Abstract：
:Autoimmune dry eye (Sjögren's syndrome, SS) is a chronic systemic disease characterized by salivary and lacrimal gland inflammation and tissue damage leading to keratoconjunctivitis sicca and xerostomia. In this review attention has been devoted to the cause of the development of oxidative injuries of the ocular surface of patients suffering from SS. It was shown that lacrimal glands and diseased conjunctival epithelium reveal increased expression of pro-inflammatory cytokines which are released into the tear fluid. A high amount of pro-inflammatory cytokines highly induce the elevated expression and activity of enzymatic systems that generate reactive oxygen and nitrogen species. An abundant amount of these toxic products leads to a decrease in antioxidants and to the formation of cytotoxic related oxidants, such as peroxynitrite. All these factors, together with reactive oxygen species from polymorphonuclear leukocytes, contribute to the development of oxidative injuries at the ocular surface. From the clinical point of view it is important that the level of severity of the above described microscopical disturbances found in conjunctival epithelial cells goes parallel with the level of severity of dry eye symptoms.
journal_name
Histol Histopatholjournal_title
Histology and histopathologyauthors
Cejková J,Ardan T,Cejka C,Malec J,Jirsová K,Filipec M,Ruzicková E,Dotrelová D,Brunová Bdoi
10.14670/HH-24.1357subject
Has Abstractpub_date
2009-10-01 00:00:00pages
1357-65issue
10eissn
0213-3911issn
1699-5848journal_volume
24pub_type
杂志文章,评审abstract：:This study explores the possibility of a regulatory role for cytokine IL-10 in platelet aggregation as an active vascular repair mechanism. Endothelial cells from human umbilical cord vein were cultured in the presence of different IL-10 concentrations (0-100 ng/ml). Platelet-rich plasma was then added to these cultur...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-18.695
更新日期：2003-07-01 00:00:00
abstract：UNLABELLED:The aim of this work was to evaluate the effect of magnesium sulphate (MgSO4) administration on blood-brain barrier (BBB) permeabilization after cerebral hypoxia-ischemia (HI) induced by partial occlusion of the umbilical cord of premature fetal lambs. We also characterized BBB dysfunction in terms of the le...
journal_title：Histology and histopathology
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更新日期：2009-09-01 00:00:00
abstract：AIMS:Gastric hyperplastic polyps (GHPs) are the most common polypoid lesion of the stomach, and their malignant potential has been demonstrated. In the present study, we evaluated the mucin phenotypes of GHPs and investigated the relationships among mucin phenotypes and clinical-pathological factors, proliferative acti...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-29.343
更新日期：2014-03-01 00:00:00
abstract：:The salamanderfish, Lepidogalaxias salamandroides (Galaxiidae, Teleostei) is endemic to southwestern Australia and inhabits shallow, freshwater pools which evaporate during the hot summer months. Burrowing into the substrate in response to falling water levels allows these fish to aestivate for extended periods of tim...
journal_title：Histology and histopathology
pub_type： 杂志文章
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journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-17.107
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journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-18.1115
更新日期：2003-10-01 00:00:00
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journal_title：Histology and histopathology
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journal_title：Histology and histopathology
pub_type： 杂志文章
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journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1992-04-01 00:00:00
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journal_title：Histology and histopathology
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更新日期：2006-11-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2000-07-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-18-126
更新日期：2019-12-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1994-04-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：
更新日期：1995-01-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：
更新日期：1997-07-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-21.713
更新日期：2006-07-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-11-807
更新日期：2016-12-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-22.603
更新日期：2007-06-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章,评审
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更新日期：2008-10-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-20.543
更新日期：2005-04-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章
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更新日期：2008-06-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章,评审
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更新日期：2020-09-01 00:00:00
abstract：BACKGROUND:Little is known regarding the role of redox balance regulators in metastatic melanomas, but there is some evidence for a link between epithelial-to-mesenchymal transition (EMT) and cellular redox status. METHODS:We compared the immunohistochemical expression of nuclear factor erythroid-2-related factor 2 (N...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-11-778
更新日期：2017-02-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章
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更新日期：2015-12-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章
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更新日期：2019-10-01 00:00:00
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journal_title：Histology and histopathology
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更新日期：1992-04-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
