Somatostatinoma: collision with neurofibroma and ultrastructural features.

Abstract:

:The clinical presentation, histopathology and immunoelectron microscopic features of two cases of duodenal somatostatinoma are described, one of which is a hitherto unreported example of a collision tumour with a neurofibroma. Ultrastructural morphometric immunoelectron microscopy studies revealed the presence of four types of cells in both tumours, but there was no difference in the proportions of these cells between the collision tumour and the non-collision tumour. Neurosecretory granules ranging in size from 255-815 nm were generally larger than those previously reported for somatostatinomas and somatostatin was identified in granules of all sizes across this range. Neither tumour was associated with the somatostatinoma syndrome comprising associated diabetes mellitis, steatorrhoea and cholelithiasis.

journal_name

Histol Histopathol

authors

Varikatt W,Yong JL,Killingsworth MC

doi

10.14670/HH-21.1171

subject

Has Abstract

pub_date

2006-11-01 00:00:00

pages

1171-80

issue

11

eissn

0213-3911

issn

1699-5848

journal_volume

21

pub_type

杂志文章
  • Cyclosporin A-induced changes of the thymic microenvironment. A review of morphological studies.

    abstract::Cyclosporin A is an immunosuppressive drug, which disrupts the activation of peripheral T-lymphocyte pool and blocks the maturation of thymocytes within the thymus. Normally, thymic nonlymphoid cells provide the optimal inductive microenvironment for development of T-lymphocytes. After application of cyclosporin A the...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-13.1183

    authors: Milićević NM,Milićević Z

    更新日期:1998-10-01 00:00:00

  • Ocular surface injuries in autoimmune dry eye. The severity of microscopical disturbances goes parallel with the severity of symptoms of dryness.

    abstract::Autoimmune dry eye (Sjögren's syndrome, SS) is a chronic systemic disease characterized by salivary and lacrimal gland inflammation and tissue damage leading to keratoconjunctivitis sicca and xerostomia. In this review attention has been devoted to the cause of the development of oxidative injuries of the ocular surfa...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-24.1357

    authors: Cejková J,Ardan T,Cejka C,Malec J,Jirsová K,Filipec M,Ruzicková E,Dotrelová D,Brunová B

    更新日期:2009-10-01 00:00:00

  • Regulation of inflammatory cytokines for spinal cord injury recovery.

    abstract::Spinal cord injury (SCI) is one of the most destructive traumatic diseases in human beings. The balance of inflammation in the microenvironment is crucial to the repair process of spinal cord injury. Inflammatory cytokines are direct mediators of local lesion inflammation and affect the prognosis of spinal cord injury...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-18-262

    authors: Lin S,Xu C,Lin J,Hu H,Zhang C,Mei X

    更新日期:2020-10-01 00:00:00

  • Immunohistochemical expression and localization of MMP-9, MMP-13, E-Cadherin and Ki-67 in road pavers' skin chronically exposed to bitumen products.

    abstract::To investigate the matrix metalloproteinase (MMP)-9, (MMP)-13, E-Cadherin and Ki-67 expressions in road pavers' skin chronically exposed to bitumen products in order to contribute to a better understanding of the earlier tissue alteration. Skin punch biopsies from 16 daily exposed workers and a control group were stud...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-18-116

    authors: Loreto C,Lombardo C,Caltabiano R,Filetti V,Vitale E,Seminara D,Castorina S,Fenga C,Ledda C,Rapisarda V

    更新日期:2019-10-01 00:00:00

  • Comparative in vivo and in vitro models to approach the cellular basis of endotoxic shock. The role of sinusoidal liver cells.

    abstract::During endotoxic shock, the liver exerts a lipopolysaccharide (LPS) clearance function with the participation of both parenchymal and sinusoidal cells. Liver damage could be caused by LPS direct action, hypoxia and/or inflammatory mediators released by Kupffer cells. The aim of this study is to establish an experiment...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Pagani R,Portolés MT,Arahuetes R,Ainaga MJ,Machín C,Rua C

    更新日期:1996-07-01 00:00:00

  • Persistence of Cajal-Retzius cells in the adult human cerebral cortex. An immunohistochemical study.

    abstract::The presence of Cajal-Retzius cells in the adult human prefrontal and visual cortices has been demonstrated with calcium binding protein immunocytochemistry and NADPH-diaphorase histochemistry. These cells expressed parvalbumin, calbindin and calretinin calcium binding proteins and displayed NADPH-diaphorase enzyme ac...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-14.487

    authors: Martín R,Gutiérrez A,Peñafiel A,Marín-Padilla M,de la Calle A

    更新日期:1999-04-01 00:00:00

  • The distribution of corticotropin-releasing factor immunoreactive neurons and nerve fibres in the brain of Gambusia affinis and Salmo trutta.

    abstract::The study was carried out on the distribution of neurons and fibres which contain the Corticotropin releasing factor-like (CRF) immunoreactivity in the encephalon of two species of teleosts, Gambusia affinis and Salmo trutta. The peroxidase-antiperoxidase (PAP) immunocytochemical technique was employed. The present st...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Coto-Montes A,García-Fernández JM,del Brío MA,Riera P

    更新日期:1994-04-01 00:00:00

  • Cell proliferation and apoptosis in stromal corneal dystrophies.

    abstract::The aim of our study was to evaluate corneal cell proliferation and apoptosis in cases of granular, macular and lattice dystrophy, and to provide evidence which may help to clarify whether apoptosis is a pathogenic factor in any of these dystrophies. The study group comprised 39 eyes (from 33 patients) which had under...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,多中心研究

    doi:10.14670/HH-22.837

    authors: Szentmáry N,Takács L,Berta A,Szende B,Süveges I,Módis L

    更新日期:2007-08-01 00:00:00

  • Detection of platelet-derived growth factor-alpha (PDGF-A) protein in cells of Leydig lineage in the postnatal rat testis.

    abstract::Platelet-derived growth factor-A (PDGF-A) is a locally produced growth factor in the rat testis secreted by both Sertoli cells and Leydig cells. It has been suggested that PDGF-A may be involved in modulation of testosterone production and may be essential to Leydig cell differentiation, however it is not known at wha...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-21.1295

    authors: Fecteau KA,Mrkonjich L,Mason JI,Mendis-Handagama SM

    更新日期:2006-12-01 00:00:00

  • Morphology of epiphyseal apparatus of a ranid frog (Rana Esculenta)

    abstract::Morphological, histochemical and ultrastructural investigations on epiphyseal apparatus of Rana Esculenta were made. The most important findings were the following: 1) metaphyseal cartilage is localized inside proximal diaphyseal compact bone as a plug; 2) metaphyseal cartilage do not reduce in thickness during ageing...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Dell'Orbo C,Gioglio L,Quacci D

    更新日期:1992-04-01 00:00:00

  • Controversial relationship between the expression of the RB pathway components and RB protein phosphorylation in human breast cancer.

    abstract::Recent data challenge the relevance of the RB pathway to cancer based on RB inactivation, at least in breast tumors. To obtain information on the actual role of the components of the RB pathway in tumor progression we decided to investigate whether their quantitative changes were associated with variations in the leve...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-22.769

    authors: Montanaro L,Vici M,Donati G,Ceccarelli C,Santini D,Treré D,Derenzini M

    更新日期:2007-07-01 00:00:00

  • Epithelial integrity, cell death and cell loss in mammalian small intestine.

    abstract::In recent years, the different mechanisms of epithelial cell loss which occur in mammalian and avian small intestine have been re-investigated. Information is now available for a variety of mammalian types and mechanisms can be divided into two major classes: [i] those preserving epithelial integrity by maintaining in...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-14.257

    authors: Mayhew TM,Myklebust R,Whybrow A,Jenkins R

    更新日期:1999-01-01 00:00:00

  • Effects of thyroid hormones on Leydig cells in the postnatal testis.

    abstract::Thyroid hormones (TH) stimulate oxidative metabolism in many tissues in the body, but testis is not one of them. Therefore, in this sense, testis is not considered as a target organ for TH. However, recent findings clearly show that TH have significant functions on the testis in general, and Leydig cells in particular...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-19.985

    authors: Mendis-Handagama SM,Ariyaratne HB

    更新日期:2004-07-01 00:00:00

  • Ecophysiological responses of the seminal vesicle of Libyan jird (Meriones libycus) to the Saharan conditions: histological, morphometric and immunohistochemical analysis.

    abstract::The Libyan jird (Meriones libycus) is a nocturnal Saharan Rodent submitted to a seasonal cycle of reproduction characterized by a short active period during spring and beginning of summer, and a long phase of sexual quiescence from the end of summer until the end of winter. During this cycle, the male reproductive org...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-22.603

    authors: Belhocine M,Gernigon-Spychalowicz T,Robert AM,Schoevaert D,Bennazzoug Y,Exbrayat JM

    更新日期:2007-06-01 00:00:00

  • Glucose transporter expression in developing fetal lungs and lung neoplasms.

    abstract::Glucose uptake and metabolism are essential for proliferation and survival of cells, and are supposed to be enhanced in actively proliferating cell systems such as embryonic and cancer tissues. Glucose uptake is usually carried out through glucose transporters. In the developing fetal lung, metabolism of glucose is th...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-14.895

    authors: Ito T,Noguchi Y,Udaka N,Kitamura H,Satoh S

    更新日期:1999-07-01 00:00:00

  • Effects of Helicobacter pylori on biological characteristics of gastric epithelial cells.

    abstract::Infection with Helicobacter pylori (H. pylori) strains is linked to an increased risk of inflammation and gastric cancer. To investigate the effects of H. pylori on biological characteristics of gastric epithelial cells SGC-7901, derived from human adenocarcinoma, morphological appearances of both the pathogen and the...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-27.1079

    authors: Wang P,Mei J,Tao J,Zhang N,Tian H,Fu GH

    更新日期:2012-08-01 00:00:00

  • Histopathological changes in the eyes in systemic lupus erythematosus: an electron microscope and immunohistochemical study.

    abstract::This paper reports the histopathological findings in the eyes of a 26-year-old female patient diagnosed with systemic lupus erythematosus (SLE) with peripheral neuropathy. The patient had no significant ocular problems. She died of pneumonia after two years of suffering. The eyeballs were procured at autopsy and the r...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-20.373

    authors: Nag TC,Wadhwa S

    更新日期:2005-04-01 00:00:00

  • Immunocytochemical localization of the vacuolar H(+)-ATPase pump in the kidney.

    abstract::In this article we review immunocytochemical localization studies using a monoclonal antibody raised against the 31 kD subunit of bovine H(+)-ATPase, and indirect immunofluorescent staining. In the proximal tubules there is intense H(+)-ATPase staining along the brush borders of S1 and S2, and linear subvillar invagin...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:

    authors: Bastani B

    更新日期:1997-07-01 00:00:00

  • Serotonin-producing pancreatic endocrine tumour. Histological, ultrastructural and immunohistochemical study of a case.

    abstract::Serotonin-producing pancreatic endocrine tumours are rare neoplasms which in most cases exhibit malignant biological behaviour. These tumours, in the majority of the well-documented cases, are composed of argyrophil- and argentaffin-positive cells which contain large pleomorphic neurosecretory granules. In contrast, a...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Kanavaros P,Hoang C,Le Bodic MF,Polivka M,Hautefeuille P

    更新日期:1990-07-01 00:00:00

  • Hormonal receptors, cell proliferation fraction (Ki-67) and c-erbB-2 amplification in breast cancer. Relationship between differentiation degree and axillary lymph node metastases.

    abstract::In view of the limitations of conventional prognostic factors such as differentiation degree, metastatic lymph nodes, hormonal receptors and others, especially when early lesions are found, additional new markers have been studied, such as gene amplification and cell proliferation index, in order to choose the appropr...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Sirvent JJ,Santafé M,Salvadó MT,Alvaro T,Raventós A,Palacios J

    更新日期:1994-07-01 00:00:00

  • Pancreatic duct infiltration in the low-dose streptozocin-treated mouse.

    abstract::The pancreatic-duct system was observed during the initial stage of type 1 diabetes in C57BL/6J mice rendered diabetic with low doses of streptozocin. Light microscopy revealed that the ducts located in close proximity to islets (islet ducts) were involved in the infiltrating process: inflammatory cells extended from ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Papaccio G,Strate C,Linn T

    更新日期:1994-07-01 00:00:00

  • New insights into the cytoplasmic function of PML.

    abstract::PML is a tumour suppressor inactivated in Acute Promyelocytic Leukaemia (APL). PML is the essential component of a subnuclear structure called the PML nuclear body (PML-NB), which is disrupted in APL. By targeting different cellular proteins to this structure, PML can either hamper or potentiate their functions. The P...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-22.937

    authors: Salomoni P,Bellodi C

    更新日期:2007-08-01 00:00:00

  • The combination of strong immunohistochemical mtTFA expression and a high survivin index predicts a shorter disease-specific survival in pancreatic ductal adenocarcinoma.

    abstract::Mitochondrial transcription factor A (mtTFA) plays a crucial role in both the transcription and maintenance of mitochondrial DNA. A high expression of mtTFA has been demonstrated in several solid tumors, and is closely associated with cancer cell survival/apoptosis and growth. However, its expression pattern in pancre...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-30.193

    authors: Kimura T,Kitada S,Uramoto H,Zhi L,Kawatsu Y,Takeda T,Horie S,Nabeshima A,Noguchi H,Sasaguri Y,Izumi H,Kohno K,Yamada S

    更新日期:2015-02-01 00:00:00

  • Metalloproteinase expression by control and telomerase immortalized human endometrial endothelial cells.

    abstract::Vascular endothelial cells play a critical role in the maintenance of endometrial homeostasis. Indeed many pathological conditions causing abnormal endometrial bleeding including progestin only contraception, hormone replacement therapy, endometrial polyps, myomas, hyperplasia and cancer are associated with aberrant a...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-20.719

    authors: Krikun G,Mor G,Huang J,Schatz F,Lockwood CJ

    更新日期:2005-07-01 00:00:00

  • Cells with morphological and immunohistochemical features of hepatic stellate cells (Ito cells) form an extralittoral (extrasinusoidal) compartment in the cirrhotic rat liver.

    abstract::Systematic studies on hepatic stellate cells and myofibroblasts have so far mainly focused on cells located in the perisinusoidal space of Disse, the so-called littoral compartment. Here, these cells play a key role for intralobular fibrogenesis and sinusoidal capillarization. However, advanced hepatic fibrosis and ci...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-14.719

    authors: Zimmermann A,Zimmermann H,Fellay M,Reichen J

    更新日期:1999-07-01 00:00:00

  • Interocular effect of intravitreal injection of 6-hydroxydopamine and dopamine on spinule formation in teleost retina.

    abstract::Terminal dendrites of cone horizontal cells (HCs) in teleost retinas show numerous spine-like protrusions named spinules, which are invaginated into the cone pedicles during light-adaptation, but retracted during dark-adaptation. Somata of HC show nematosomes whose size decreases as the number of spinules increases. M...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-17.721

    authors: García M,Grzywacz NM,De Juan J

    更新日期:2002-01-01 00:00:00

  • Renal clear-cell carcinoma: an ultrastructural study on the junctional complexes.

    abstract::Junctional complexes such as tight junctions, adherens junctions, and desmosomes play crucial roles in the structure and function of epithelial cells. These junctions are involved in increasing cell-cell contact and as well serve as signaling centers regulating multiple functions in epithelial cells. Carcinoma cell li...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-20.35

    authors: Kim G,Rajasekaran SA,Thomas G,Rosen EA,Landaw EM,Shintaku P,Lassman C,Said J,Rajasekaran AK

    更新日期:2005-01-01 00:00:00

  • Studies with the Golgi method in central gangliogliomas and dysplastic gangliocytoma of the cerebellum (Lhermitte-Duclos disease).

    abstract::The rapid Golgi method, combined with current optical and electronmicroscopical techniques, was used in three central gangliogliomas and in one dysplastic gangliocytoma of the cerebellum to study the morphology of ganglionic cells. Gangliogliomas were composed of bipolar, fusiform and radiate cells with dense core and...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Ferrer I,Martí E,Guionnet N,Bella R,Serrano T,Towse J,Conesa G,Isamat F

    更新日期:1990-07-01 00:00:00

  • Insights into iron and nuclear factor-kappa B (NF-kappaB) involvement in chronic inflammatory processes in peritoneal endometriosis.

    abstract::Endometriosis is a chronic pelvic inflammatory process. Local inflammation is known to play a role in pain and infertility associated with the disease, and may be extensively involved in molecular and cellular processes leading to endometriosis development. In this review, we focus on two inflammatory mediators clearl...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-26.1083

    authors: Defrère S,González-Ramos R,Lousse JC,Colette S,Donnez O,Donnez J,Van Langendonckt A

    更新日期:2011-08-01 00:00:00

  • Histology and ultrastructure of the pineal organ in the domestic goose.

    abstract::The pineal organs of 14-week-old domestic geese were investigated with light and electron microscopy. The pineals consisted of a wide distal part and a narrow middle-proximal one. The glands were attached to the intercommissural region via the choroid plexus. The pineal parenchyma was formed by round or elongated foll...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-21.1075

    authors: Prusik M,Lewczuk B,Nowicki M,Przybylska-Gornowicz B

    更新日期:2006-10-01 00:00:00