Abstract:
INTRODUCTION:It is difficult to prevent and treat intra- and peri-neural fibrosis after peripheral nerve surgery. Many authors have attempted to develop and verify the effectiveness of substances to decrease the formation of adherences in different tissues. MATERIAL AND METHODS:this study aimed to assess the effectiveness of a barrier of oxidized regenerated cellulose (ORC) to reduce adherence and perineural fibrosis in a model of surgical perineural induced fibrosis in rat sciatic nerve in 40 rats. After tissue aggression, the nerve of the right rear limb was wrapped in ORC and the left limb served as control. Animals were killed at 3 and 6 weeks, and nerves and muscle mass were extracted en bloc. Connective tissue was quantified by conventional histopathological techniques and Fibrosis HR(R) automatic image analysis. RESULTS:No significant differences were found in intra- or peri-neural induced fibrosis between control nerves (6.88% and 8.90%, respectively) and treated nerves (6.57% and 9.90%) at 3 or 6 weeks (10.41% and 12.51% in controls; 11.85% and 15.72% in treated nerves). Inflammatory phenomena and granulomatous reactions were more frequent in treated animals. CONCLUSIONS:ORC conferred no advantage in prevention of nerve fibrosis and might have interfered with healing.
journal_name
Histol Histopatholjournal_title
Histology and histopathologyauthors
Hernández-Cortés P,Peregrina M,Aneiros-Fernández J,Tassi M,Pajares-López M,Toledo M,O'Valle Fdoi
10.14670/HH-25.741subject
Has Abstractpub_date
2010-06-01 00:00:00pages
741-7issue
6eissn
0213-3911issn
1699-5848journal_volume
25pub_type
杂志文章abstract::This study deals with myocardial preservation after 24 hours of continuous, hypothermic and oxygenated perfusion with Cape Town (CT) solution, focusing on the morphological changes produced by preservation and reperfusion, and their possible relationship to the composition of the solution and the immediate hemodynamic...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-13.21
更新日期:1998-01-01 00:00:00
abstract::To clarify the role of REG IV, a new member of the regenerating gene (REG) family, in tumorigenesis and progression of colorectal carcinoma (CRC), 320 CRC specimens, 123 corresponding adjacent non-cancerous mucosa (ANCMs), 46 corresponding non-adjacent non-cancerous mucosa (NANCMs) and 86 adenomas were investigated im...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-25.473
更新日期:2010-04-01 00:00:00
abstract::A current concern about the biological effects of electromagnetic fields (EMF) is increasing with the wide spread use of X-band microwaves (MW, 8-10 GHz range). Gigahertz transverse electromagnetic (GTEM) field flat transmission lines are currently being used for experimental exposure of biological samples to high fre...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-26.1187
更新日期:2011-09-01 00:00:00
abstract::Angiogenesis and bone formation are coupled during skeletal development and fracture healing. This relationship, although known for some time, has not been properly explored. Advances in the discovery of how angiogenesis is regulated in physiological processes like embryogenesis, endometrial regeneration and wound hea...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-27.559
更新日期:2012-05-01 00:00:00
abstract:AIMS:The prognostic application of YES1 in epithelial ovarian cancer (EOC) is currently unclear. We aimed to investigate the expression of YES1 and its correlation with survival outcome in patients with EOC. METHODS:A retrospective study of patients diagnosed with EOC at the Cancer Center, Sun Yat-Sen University, Guan...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-18-203
更新日期:2020-07-01 00:00:00
abstract::Current data on the localization of neuropeptide Y-related peptides in the hypothalamo-pituitary-adrenal gland (HPA) axis as well as the effects of these peptides on the function of cells comprising HPA axis are presented and discussed. The action of neuropeptide Y, peptide YY, and pancreatic polypeptide on HPA axis a...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:
更新日期:1996-04-01 00:00:00
abstract::Leukemias, a heterogeneous group of hematological disorders, are characterized by ineffective hematopoiesis and morphologic abnormalities of hematopoietic cells. Thrombocytopenia is a common problem among leukemia types that can lead to hemorrhagic complications in patients. The purpose of this review article is to id...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-11-976
更新日期:2018-09-01 00:00:00
abstract:INTRODUCTION:Germline mutations in the tumour suppressor gene dyskeratosis congenit 1 (DKC1) cause the cancer prone syndrome called X-linked dyskeratosis congenita. The present study aims to determine whether mutations of the DKC1 gene may also be present in frequent human sporadic cancers (breast, colon and lung cance...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-28.365
更新日期:2013-03-01 00:00:00
abstract::Since bone marrow stromal cells (MSCs) are easily accessible both from healthy donors and patients, and can be expanded on a therapeutic scale, they have attracted attention for cell-based therapy. MSCs contribute to the protection of host tissue after transplantation by Immune modulation and trophic effect. They also...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-24.631
更新日期:2009-05-01 00:00:00
abstract::Chaperone-mediated autophagy (CMA), a selective form of autophagy, where cellular proteins with KFERQ-like motif are targeted to the lysosome for degradation, is necessary to maintain cellular homeostasis. The role of CMA in neurodegenerative diseases has been extensively studied in the past decades, with defects in t...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-18-202
更新日期:2020-07-01 00:00:00
abstract::We compared characteristic lesions occurring in chickens and domestic ducks naturally infected with H5N1 HPAI virus in April and May 2008. Infected chickens generally exhibited pale-green, watery diarrhoea, depression, neurological signs and cyanosis of wattles and combs, and infected ducks generally exhibited neurolo...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-26.167
更新日期:2011-02-01 00:00:00
abstract::In mouse embryos, the expression of Blimp1 has recently revealed a population of allocated primordial germ cell precursors 24 hours earlier than previously thought. Those 'blimped' precursors have been shown to give rise, by mitotic division, to germ cells only and no other cell lineages. Here, we try to understand th...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-23.1553
更新日期:2008-12-01 00:00:00
abstract::CD24 is known to be an important diagnostic and prognostic marker of several major cancers affecting females. We aimed to determine CD24 expression in normal, hyperplastic, and carcinomatous endometrium and its correlation with estrogen and progesterone receptor expression. A total of 271 cases including 62 normal/atr...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-24.309
更新日期:2009-03-01 00:00:00
abstract::Fatty acid binding proteins (FABPs) are 15-kDa proteins responsible for the transport of fatty acids both intracellularly and extracellularly. Consisting of 12 different isoforms, some of the proteins have been found to be released in the serum and to be correlated with various diseases including cancer. Differential ...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-18-014
更新日期:2019-01-01 00:00:00
abstract::Using histopathological analysis of semi-thin sections stained with toluidine blue, we observed profound pathological changes in the islets of Langerhans of hamsters infected with the scrapie agent (strain 139H). These included cytoplasmic vesicles, nuclear swelling, and vacuolization in the islet cells. Two types of ...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1996-01-01 00:00:00
abstract::The liver represents a site of expression of neurotrophins and their receptors. We have characterized the expression and intracellular localization of the nerve growth factor (NGF) receptor, Trk-A, in liver cells in vivo and in vitro. In both normal and fibrotic liver tissue, Trk-A immunostaining was present in differ...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-23.327
更新日期:2008-03-01 00:00:00
abstract::This study was conducted to determine the effects of extracts obtained from both normal and denervated muscles on different muscle types. Wistar rats were used and were divided into a control group and four experimental groups. Each experimental group was treated intraperitoneally during 10 consecutive days with a dif...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-11-776
更新日期:2016-12-01 00:00:00
abstract::Epidemiologic studies have suggested that elderly patients who consumed diets rich in antioxidants throughout their lives are less likely to be afflicted with age-related macular degeneration (AMD). This led to the Age-Related Eye Disease Study, which showed that supplements containing antioxidant vitamins and zinc re...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-22.1301
更新日期:2007-12-01 00:00:00
abstract::The aim of the present work was to study the morphological implications between the elastin and the phenotypic expression of the vascular smooth muscle cells. For this purpose, sixty human tortuous arteries from different territories have been studied. We have measured the morphometric indexes Intimal Thickening Index...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-15.95
更新日期:2000-01-01 00:00:00
abstract::Glucose uptake and metabolism are essential for proliferation and survival of cells, and are supposed to be enhanced in actively proliferating cell systems such as embryonic and cancer tissues. Glucose uptake is usually carried out through glucose transporters. In the developing fetal lung, metabolism of glucose is th...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-14.895
更新日期:1999-07-01 00:00:00
abstract::Gp96 is the endoplasmic reticulum (ER)-resident molecular chaperone, which is involved in the correction of unfolded proteins, in the activation of proteasome-dependent ER-associated degradation of the misfolded proteins, and in activation of the protein translation that modulates polypeptide traffic into the ER. Furt...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-28.61
更新日期:2013-01-01 00:00:00
abstract::The anabolic androgenic steroid nandrolone decanoate has minimal androgenic effects and, thus, is widely used to induce muscle hypertrophy in both patients and athletes. Although increases in satellite cell numbers and satellite cells giving rise to new myonuclei are associated with hypertrophy in many experimental mo...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-25.133
更新日期:2010-02-01 00:00:00
abstract::In order to reveal modulation of the number of pulmonary neuroendocrine cells (PNEC) in interstitial lung diseases and to clarify significance of cell proliferation activity in occurrence of PNEC, we counted airway PNEC of the patients of idiopathic interstitial pneumonia, secondary interstitial pneumonia and control ...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-17.1121
更新日期:2002-10-01 00:00:00
abstract::Pulmonary fibrosis is a common response to various injuries to the lung. The resolution of a fibroproliferative response after lung injury is key to survival. Although there are various initiating factors or causes, the terminal stages are characterized by proliferation and progressive accumulation of connective tissu...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-19.867
更新日期:2004-07-01 00:00:00
abstract::Equine endometritis eosinophilica (EE) is rarely described and its diagnostic criteria are not defined. The aim of this study was to characterize histological features of EE. A data base (1995-2013) was searched for biopsies with increased eosinophils. This study included all biopsies with this diagnosis and represent...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-11-872
更新日期:2017-11-01 00:00:00
abstract::Fibrosis is a pathological feature of most chronic diseases and leads to the dysfunction of various organs. However, there is currently no effective method for treating fibrosis. In recent years, a small gas, sulfur dioxide (SO₂), which can be generated endogenously in mammals, has been found to have vasorelaxation ac...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-18-169
更新日期:2019-12-01 00:00:00
abstract::Erythema dyschromicum perstans (EDP) and vitiligo are two cutaneous pigmentary dermatoses of unknown etiology. In the present study, the leukocyte infiltrates in the affected skin of EDP and vitiligo patients were studied using the avidin-biotin (ABC) immunoperoxidase technique and monoclonal antibodies which recognis...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1987-07-01 00:00:00
abstract::Src, a 60 kDa non-receptor tyrosine kinase, is the product of normal c-src of the human genome and member of the Src protein tyrosine kinases family (SFK). As described by Martin and Rous, a genetic recombination between c-src and the RSV oncogene of Rous sarcoma virus results in a modified Src protein, with increased...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-27.677
更新日期:2012-06-01 00:00:00
abstract::Peritumoral brain edema (PTBE) is considered to be one of the main biological behaviors of brain glioma. However, the histopathological features of PTBE remain imprecisely defined. We analyzed the histopathological characteristics in the PTBE area of 22 cases of glioma. Microscopically, the pre-existing basic structur...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-11-607
更新日期:2015-09-01 00:00:00
abstract::During endotoxic shock, the liver exerts a lipopolysaccharide (LPS) clearance function with the participation of both parenchymal and sinusoidal cells. Liver damage could be caused by LPS direct action, hypoxia and/or inflammatory mediators released by Kupffer cells. The aim of this study is to establish an experiment...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1996-07-01 00:00:00