Abstract：
:Glucose uptake and metabolism are essential for proliferation and survival of cells, and are supposed to be enhanced in actively proliferating cell systems such as embryonic and cancer tissues. Glucose uptake is usually carried out through glucose transporters. In the developing fetal lung, metabolism of glucose is thought to be an important process in cell proliferation, differentiation and maturation. Active glucose uptake could result in accumulation of glycogen in epithelial cells, and utilization of glycogen could be a critical phenomenon for lung epithelial development. In hamsters, although facilitative glucose transporter isoform 1 (GLUT1) and isoform 4 (GLUT4) are not detected in adult lungs, expression of them is detected with immunohistochemical and Western blot analyses in the developing fetal lungs. In human lung carcinomas, GLUT1 expression is seen in most cases of lung carcinoma, and is seen especially frequently in squamous cell carcinoma. GLUT1 expression in adenocarcinoma of the lung is correlated with reduced cell differentiation, larger tumor size and positive lymph node metastasis. A few cases of lung carcinoma show positive staining for GLUT3 and GLUT4. Thus, expression of some facilitative glucose transporter isoforms is detected in developing fetal epithelium and in lung carcinomas. Overexpression of them could enhance uptake of glucose into these cells, and the increased influx of glucose could be involved in active cell proliferation, which is a common character of the developing lung epithelium and carcinoma.
journal_name
Histol Histopatholjournal_title
Histology and histopathologyauthors
Ito T,Noguchi Y,Udaka N,Kitamura H,Satoh Sdoi
10.14670/HH-14.895subject
Has Abstractpub_date
1999-07-01 00:00:00pages
895-904issue
3eissn
0213-3911issn
1699-5848journal_volume
14pub_type
杂志文章,评审abstract：:Targeting essential cellular pathways that determine neuronal and vascular survival can foster a successful therapeutic platform for the treatment of a wide variety of degenerative disorders in the central nervous system. In particular, oxidative cellular injury can precipitate several nervous system disorders that ma...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-19.495
更新日期：2004-04-01 00:00:00
abstract：:Glomerular alterations of experimental diabetes mellitus are observed in animals submitted to a reduction in renal mass, suggesting that some mechanisms responsible for the progression of renal disease are common. The aim of this study was to investigate the effect of nephrectomy on the renal function and morphology o...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-19.1085
更新日期：2004-10-01 00:00:00
abstract：:The characteristics and distribution pattern of retinal afferent terminals making synaptic contacts on narrow field vertical neurons in the stratum griseum superficiale of the rabbit superior colliculus were studied using the Golgi-gold substitution technique in combination with either autoradiographic or degenerative...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-28.61
更新日期：2013-01-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-15.1151
更新日期：2000-10-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-11-640
更新日期：2015-12-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-27.1599
更新日期：2012-12-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-21.873
更新日期：2006-08-01 00:00:00
abstract：:Pneumadin (PNM) is a biologically active decapeptide, which has previously been found to enhanced rat adrenal growth; the mechanism is indirect and probably involves the stimulation of both arginine-vasopressin (AVP) and ACTH release. The effects of 2- and 6-day PNM administration on the atrophic adrenal cortices of r...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1997-07-01 00:00:00
abstract：:Sixty male Wistar rats were used for this experiment and assigned at random to the control group or to the stimulation method. Control rats show cerebral asymmetry with right bias at the frontal and occipital lobes. In the case of stimulated rats the differences from the occipital zone increase while those from the fr...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1992-07-01 00:00:00
abstract：:Epidemiologic studies have suggested that elderly patients who consumed diets rich in antioxidants throughout their lives are less likely to be afflicted with age-related macular degeneration (AMD). This led to the Age-Related Eye Disease Study, which showed that supplements containing antioxidant vitamins and zinc re...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-22.1301
更新日期：2007-12-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：
更新日期：1993-01-01 00:00:00
abstract：:HNK-1 positive (HNK-1+) cells in human peripheral blood and lymph nodes were comparatively analysed by means of immunohistochemistry and immunoelectron microscopy. In peripheral blood, the HNK-1+ cells were grouped into large granular lymphocytes (LGLs), small lymphocytes and intermediate forms, all of which had many ...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1989-04-01 00:00:00
abstract：:The matrix metalloproteinases (MMPs) are a family of proteolytic zinc-containing enzymes, which are responsible for the breakdown of the extracellular matrix components in pathological and physiological conditions. They are involved in basement membrane disruption, stroma and blood vessel penetration, metastasis and m...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-21.603
更新日期：2006-06-01 00:00:00
abstract：:In the last years, it has been reported that bone marrow stromal cells (BMSC) are able to differentiate towards a neuronal phenotype, in vitro as well as in vivo, and consequently, the possible use of these cells for the treatment of neurological diseases has acquired enormous importance. The objective of this review ...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-24.107
更新日期：2009-01-01 00:00:00
abstract：:To determine the appropriate time for bone reconstruction after irradiation, the healing process after autogenous iliac bone transplantation in the irradiated parietal bone was examined by scanning electron microscopy and light microscopy. Bone transplantation was carried out at the second and the fourth weeks after C...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-15.7
更新日期：2000-01-01 00:00:00
abstract：INTRODUCTION:It is difficult to prevent and treat intra- and peri-neural fibrosis after peripheral nerve surgery. Many authors have attempted to develop and verify the effectiveness of substances to decrease the formation of adherences in different tissues. MATERIAL AND METHODS:this study aimed to assess the effective...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-25.741
更新日期：2010-06-01 00:00:00
abstract：:Dramatical development of molecular genetics has been disclosing the molecular mechanism of Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD). DMD gene product, dystrophin, is a submembranous cytoskeletal protein and many dystrophin-associated proteins (DAPs) have been identified, such as utrophin,...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-15.753
更新日期：2000-07-01 00:00:00
abstract：:Early observations that cultured mesenchymal stem cells (MSCs) could be induced to exhibit certain characteristics of osteocytes and chondrocytes led to the proposal that they could be transplanted for tissue repair through cellular differentiation. Therefore, many subsequent preclinical studies with transplanted MSCs...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-28.1109
更新日期：2013-09-01 00:00:00
abstract：:The study was carried out on the distribution of neurons and fibres which contain the Corticotropin releasing factor-like (CRF) immunoreactivity in the encephalon of two species of teleosts, Gambusia affinis and Salmo trutta. The peroxidase-antiperoxidase (PAP) immunocytochemical technique was employed. The present st...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1994-04-01 00:00:00
abstract：:Thrombospondin-1 (TSP-1) is a matrix protein implicated in mechanisms of wound healing. TSP-1 contains the sequence cysteine-serine-valine-threonine-cysteine-glycine (CSVTCG) that has been shown to function primarily as a cell adhesion domain. Our laboratory has isolated a novel receptor specific for the CSVTCG adhesi...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-13.967
更新日期：1998-10-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-27.1079
更新日期：2012-08-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1992-07-01 00:00:00
abstract：:The growth of a transplantable murine non-Hodgkin lymphoma tumour, developing either intraperitoneally as an ascites tumour or subcutaneously as a solid tumour, has been shown to be markedly diminished by including phytohaemagglutinin (PHA), a lectin present in raw kidney bean (Phaseolus vulgaris) in the diet. In NMRI...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-13.575
更新日期：1998-04-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-17.199
更新日期：2002-01-01 00:00:00
abstract：:Fatty acid binding proteins (FABPs) are 15-kDa proteins responsible for the transport of fatty acids both intracellularly and extracellularly. Consisting of 12 different isoforms, some of the proteins have been found to be released in the serum and to be correlated with various diseases including cancer. Differential ...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-18-014
更新日期：2019-01-01 00:00:00
abstract：:Chaperone-mediated autophagy (CMA), a selective form of autophagy, where cellular proteins with KFERQ-like motif are targeted to the lysosome for degradation, is necessary to maintain cellular homeostasis. The role of CMA in neurodegenerative diseases has been extensively studied in the past decades, with defects in t...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-18-202
更新日期：2020-07-01 00:00:00
abstract：:The possibility of resuscitating livers after warm ischaemia has been recently suggested. The aim of the present investigation was to analyse the effects of anoxia on the morphology of hepatic cells, to determine whether these effects are reversible after providing a resuscitation period between warm ischaemia (WI) an...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：:To understand the role of microtubules and microfilaments in regulating endothelial monolayer integrity and repair, and since microtubules and microfilaments show some co-alignment in endothelial cells, we tested the hypothesis that microtubules organize microfilament distribution. Disruption of microtubules with colc...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-20.455
更新日期：2005-04-01 00:00:00
abstract：:The aim of this study was to demonstrate the morphology and matrix synthesis of embryonic rat liver cells (day 18 of gestation) in organoid cultures (high density cultures) with electron microscopic and immunomorphological techniques. For this purpose the cells of embryonic rat livers were isolated enzymatically and g...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1991-04-01 00:00:00
