The role of TET family proteins and 5-hydroxymethylcytosine in human tumors.


:Tumorigenesis correlates with hypermethylation of tumor suppressors and hypomethylation of oncogenes. DNA methyltransferases (DNMTs) catalyze DNA methylation, and mutations and aberrant expression in DNMT genes are found in multiple human tumors. The discovery of the DNA demethylation function of TET proteins has opened up new avenues for the study of DNA methylation regulation. TET proteins regulate the DNA demethylation pathway through oxidizing 5-mC into 5-hmC, 5-fC, and 5-aC. TET genes have been reported to be frequently mutated in hematopoietic malignancies and are associated with the malignant transformation of cells. Loss-of-function mutations in TET genes have not been reported in human solid tumors. However, 5-hmC has been found to be reduced in various solid tumors, indicating that TET genes may contribute to cellular transformation via regulation of DNA demethylation. As a new epigenetic modification, 5-hmC may be a useful biomarker for the diagnosis of cancers. To better understand the roles of TET and 5-hmC in tumors, the biological functions of TET and 5-hmC should be studied further.


Histol Histopathol


Wu YC,Ling ZQ




Has Abstract


2014-08-01 00:00:00














  • Dietary aluminium and renal failure in the koala (Phascolarctos cinereus).

    abstract::The study investigated the link between the potentially nephrotoxic levels of aluminium ingested in the natural diet of eucalypt leaves by koalas in the Adelaide Hills, South Australia, and the high incidence of renal failure in koalas within this habitat. Routine histology of kidney specimens revealed no pathologies ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Haynes JI,Askew MJ,Leigh C

    更新日期:2004-07-01 00:00:00

  • Nandrolone decanoate increases satellite cell numbers in the chicken pectoralis muscle.

    abstract::The anabolic androgenic steroid nandrolone decanoate has minimal androgenic effects and, thus, is widely used to induce muscle hypertrophy in both patients and athletes. Although increases in satellite cell numbers and satellite cells giving rise to new myonuclei are associated with hypertrophy in many experimental mo...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Allouh MZ,Rosser BW

    更新日期:2010-02-01 00:00:00

  • Localization of androgen and estrogen receptors in rat and primate tissues.

    abstract::There is now evidence that estrogens and androgens are exerting their effects in different tissues throughout the body. In order to determine the sites of action of these steroids, studies have been performed to identify at the cellular level the localization of androgen receptor (AR) and the two estrogen receptor (ER...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Pelletier G

    更新日期:2000-10-01 00:00:00

  • Morphometric study on the interhemispheric asymmetries in the Wistar rat and the effects of early experience.

    abstract::Sixty male Wistar rats were used for this experiment and assigned at random to the control group or to the stimulation method. Control rats show cerebral asymmetry with right bias at the frontal and occipital lobes. In the case of stimulated rats the differences from the occipital zone increase while those from the fr...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Isasa Chueca JA,Lahoz Gimeno M,Redondo Marco JA

    更新日期:1992-07-01 00:00:00

  • Coexistence of serotonin and cholecystokinin in paraneurons of the foetal sheep lung.

    abstract::The coexistence of serotonin and cholecystokinin was studied in foetal sheep lungs at pseudoglandular stage of development by light microscopic immunohistochemistry. The coexistence was examined by staining consecutive sections with the different antibodies. Serotonin and cholecystokinin immunoreactivity was found wit...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Balaguer L,Romano J,Ruiz-Pesini P

    更新日期:1994-01-01 00:00:00

  • Mad2 and spindle assembly checkpoint function during meiosis I in mammalian oocytes.

    abstract::During mammalian mitosis, a proofreading network called the spindle assembly checkpoint (SAC) is indispensable for ensuring the fidelity of chromosome segregation. An inhibitory SAC signal is deputed to inhibits mitotic cell-cycle progression in response to misaligned chromosomes until such imperfections are rectified...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Homer HA

    更新日期:2006-08-01 00:00:00

  • Antioxidant enzymes in renal cell carcinoma.

    abstract::The aim of the study was to estimate the significance of oxidative/nitrosative damage and expression of antioxidant enzymes in renal cell carcinomas (RCC). For this we investigated immunohistochemically six antioxidant enzymes (AOEs) including MnSOD, ECSOD, thioredoxin, thioredoxin reductase, and gammaglutamyl cystein...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Soini Y,Kallio JP,Hirvikoski P,Helin H,Kellokumpu-Lehtinen P,Tammela TL,Peltoniemi M,Martikainen PM,Kinnula LV

    更新日期:2006-02-01 00:00:00

  • Nuclear localization of TRK-A in liver cells.

    abstract::The liver represents a site of expression of neurotrophins and their receptors. We have characterized the expression and intracellular localization of the nerve growth factor (NGF) receptor, Trk-A, in liver cells in vivo and in vitro. In both normal and fibrotic liver tissue, Trk-A immunostaining was present in differ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Bonacchi A,Taddei ML,Petrai I,Efsen E,Defranco R,Nosi D,Torcia M,Rosini P,Formigli L,Rombouts K,Zecchi S,Milani S,Pinzani M,Laffi G,Marra F

    更新日期:2008-03-01 00:00:00

  • Ultrastructural substrates for increased lung water content in experimental pulmonary edema.

    abstract::We examined the relationship between the incidence of ultrastructural changes in the alveolar septum and the extravascular lung water content. Pulmonary edema was induced in 18 mongrel dogs by either dextran (n = 12) or alloxan (n = 6) administration. Six other dogs served as controls. Extravascular lung water content...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Oda H,Arakawa M,Kambara K,Nakahara K,Segawa T,Ando F,Kawada T,Hirakawa S,Shoumura S,Isono H

    更新日期:1993-01-01 00:00:00

  • Ultrastructural characterization of calcification onset and progression in subdermally implanted aortic valves. Histochemical and spectrometric data.

    abstract::Detailed characterization of the subdermal model is a significant tool for better understanding of calcification mechanisms occurring in heart valves. In previous ultrastructural investigation on six-week-implantated aortic valve leaflets, modified pre-embedding glutaraldehyde-cuprolinic-blue reactions (GA-CB) enabled...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Ortolani F,Bonetti A,Tubaro F,Petrelli L,Contin M,Nori SL,Spina M,Marchini M

    更新日期:2007-03-01 00:00:00

  • Structural and ultrastructural hepatic changes in experimental canine leishmaniasis.

    abstract::Six 4 month-old beagles were inoculated with Leishmania donovani infantum, three of them intraperitoneally (Group A) and the other three intravenously (Group B). The animals from Group A were killed 109, 433 and 592 days after inoculation and animals from Group B 109, 171 and 334 after inoculation. The liver of each o...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: González JL,Rollán E,Novoa C,Castaño M

    更新日期:1988-10-01 00:00:00

  • Effects of pinealectomy on the ultrastructure of the golden hamster parathyroid gland.

    abstract::Ultrastructural changes of the parathyroid glands of pinealectomized golden hamsters were investigated. The main changes in the parathyroid glands 1 hour and 1 day after pinealectomy compared with the control and sham-operated groups were an increase of the Golgi complexes, cisternae of the granular endoplasmic reticu...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Chen H,Shoumura S,Emura S,Utsumi M,Yamahira T,Isono H

    更新日期:1990-10-01 00:00:00

  • Microglia and prion disease: a review.

    abstract::Prion diseases are characterized by the accumulation of PrPSc, an altered isoform of a normal cellular protein, PrPc. The prion hypothesis holds that the process of conformational change from PrPc to PrPSc under the influence of PrPSc constitutes the basic infectious mechanism in prion diseases. It is still unknown wh...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Brown DR,Kretzschmar HA

    更新日期:1997-07-01 00:00:00

  • Serotonin-producing pancreatic endocrine tumour. Histological, ultrastructural and immunohistochemical study of a case.

    abstract::Serotonin-producing pancreatic endocrine tumours are rare neoplasms which in most cases exhibit malignant biological behaviour. These tumours, in the majority of the well-documented cases, are composed of argyrophil- and argentaffin-positive cells which contain large pleomorphic neurosecretory granules. In contrast, a...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Kanavaros P,Hoang C,Le Bodic MF,Polivka M,Hautefeuille P

    更新日期:1990-07-01 00:00:00

  • In vivo toxicity of the ribosome-inactivating lectin ebulin f in elderly mice.

    abstract::Ebulin f is a ribosome-inactivating protein (RIP) present in green fruits of the dwarf elder (Sambucus ebulus L). Since dwarf elder fruits are used for food and as a medicine, we assessed the study of toxicological effects and safety of ebulin f in elderly mice, comparing these results with those reported in young ani...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Garrosa M,Jiménez P,Córdoba-Díaz D,García-Recio V,Gayoso S,Rojo MÁ,Gayoso MJ,Girbés T

    更新日期:2018-09-01 00:00:00

  • Bone marrow histopathology in chronic myelogenous leukemia (CML)--evaluation of distinctive features with clinical impact.

    abstract::Bone marrow features in stable-phase chronic myelogenous leukemia (CML) are characterized by a striking heterogeneity which is determinable by appropriate means including representative pre-treatment trephine biopsies, immunohistochemistry and morphometry. Cell lineages involved to a variable extent consist not only o...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Thiele J,Kvasnicka HM,Fischer R

    更新日期:1999-10-01 00:00:00

  • Implications of androgen receptor and FUS expression on tumor progression in urothelial carcinoma.

    abstract::Androgen receptor (AR) interact with many pathways involved in bladder cancer development and progression. FUS (fused in liposarcoma), a multifunctional protein essential for different cellular processes, has been demonstrated as a key link between androgen receptor signaling and cell-cycle progression in prostate can...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Abd Raboh NM,Hakim SA,Abd El Atti RM

    更新日期:2020-12-23 00:00:00

  • Complex and elementary histological scoring systems for articular cartilage repair.

    abstract::The repair of articular cartilage defects is increasingly moving into the focus of experimental and clinical investigations. Histological analysis is the gold standard for a valid and objective evaluation of cartilaginous repair tissue and predominantly relies on the use of established scoring systems. In the past thr...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Orth P,Madry H

    更新日期:2015-08-01 00:00:00

  • Description of primordial germ cells, oogonia, oocytes and embryo-like growth in squash preparations of tissues from hematological malignancies.

    abstract::This study evidences the presence of primordial germ cells, in tissue squash preparations and sections from hematological malignancies. Primordial germ cells were identified by their morphology, the intense PAS, PAS-D reaction and presence of calcium-activated neutral proteinase. Primordial germ cells gave rise to nuc...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Logothetou-Rella H

    更新日期:1996-10-01 00:00:00

  • Somatostatinoma: collision with neurofibroma and ultrastructural features.

    abstract::The clinical presentation, histopathology and immunoelectron microscopic features of two cases of duodenal somatostatinoma are described, one of which is a hitherto unreported example of a collision tumour with a neurofibroma. Ultrastructural morphometric immunoelectron microscopy studies revealed the presence of four...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Varikatt W,Yong JL,Killingsworth MC

    更新日期:2006-11-01 00:00:00

  • Eosinophils and airway nerves in asthma.

    abstract::In the lungs, neuronal M2 muscarinic receptors limit the release of acetylcholine from postganglionic cholinergic nerves. However, these receptors are not functional under certain circumstances in animal models of hyperreactivity such as occurs after exposure of sensitised animals to an allergen or during a respirator...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Costello RW,Jacoby DB,Gleich GJ,Fryer AD

    更新日期:2000-07-01 00:00:00

  • Neutrophil gelatinase-associated lipocalin (NGAL) immunohistochemical expression in follicular cell-derived thyroid tumors: a novel diagnostic tool?

    abstract::Discrimination of follicular cell-derived benign and malignant tumors of the thyroid is one of the major problems encountered in surgical pathology. In the present study, we evaluated the immunohistochemical expression of NGAL, an iron-binding protein involved in the infiltrative potential of cancer cells, in a cohort...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Barresi V,Leni A,Tuccari G,Barresi G

    更新日期:2012-03-01 00:00:00

  • The relative effects of severe burn injury and pre- and post-natal protein deprivation on mandibular condyle morphology.

    abstract::The mandible has a mixed embryological origin, and its growth is associated with the secondary cartilage of the condyle process (CP). In this area, growth depends on an array of intrinsic and extrinsic factors that influence protein metabolism. In the present study, we used an adolescent rat model to evaluate the grow...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: de Oliveira BC,de Oliveira F,Martini DT,Prisco CR,da Silva Riguetti MM,Liberti EA,de Campos Boldrini S

    更新日期:2010-01-01 00:00:00

  • Hydroxy group requirement for halofuginone-dependent inhibition of muscle fibrosis and improvement of histopathology in the mdx mouse model for Duchenne muscular dystrophy.

    abstract::In Duchenne muscular dystrophy (DMD), the progressive loss of muscle and its ability to function is associated with significant fibrosis, representing the major disease complication in patients. Halofuginone, a halogenated analog of the naturally occurring febrifugine, has been shown to prevent fibrosis in various ani...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Wellner G,Mordechay S,Evans P,Genin O,Pines M,Halevy O

    更新日期:2019-07-01 00:00:00

  • High expression of PKM2 as a poor prognosis indicator is associated with radiation resistance in cervical cancer.

    abstract::Our study aimed to investigate the association of Pyruvate Kinase isozyme type M2 (PKM2) with radiation resistance in locally advanced cervical squamous cell carcinoma (LACSCC). We retrospectively reviewed 132 female patients who received primary radiation therapy to treat LACSCC at Federation Internationale of Gyneco...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Zhao Y,Shen L,Chen X,Qian Y,Zhou Q,Wang Y,Li K,Liu M,Zhang S,Huang X

    更新日期:2015-11-01 00:00:00

  • The effects of cyclophosphamide on the gonadotrophic cells of the normal rat.

    abstract::The effects of the administration of cyclophosphamide to male rats at doses of 400 mg/m2 for a period of 5 days and of 200 mg/m2 over two five-day cycles interrupted by a 21-day break reveal differences in the ultrastructural morphology of gonadotrophic cells between treated animals and normal controls. The ultrastruc...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Poblador MS,Rojas C,Raya A,Casares JA,Aparicio J,Lancho Alonso JL

    更新日期:1990-04-01 00:00:00

  • Tracing the accumulation and effects of mercury uptake in the previtellogenic ovary of crucian carp, Carassius auratus gibelio by autometallography and caspase-3 immunohistochemistry.

    abstract::The aims of the present study were to apply the AMG technique for localization of mercury at the light and electron microscopic level in the ovary of crucian carp after exposure to mercuric chloride and to find out if this heavy metal induces expression of caspase-3. Depending on the stage of ovarian follicle developm...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Zarnescu O

    更新日期:2009-02-01 00:00:00

  • Morphological, immunohistochemical and ultrastructural changes in dimethylnitrosamine [correction of dimenthylnitrosamine] induced liver injury. Effect of malotilate.

    abstract::Dimethylnitrosamine (DMN) induced liver injury in rats with cell necrosis, inflammation, hemorrhages, increased collagen type III synthesis and basement membrane component laminin and collagen IV localization in perisinusoidal sites. Malotilate ingestion during DMN treatment abolished inflammation and decreased inters...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Stenbäck F,Ala-Kokko L,Ryhänen L

    更新日期:1989-01-01 00:00:00

  • Molecular and cellular mechanisms of heterotopic ossification.

    abstract::Heterotopic ossification (HO) is a debilitating condition in which cartilage and bone forms in soft tissues such as muscle, tendon, and ligament causing immobility. This process is induced by inflammation associated with traumatic injury. In an extremely rare genetic disorder called fibrodysplasia ossificans progessiv...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Ramirez DM,Ramirez MR,Reginato AM,Medici D

    更新日期:2014-10-01 00:00:00

  • Nigral degeneration correlates with persistent activation of cerebellar Purkinje cells in MPTP-treated monkeys.

    abstract::In the present work we analyze the cerebellum of chronic parkinsonian monkeys in order to clarify whether chronic mesencephalic depletion is associated with long term activation of the cerebellar neurons in chronic Parkinsonism. In our study, we observed a persistent activation of Purkinje cells in the cerebellum of c...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Heman P,Barcia C,Gómez A,Ros CM,Ros-Bernal F,Yuste JE,de Pablos V,Fernandez-Villalba E,Toledo-Cárdenas MR,Herrero MT

    更新日期:2012-01-01 00:00:00