Frequent expression of haemopoietic and non-haemopoietic antigens by reactive plasma cells: an immunohistochemical study using formalin-fixed, paraffin-embedded tissue.

Abstract:

:Unlike other B cells, plasma cells (PC) react with only a few antibodies against haemopoietic antigens. We investigated 36 specimens exhibiting a reactive increase in PC numbers (i.e. plasmacytosis, PC hyperplasia) with a broad panel of antibodies suitable for use on formalin-fixed, paraffin-embedded tissue, and compared the findings with those obtained in 51 cases of multiple myeloma (plasmacytoma). Regardless of the immunostaining pattern for immunoglobulin light and heavy chains, reactive PC reacted with at least two and at most six of seventeen antibodies detecting haemopoietic antigens [Ber-H2/CD30 (91%), anti-leucocyte common antigen (LCA)/CD45 (86%), KP1/CD68 (64%), MB2 (57%), 4KB5/CD45RA (37%), DF-T1/CD43 (28%), UCHL1/CD45RO (20%), L26/CD20 (17%), MT2 (14%) and Mac387 (8%)], and with at least one and at most four of six antibodies against non-haemopoietic antigens [anti-epithelial membrane antigen (EMA) (94%), anti-vimentin (77%), anti-pan-cytokeratin/KL1 (74%), BMA120 (51%) and HMB45 (14%)]. Five antibodies stained reactive PC significantly more often than neoplastic PC: Ber-H2/CD30 (p < or = 0.0000), KP1/CD68 (p < or = 0.0000), anti-LCA/CD45 (p < or = 0.0000), anti-EMA (p < or = 0.0339) and anti-pancytokeratin/KL1 (p < or = 0.0000). The more frequent and more heterogeneous expression of antigens by reactive PC suggests that the aberrant immunoreactivity of neoplastic PC in plasmacytoma is not due to the process of malignant transformation in an early step of B-cell differentiation, but could reflect the heterogeneity of antigen expression by normal PC.

journal_name

Histol Histopathol

authors

Beschorner R,Horny HP,Petruch UR,Kaiserling E

doi

10.14670/HH-14.805

subject

Has Abstract

pub_date

1999-07-01 00:00:00

pages

805-12

issue

3

eissn

0213-3911

issn

1699-5848

journal_volume

14

pub_type

杂志文章
  • Killing two birds with one stone: The multifunctional roles of mesenchymal stem cells in the treatment of neurodegenerative and muscle diseases.

    abstract::Neurodegenerative and muscle diseases bear both complex and multifactorial pathologies. An efficacious and robust therapeutic option to treat these diseases is yet to be elucidated. At such a time, mesenchymal stem cells have drawn significant attention due to their immunomodulatory and regenerative properties. Accumu...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-11-951

    authors: Lee NK,Na DL,Chang JW

    更新日期:2018-07-01 00:00:00

  • Estimation and comparison of the contents of blood group B antigens in selected human tissues by microphotometric quantification of Griffonia simplicifolia agglutinin I-B4 staining with or without prior alpha-galactosidase digestion.

    abstract::Griffonia simplicifolia agglutinin I-B4 (GSAI-B4) has broader specificity for B antigen variants and can recognize the antigens in a wide variety of human tissues. Thus, the concentration range of GSAI-B4 required for staining and the susceptibility of staining to alpha-galactosidase digestion is presumed to correlate...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Ito N,Nagaike C,Morimura Y,Hatake H

    更新日期:1997-04-01 00:00:00

  • An immunohistochemical study of NFE2L2, KEAP1 and 8-hydroxy-2'-deoxyguanosine and the EMT markers SNAI2, ZEB1 and TWIST1 in metastatic melanoma.

    abstract:BACKGROUND:Little is known regarding the role of redox balance regulators in metastatic melanomas, but there is some evidence for a link between epithelial-to-mesenchymal transition (EMT) and cellular redox status. METHODS:We compared the immunohistochemical expression of nuclear factor erythroid-2-related factor 2 (N...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-11-778

    authors: Hintsala HR,Haapasaari KM,Soini Y,Karihtala P

    更新日期:2017-02-01 00:00:00

  • Localization of blood coagulation factors in the germinal centers of human Peyer's patches.

    abstract::The immunohistochemical distribution of 15 blood coagulation factors in the germinal centers (GCs) of human Peyer's patches (PPs) was studied. Although factor VIII, active alpha-thrombin, and fibrinogen were hardly evident in the GCs, the majority of coagulation factors, such as kallikrein, high-molecular-weight kinin...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Kudo S,Yamakawa M,Imai Y,Tsukamoto M

    更新日期:1992-04-01 00:00:00

  • Comparison of the dysadherin and E-cadherin expression in primary lung cancer and metastatic sites.

    abstract::Dysadherin, a cancer associated cell membrane glycoprotein, has been reported to downregulate E-cadherin. Aberrant expression of E-cadherin has been associated with the development of metastases in patients with cancer. Even though the expression of dysadherin and E-cadherin has been studied in primary non-small cell ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-25.1257

    authors: Mitselou A,Batistatou A,Nakanishi Y,Hirohashi S,Vougiouklakis T,Charalabopoulos K

    更新日期:2010-10-01 00:00:00

  • Immune complex-mediated glomerulopathy in Barbus graellsi infected with Myxobolus spp.

    abstract::Membranous glomerulonephritis caused in Barbus graellsi by myxosporidian infections have been studied by electron microscopy and immunoelectron microscopy techniques. This study indicates that Myxosporidian infection produces a chronic severe aggression. Spores reach the spleen, the kidney and the liver, where they ar...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Peribañez MA,del Cacho E,Castillo JA,Arnal MC

    更新日期:1993-10-01 00:00:00

  • Less gelatinases is associated with apolipoprotein E accumulation in glomerulosclerosis rats.

    abstract:BACKGROUND:Gelatinases include matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9). The abnormal expressions of gelatinases are implicated in the pathogenesis of extracellular matrix (ECM) accumulation. Apolipo-protein E (apoE) is an important plasma protein in cholesterol homeostasis and plays a ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-27.249

    authors: Zhou TB,Qin YH,Lei FY,Su LN,Zhao YJ,Huang WF

    更新日期:2012-02-01 00:00:00

  • Comparative in vivo and in vitro models to approach the cellular basis of endotoxic shock. The role of sinusoidal liver cells.

    abstract::During endotoxic shock, the liver exerts a lipopolysaccharide (LPS) clearance function with the participation of both parenchymal and sinusoidal cells. Liver damage could be caused by LPS direct action, hypoxia and/or inflammatory mediators released by Kupffer cells. The aim of this study is to establish an experiment...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Pagani R,Portolés MT,Arahuetes R,Ainaga MJ,Machín C,Rua C

    更新日期:1996-07-01 00:00:00

  • A truncated isoform of the PP2A B56gamma regulatory subunit reduces irradiation-induced Mdm2 phosphorylation and could contribute to metastatic melanoma cell radioresistance.

    abstract::F10, a subline of the B16 mouse melanoma cell line, is itself the parent of the more metastatic BL6 line. BL6 cells differ from F10 cells by an alteration of the gene encoding the B56gamma regulatory subunit of protein phosphatase 2A (PP2A), which results in mRNA encoding a truncated variant of the subunit (deltagamma...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-19.391

    authors: Koma YI,Ito A,Watabe K,Kimura SH,Kitamura Y

    更新日期:2004-04-01 00:00:00

  • The role of apoptosis in pulmonary fibrosis.

    abstract::Pulmonary fibrosis is a common response to various injuries to the lung. The resolution of a fibroproliferative response after lung injury is key to survival. Although there are various initiating factors or causes, the terminal stages are characterized by proliferation and progressive accumulation of connective tissu...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-19.867

    authors: Kuwano K,Hagimoto N,Nakanishi Y

    更新日期:2004-07-01 00:00:00

  • Fluoxetine may worsen hyperoxia-induced lung damage in neonatal rats.

    abstract::Fluoxetine shows controversial lung effects as it prevents pulmonary hypertension in adult rats but exposure during gestation causes pulmonary hypertension in neonatal rats. In the present study, we tested the null hypothesis that the antidepressant drug fluoxetine does not modify the development of bronchopulmonary d...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-27.1599

    authors: Porzionato A,Zaramella P,Macchi V,Grisafi D,Salmaso R,Baraldi M,Fornaro E,Tassone E,Masola V,Onisto M,Chiandetti L,De Caro R

    更新日期:2012-12-01 00:00:00

  • Ocular surface injuries in autoimmune dry eye. The severity of microscopical disturbances goes parallel with the severity of symptoms of dryness.

    abstract::Autoimmune dry eye (Sjögren's syndrome, SS) is a chronic systemic disease characterized by salivary and lacrimal gland inflammation and tissue damage leading to keratoconjunctivitis sicca and xerostomia. In this review attention has been devoted to the cause of the development of oxidative injuries of the ocular surfa...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-24.1357

    authors: Cejková J,Ardan T,Cejka C,Malec J,Jirsová K,Filipec M,Ruzicková E,Dotrelová D,Brunová B

    更新日期:2009-10-01 00:00:00

  • Synergism of imatinib, vatalanib and everolimus in the prevention of chronic lung allograft rejection after lung transplantation (LTx) in rats.

    abstract::Chronic lung allograft dysfunction (CLAD) still remains a major drawback in the outcome following lung transplantation (LTx). New therapeutic strategies are warranted. Growth factors and their receptors like platelet-derived growth factor-receptor (PDGFR) and vascular endothelial growth factor-receptor (VEGFR), may pl...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-18-088

    authors: Keil L,Schaub AL,Hirt SW,Schmid C,Lehle K,von Suesskind-Schwendi M

    更新日期:2019-07-01 00:00:00

  • Oncocytic adenoma of the nasal cavity. A case report.

    abstract::The authors present a case of benign oncocytoma (oxyphil cell adenoma) of the nasal cavity in a young woman. This is the fifth case reported in that region. Immunohistochemical stains revealed positivity only for cytokeratin. ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Miracco C,Sensini I,Vessio G,Luzi P

    更新日期:1986-01-01 00:00:00

  • Histological approach to Bacillus subtilis colony-biofilm: evolving internal architecture and sporulation dynamics.

    abstract::Bacillus subtilis has been used as a classic model to study biofilm formation and sporulation process. Colonies of wild-type strains usually have a complex external morphology, but the details of their internal architecture are still undisclosed. Since bacterial biofilms fulfill the criteria to be considered tissues, ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-28.1351

    authors: Gómez-Aguado F,Corcuera MT,Gómez-Lus ML,de la Parte MA,Ramos C,García-Rey C,Alonso MJ,Prieto J

    更新日期:2013-10-01 00:00:00

  • Acetylcholinesterase-positive afferent axons in mucosa of urinary bladder of adult cats: retrograde tracing and degeneration studies.

    abstract::Acetylcholinesterase (AchE)-positive afferent axons in the mucosa of the cat urinary bladder were examined in the present experiments. Small-sized dorsal root ganglion cells containing AchE enzyme activity were labelled by injection of retrograde tracer (wheat germ agglutinin conjugated to enzymatically inactive horse...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Wakabayashi Y,Kojima Y,Makiura Y,Tomoyoshi T,Maeda T

    更新日期:1995-07-01 00:00:00

  • The combined effect of honey and olive oil against methotrexate mediated hepatotoxicity in rats: A biochemical, histological and immunohistological study.

    abstract:BACKGROUND:Honey and olive oil are natural products that have high nutritional values, and therapeutic properties. Cytotoxic drugs, like methotrexate (MTX) are used to treat malignancies in tumour cells; however, these drugs also have serious side effects that could threaten the patient's life. AIM:To evaluate the pot...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-18-126

    authors: Alturkistani HA,Abuzinadah OAH,Kelany AM,Abd El-Aziz GS,Alrafiah AR

    更新日期:2019-12-01 00:00:00

  • Current understanding of macrophage type 1 cytokine responses during intracellular infections.

    abstract::Macrophages are important effector cells in cell-mediated immunity against intracellular infection. Among cytokines that macrophages are able to release are IL-12 and TNF alpha. IL-12 is a critical linker between the innate and adaptive cell-mediated immunity, capable of Th1 differentiation and IFN gamma release by T ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-15.199

    authors: Xing Z

    更新日期:2000-01-01 00:00:00

  • Immunohistological signposts in central nervous system tumours with neuronal differentiation.

    abstract::25 neuronal tumours with a panel of antibodies were studied and it was found that vimentin was present in 15 tumours. It was also found in a few cells within rosettes. PGP 9.5 showed a somatic pattern of staining with nuclear and perinuclear positivity in 23. Neurofilament reactivity was found in 14. Retinal S-antigen...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Cruz-Sánchez FF,Rossi ML,Rodríguez-Prados S,Cusi V,Coakham HB

    更新日期:1991-10-01 00:00:00

  • In vivo cellular uptake of bismuth ions from shotgun pellets.

    abstract::Shotgun pellets containing bismuth (Bi) are widely used and may cause a rather intense exposure of some wild animals to Bi. A Bi shotgun pellet was implanted intramuscularly in the triceps surae muscle of 18 adult male Wistar rats. Another group of 9 animals had a Bi shotgun pellet implanted intracranially in the neoc...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-18.781

    authors: Stoltenberg M,Locht L,Larsen A,Jensen D,Danscher G

    更新日期:2003-07-01 00:00:00

  • Microtubules regulate aortic endothelial cell actin microfilament reorganization in intact and repairing monolayers.

    abstract::To understand the role of microtubules and microfilaments in regulating endothelial monolayer integrity and repair, and since microtubules and microfilaments show some co-alignment in endothelial cells, we tested the hypothesis that microtubules organize microfilament distribution. Disruption of microtubules with colc...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-20.455

    authors: Lee JS,Gotlieb AI

    更新日期:2005-04-01 00:00:00

  • Subcutaneous fat necrosis of newborn children.

    abstract::We report a case of subcutaneous fat necrosis of a newborn child which appeared 9 days after birth and was cured without any complications. We propose the reclassification of the etiological factors accompanying this lesion by classifying them in a plurietiological syndrome with some basic or essential factors and oth...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Salas Valién JS,Ribas Ariño MT,Egido Romo M,Palau Benavides MT

    更新日期:1990-01-01 00:00:00

  • Skeletal muscle abnormalities associated with occupational exposure to mercury vapours.

    abstract::There is scarce information on the possible effects of chronic exposure to mercury on skeletal muscle. Dental personnel are frequently exposed to inhalation of metallic mercury vapours. The skeletal muscle of five technicians and one dentist (females, age 36-55) was studied. All of them presented symptoms of chronic m...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-15.673

    authors: Nadorfy-López E,Torres SH,Finol H,Méndez M,Bello B

    更新日期:2000-07-01 00:00:00

  • Recent development of in vivo cryotechnique to cryobiopsy for living animals.

    abstract::Various microscopic methods have been used to analyze the morphology and molecular distribution of cells and tissues. Using conventional procedures, however, ischemic or anoxic artifacts are inevitably caused by tissue-resection or perfusion-fixation. The in vivo cryotechnique (IVCT) was developed to overcome these pr...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-22.1281

    authors: Ohno N,Terada N,Saitoh S,Zhou H,Fujii Y,Ohno S

    更新日期:2007-11-01 00:00:00

  • Cisplatin treatment of NIH/3T3 cultures induces a form of autophagic death in polyploid cells.

    abstract::The effects induced by different concentrations (50, 75, 100 microM) of the cytostatic drug cisplatin (cDDP) in NIH/3T3 cells were analyzed. Sub-confluent cultures of this mouse fibroblast line, obtained after serum deprivation, showed the presence of aneuploid/polyploid cells with ploidy values ranging from 4c to 24c...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-23.717

    authors: Spano A,Monaco G,Barni S,Sciola L

    更新日期:2008-06-01 00:00:00

  • Expression of the Shwachman-Bodian-Diamond syndrome (SBDS) protein in human pancreatic cancer and chronic pancreatitis.

    abstract:BACKGROUND:The Shwachman-Bodian-Diamond syndrome (SBDS) protein is a member of a highly conserved family which influences RNA activation and is associated with pancreatic, skeletal and bone marrow deficiencies, as well as hematological malignancies. METHODS:In this study, the expression and localization of SBDS were i...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-23.819

    authors: Kayed H,Bekasi S,Keleg S,Welsch T,Esposito I,Shimamura A,Michalski CW,Friess H,Kleeff J

    更新日期:2008-07-01 00:00:00

  • Melanopsin-expressing retinal ganglion cells in aging and disease.

    abstract::Melanopsin-expressing retinal ganglion cells (mRGCs) constitute a system in the mammalian retina used for irradiance detection, regulating non-image forming functions, such as photoentrainment of circadian rhythms, control of the pupillary light reflex, masking response, light-regulated melatonin secretion, and modula...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-18-138

    authors: Esquiva G,Hannibal J

    更新日期:2019-12-01 00:00:00

  • Unexpected presence of the neurotrophins NGF and BDNF and the neurotrophin receptor p75 in the tendon cells of the human Achilles tendon.

    abstract::Neurotrophins are substances that have been shown to be important in growth and remodelling phases in different types of tissue. There is no information concerning the possible occurrences of neurotrophins and their receptors in tendons. In this study, sections of both chronic painful (tendinosis) and pain-free (non-t...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-24.839

    authors: Bagge J,Lorentzon R,Alfredson H,Forsgren S

    更新日期:2009-07-01 00:00:00

  • The presence of the mu-opioid receptor in the isthmus of mare oviduct.

    abstract::The presence of the mu-opioid receptor and the type of glycosylation in the third extra-cellular loop of this receptor was investigated in the isthmus of mare oviduct during oestrus by means of immunoblotting and immunohistochemistry combined with enzymatic (N-glycosidase F and O-glycosidase) and chemical (beta-elimin...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-23.555

    authors: Desantis S,Albrizio M,Ventriglia G,Deflorio M,Guaricci AC,Minoia R,De Metrio G

    更新日期:2008-05-01 00:00:00

  • Ewing sarcoma and the new emerging Ewing-like sarcomas: (CIC and BCOR-rearranged-sarcomas). A systematic review.

    abstract::Ewing-like sarcomas (ELS) are a heterogenous group of tumors that frequently affect pediatric and young adult patients. Accurate classification and distinction from the Ewing sarcoma family of tumor (ESFT) is decisive in patient management. ELS share a significant morphologic, immunohistochemical and clinical overlap ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-11-792

    authors: Machado I,Navarro S,Llombart-Bosch A

    更新日期:2016-11-01 00:00:00