Abstract:
AIMS:Gastric hyperplastic polyps (GHPs) are the most common polypoid lesion of the stomach, and their malignant potential has been demonstrated. In the present study, we evaluated the mucin phenotypes of GHPs and investigated the relationships among mucin phenotypes and clinical-pathological factors, proliferative activity and p53 expression in GHPs. METHODS:The CD10, MUC2, MUC5AC and MUC6 expression patterns of 238 GHPs were examined by immunohistochemical staining. The GHP mucin phenotypes were divided into 4 subtypes: the gastric mucin phenotype (G-type), the intestinal mucin phenotype (I-type), the mixed or gastrointestinal mucin phenotype (GI-type) and the unclassified mucin phenotype (U-type). RESULTS:The G and GI types were observed in 58% and 42% of the GHPs, respectively. However, no I or U type GHPs were found in the present study. The GI type was more common in lesions with dysplasia or carcinoma than in polyps without dysplasia or carcinoma (P<0.001). P53-positivity rate and high index of Ki-67 tumors were significantly more common in the GI-type than in the G-type polyps (P<0.001). CONCLUSIONS:The mucin phenotype may serve as a useful marker for the malignant potential of GHPs, and GI-type GHPs should be considered to be a lesion with malignant potential.
journal_name
Histol Histopatholjournal_title
Histology and histopathologyauthors
Li J,Wu LH,Shi Y,Li HM,Song MY,Jiao YFdoi
10.14670/HH-29.343subject
Has Abstractpub_date
2014-03-01 00:00:00pages
343-51issue
3eissn
0213-3911issn
1699-5848pii
HH-11-391journal_volume
29pub_type
杂志文章abstract::The anabolic androgenic steroid nandrolone decanoate has minimal androgenic effects and, thus, is widely used to induce muscle hypertrophy in both patients and athletes. Although increases in satellite cell numbers and satellite cells giving rise to new myonuclei are associated with hypertrophy in many experimental mo...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-25.133
更新日期:2010-02-01 00:00:00
abstract::The pancreatic-duct system was observed during the initial stage of type 1 diabetes in C57BL/6J mice rendered diabetic with low doses of streptozocin. Light microscopy revealed that the ducts located in close proximity to islets (islet ducts) were involved in the infiltrating process: inflammatory cells extended from ...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1994-07-01 00:00:00
abstract::The morphology of the rat duodenum after chronic treatment with 15% (v/v) ethanol and 4% (v/v) pentanol was studied. Male Wistar rats of experimental groups were given ethanol and pentanol for 15 weeks with food and fluid freely available. Ethanol-15% and 4% pentanol-fed rats showed a significantly reduced fluid and f...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-17.199
更新日期:2002-01-01 00:00:00
abstract::A study was undertaken to analyze the spatio-temporal pattern of mesenchymal cell proliferation in the developing palate of quail. Quail embryos were grown in shell-less culture. The developing palates were labelled with 3H-thymidine between culture days 2-6 (which corresponded in vivo incubation days 5-9), and proces...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1995-07-01 00:00:00
abstract::An immunohistochemical study of matrix metalloproteinases (MMP-2 and MMP-9) or gelatinase (gelatinase A and gelatinase B) was performed on the seminal vesicles and ventral prostate of the Libyan jird (Meriones libycus) collected in the Beni-Abbes area during breeding period (spring and early summer), during resting ph...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-25.619
更新日期:2010-05-01 00:00:00
abstract::The clinical presentation, histopathology and immunoelectron microscopic features of two cases of duodenal somatostatinoma are described, one of which is a hitherto unreported example of a collision tumour with a neurofibroma. Ultrastructural morphometric immunoelectron microscopy studies revealed the presence of four...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-21.1171
更新日期:2006-11-01 00:00:00
abstract::Nitric oxide (NO) is a biological messenger molecule produced by one of the essential amino acids L-arginine by the catalytic action of the enzyme NO synthase (NOS). The dual role of NO as a protective or toxic molecule is due to several factors, such as; the isoform of NOS involved, concentration of NO and the type o...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-21.445
更新日期:2006-04-01 00:00:00
abstract::Parkinson's disease (PD) is a neurodegenerative disorder characterized by progressive cell loss confined mostly to dopaminergic neurons of the substantia nigra. Several factors, including oxidative stress, and decreased activity of complex I mitochondrial respiratory chain, are involved in the degenerative process. Ye...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract::The characteristics and distribution pattern of retinal afferent terminals making synaptic contacts on narrow field vertical neurons in the stratum griseum superficiale of the rabbit superior colliculus were studied using the Golgi-gold substitution technique in combination with either autoradiographic or degenerative...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract::We examined morphological characteristics of the carotid body of spontaneously hypertensive rats (SHR), those of age-matched normotensive Wistar rats (NWR), and age-matched genetically comparable Wistar Kyoto rats (WKY). We examined the distribution and abundance of four different regulatory neuropeptides: substance P...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-26.369
更新日期:2011-03-01 00:00:00
abstract::Gp96 is the endoplasmic reticulum (ER)-resident molecular chaperone, which is involved in the correction of unfolded proteins, in the activation of proteasome-dependent ER-associated degradation of the misfolded proteins, and in activation of the protein translation that modulates polypeptide traffic into the ER. Furt...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-28.61
更新日期:2013-01-01 00:00:00
abstract::Sex steroid hormones are involved in regulation of skin development and functions as well as in some skin pathological events. To determine the sites of action of estrogens, androgens and progestins, studies have been performed during the recent years to accurately localize receptors for each steroid hormone in human ...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-19.629
更新日期:2004-04-01 00:00:00
abstract::We have studied the occurrence and specific features of liver cell dysplasia (LCD) in Chinese patients showing liver cirrhosis with or without hepatocellular carcinoma (HCC). Three types of LCD (SLCD, LLCDo, LLCDe) were morphologically defined, and these types were further analyzed using karyometry, estimation of nucl...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
abstract::The matrix metalloproteinases (MMPs) are a family of proteolytic zinc-containing enzymes, which are responsible for the breakdown of the extracellular matrix components in pathological and physiological conditions. They are involved in basement membrane disruption, stroma and blood vessel penetration, metastasis and m...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-21.603
更新日期:2006-06-01 00:00:00
abstract::The purpose of this study is to visualize topographical changes of serum proteins, albumin and immunoglobulin, passing through mouse glomerular capillary loops and their reabsorption in renal proximal tubules by immunohistochemistry in combination with our "in vivo cryotechnique". The "in vivo cryotechnique" was perfo...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-20.807
更新日期:2005-07-01 00:00:00
abstract::Early observations that cultured mesenchymal stem cells (MSCs) could be induced to exhibit certain characteristics of osteocytes and chondrocytes led to the proposal that they could be transplanted for tissue repair through cellular differentiation. Therefore, many subsequent preclinical studies with transplanted MSCs...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-28.1109
更新日期:2013-09-01 00:00:00
abstract::The ultrastructure of the atrial myocardium in the monkey (Macaca fascicularis) was studied after bilateral cervical vagotomy and survival times of 100, 175 and 367 days. Changes were observed in the nucleus and the cytoplasm of the myocyte. Sequestered within the nuclei of the affected myocytes were cytoplasmic organ...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1989-07-01 00:00:00
abstract::The possible involvement of endogenous vasoactive intestinal peptide (VIP), cholecystokinin (CCK) and neurotensin (NT) in the control of thymocyte proliferation has been investigated in vivo in the immature rat. For this task, we have studied the effects of the administration of selective antagonists of the receptors ...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-16.155
更新日期:2001-01-01 00:00:00
abstract::HtrA1 is a secreted protein which behaves as a molecular chaperone at low temperatures and as a serine protease at high temperatures. When the placenta escapes the normal growth control mechanisms, which are present during normal pregnancy, it may develop trophoblastic diseases, such as hydatidiform mole and choriocar...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-24.1213
更新日期:2009-10-01 00:00:00
abstract::The vacuolar-type H(+)-ATPases (V-ATPases) are a family of multi-subunit ATP-dependent proton pumps involved in diverse cellular processes, including acid/base homeostasis, receptor-mediated endocytosis, processing of proteins and signaling molecules, targeting of lysosomal enzymes, and activation of various degradati...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-25.1611
更新日期:2010-12-01 00:00:00
abstract::Morphological and biochemical alterations have been described in neurons of the aged human brain. However, the cell death process associated with neuronal senescence remains to be elucidated. Apoptosis and autophagic degeneration, two modes of programmed cell death described in embryogenesis and tissue renewal in adul...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1997-07-01 00:00:00
abstract::Recent evidence has shown that vascular function depends not only on cells within the vessels, but is also significantly modulated by circulating cells derived from the bone marrow. A number of studies indicate that an early reendothelialization by circulating endothelial precursors after vascular injury prevents exce...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-22.547
更新日期:2007-05-01 00:00:00
abstract::PML is a tumour suppressor inactivated in Acute Promyelocytic Leukaemia (APL). PML is the essential component of a subnuclear structure called the PML nuclear body (PML-NB), which is disrupted in APL. By targeting different cellular proteins to this structure, PML can either hamper or potentiate their functions. The P...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-22.937
更新日期:2007-08-01 00:00:00
abstract::Oral squamous cell carcinoma (OSCC) is the most common malignancy of the oral cavity with a poor 5-year survival rate, due in large part to the presence of metastatic disease at initial diagnosis. In recent years, a number of studies have examined the oral tumor microenvironment to asses the potential dynamic balance ...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-25.917
更新日期:2010-07-01 00:00:00
abstract::We review here the 14 members of the Monocarboxylate transporter family (MCTs), their relationship based on sequence homology. The range of substrates transported by different members of this family extends from the standard monocarboxylate metabolites, lactic and pyruvic acids, to aromatic amino acids and thyroid hor...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-24.243
更新日期:2009-02-01 00:00:00
abstract::In the kidney, prostaglandin (PG) E2 is the main PG, playing important roles in maintaining homeostasis or development of pathological settings. Roles of PGE2 in renal lesions remain to be clarified. The expression patterns of PGE2 synthesis enzymes such as cyclooxygenase (COX)-1, COX-2 and microsomal PGE synthase (mP...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-25.995
更新日期:2010-08-01 00:00:00
abstract::Transforming growth factor-beta1 (TGF-1beta) has been shown to modulate both cell proliferation and the synthesis of extracellular matrix by vascular cells. This study was aimed to establish the temporal correlation between TGF-beta1 expression, the expression of the extracellular matrix protein fibronectin, and plaqu...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-15.421
更新日期:2000-04-01 00:00:00
abstract::Beta-catenin expression in small cell lung carcinomas (SCLC) was investigated by immunohistochemical method using antibodies against beta-catenin. 50 pre-treatment biopsies were examined and the relationship between beta-catenin expression and the patients' relevant clinical characteristics, response to chemotherapy, ...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-16.353
更新日期:2001-04-01 00:00:00
abstract::Targeting essential cellular pathways that determine neuronal and vascular survival can foster a successful therapeutic platform for the treatment of a wide variety of degenerative disorders in the central nervous system. In particular, oxidative cellular injury can precipitate several nervous system disorders that ma...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-19.495
更新日期:2004-04-01 00:00:00
abstract::Adult stem cells (ASC)--able to self renew and to intervene in maintaining the structural and functional integrity of their original tissue--can express greater plasticity than traditionally attributed to them, adopting functional phenotypes and expression profiles of cells from other tissues. Therefore, they could be...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-21.995
更新日期:2006-09-01 00:00:00