Abstract：
:β-lapachone is a quinone of lapachol extracted from the bark of lapacho tree. Recent findings demonstrated that punched skin wounds of mice healed faster with β-lapachone treatment. The present study investigates the effects of β-lapachone on burn-wound skin of C57BL/6 mice injured by a 100 °C iron stick. Our results indicated that wounds treated with β-lapachone recovered faster than those treated with control ointment containing no β-lapachone. On the third day after burning, the area of β-lapachone treated-wound was 30% smaller than wound treated with control ointment. H&E and immunohistochemistry staining showed that burn-wound skin treated with ointment containing β-lapachone healed faster in its epidermis, dermis, and underlying connective tissues with more macrophages appeared than those treated with control ointment alone. RAW264.7 cell, a macrophage-like cell line derived from BALB/C mice, was used as a model for scrutinizing the effect of β-lapachone on macrophages. We found that the proliferation and the secretion of EGF and VEGF by macrophages were higher in cultures treated with β-lapachone and that ß-lapachone can also increase the release of EGF with TNF-α pretreatment. We conclude that β-lapachone plays an important role in accelerating burn wound healing, and that β-lapachone not only can raise the proliferation of macrophages but also increase the release of VEGF from macrophages.
journal_name
Histol Histopatholjournal_title
Histology and histopathologyauthors
Fu SC,Chau YP,Lu KS,Kung HNdoi
10.14670/HH-26.905subject
Has Abstractpub_date
2011-07-01 00:00:00pages
905-14issue
7eissn
0213-3911issn
1699-5848journal_volume
26pub_type
杂志文章abstract：:The distribution of peptidergic nerves in canine mammary tissues was studied by immunohistochemical techniques. In addition, the general and the noradrenergic innervations were demonstrated using protein gene product 9.5 and tyrosine hydroxylase immunoreactivities as markers, respectively. Tissue specimens from the ca...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-22.1175
更新日期：2007-11-01 00:00:00
abstract：:It has been commonly supposed that adult stem cells co-localize with supporting cells within specific regions or specialized microenvironment in each tissue/organ, called stem cell niche. This concept was based on the assumption that stem cells are intrinsically hierarchical in nature. However, recent data indicate th...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-25.397
更新日期：2010-03-01 00:00:00
abstract：:There is scarce information on the possible effects of chronic exposure to mercury on skeletal muscle. Dental personnel are frequently exposed to inhalation of metallic mercury vapours. The skeletal muscle of five technicians and one dentist (females, age 36-55) was studied. All of them presented symptoms of chronic m...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-15.673
更新日期：2000-07-01 00:00:00
abstract：:Correlated stereological and functional studies were performed on the effect of massive ACTH doses on adrenal cortex of the female hamster. ACTH resulted in a marked increase in adrenal gland weight at day 6 of treatment followed by a drop at day 9. Stereology showed significant enlargement of the zona fasciculata (ZF...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:Tumorigenesis correlates with hypermethylation of tumor suppressors and hypomethylation of oncogenes. DNA methyltransferases (DNMTs) catalyze DNA methylation, and mutations and aberrant expression in DNMT genes are found in multiple human tumors. The discovery of the DNA demethylation function of TET proteins has open...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-29.991
更新日期：2014-08-01 00:00:00
abstract：:The purpose of this investigation was to clarify the mechanisms of amyloid fibril formation in human lymph nodes. In our present study, amyloid deposition was observed diffusely in all compartments of the lymph nodes. The deposition form showed extremely characteristic findings in its morphological features. Namely, a...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1986-07-01 00:00:00
abstract：:The photoreceptors of the barred owl (Strix varia) consist of rods, single cones and unequal double cones present in a ratio of about 35:1:3. In the light-adapted condition the rods are of uniform diameter along their entire length and are therefore not felt to undergo photomechanical changes. The rod outer segment co...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：:The matrix metalloproteinases (MMPs) are a family of proteolytic zinc-containing enzymes, which are responsible for the breakdown of the extracellular matrix components in pathological and physiological conditions. They are involved in basement membrane disruption, stroma and blood vessel penetration, metastasis and m...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-21.603
更新日期：2006-06-01 00:00:00
abstract：:The aim of this study was to examine the effects of timolol in an experimental model of elevated intraocular pressure (IOP). Three episcleral veins of rats with normal IOP were cauterized. Three months later we examined the effects on anterograde axonal transport from the retinal ganglion cells (RGCs) to the superior ...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-20.1077
更新日期：2005-10-01 00:00:00
abstract：:Dysadherin, a cancer associated cell membrane glycoprotein, has been reported to downregulate E-cadherin. Aberrant expression of E-cadherin has been associated with the development of metastases in patients with cancer. Even though the expression of dysadherin and E-cadherin has been studied in primary non-small cell ...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-25.1257
更新日期：2010-10-01 00:00:00
abstract：:In order to reveal modulation of the number of pulmonary neuroendocrine cells (PNEC) in interstitial lung diseases and to clarify significance of cell proliferation activity in occurrence of PNEC, we counted airway PNEC of the patients of idiopathic interstitial pneumonia, secondary interstitial pneumonia and control ...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-17.1121
更新日期：2002-10-01 00:00:00
abstract：:Chronic liver diseases are commonly associated with tissue hypoxia that may cause inflammation, oxidative stress, liver cell injury and increased nuclear transcriptional regulation. The hepatic response to chronic hypoxia at the molecular level has not yet been clearly understood until now. The aim of this study is to...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：2013-04-01 00:00:00
abstract：:The low density lipoprotein receptor-related protein (LRP) 1 is a ubiquitously expressed, versatile cell surface transmembrane receptor involved in embryonic development and adult tissue homeostasis. LRP1 binds and endocytoses a broad spectrum of over 40 ligands identified thus far, including lipoproteins, extracellul...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-11-746
更新日期：2016-07-01 00:00:00
abstract：:Serotonin-producing pancreatic endocrine tumours are rare neoplasms which in most cases exhibit malignant biological behaviour. These tumours, in the majority of the well-documented cases, are composed of argyrophil- and argentaffin-positive cells which contain large pleomorphic neurosecretory granules. In contrast, a...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1990-07-01 00:00:00
abstract：:The need for an immunophenotypical referential framework relative to lymphoid follicle has led us to apply a panel of monoclonal and polyclonal antibodies, by means of a sensitive immunostaining method. Lymphoid follicle is an immunophenotypically complex structure made up of three lymphoid populations (B, being its b...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：:This paper reports the histopathological findings in the eyes of a 26-year-old female patient diagnosed with systemic lupus erythematosus (SLE) with peripheral neuropathy. The patient had no significant ocular problems. She died of pneumonia after two years of suffering. The eyeballs were procured at autopsy and the r...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-20.373
更新日期：2005-04-01 00:00:00
abstract：:Dimethylnitrosamine (DMN) induced liver injury in rats with cell necrosis, inflammation, hemorrhages, increased collagen type III synthesis and basement membrane component laminin and collagen IV localization in perisinusoidal sites. Malotilate ingestion during DMN treatment abolished inflammation and decreased inters...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:Beta-catenin expression in small cell lung carcinomas (SCLC) was investigated by immunohistochemical method using antibodies against beta-catenin. 50 pre-treatment biopsies were examined and the relationship between beta-catenin expression and the patients' relevant clinical characteristics, response to chemotherapy, ...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-16.353
更新日期：2001-04-01 00:00:00
abstract：:Mitochondrial transcription factor A (mtTFA) plays a crucial role in both the transcription and maintenance of mitochondrial DNA. A high expression of mtTFA has been demonstrated in several solid tumors, and is closely associated with cancer cell survival/apoptosis and growth. However, its expression pattern in pancre...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-30.193
更新日期：2015-02-01 00:00:00
abstract：:The Farnesoid X Receptor (FXR) is a member of the nuclear receptor superfamily of ligand-activated transcription factors, which plays crucial role in bile acid, cholesterol, lipid and glucose metabolism, as well as in the development of atherosclerosis, intestinal bacterial growth and liver regeneration. FXR is also i...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-27.835
更新日期：2012-07-01 00:00:00
abstract：:Introduction. Lichen planus (LP) is a chronic cytokine-mediated disease of possible auto-immune etiology. 25% of men have anogenital manifestations. Erosive penile LP causes a scarring phimosis of the foreskin in uncircumcised men. Mast cells as potent immune modulators have been implicated in a number of autoimmune a...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-29.1017
更新日期：2014-08-01 00:00:00
abstract：:HtrA1 is a secreted protein which behaves as a molecular chaperone at low temperatures and as a serine protease at high temperatures. When the placenta escapes the normal growth control mechanisms, which are present during normal pregnancy, it may develop trophoblastic diseases, such as hydatidiform mole and choriocar...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-24.1213
更新日期：2009-10-01 00:00:00
abstract：:Circadian and seasonal variations were observed in the karyometric index of pinealocytes in the cortical and medullary regions of the distal pineal body. The study involved 70 Wistar rats over a 24-hour interval (0:6, 10:00, 14:00, 18:00, 22:00, 02:00, 06:00 h) during two natural photoluminous periods, i.e. late summe...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1992-10-01 00:00:00
abstract：:The mandible has a mixed embryological origin, and its growth is associated with the secondary cartilage of the condyle process (CP). In this area, growth depends on an array of intrinsic and extrinsic factors that influence protein metabolism. In the present study, we used an adolescent rat model to evaluate the grow...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-25.45
更新日期：2010-01-01 00:00:00
abstract：:Representative tumour sections from 468 patients with invasive breast cancer were immunostained for cyclooxygenase-2 (COX-2) and evaluated. The relationships between COX-2 expression, clinical outcome and various clinicopathological variables, including tumour vascularity and disseminated tumour cells (DTC) in the bon...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-27.1315
更新日期：2012-10-01 00:00:00
abstract：:Dramatical development of molecular genetics has been disclosing the molecular mechanism of Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD). DMD gene product, dystrophin, is a submembranous cytoskeletal protein and many dystrophin-associated proteins (DAPs) have been identified, such as utrophin,...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-15.753
更新日期：2000-07-01 00:00:00
abstract：:The techniques for light and electron microscopic radioautography developed in our laboratory are described. The outlines of the applications to various tissues and organs are also briefly summarized. First, the techniques are explained in detail. These techniques can be divided into two categories, i.e., chemical fix...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：
更新日期：1997-10-01 00:00:00
abstract：:Bacillary angiomatosis (BA) is a reactive vasoproliferative lesion occurring almost exclusively in immunocompromised individuals in response to infection by a bacillus closely related to Rochalimaea quintana. The commonest site of involvement is the skin, in the form of multiple erythematous nodules, but bacillary ang...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：
更新日期：1992-01-01 00:00:00
abstract：:Sialoderivatives expressed in the rabbit oviduct under hormonal treatment have been investigated in situ by lectin histochemistry with a view to specifying further regional and temporal specializations which enable ampulla and isthmus to play distinct roles in the reproductive events. Application of MAL II and SNA lec...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-19.1175
更新日期：2004-10-01 00:00:00
abstract：:Current data on the influence of neuropeptides on the growth, structure and function of cells comprising the hypothalamo-pituitary-adrenal axis were presented and discussed. The action of vasopressin, oxytocin, neurotensin, bombesin, neuropeptide Y, substance P and VIP have been evaluated. The hypothesis has been intr...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：
更新日期：1993-01-01 00:00:00
