DEC1 expression in 1p-aberrant oligodendroglial neoplasms.


BACKGROUND:Expression of hypoxia-related tissue factors in 1p-aberrant oligodendroglial neoplasms diminishes patient outcome. Differentiated embryo-chondrocyte expressed gene 1 (DEC1) has been described as novel hypoxia-related tissue factor. In our study, we assessed the expression of DEC1 in 1p aberrant oligodendroglial neoplasms and its association with necrosis and expression of hypoxia-inducible factor 1alpha (HIF-1alpha), carbonic anhydrase-9 (CA9), and vascular endothelial growth factor-mRNA (VEGF). MATERIALS AND METHODS:44 primary and 16 recurrent oligodendroglial neoplasms with 1p-aberrations were investigated immunohistochemically for the expression of DEC1, HIF-1alpha, and CA9. Expression of VEGF was investigated using in situ hybridization. DEC1 expression was correlated with necrosis and with expression of HIF-1alpha, CA9, and VEGF. RESULTS:DEC1 was expressed in tumor cell nuclei, and occasionally in nuclei of endothelial cells, and glial and neuronal cells of surrounding brain tissue. High expression (>10% of tumor cells immunolabeled) of DEC1 was found in 56 cases, low expression (<10% of tumor cells immunolabeled) was found in 3 cases. In 1 case no expression of DEC1 was evident. DEC1 expression showed no topographical association with necrosis or expression of HIF-1alpha, CA9, or VEGF. CONCLUSION:DEC1 expression is found in the majority of 1p-aberrant oligodendroglial neoplasms and does not correlate with necrosis or expression of HIF-1alpha, CA9, VEGF. Thus, immunohistochemical analysis of DEC1 expression is in our hands not suitable for detection of tissue hypoxia in this type of primary brain tumor.


Histol Histopathol


Preusser M,Birner P,Ambros IM,Ambros PF,Budka H,Harris AL,Hainfellner JA




Has Abstract


2005-10-01 00:00:00












  • Efficient uptake of mannosylated proteins by a human Schwann cell line.

    abstract::Complex carbohydrate structures are essential molecules of infectious microbes and host cells, and are involved in cell signaling associated with inflammatory and immune responses. The uptake of mannose-tailed glycans is usually carried out by macrophages, dendritic cells (DCs), and other professional phagocytes to tr...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Baetas-da-Cruz W,Alves L,Guimarães EV,Santos-Silva A,Pessolani MC,Barbosa HS,Corte-Real S,Cavalcante LA

    更新日期:2009-08-01 00:00:00

  • Hypophyseal pathology in AIDS.

    abstract::One hundred and eleven pituitary glands of patients (93 males, 18 females; mean age 32 years, 5 months) who died of fully developed AIDS or ARC were examined under light microscopy with the aid of immunohistochemistry. On post mortem (p.m.) examination a wide series of multiorgan alterations was noticed. Microscopical...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Mosca L,Costanzi G,Antonacci C,Boldorini R,Carboni N,Cristina S,Liverani C,Parravicini C,Pirolo A,Vago L

    更新日期:1992-04-01 00:00:00

  • Ultrastructural characterization of calcification onset and progression in subdermally implanted aortic valves. Histochemical and spectrometric data.

    abstract::Detailed characterization of the subdermal model is a significant tool for better understanding of calcification mechanisms occurring in heart valves. In previous ultrastructural investigation on six-week-implantated aortic valve leaflets, modified pre-embedding glutaraldehyde-cuprolinic-blue reactions (GA-CB) enabled...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Ortolani F,Bonetti A,Tubaro F,Petrelli L,Contin M,Nori SL,Spina M,Marchini M

    更新日期:2007-03-01 00:00:00

  • Studies on the involvement of endogenous neuropeptides in the control of thymocyte proliferation in the rat.

    abstract::The possible involvement of endogenous vasoactive intestinal peptide (VIP), cholecystokinin (CCK) and neurotensin (NT) in the control of thymocyte proliferation has been investigated in vivo in the immature rat. For this task, we have studied the effects of the administration of selective antagonists of the receptors ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Trejter M,Warchol JB,de Caro R,Brelinska R,Nussdorfer GG,Malendowicz LK

    更新日期:2001-01-01 00:00:00

  • STAT and SMAD signaling in cancer.

    abstract::STAT and SMAD often exert opposite biological effects on diverse cellular functions. Recent studies have shown that STAT can interface with SMAD at molecular level and that some novel molecules, such as SOCS (also called CIS) and APRO6 (also called TOB), modulate this signaling. A cofactor p300/CBP might act as a brid...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Iwamoto T,Oshima K,Seng T,Feng X,Oo ML,Hamaguchi M,Matsuda S

    更新日期:2002-01-01 00:00:00

  • An immunohistochemical study of NFE2L2, KEAP1 and 8-hydroxy-2'-deoxyguanosine and the EMT markers SNAI2, ZEB1 and TWIST1 in metastatic melanoma.

    abstract:BACKGROUND:Little is known regarding the role of redox balance regulators in metastatic melanomas, but there is some evidence for a link between epithelial-to-mesenchymal transition (EMT) and cellular redox status. METHODS:We compared the immunohistochemical expression of nuclear factor erythroid-2-related factor 2 (N...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Hintsala HR,Haapasaari KM,Soini Y,Karihtala P

    更新日期:2017-02-01 00:00:00

  • Immunohistochemical expression and localization of MMP-9, MMP-13, E-Cadherin and Ki-67 in road pavers' skin chronically exposed to bitumen products.

    abstract::To investigate the matrix metalloproteinase (MMP)-9, (MMP)-13, E-Cadherin and Ki-67 expressions in road pavers' skin chronically exposed to bitumen products in order to contribute to a better understanding of the earlier tissue alteration. Skin punch biopsies from 16 daily exposed workers and a control group were stud...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Loreto C,Lombardo C,Caltabiano R,Filetti V,Vitale E,Seminara D,Castorina S,Fenga C,Ledda C,Rapisarda V

    更新日期:2019-10-01 00:00:00

  • A potential ex vivo infection model of human induced pluripotent stem cell-3D organoids beyond coronavirus disease 2019.

    abstract::The novel coronavirus disease 2019 (COVID-19) outbreak began in the city of Wuhan, whereupon it rapidly spread throughout China and subsequently across the world. Rapid transmission of COVID-19 has caused wide-spread panic. Many established medications have been used to treat the disease symptoms; however, no specific...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Zhou H,Liu LP,Fang M,Li YM,Zheng YW

    更新日期:2020-10-01 00:00:00

  • Topoisomerase 1A, HER/2neu and Ki67 expression in paired primary and relapse ovarian cancer tissue samples.

    abstract::In the present study we examined prognostic value of immunohistochemical estimation of topoisomerase 1A (TOP 1A) and HER-2/neu expression in ovarian cancers treated with platinum-based drugs but not with topotecan and the relation between expression of these proteins on the one hand and intensity of proliferation (Ki6...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Surowiak P,Materna V,Kaplenko I,Spaczynski M,Dietel M,Lage H,Zabel M

    更新日期:2006-07-01 00:00:00

  • Duodenal microanatomy of the domestic cat (Felis catus).

    abstract::Duodenal samples were taken from similar locations in six cats, processed, stained, and examined via light microscope. There were no prominent circular folds (plicae circulares) or stratum compactum (lamina subglandularis). The 1072 microns x 201 microns villi were covered by 46 microns high columnar epitheliocytes pr...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Henry RW,al-Bagdadi FK

    更新日期:1986-10-01 00:00:00

  • Immunohistochemical characterisation of dorsal root ganglia neurons supplying the porcine mammary gland.

    abstract::The present study investigated the chemical coding of mammary gland-projecting dorsal root ganglia (DRG) neurons using double-labelling immunohistochemistry. Earlier investigations revealed the presence of Fast blue - positive (FB+) neurons in Th9-Th12 DRG after injection of the tracer into the second, right thoracic ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Franke-Radowiecka A

    更新日期:2011-12-01 00:00:00

  • Immunoexpression of gelatinase (MMP-2 and MMP-9) in the seminal vesicles and ventral prostate of Libyan jird (Meriones libycus) during the seasonal cycle of reproduction.

    abstract::An immunohistochemical study of matrix metalloproteinases (MMP-2 and MMP-9) or gelatinase (gelatinase A and gelatinase B) was performed on the seminal vesicles and ventral prostate of the Libyan jird (Meriones libycus) collected in the Beni-Abbes area during breeding period (spring and early summer), during resting ph...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Belhocine M,Gernigon-Spychalowicz T,Jacob MP,Benazzoug Y,Exbrayat JM

    更新日期:2010-05-01 00:00:00

  • The combined effect of honey and olive oil against methotrexate mediated hepatotoxicity in rats: A biochemical, histological and immunohistological study.

    abstract:BACKGROUND:Honey and olive oil are natural products that have high nutritional values, and therapeutic properties. Cytotoxic drugs, like methotrexate (MTX) are used to treat malignancies in tumour cells; however, these drugs also have serious side effects that could threaten the patient's life. AIM:To evaluate the pot...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Alturkistani HA,Abuzinadah OAH,Kelany AM,Abd El-Aziz GS,Alrafiah AR

    更新日期:2019-12-01 00:00:00

  • Selective immunolabeling of early gestational cytotrophoblast and its neoplastic counterpart by the monoclonal antibody Ber-EP4.

    abstract::This report presents preliminary observations on the distribution of an epithelial surface antigen in human trophoblastic cells studied with the monoclonal antibody Ber-EP4 by means of an immunoperoxidase technique. Three cases of gestational choriocarcinoma and 20 cases of both villous and extravillous trophoblast, i...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Babury RA,Moscovic EA

    更新日期:1993-04-01 00:00:00

  • M1- and M2-macrophage polarization in thioacetamide (TAA)-induced rat liver lesions; a possible analysis for hepato-pathology.

    abstract::"Classically activated macrophages (M1)" and "alternatively activated macrophages (M2)", which appear in injured tissues, control either inflammation or remodeling. The mechanism remains unclear. To clarify the M1-/M2-macrophage polarization in acute liver injury, M1- and M2-related factors were analysed in F344 rats ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Wijesundera KK,Izawa T,Murakami H,Tennakoon AH,Golbar HM,Kato-Ichikawa C,Tanaka M,Kuwamura M,Yamate J

    更新日期:2014-04-01 00:00:00

  • Comparative in vivo and in vitro models to approach the cellular basis of endotoxic shock. The role of sinusoidal liver cells.

    abstract::During endotoxic shock, the liver exerts a lipopolysaccharide (LPS) clearance function with the participation of both parenchymal and sinusoidal cells. Liver damage could be caused by LPS direct action, hypoxia and/or inflammatory mediators released by Kupffer cells. The aim of this study is to establish an experiment...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Pagani R,Portolés MT,Arahuetes R,Ainaga MJ,Machín C,Rua C

    更新日期:1996-07-01 00:00:00

  • Vacuolar-type proton pump ATPases: roles of subunit isoforms in physiology and pathology.

    abstract::The vacuolar-type H(+)-ATPases (V-ATPases) are a family of multi-subunit ATP-dependent proton pumps involved in diverse cellular processes, including acid/base homeostasis, receptor-mediated endocytosis, processing of proteins and signaling molecules, targeting of lysosomal enzymes, and activation of various degradati...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Sun-Wada GH,Wada Y

    更新日期:2010-12-01 00:00:00

  • Bone marrow stromal cells for spinal cord repair: a challenge for contemporary neurobiology.

    abstract::In the last years, it has been reported that bone marrow stromal cells (BMSC) are able to differentiate towards a neuronal phenotype, in vitro as well as in vivo, and consequently, the possible use of these cells for the treatment of neurological diseases has acquired enormous importance. The objective of this review ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Vaquero J,Zurita M

    更新日期:2009-01-01 00:00:00

  • Use of a fibroblastic matrix improves the results of mesothelial-cell seeding on vascular prostheses of polytetrafluoroethylene.

    abstract::Mesothelial cells (MC) obtained from the human omentum are a good alternative to the use of endothelial cells (EC) as a covering for vascular prostheses of polytetrafluoroethylene (PTFE), given the antithrombogenic properties and good behavior in vitro of mesothelial cells. We studied the behaviour of mesothelial cell...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Buján J,García-Honduvilla N,Hernando A,Bellón JM

    更新日期:1995-10-01 00:00:00

  • Cell proliferation and apoptosis in stromal corneal dystrophies.

    abstract::The aim of our study was to evaluate corneal cell proliferation and apoptosis in cases of granular, macular and lattice dystrophy, and to provide evidence which may help to clarify whether apoptosis is a pathogenic factor in any of these dystrophies. The study group comprised 39 eyes (from 33 patients) which had under...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,多中心研究


    authors: Szentmáry N,Takács L,Berta A,Szende B,Süveges I,Módis L

    更新日期:2007-08-01 00:00:00

  • Immunohistochemistry of connexin43 and zonula occludens-1 in the myocardium as markers of early ischemia in autopsy material.

    abstract::Immunohistochemistry of the terminal complement complex (C5b-9) and fibronectin (FN) is useful to detect myocardial ischemia preceding necrosis in the postmortem diagnosis of sudden cardiac death. The present immunohistochemical study examined connexin43 (Cx43) and zonula occludens-1 (ZO-1) as markers of early myocard...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Kawamoto O,Michiue T,Ishikawa T,Maeda H

    更新日期:2014-06-01 00:00:00

  • Novel PD-L1 mAb HC16 reveals upregulation of PD-L1 in BAC subtype.

    abstract::Programmed death-ligand 1 (PD-L1) is an inhibitory transmembrane protein that can prevent autoimmune response. Upregulated PD-L1 serves as a predictive biomarker for patients who may respond well to immune checkpoint therapies. However, variable associations of PD-L1 level with prognoses have been reported. In this st...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Su BC,Ting CH,Lee KY,Wu SM,Feng PH,Chan YF,Chen JY

    更新日期:2020-10-28 00:00:00

  • Expression of matrix metalloproteinase-9 (gelatinase B) in benign, premalignant and malignant laryngeal lesions.

    abstract::The matrix metalloproteinases (MMPs) are a family of proteolytic zinc-containing enzymes, which are responsible for the breakdown of the extracellular matrix components in pathological and physiological conditions. They are involved in basement membrane disruption, stroma and blood vessel penetration, metastasis and m...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Peschos D,Damala C,Stefanou D,Tsanou E,Assimakopoulos D,Vougiouklakis T,Charalabopoulos K,Agnantis NJ

    更新日期:2006-06-01 00:00:00

  • Molecules of cell adhesion and extracellular matrix proteolysis in oral squamous cell carcinoma.

    abstract::Oral squamous cell carcinoma (OSCC) is the most common malignancy of the oral cavity with a poor 5-year survival rate, due in large part to the presence of metastatic disease at initial diagnosis. In recent years, a number of studies have examined the oral tumor microenvironment to asses the potential dynamic balance ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Shi Z,Stack MS

    更新日期:2010-07-01 00:00:00

  • Ultrastructure of the chronically vagotomised atrial myocardium in the monkey (Macaca fascicularis).

    abstract::The ultrastructure of the atrial myocardium in the monkey (Macaca fascicularis) was studied after bilateral cervical vagotomy and survival times of 100, 175 and 367 days. Changes were observed in the nucleus and the cytoplasm of the myocyte. Sequestered within the nuclei of the affected myocytes were cytoplasmic organ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Wong WC,Yick TY,Ling EA

    更新日期:1989-07-01 00:00:00

  • Glucocorticoid receptor changes its cellular location with breast cancer development.

    abstract::Glucocorticoids play a major role in attenuation of the inflammatory response and they are useful in the primary combination chemotherapy of breast cancer, since in vitro studies have demonstrated an antiproliferative effect in human breast cancer cells. In contrast, it was recently shown that glucocorticoids protect ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Conde I,Paniagua R,Fraile B,Lucio J,Arenas MI

    更新日期:2008-01-01 00:00:00

  • Expression of the proto-oncogene c-fos and the immunolocalization of c-fos, phosphorylated c-fos and estrogen receptor beta in the human testis.

    abstract::Spermatogenesis is under the control of a complex endocrine and paracrine system, including estrogen receptor (ER) signaling. In many target cells, ER promotes the transcription of c-fos and other proto-oncogenes to regulate cell growth and differentiation. Thus, in this study we evaluated the expression of the proto-...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Araújo FC,Oliveira CA,Reis AB,Del Puerto HL,Martins AS,Reis FM

    更新日期:2009-12-01 00:00:00

  • Ultrastructural studies on myofibrillogenesis and neogenesis of skeletal muscles after prolonged traction in rabbits.

    abstract::Little is known about the morphological response of muscle after long term traction. The purpose of this study was to investigate the morphological changes of skeletal muscle during limb lengthening. After application of mini-extraskeletal fixator, the hindlimb of New Zealand white rabbit was osteotomized and then slo...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Sun JS,Hou SM,Hang YS,Liu TK,Lu KS

    更新日期:1996-04-01 00:00:00

  • The prognostic significance of thymidine phosphorylase, thymidylate synthase and dihydropyrimidine dehydrogenase mRNA expressions in breast carcinomas.

    abstract::Thymidine phosphorylase (TP), thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) have been indicated as possible predictive markers for epithelial malignancies. All these three enzymes are actively involved in 5-FU metabolism. In this report, we investigated mRNA expression of these factors with real-...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Li H,Suo Z,Zhang Y,Risberg B,Karlsson MG,Villman K,Nesland JM

    更新日期:2004-01-01 00:00:00

  • The effect of somatostatin analog octreotide on diethylstilbestrol-induced prolactin secretion, cell proliferation and vascular changes in the rat anterior pituitary gland.

    abstract::The effects of diethylstilbestrol (DES) and of long-acting somatostatin analog, octreotide (SMS) on the rat anterior pituitary microvasculature have been studied by means of computer-assisted image analysis. Additionally, the effects of DES and SMS on prolactin secretion and anterior pituitary cell proliferation have ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Pawlikowski M,Kunert-Radek J,Grochal M,Zieliński K,Kulig A

    更新日期:1997-10-01 00:00:00