Abstract:
:To clarify the role of REG IV, a new member of the regenerating gene (REG) family, in tumorigenesis and progression of colorectal carcinoma (CRC), 320 CRC specimens, 123 corresponding adjacent non-cancerous mucosa (ANCMs), 46 corresponding non-adjacent non-cancerous mucosa (NANCMs) and 86 adenomas were investigated immunohistochemically to compare REG IV expression with clinicopathological features. In addition, double immunofluorescence labeling was performed to analyze the localization of REG IV and the intestinal mucin, MUC2. The expression of REG IV in CRCs was significantly lower than in NANCMs, ANCMs or adenomas, and inversely correlated with poor differentiation and venous invasion. In cases of ANCM, REG IV expression was positively correlated with the depth of invasion, lymph node metastasis and Duke's staging of corresponding cases. The expression of REG IV in CRC was significantly linked to that of MUC2 and the EGFR phosphorylated on Tyr1068, but not to that of MUC5AC, EGFR, Akt, or Akt phosphorylated on Ser473 or Thr308. The double immunofluorescence revealed coexpression, but independent localization, of REG IV and MUC2 in NANCMs, ANCMs, adenomas and CRCs, except for mucinous carcinomas. Univariate analysis using the Kaplan-Meier method indicated no correlation between REG IV expression and the cumulative survival rate of CRC patients. In conclusion, REG IV expression was upregulated in ANCMs and adenomas, then decreased in CRCs. This indicated that REG IV overexpression may be an early event in CRC carcinogenesis. Its expression in CRCs was positively linked to MUC2 and phosphorylation of the EGFR on Tyr1068, suggesting that REG IV may be a useful marker for intestinal type mucinous carcinoma and a good candidate as a molecular therapeutic target for CRCs.
journal_name
Histol Histopatholjournal_title
Histology and histopathologyauthors
Li XH,Zheng Y,Zheng HC,Takahashi H,Yang XH,Masuda S,Takano Ydoi
10.14670/HH-25.473subject
Has Abstractpub_date
2010-04-01 00:00:00pages
473-84issue
4eissn
0213-3911issn
1699-5848journal_volume
25pub_type
杂志文章abstract::Sex steroid hormones are involved in regulation of skin development and functions as well as in some skin pathological events. To determine the sites of action of estrogens, androgens and progestins, studies have been performed during the recent years to accurately localize receptors for each steroid hormone in human ...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-19.629
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abstract::A novel family of evolutionally conserved neuronal guidance cues, including ligands (i.e., Slit, netrin, epherin, and semaphorin) and their corresponding receptors (i.e., Robo, DCC/Unc5, Eph and plexin/ neuropilin), has been identified to play a crucial role in axon pathfinding and branching as well as neuronal cell m...
journal_title:Histology and histopathology
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journal_title:Histology and histopathology
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journal_title:Histology and histopathology
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journal_title:Histology and histopathology
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journal_title:Histology and histopathology
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更新日期:2005-01-01 00:00:00
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journal_title:Histology and histopathology
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更新日期:1986-10-01 00:00:00
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journal_title:Histology and histopathology
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更新日期:2020-06-01 00:00:00
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journal_title:Histology and histopathology
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doi:10.14670/HH-29.1281
更新日期:2014-10-01 00:00:00
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journal_title:Histology and histopathology
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doi:10.14670/HH-24.107
更新日期:2009-01-01 00:00:00
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journal_title:Histology and histopathology
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更新日期:2017-03-01 00:00:00
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journal_title:Histology and histopathology
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journal_title:Histology and histopathology
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更新日期:2014-06-01 00:00:00
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journal_title:Histology and histopathology
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journal_title:Histology and histopathology
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journal_title:Histology and histopathology
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journal_title:Histology and histopathology
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更新日期:2002-01-01 00:00:00
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journal_title:Histology and histopathology
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journal_title:Histology and histopathology
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journal_title:Histology and histopathology
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journal_title:Histology and histopathology
pub_type: 杂志文章
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