Abstract：
:Although traditionally little attention has been paid to the interplay between neurotrophins and the cell cycle, a number of recent findings suggest an important role for these growth factors in the regulation of this aspect of the cellular physiology. In this article, we review the evidence from a number of studies that neurotrophins can influence cell cycle progression or mitotic cycle arrest both in the nervous system as well as in other cell types. The contrary response of different cells to neurotrophins in terms of cell cycle regulation derives in part from the fact that these factors use two different receptor types to transmit their signals: members of the Trk family and the p75 neurotrophin receptor (p75NTR). With this in mind, we outline the current state of our knowledge regarding the molecular basis underlying the control of cell cycle progression by neurotrophins. We focus our interest on the receptors that transduce these signals and, in particular, the striking finding that p75NTR interacts with proteins that can promote mitotic cycle arrest. Finally, we discuss the mechanisms of cell death mediated by p75NTR in the context of cell cycle regulation.
journal_name
Histol Histopatholjournal_title
Histology and histopathologyauthors
López-Sánchez N,Frade JMdoi
10.14670/HH-17.1227subject
Has Abstractpub_date
2002-10-01 00:00:00pages
1227-37issue
4eissn
0213-3911issn
1699-5848journal_volume
17pub_type
杂志文章,评审abstract：AIMS:The expression patterns of TGFB signaling proteins, such as TGFB1/2, TGFBR1(ALK5), TGFBR2, SMAD1/2/3, SMAD2/3, SMAD4, SMAD7, and of downstream targets of TGFB signaling, CDKN1A (p21CIP1), CDKN1B (p27KIP1), MYC, CDC25A, TP53, and RELA (p65NF-kB) were investigated in gastric carcinomas and other gastric lesions. ME...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-23.1439
更新日期：2008-12-01 00:00:00
abstract：:Ewing-like sarcomas (ELS) are a heterogenous group of tumors that frequently affect pediatric and young adult patients. Accurate classification and distinction from the Ewing sarcoma family of tumor (ESFT) is decisive in patient management. ELS share a significant morphologic, immunohistochemical and clinical overlap ...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-11-792
更新日期：2016-11-01 00:00:00
abstract：:Oligodendrocytes are the myelinating cells of the central nervous system. Since many studies of demyelinating diseases focus their research on this cell type, there is growing interest for obtaining reliable markers that can specifically recognize oligodendroglia. Established markers are the myelin-associated neurite ...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-11-640
更新日期：2015-12-01 00:00:00
abstract：:Soft dental tissues have been identified as easily accessible sources of multipotent postnatal stem cells. Dental stem cells are mesenchymal stem cells (MSC) capable of differentiating into at least three distinct cell lineages: osteo/odontogenic, adipogenic and neurogenic. They express various markers including those...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-29.699
更新日期：2014-06-01 00:00:00
abstract：:The coexistence of serotonin and cholecystokinin was studied in foetal sheep lungs at pseudoglandular stage of development by light microscopic immunohistochemistry. The coexistence was examined by staining consecutive sections with the different antibodies. Serotonin and cholecystokinin immunoreactivity was found wit...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：:Smads are signal transducers for the members of the TGF-beta superfamily. Of these Smads, Smad4 is essential for TGF-beta signaling. The purpose of this study was to elucidate Smad4 expression and localization in 65 gastric adenomas, 49 intestinal-type and 39 diffuse type of gastric adenocarcinomas (including 12 cases...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-20.543
更新日期：2005-04-01 00:00:00
abstract：:It has been commonly supposed that adult stem cells co-localize with supporting cells within specific regions or specialized microenvironment in each tissue/organ, called stem cell niche. This concept was based on the assumption that stem cells are intrinsically hierarchical in nature. However, recent data indicate th...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-25.397
更新日期：2010-03-01 00:00:00
abstract：AIMS:Gastric hyperplastic polyps (GHPs) are the most common polypoid lesion of the stomach, and their malignant potential has been demonstrated. In the present study, we evaluated the mucin phenotypes of GHPs and investigated the relationships among mucin phenotypes and clinical-pathological factors, proliferative acti...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-29.343
更新日期：2014-03-01 00:00:00
abstract：:Current data on the influence of neuropeptides on the growth, structure and function of cells comprising the hypothalamo-pituitary-adrenal axis were presented and discussed. The action of vasopressin, oxytocin, neurotensin, bombesin, neuropeptide Y, substance P and VIP have been evaluated. The hypothesis has been intr...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：
更新日期：1993-01-01 00:00:00
abstract：:Macrophages are important effector cells in cell-mediated immunity against intracellular infection. Among cytokines that macrophages are able to release are IL-12 and TNF alpha. IL-12 is a critical linker between the innate and adaptive cell-mediated immunity, capable of Th1 differentiation and IFN gamma release by T ...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-15.199
更新日期：2000-01-01 00:00:00
abstract：:Epidemiologic studies have suggested that elderly patients who consumed diets rich in antioxidants throughout their lives are less likely to be afflicted with age-related macular degeneration (AMD). This led to the Age-Related Eye Disease Study, which showed that supplements containing antioxidant vitamins and zinc re...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-22.1301
更新日期：2007-12-01 00:00:00
abstract：:Monoclonal antibody against histiocytosis X cells (HXCs) was established. The antigen was the cell membrane of HXCs from the submandibular lesion of a 63-year-old man who had been diagnosed as an adult type of histiocytosis X (HX) and whose HXCs had numerous Birbeck granules (BGs). The obtained monoclonal antibody, na...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1992-07-01 00:00:00
abstract：:Cancer is the subject of intense research around the world, but many questions about how the disease works remain unanswered. How exactly does cancer start and how do tumours grow? In fact, at present there are ten times more anticancer drugs being tested in clinical trials than there were 15 years ago. However, many ...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-27.157
更新日期：2012-02-01 00:00:00
abstract：:In the present study we examined prognostic value of immunohistochemical estimation of topoisomerase 1A (TOP 1A) and HER-2/neu expression in ovarian cancers treated with platinum-based drugs but not with topotecan and the relation between expression of these proteins on the one hand and intensity of proliferation (Ki6...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-21.713
更新日期：2006-07-01 00:00:00
abstract：:Nitric oxide (NO) is a biological messenger molecule produced by one of the essential amino acids L-arginine by the catalytic action of the enzyme NO synthase (NOS). The dual role of NO as a protective or toxic molecule is due to several factors, such as; the isoform of NOS involved, concentration of NO and the type o...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-21.445
更新日期：2006-04-01 00:00:00
abstract：:Osteoarthritis (OA) is characterized by cartilage attrition, subchondral bone remodeling, osteophyte formation and synovial inflammation. Perturbed homeostasis caused by inflammation, oxidative stress, mitochondrial dysfunction and proapoptotic/antiapoptotic dysregulation is known to impair chondrocyte survival in joi...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-26.1265
更新日期：2011-10-01 00:00:00
abstract：:Dimethylnitrosamine (DMN) induced liver injury in rats with cell necrosis, inflammation, hemorrhages, increased collagen type III synthesis and basement membrane component laminin and collagen IV localization in perisinusoidal sites. Malotilate ingestion during DMN treatment abolished inflammation and decreased inters...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:Thymidine phosphorylase (TP), thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) have been indicated as possible predictive markers for epithelial malignancies. All these three enzymes are actively involved in 5-FU metabolism. In this report, we investigated mRNA expression of these factors with real-...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-19.129
更新日期：2004-01-01 00:00:00
abstract：:Sample preparation of dental tissues for quantitative electron microprobe analysis has not been critically examined because of the highly mineralized nature of these structures. The present study was designed to establish the most suitable method for the electron probe quantitative determination of calcium in human pe...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-13.109
更新日期：1998-01-01 00:00:00
abstract：:Melanocytes characterized by their tyrosinase activity, melanosomes and dendrites locate in the basal layer of epidermis and hair bulb in the skin of mice. Melanocytes differentiate from undifferentiated melanoblasts derived from embryonic neural crest. Melanocyte-stimulating hormone plays an important role in the reg...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：
更新日期：1995-01-01 00:00:00
abstract：:Transforming growth factor-beta1 (TGF-1beta) has been shown to modulate both cell proliferation and the synthesis of extracellular matrix by vascular cells. This study was aimed to establish the temporal correlation between TGF-beta1 expression, the expression of the extracellular matrix protein fibronectin, and plaqu...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-15.421
更新日期：2000-04-01 00:00:00
abstract：:Src, a 60 kDa non-receptor tyrosine kinase, is the product of normal c-src of the human genome and member of the Src protein tyrosine kinases family (SFK). As described by Martin and Rous, a genetic recombination between c-src and the RSV oncogene of Rous sarcoma virus results in a modified Src protein, with increased...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-27.677
更新日期：2012-06-01 00:00:00
abstract：:Light and electron microscopy were used to analyze the epithelial lining of odontogenic cysts excised from edentulous regions of the jaws. Clinically, three cases were identified as keratocysts, and 21 cases as cysts other than keratocysts ("non-keratocysts"). The epithelium of the former was found to achieve keratini...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1996-04-01 00:00:00
abstract：:The rapid Golgi method, combined with current optical and electronmicroscopical techniques, was used in three central gangliogliomas and in one dysplastic gangliocytoma of the cerebellum to study the morphology of ganglionic cells. Gangliogliomas were composed of bipolar, fusiform and radiate cells with dense core and...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1990-07-01 00:00:00
abstract：:A number of tumor suppressor and tumor-related genes exhibit promoter hypermethylation with resulting gene silencing in human cancers. In addition, several gene promoters have also been shown to become hypermethylated in non-neoplastic cells during aging. To assess the physiological consequence and clinical significan...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-19.221
更新日期：2004-01-01 00:00:00
abstract：:The Libyan jird (Meriones libycus) is a nocturnal Saharan Rodent submitted to a seasonal cycle of reproduction characterized by a short active period during spring and beginning of summer, and a long phase of sexual quiescence from the end of summer until the end of winter. During this cycle, the male reproductive org...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-22.603
更新日期：2007-06-01 00:00:00
abstract：:Hereditary hemochromatosis (HH) is an inherited iron overload disorder characterized by normal iron-driven erythropoiesis and abnormal iron metabolism, leading to excess iron deposited in parenchymal cells of liver, heart, and endocrine glands. Iron hormone, hepcidin, plays a critical role in iron homeostasis through ...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-11-762
更新日期：2016-08-01 00:00:00
abstract：:The study was carried out on the distribution of neurons and fibres which contain the Corticotropin releasing factor-like (CRF) immunoreactivity in the encephalon of two species of teleosts, Gambusia affinis and Salmo trutta. The peroxidase-antiperoxidase (PAP) immunocytochemical technique was employed. The present st...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1994-04-01 00:00:00
abstract：:Spinal cord injury (SCI) is one of the most destructive traumatic diseases in human beings. The balance of inflammation in the microenvironment is crucial to the repair process of spinal cord injury. Inflammatory cytokines are direct mediators of local lesion inflammation and affect the prognosis of spinal cord injury...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-18-262
更新日期：2020-10-01 00:00:00
abstract：:TNFalpha exerts apoptosis throughout an intracellular transduction pathway that involves the kinase proteins TRAF-2 (integration point of apoptotic and survival signals), ASK1 (pro-apoptotic protein), MEK-4 (p38 activator and metastasis suppressor gene), JNK (stress mitogen activated protein kinase) and the transcript...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-23.1279
更新日期：2008-10-01 00:00:00
