Abstract:
:Hereditary hemochromatosis (HH) is an inherited iron overload disorder characterized by normal iron-driven erythropoiesis and abnormal iron metabolism, leading to excess iron deposited in parenchymal cells of liver, heart, and endocrine glands. Iron hormone, hepcidin, plays a critical role in iron homeostasis through interaction with ferroportin (FPN), a major cellular iron exporter. Hepcidin is encoded by hepcidin antimicrobial peptide (HAMP). Mutations in hepcidin and any genes that regulate the biology of hepcidin, including hemochromatosis genes (HFE), Hemojuvelin (HJV), transferring receptor 2 (TFR2) and FPN, result in hemochromatosis. The identification of hepcidin and its role will provide a better understanding for pathogenesis of HH.
journal_name
Histol Histopatholjournal_title
Histology and histopathologyauthors
Liu J,Pu C,Lang L,Qiao L,Abdullahi MA,Jiang Cdoi
10.14670/HH-11-762subject
Has Abstractpub_date
2016-08-01 00:00:00pages
833-40issue
8eissn
0213-3911issn
1699-5848pii
HH-11-762journal_volume
31pub_type
杂志文章,评审abstract::A rat IgG2a monoclonal antibody against a stage-specific fetal glycoprotein with a molecular mass of 68 kDa (FGP68) was produced and applied to paraffin sections. This monoclonal antibody was used to compare the expression of FGP68 with that of both alpha-fetoprotein (AFP) and carcinoembryonic antigen (CEA) in 75 hepa...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-19.701
更新日期:2004-07-01 00:00:00
abstract::Platelet-collagen interaction is a complex event that involves ligand-receptor interaction. There are many adhesive non-integrin receptors for platelets to interact with various types of collagens. These non-integrin receptors also serve as signal transducers both from the outside of platelets to the inside and possib...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-14.579
更新日期:1999-04-01 00:00:00
abstract::Neurodegenerative and muscle diseases bear both complex and multifactorial pathologies. An efficacious and robust therapeutic option to treat these diseases is yet to be elucidated. At such a time, mesenchymal stem cells have drawn significant attention due to their immunomodulatory and regenerative properties. Accumu...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-11-951
更新日期:2018-07-01 00:00:00
abstract::Circadian and seasonal variations were observed in the karyometric index of pinealocytes in the cortical and medullary regions of the distal pineal body. The study involved 70 Wistar rats over a 24-hour interval (0:6, 10:00, 14:00, 18:00, 22:00, 02:00, 06:00 h) during two natural photoluminous periods, i.e. late summe...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1992-10-01 00:00:00
abstract::Unlike other B cells, plasma cells (PC) react with only a few antibodies against haemopoietic antigens. We investigated 36 specimens exhibiting a reactive increase in PC numbers (i.e. plasmacytosis, PC hyperplasia) with a broad panel of antibodies suitable for use on formalin-fixed, paraffin-embedded tissue, and compa...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-14.805
更新日期:1999-07-01 00:00:00
abstract::The study aimed at determining levels of metallothionein (MT) and Ki-67 antigen expression in adenocarcinomas of large intestine and examining relation of the expression levels with various clinical and pathological variables. The studies were performed on 81 cases of large intestine adenocarcinoma. Using immunocytoch...
journal_title:Histology and histopathology
pub_type: 临床试验,杂志文章
doi:10.14670/HH-18.401
更新日期:2003-04-01 00:00:00
abstract::Elevated plasma levels of C-reactive protein (CRP) are associated with increased risk of cardiovascular disease. CRP immunoreactive protein is also detected in the lesions of atherosclerosis. However, it is not known whether the CRP contents of atherosclerotic lesions are associated with the initiation and progression...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-27.529
更新日期:2012-04-01 00:00:00
abstract::The techniques for light and electron microscopic radioautography developed in our laboratory are described. The outlines of the applications to various tissues and organs are also briefly summarized. First, the techniques are explained in detail. These techniques can be divided into two categories, i.e., chemical fix...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:
更新日期:1997-10-01 00:00:00
abstract::Vascular endothelial cells play a critical role in the maintenance of endometrial homeostasis. Indeed many pathological conditions causing abnormal endometrial bleeding including progestin only contraception, hormone replacement therapy, endometrial polyps, myomas, hyperplasia and cancer are associated with aberrant a...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-20.719
更新日期:2005-07-01 00:00:00
abstract::Neurons of the substantia nigra show severe morphological changes in Parkinson's disease. Pathological alterations of cell bodies have been described, whereas those of neuronal processes have hardly been investigated. Golgi impregnation has been the chosen method for demonstrating neuronal processes and dendritic and ...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1991-07-01 00:00:00
abstract::Histochemical distribution of glycoproteins, carbohydrates and proteins rich in different amino acids were studied using histological and histochemical procedures, in Senegal sole, Solea senegalensis (Kaup, 1858) larvae from hatching until day 15. Glycogen, proteins and glycoproteins were detected in the yolk-sac of t...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1996-10-01 00:00:00
abstract::The effects of cadmium exposure on the protein secretory functions of cultured neonatal rat hepatocytes were analyzed by both two-dimensional polyacrylamide gel electrophoresis (2D-PAGE) and electron microscopy. [35S]Methionine-labelled protein secretion was significantly depressed by cadmium exposure in a dose-depend...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1991-01-01 00:00:00
abstract::Factor H (FH) is the predominant soluble inhibitor of the complement system. With a concentration of 200-800 microg/ml in human and rat plasma it acts as a cofactor for the soluble factor I (FI)-mediated cleavage of the component C3b to iC3b. Furthermore it competes with factor B for binding to C3b and C3(H2O) and pro...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-21.93
更新日期:2006-01-01 00:00:00
abstract::During endotoxic shock, the liver exerts a lipopolysaccharide (LPS) clearance function with the participation of both parenchymal and sinusoidal cells. Liver damage could be caused by LPS direct action, hypoxia and/or inflammatory mediators released by Kupffer cells. The aim of this study is to establish an experiment...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1996-07-01 00:00:00
abstract::The effect of chronic alcoholism on the human hippocampus was studied in 21 patients, divided in 4 groups: Group A under 45 years, group B 46-59 years, group C 60-69, and Group D over 70 years; and compared with age-matched control patients who died without neurological complications. The gyrus dentatus and the ammoni...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1990-07-01 00:00:00
abstract::The aim of our study was to document whether relationships existed among bone morphogenetic proteins (BMPs), peripheral nerve and neoplastic lesions of nerve sheath tumors. The mRNA transcriptions of BMP-2, 3, 4 and 5 in 10 cases of schwannoma, three cases of malignant schwannoma and two cases of trigeminal neuralgia ...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-16.1013
更新日期:2001-10-01 00:00:00
abstract::Transforming growth factor-betas (TGF-betas) are multifunctional cytokines that exist in 3 isoforms in mammals. The TGF-betas are ubiquitously expressed and all isoforms are secreted as biologically inactive precursors called latent TGF-beta (L-TGF-beta). L-TGF-betas are generally not effective molecules because they ...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-16.541
更新日期:2001-04-01 00:00:00
abstract::Cell-cell and cell-extracellular matrix adhesion are critical aspects of platelet function, regulating interactions between circulating platelets in the bloodstream with the blood vessel wall. In haemostasis, platelets adhere to the subendothelial matrix of a damaged vessel, spread over the surface and recruit additio...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-13.837
更新日期:1998-07-01 00:00:00
abstract::Six 4 month-old beagles were inoculated with Leishmania donovani infantum, three of them intraperitoneally (Group A) and the other three intravenously (Group B). The animals from Group A were killed 109, 433 and 592 days after inoculation and animals from Group B 109, 171 and 334 after inoculation. The liver of each o...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1988-10-01 00:00:00
abstract::Thymidine phosphorylase (TP), thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) have been indicated as possible predictive markers for epithelial malignancies. All these three enzymes are actively involved in 5-FU metabolism. In this report, we investigated mRNA expression of these factors with real-...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-19.129
更新日期:2004-01-01 00:00:00
abstract::Src, a 60 kDa non-receptor tyrosine kinase, is the product of normal c-src of the human genome and member of the Src protein tyrosine kinases family (SFK). As described by Martin and Rous, a genetic recombination between c-src and the RSV oncogene of Rous sarcoma virus results in a modified Src protein, with increased...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-27.677
更新日期:2012-06-01 00:00:00
abstract::In the kidney, prostaglandin (PG) E2 is the main PG, playing important roles in maintaining homeostasis or development of pathological settings. Roles of PGE2 in renal lesions remain to be clarified. The expression patterns of PGE2 synthesis enzymes such as cyclooxygenase (COX)-1, COX-2 and microsomal PGE synthase (mP...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-25.995
更新日期:2010-08-01 00:00:00
abstract::Dramatical development of molecular genetics has been disclosing the molecular mechanism of Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD). DMD gene product, dystrophin, is a submembranous cytoskeletal protein and many dystrophin-associated proteins (DAPs) have been identified, such as utrophin,...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-15.753
更新日期:2000-07-01 00:00:00
abstract::Most patients with ovarian cancers relapse, and treatment failure has often been attributed to chemoresistance in tumor cells. Emerging evidence indicates that tumor heterogeneity may play an equally important role. Although the idea of tumor heterogeneity is not new, little attention has been focused on applying it t...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-30.173
更新日期:2015-02-01 00:00:00
abstract::The purpose of this investigation was to clarify the mechanisms of amyloid fibril formation in human lymph nodes. In our present study, amyloid deposition was observed diffusely in all compartments of the lymph nodes. The deposition form showed extremely characteristic findings in its morphological features. Namely, a...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1986-07-01 00:00:00
abstract::The histological and ultrastructural features, as well as the immunoreactivity of one case of uncommon primary papillary and psammomatous adenocarcinoma of the umbilicus are studied in the present work. The observations have been undertaken in a nine-year follow-up, and have included the primitive tumour, two local re...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1993-10-01 00:00:00
abstract::The response of the SON to various forms of stress is well documented. However, the effect of operative stress, which is a common and important clinical event requiring the mediation of vasopressin, has largely escaped attention. The present report describes the ultrastructural changes in the neurons of the caudal (re...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1988-04-01 00:00:00
abstract::Aurora A and Aurora B are serine-threonine kinase proteins which have both been implicated in human carcinogenesis through development of aneuploidy and chromosomal instability. The aim of the study is to assess the correlation of both markers with clinical and pathological parameters in patients with bladder cancer o...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-25.1371
更新日期:2010-11-01 00:00:00
abstract::The distribution of peptidergic nerves in canine mammary tissues was studied by immunohistochemical techniques. In addition, the general and the noradrenergic innervations were demonstrated using protein gene product 9.5 and tyrosine hydroxylase immunoreactivities as markers, respectively. Tissue specimens from the ca...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-22.1175
更新日期:2007-11-01 00:00:00
abstract:BACKGROUND:Little is known regarding the role of redox balance regulators in metastatic melanomas, but there is some evidence for a link between epithelial-to-mesenchymal transition (EMT) and cellular redox status. METHODS:We compared the immunohistochemical expression of nuclear factor erythroid-2-related factor 2 (N...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-11-778
更新日期:2017-02-01 00:00:00