Abstract:
:Transforming growth factor-betas (TGF-betas) are multifunctional cytokines that exist in 3 isoforms in mammals. The TGF-betas are ubiquitously expressed and all isoforms are secreted as biologically inactive precursors called latent TGF-beta (L-TGF-beta). L-TGF-betas are generally not effective molecules because they are unable to interact with their receptors. However, the removal of or conformational change of the precursor protein called the latency associated peptide (LAP) results in the generation of biologically active TGF-beta. In vitro active TGF-beta has many biological effects but from a clinical point of view one of the most recognized associations of aberrant TGF-beta production is with diseases characterized by enhanced connective tissue synthesis. Recently a number of observations in the context of fibrotic disorders suggest mechanisms of activation of L-TGF-beta1 in vivo. The recognition of mechanisms that activate L-TGF-beta1 in vivo offers the possibility of interfering with the activation of L-TGF-beta1 for therapeutic purposes.
journal_name
Histol Histopatholjournal_title
Histology and histopathologyauthors
Khalil Ndoi
10.14670/HH-16.541subject
Has Abstractpub_date
2001-04-01 00:00:00pages
541-51issue
2eissn
0213-3911issn
1699-5848journal_volume
16pub_type
杂志文章,评审abstract::Thrombospondin-1 (TSP-1) is a matrix protein implicated in mechanisms of wound healing. TSP-1 contains the sequence cysteine-serine-valine-threonine-cysteine-glycine (CSVTCG) that has been shown to function primarily as a cell adhesion domain. Our laboratory has isolated a novel receptor specific for the CSVTCG adhesi...
journal_title:Histology and histopathology
pub_type: 杂志文章
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journal_title:Histology and histopathology
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journal_title:Histology and histopathology
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journal_title:Histology and histopathology
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journal_title:Histology and histopathology
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journal_title:Histology and histopathology
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journal_title:Histology and histopathology
pub_type: 杂志文章,多中心研究
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journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:
更新日期:1994-10-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 临床试验,杂志文章
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journal_title:Histology and histopathology
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更新日期:1995-10-01 00:00:00
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journal_title:Histology and histopathology
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doi:
更新日期:1997-01-01 00:00:00
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更新日期:1997-07-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
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更新日期:2014-08-01 00:00:00
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journal_title:Histology and histopathology
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journal_title:Histology and histopathology
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1995-07-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
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journal_title:Histology and histopathology
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更新日期:2007-05-01 00:00:00
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更新日期:1997-10-01 00:00:00
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journal_title:Histology and histopathology
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