Emerging role of fatty acid binding proteins in cancer pathogenesis.

abstract：:Src, a 60 kDa non-receptor tyrosine kinase, is the product of normal c-src of the human genome and member of the Src protein tyrosine kinases family (SFK). As described by Martin and Rous, a genetic recombination between c-src and the RSV oncogene of Rous sarcoma virus results in a modified Src protein, with increased...

journal_title：Histology and histopathology

authors： Chatzizacharias NA,Kouraklis GP,Giaginis CT,Theocharis SE

更新日期：2012-06-01 00:00:00

abstract：:Takeda-G-protein-receptor-5 (TGR5) is a receptor for bile acids and its expression has been described in a variety of tissues and species. Characterization of TGR5 distribution and function has been investigated in drug discovery for the treatment of metabolic diseases in humans. Because dogs are one of the species us...

journal_title：Histology and histopathology

authors： Giaretta PR,Suchodolski JS,Blick AK,Steiner JM,Lidbury JA,Rech RR

更新日期：2019-01-01 00:00:00

abstract：:A number of tumor suppressor and tumor-related genes exhibit promoter hypermethylation with resulting gene silencing in human cancers. In addition, several gene promoters have also been shown to become hypermethylated in non-neoplastic cells during aging. To assess the physiological consequence and clinical significan...

journal_title：Histology and histopathology

authors： Tamura G

更新日期：2004-01-01 00:00:00

abstract：AIMS:The prognostic application of YES1 in epithelial ovarian cancer (EOC) is currently unclear. We aimed to investigate the expression of YES1 and its correlation with survival outcome in patients with EOC. METHODS:A retrospective study of patients diagnosed with EOC at the Cancer Center, Sun Yat-Sen University, Guan...

journal_title：Histology and histopathology

authors： Zhou Y,Chen P,Huang Q,Wan T,Jiang Y,Jiang S,Yan S,Zheng M

更新日期：2020-07-01 00:00:00

abstract：:The endocrine cells in the gastrointestinal tract of the musk shrew were studied immunohistochemically. Eleven kinds of endocrine cells, immunoreactive for serotonin, somatostatin, gastrin, cholecistokinin, gastric inhibitory polypeptide, motilin, secretin, neurotensin, pancreatic glucagon, enteroglucagon and bovine p...

journal_title：Histology and histopathology

authors： Kitamura N,Yamada J,Watanabe T,Yamashita T

更新日期：1990-01-01 00:00:00

abstract：:In the lungs, neuronal M2 muscarinic receptors limit the release of acetylcholine from postganglionic cholinergic nerves. However, these receptors are not functional under certain circumstances in animal models of hyperreactivity such as occurs after exposure of sensitised animals to an allergen or during a respirator...

journal_title：Histology and histopathology

authors： Costello RW,Jacoby DB,Gleich GJ,Fryer AD

更新日期：2000-07-01 00:00:00

abstract：:The importance of molybdenum-containing enzymes in the pathophysiology of a number of clinical disorders necessitates a comprehensive understanding of their histological localization and expression. The objectives of this review are to cover such enzymes so far reported and their enzyme- and immunohistochemical locali...

journal_title：Histology and histopathology

authors： Moriwaki Y,Yamamoto T,Higashino K

更新日期：1997-04-01 00:00:00

abstract：:Heterotopic ossification (HO) is a debilitating condition in which cartilage and bone forms in soft tissues such as muscle, tendon, and ligament causing immobility. This process is induced by inflammation associated with traumatic injury. In an extremely rare genetic disorder called fibrodysplasia ossificans progessiv...

journal_title：Histology and histopathology

authors： Ramirez DM,Ramirez MR,Reginato AM,Medici D

更新日期：2014-10-01 00:00:00

abstract：:TNFalpha exerts apoptosis throughout an intracellular transduction pathway that involves the kinase proteins TRAF-2 (integration point of apoptotic and survival signals), ASK1 (pro-apoptotic protein), MEK-4 (p38 activator and metastasis suppressor gene), JNK (stress mitogen activated protein kinase) and the transcript...

journal_title：Histology and histopathology

authors： Royuela M,Rodríguez-Berriguete G,Fraile B,Paniagua R

更新日期：2008-10-01 00:00:00

abstract：:The study aimed at determining levels of metallothionein (MT) and Ki-67 antigen expression in adenocarcinomas of large intestine and examining relation of the expression levels with various clinical and pathological variables. The studies were performed on 81 cases of large intestine adenocarcinoma. Using immunocytoch...

journal_title：Histology and histopathology

authors： Dziegiel P,Forgacz J,Suder E,Surowiak P,Kornafel J,Zabel M

更新日期：2003-04-01 00:00:00

abstract：:In the cutaneous nerves, unmyelinated nerve fibers outnumber the myelinated ones but are scarcely analyzed, especially at autopsy. This indifference toward the pathology of unmyelinated nerve fibers may be due to the necessity of electron microscopic analyses and, more importantly, the obscurity of pathological altera...

journal_title：Histology and histopathology

authors： Kanda T

更新日期：2000-01-01 00:00:00

abstract：:Hereditary hemochromatosis (HH) is an inherited iron overload disorder characterized by normal iron-driven erythropoiesis and abnormal iron metabolism, leading to excess iron deposited in parenchymal cells of liver, heart, and endocrine glands. Iron hormone, hepcidin, plays a critical role in iron homeostasis through ...

journal_title：Histology and histopathology

authors： Liu J,Pu C,Lang L,Qiao L,Abdullahi MA,Jiang C

更新日期：2016-08-01 00:00:00

abstract：:Platelet-derived growth factor-A (PDGF-A) is a locally produced growth factor in the rat testis secreted by both Sertoli cells and Leydig cells. It has been suggested that PDGF-A may be involved in modulation of testosterone production and may be essential to Leydig cell differentiation, however it is not known at wha...

journal_title：Histology and histopathology

authors： Fecteau KA,Mrkonjich L,Mason JI,Mendis-Handagama SM

更新日期：2006-12-01 00:00:00

abstract：:The low density lipoprotein receptor-related protein (LRP) 1 is a ubiquitously expressed, versatile cell surface transmembrane receptor involved in embryonic development and adult tissue homeostasis. LRP1 binds and endocytoses a broad spectrum of over 40 ligands identified thus far, including lipoproteins, extracellul...

journal_title：Histology and histopathology

authors： Wujak L,Markart P,Wygrecka M

更新日期：2016-07-01 00:00:00

abstract：:Morphological, histochemical and ultrastructural investigations on epiphyseal apparatus of Rana Esculenta were made. The most important findings were the following: 1) metaphyseal cartilage is localized inside proximal diaphyseal compact bone as a plug; 2) metaphyseal cartilage do not reduce in thickness during ageing...

journal_title：Histology and histopathology

authors： Dell'Orbo C,Gioglio L,Quacci D

更新日期：1992-04-01 00:00:00

abstract：:Nitric oxide (NO) has opened a new and vigorous field of biological and clinical experimentation as evidenced presently by about one hundred original publications every week. Being a biological signal under physiological conditions, NO may be to pathologically affected tissues. Major insights into the ...

journal_title：Histology and histopathology

authors： Wolf G

更新日期：1997-01-01 00:00:00

abstract：:The presence of the mu-opioid receptor and the type of glycosylation in the third extra-cellular loop of this receptor was investigated in the isthmus of mare oviduct during oestrus by means of immunoblotting and immunohistochemistry combined with enzymatic (N-glycosidase F and O-glycosidase) and chemical (beta-elimin...

journal_title：Histology and histopathology

authors： Desantis S,Albrizio M,Ventriglia G,Deflorio M,Guaricci AC,Minoia R,De Metrio G

更新日期：2008-05-01 00:00:00

abstract：:Calcium/calmodulin-dependent protein kinase II (CaMKII) is considered one of the key intracellular signaling proteins for development of neuropathy. We analyzed the expression of total CaMKII (tCaMKII) and its alpha, beta, gamma and delta isoforms in dorsal root ganglia (DRG) in a rat model of Diabetes mellitus type I...

journal_title：Histology and histopathology

authors： Ferhatovic L,Jelicic Kadic A,Boric M,Puljak L

更新日期：2014-05-01 00:00:00

abstract：:Representative tumour sections from 468 patients with invasive breast cancer were immunostained for cyclooxygenase-2 (COX-2) and evaluated. The relationships between COX-2 expression, clinical outcome and various clinicopathological variables, including tumour vascularity and disseminated tumour cells (DTC) in the bon...

journal_title：Histology and histopathology

authors： Dhakal HP,Naume B,Synnestvedt M,Borgen E,Kaaresen R,Schlichting E,Wiedswang G,Bassarova A,Holm R,Giercksky KE,Nesland JM

更新日期：2012-10-01 00:00:00

abstract：:The effects of diethylstilbestrol (DES) and of long-acting somatostatin analog, octreotide (SMS) on the rat anterior pituitary microvasculature have been studied by means of computer-assisted image analysis. Additionally, the effects of DES and SMS on prolactin secretion and anterior pituitary cell proliferation have ...

journal_title：Histology and histopathology

authors： Pawlikowski M,Kunert-Radek J,Grochal M,Zieliński K,Kulig A

更新日期：1997-10-01 00:00:00

abstract：:This study was conducted to determine the effects of extracts obtained from both normal and denervated muscles on different muscle types. Wistar rats were used and were divided into a control group and four experimental groups. Each experimental group was treated intraperitoneally during 10 consecutive days with a dif...

journal_title：Histology and histopathology

authors： Agüera E,Castilla S,Luque E,Jimena I,Leiva-Cepas F,Ruz-Caracuel I,Peña J

更新日期：2016-12-01 00:00:00

abstract：:A rat IgG2a monoclonal antibody against a stage-specific fetal glycoprotein with a molecular mass of 68 kDa (FGP68) was produced and applied to paraffin sections. This monoclonal antibody was used to compare the expression of FGP68 with that of both alpha-fetoprotein (AFP) and carcinoembryonic antigen (CEA) in 75 hepa...

journal_title：Histology and histopathology

authors： Kato M,Shinozawa T,Kato S,Terada T

更新日期：2004-07-01 00:00:00

abstract：:Cyclin A, cyclin E, BUBR1, MAD2 and Aurora A are all cell-cycle regulatory proteins and have been proven to play crucial roles in carcinogenesis. However, their expression patterns in invasive ductal breast carcinoma (IDBC) are controversial and unclear. In this study, we examined the expression status of these candid...

journal_title：Histology and histopathology

authors： Du J,Du Q,Zhang Y,Sajdik C,Ruan Y,Tian XX,Fang WG

更新日期：2011-06-01 00:00:00

abstract：:The reactivity of endothelial cells to putative endothelial cell-specific markers varies with species, with vessel size and with the organ studied. To determine their value in studies of fetal rat lung, and whether organ immaturity would also influence reactivity, we studied endothelial cell immunoreactivity to antibo...

journal_title：Histology and histopathology

authors： Han RN,Tanswell AK,Post M

更新日期：1992-10-01 00:00:00

abstract：:The novel coronavirus disease 2019 (COVID-19) outbreak began in the city of Wuhan, whereupon it rapidly spread throughout China and subsequently across the world. Rapid transmission of COVID-19 has caused wide-spread panic. Many established medications have been used to treat the disease symptoms; however, no specific...

journal_title：Histology and histopathology

authors： Zhou H,Liu LP,Fang M,Li YM,Zheng YW

更新日期：2020-10-01 00:00:00

abstract：:Chaperone-mediated autophagy (CMA), a selective form of autophagy, where cellular proteins with KFERQ-like motif are targeted to the lysosome for degradation, is necessary to maintain cellular homeostasis. The role of CMA in neurodegenerative diseases has been extensively studied in the past decades, with defects in t...

journal_title：Histology and histopathology

authors： Hou T,Fan Y,Dan W,Liu B,Wang Z,Zeng J,Li L

更新日期：2020-07-01 00:00:00

abstract：:Shotgun pellets containing bismuth (Bi) are widely used and may cause a rather intense exposure of some wild animals to Bi. A Bi shotgun pellet was implanted intramuscularly in the triceps surae muscle of 18 adult male Wistar rats. Another group of 9 animals had a Bi shotgun pellet implanted intracranially in the neoc...

journal_title：Histology and histopathology

authors： Stoltenberg M,Locht L,Larsen A,Jensen D,Danscher G

更新日期：2003-07-01 00:00:00

abstract：:The view of how astrocytes, a type of glial cells, contribute to the functioning of the central nervous system (CNS) has changed greatly in the last decade. Although glial cells outnumber neurons in the mammalian brain, it was considered for over a century that they played a subservient role to neurons. This view chan...

journal_title：Histology and histopathology

authors： Potokar M,Stenovec M,Kreft M,Gabrijel M,Zorec R

更新日期：2011-02-01 00:00:00

abstract：:Membranous glomerulonephritis caused in Barbus graellsi by myxosporidian infections have been studied by electron microscopy and immunoelectron microscopy techniques. This study indicates that Myxosporidian infection produces a chronic severe aggression. Spores reach the spleen, the kidney and the liver, where they ar...

journal_title：Histology and histopathology

authors： Peribañez MA,del Cacho E,Castillo JA,Arnal MC

更新日期：1993-10-01 00:00:00

abstract：:A study was undertaken to analyze the spatio-temporal pattern of mesenchymal cell proliferation in the developing palate of quail. Quail embryos were grown in shell-less culture. The developing palates were labelled with 3H-thymidine between culture days 2-6 (which corresponded in vivo incubation days 5-9), and proces...

journal_title：Histology and histopathology

authors： Hehn BM,Young AV,Shah RM

更新日期：1995-07-01 00:00:00