    abstract:BACKGROUND:The Shwachman-Bodian-Diamond syndrome (SBDS) protein is a member of a highly conserved family which influences RNA activation and is associated with pancreatic, skeletal and bone marrow deficiencies, as well as hematological malignancies. METHODS:In this study, the expression and localization of SBDS were i...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-23.819

    authors: Kayed H,Bekasi S,Keleg S,Welsch T,Esposito I,Shimamura A,Michalski CW,Friess H,Kleeff J

    更新日期:2008-07-01 00:00:00

  • Toxicity of non-steroidal anti-inflammatory drugs: a review of melatonin and diclofenac sodium association.

    abstract::Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for the purpose of anti-inflammation, antipyretic, and analgesia. For this aim, they are used for the alleviation of pain, fever, and inflammation associated with rheumatoid arthritis, sports injuries, and temporary pain. However, treatment with NSAIDs may ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-27.417

    authors: Aygün D,Kaplan S,Odaci E,Onger ME,Altunkaynak ME

    更新日期:2012-04-01 00:00:00

  • Morphology, differentiation and matrix production of liver cells in organoid cultures (high density cultures) of fetal rat livers.

    abstract::The aim of this study was to demonstrate the morphology and matrix synthesis of embryonic rat liver cells (day 18 of gestation) in organoid cultures (high density cultures) with electron microscopic and immunomorphological techniques. For this purpose the cells of embryonic rat livers were isolated enzymatically and g...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Elkasaby A,Xu D,Schröter-Kermani C,Merker HJ

    更新日期:1991-04-01 00:00:00

  • Skeletal muscle abnormalities associated with occupational exposure to mercury vapours.

    abstract::There is scarce information on the possible effects of chronic exposure to mercury on skeletal muscle. Dental personnel are frequently exposed to inhalation of metallic mercury vapours. The skeletal muscle of five technicians and one dentist (females, age 36-55) was studied. All of them presented symptoms of chronic m...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-15.673

    authors: Nadorfy-López E,Torres SH,Finol H,Méndez M,Bello B

    更新日期:2000-07-01 00:00:00

  • Unexpected presence of the neurotrophins NGF and BDNF and the neurotrophin receptor p75 in the tendon cells of the human Achilles tendon.

    abstract::Neurotrophins are substances that have been shown to be important in growth and remodelling phases in different types of tissue. There is no information concerning the possible occurrences of neurotrophins and their receptors in tendons. In this study, sections of both chronic painful (tendinosis) and pain-free (non-t...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-24.839

    authors: Bagge J,Lorentzon R,Alfredson H,Forsgren S

    更新日期:2009-07-01 00:00:00

  • Histology of skeletal muscle reconstructed by means of the implantation of autologous adipose tissue: an experimental study.

    abstract::The purpose of this study was to determine the histological characteristics of a skeletal muscle reconstructed by means of the implantation of autologous adipose tissue following an experimentally-induced volumetric muscle loss. A cylindrical piece in the belly of the rat anterior tibial muscle was removed. In the hol...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-18-163

    authors: Leiva-Cepas F,Jimena I,Ruz-Caracuel I,Luque E,Villalba R,Peña-Amaro J

    更新日期:2020-05-01 00:00:00

  • Use of a fibroblastic matrix improves the results of mesothelial-cell seeding on vascular prostheses of polytetrafluoroethylene.

    abstract::Mesothelial cells (MC) obtained from the human omentum are a good alternative to the use of endothelial cells (EC) as a covering for vascular prostheses of polytetrafluoroethylene (PTFE), given the antithrombogenic properties and good behavior in vitro of mesothelial cells. We studied the behaviour of mesothelial cell...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Buján J,García-Honduvilla N,Hernando A,Bellón JM

    更新日期:1995-10-01 00:00:00

  • Oxidative damage in age-related macular degeneration.

    abstract::Epidemiologic studies have suggested that elderly patients who consumed diets rich in antioxidants throughout their lives are less likely to be afflicted with age-related macular degeneration (AMD). This led to the Age-Related Eye Disease Study, which showed that supplements containing antioxidant vitamins and zinc re...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-22.1301

    authors: Shen JK,Dong A,Hackett SF,Bell WR,Green WR,Campochiaro PA

    更新日期:2007-12-01 00:00:00

  • CD34+ stromal cells/fibroblasts/fibrocytes/telocytes as a tissue reserve and a principal source of mesenchymal cells. Location, morphology, function and role in pathology.

    abstract::We review the morphofunctional characteristics of CD34+ stromal fibroblastic/fibrocytic cells (CD34+ SFCs) and report our observations. We consider the following aspects of CD34+ SFCs: A) The confusing terms applied to this cell type, often combining the prefix CD34 with numerous names, including fibroblasts, fibrocyt...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-29.831

    authors: Díaz-Flores L,Gutiérrez R,García MP,Sáez FJ,Díaz-Flores L Jr,Valladares F,Madrid JF

    更新日期:2014-07-01 00:00:00

  • Melanopsin-expressing retinal ganglion cells in aging and disease.

    abstract::Melanopsin-expressing retinal ganglion cells (mRGCs) constitute a system in the mammalian retina used for irradiance detection, regulating non-image forming functions, such as photoentrainment of circadian rhythms, control of the pupillary light reflex, masking response, light-regulated melatonin secretion, and modula...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-18-138

    authors: Esquiva G,Hannibal J

    更新日期:2019-12-01 00:00:00

  • Control of the cell cycle by neurotrophins: lessons from the p75 neurotrophin receptor.

    abstract::Although traditionally little attention has been paid to the interplay between neurotrophins and the cell cycle, a number of recent findings suggest an important role for these growth factors in the regulation of this aspect of the cellular physiology. In this article, we review the evidence from a number of studies t...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-17.1227

    authors: López-Sánchez N,Frade JM

    更新日期:2002-10-01 00:00:00

  • Hypophyseal pathology in AIDS.

    abstract::One hundred and eleven pituitary glands of patients (93 males, 18 females; mean age 32 years, 5 months) who died of fully developed AIDS or ARC were examined under light microscopy with the aid of immunohistochemistry. On post mortem (p.m.) examination a wide series of multiorgan alterations was noticed. Microscopical...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Mosca L,Costanzi G,Antonacci C,Boldorini R,Carboni N,Cristina S,Liverani C,Parravicini C,Pirolo A,Vago L

    更新日期:1992-04-01 00:00:00

  • Bronchial-associated lymphoid tissue (BALT) response to airway challenge with cigarette smoke, bovine antigen and anti-pulmonary serum.

    abstract::The bronchial-associated lymphoid tissue (BALT) is a lymphoepithelial organ, related to the immune defence of the lung and to alveolar clearance, which changes size in certain states of disease. Changes in the size of BALT were quantified and compared, and Spearman's test was used to test the relation with the bronchi...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Escolar Castellón JD,Escolar Castellón A,Roche Roche PA,Miñana Amada C

    更新日期:1992-07-01 00:00:00

  • Benign mast cell hyperplasia and atypical mast cell infiltrates in penile lichen planus in adult men.

    abstract::Introduction. Lichen planus (LP) is a chronic cytokine-mediated disease of possible auto-immune etiology. 25% of men have anogenital manifestations. Erosive penile LP causes a scarring phimosis of the foreskin in uncircumcised men. Mast cells as potent immune modulators have been implicated in a number of autoimmune a...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-29.1017

    authors: Regauer S,Beham-Schmid C

    更新日期:2014-08-01 00:00:00

  • Potential therapeutic effect of SO₂ on fibrosis.

    abstract::Fibrosis is a pathological feature of most chronic diseases and leads to the dysfunction of various organs. However, there is currently no effective method for treating fibrosis. In recent years, a small gas, sulfur dioxide (SO₂), which can be generated endogenously in mammals, has been found to have vasorelaxation ac...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-18-169

    authors: Wang XB,Cui H,Du JB

    更新日期:2019-12-01 00:00:00

  • Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease.

    abstract::Parkinson's disease (PD) is a neurodegenerative disorder characterized by progressive cell loss confined mostly to dopaminergic neurons of the substantia nigra. Several factors, including oxidative stress, and decreased activity of complex I mitochondrial respiratory chain, are involved in the degenerative process. Ye...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Anglade P,Vyas S,Javoy-Agid F,Herrero MT,Michel PP,Marquez J,Mouatt-Prigent A,Ruberg M,Hirsch EC,Agid Y

    更新日期:1997-01-01 00:00:00