Abstract:
:Tumorigenesis correlates with hypermethylation of tumor suppressors and hypomethylation of oncogenes. DNA methyltransferases (DNMTs) catalyze DNA methylation, and mutations and aberrant expression in DNMT genes are found in multiple human tumors. The discovery of the DNA demethylation function of TET proteins has opened up new avenues for the study of DNA methylation regulation. TET proteins regulate the DNA demethylation pathway through oxidizing 5-mC into 5-hmC, 5-fC, and 5-aC. TET genes have been reported to be frequently mutated in hematopoietic malignancies and are associated with the malignant transformation of cells. Loss-of-function mutations in TET genes have not been reported in human solid tumors. However, 5-hmC has been found to be reduced in various solid tumors, indicating that TET genes may contribute to cellular transformation via regulation of DNA demethylation. As a new epigenetic modification, 5-hmC may be a useful biomarker for the diagnosis of cancers. To better understand the roles of TET and 5-hmC in tumors, the biological functions of TET and 5-hmC should be studied further.
journal_name
Histol Histopatholjournal_title
Histology and histopathologyauthors
Wu YC,Ling ZQdoi
10.14670/HH-29.991subject
Has Abstractpub_date
2014-08-01 00:00:00pages
991-7issue
8eissn
0213-3911issn
1699-5848pii
HH-11-469journal_volume
29pub_type
杂志文章,评审abstract::Morphological, histochemical and ultrastructural investigations on epiphyseal apparatus of Rana Esculenta were made. The most important findings were the following: 1) metaphyseal cartilage is localized inside proximal diaphyseal compact bone as a plug; 2) metaphyseal cartilage do not reduce in thickness during ageing...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1992-04-01 00:00:00
abstract::Experimental Doxorubicin-exposure in utero is correlated with foetal oesophageal atresia, tracheo-oesophageal fistula, axial alterations. While gastrointestinal and respiratory defects have been largely investigated, only sporadic data have been published to date on notochordal and vertebral defects. The aim of this w...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-17.31
更新日期:2002-01-01 00:00:00
abstract::To date, no detailed knowledge from animal experiments is available on the kind and extent of osseous and mineral metabolic disorders in genetically determined, insulin-dependent Type I diabetes. The purpose of this study was to examine the influence of the diabetic metabolic state in spontaneously diabetic BB/O(ttawa...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-18.111
更新日期:2003-01-01 00:00:00
abstract::Neurotrophins are substances that have been shown to be important in growth and remodelling phases in different types of tissue. There is no information concerning the possible occurrences of neurotrophins and their receptors in tendons. In this study, sections of both chronic painful (tendinosis) and pain-free (non-t...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-24.839
更新日期:2009-07-01 00:00:00
abstract::We examined the relationship between the incidence of ultrastructural changes in the alveolar septum and the extravascular lung water content. Pulmonary edema was induced in 18 mongrel dogs by either dextran (n = 12) or alloxan (n = 6) administration. Six other dogs served as controls. Extravascular lung water content...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract::Morphological and biochemical alterations have been described in neurons of the aged human brain. However, the cell death process associated with neuronal senescence remains to be elucidated. Apoptosis and autophagic degeneration, two modes of programmed cell death described in embryogenesis and tissue renewal in adul...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1997-07-01 00:00:00
abstract::Versican, a large extracellular matrix proteoglycan accumulates in tumor stroma and plays a key role in both malignant transformation and tumor progression. Increased versican expression has been observed in a wide range of malignant tumors, and has been associated with both cancer relapse and poor patient outcomes in...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-28.701
更新日期:2013-06-01 00:00:00
abstract::Within the last few years, advances have been made regarding perivascular nerves and the endothelium of the vascular system, both potentially important in the understanding of the mechanisms of local control of blood flow. Endothelin-1 (ET-1) has been identified in rat cerebrovascular nerves, neuropeptide Y (NPY) has ...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-17.591
更新日期:2002-04-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-25.133
更新日期:2010-02-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-16.883
更新日期:2001-07-01 00:00:00
abstract::We used antisera to pure atrial natriuretic peptide to localise this peptide by immunocytochemistry in rat and human tissue. We showed that both rat and human atrial cardiocytes gave a positive reaction while ventricular cardiocytes were consistently negative. Peripheral islet cells in rat but not in human pancreas al...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1986-04-01 00:00:00
abstract::Human epithelium contains keratin, which is expressed during differentiation. Depending on the target cell type, different types of keratin are expressed, and their alterations seem to represent changes in cell properties. The basal cells of oral epithelium express keratin 5 (K5), K14, K15 and K19, but their alteratio...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-27.949
更新日期:2012-07-01 00:00:00
abstract::Heterotopic ossification (HO) is a debilitating condition in which cartilage and bone forms in soft tissues such as muscle, tendon, and ligament causing immobility. This process is induced by inflammation associated with traumatic injury. In an extremely rare genetic disorder called fibrodysplasia ossificans progessiv...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-29.1281
更新日期:2014-10-01 00:00:00
abstract::The pineal organs of 14-week-old domestic geese were investigated with light and electron microscopy. The pineals consisted of a wide distal part and a narrow middle-proximal one. The glands were attached to the intercommissural region via the choroid plexus. The pineal parenchyma was formed by round or elongated foll...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-21.1075
更新日期:2006-10-01 00:00:00
abstract::Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for the purpose of anti-inflammation, antipyretic, and analgesia. For this aim, they are used for the alleviation of pain, fever, and inflammation associated with rheumatoid arthritis, sports injuries, and temporary pain. However, treatment with NSAIDs may ...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-27.417
更新日期:2012-04-01 00:00:00
abstract::CD24 is known to be an important diagnostic and prognostic marker of several major cancers affecting females. We aimed to determine CD24 expression in normal, hyperplastic, and carcinomatous endometrium and its correlation with estrogen and progesterone receptor expression. A total of 271 cases including 62 normal/atr...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-24.309
更新日期:2009-03-01 00:00:00
abstract::Unlike other B cells, plasma cells (PC) react with only a few antibodies against haemopoietic antigens. We investigated 36 specimens exhibiting a reactive increase in PC numbers (i.e. plasmacytosis, PC hyperplasia) with a broad panel of antibodies suitable for use on formalin-fixed, paraffin-embedded tissue, and compa...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-14.805
更新日期:1999-07-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-15.421
更新日期:2000-04-01 00:00:00
abstract::Discrimination of follicular cell-derived benign and malignant tumors of the thyroid is one of the major problems encountered in surgical pathology. In the present study, we evaluated the immunohistochemical expression of NGAL, an iron-binding protein involved in the infiltrative potential of cancer cells, in a cohort...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-27.329
更新日期:2012-03-01 00:00:00
abstract::The view of how astrocytes, a type of glial cells, contribute to the functioning of the central nervous system (CNS) has changed greatly in the last decade. Although glial cells outnumber neurons in the mammalian brain, it was considered for over a century that they played a subservient role to neurons. This view chan...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-26.277
更新日期:2011-02-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1992-07-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:
更新日期:1997-01-01 00:00:00
abstract::Shotgun pellets containing bismuth (Bi) are widely used and may cause a rather intense exposure of some wild animals to Bi. A Bi shotgun pellet was implanted intramuscularly in the triceps surae muscle of 18 adult male Wistar rats. Another group of 9 animals had a Bi shotgun pellet implanted intracranially in the neoc...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-18.781
更新日期:2003-07-01 00:00:00
abstract::Lymphatic vessels afferent to the popliteal nodes in young adult rats and guinea pigs were interrupted at the lowest edge of the popliteal fossa, and regressive changes in the nodes occurring 4 to 16 or 18 weeks after surgery were re-examined histologically. In the rat, some popliteal nodes were drained by lymphatic c...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1993-07-01 00:00:00
abstract::Elevated plasma levels of C-reactive protein (CRP) are associated with increased risk of cardiovascular disease. CRP immunoreactive protein is also detected in the lesions of atherosclerosis. However, it is not known whether the CRP contents of atherosclerotic lesions are associated with the initiation and progression...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-27.529
更新日期:2012-04-01 00:00:00
abstract::The aim of our study was to document whether relationships existed among bone morphogenetic proteins (BMPs), peripheral nerve and neoplastic lesions of nerve sheath tumors. The mRNA transcriptions of BMP-2, 3, 4 and 5 in 10 cases of schwannoma, three cases of malignant schwannoma and two cases of trigeminal neuralgia ...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-16.1013
更新日期:2001-10-01 00:00:00
abstract::The morphology of the rat duodenum after chronic treatment with 15% (v/v) ethanol and 4% (v/v) pentanol was studied. Male Wistar rats of experimental groups were given ethanol and pentanol for 15 weeks with food and fluid freely available. Ethanol-15% and 4% pentanol-fed rats showed a significantly reduced fluid and f...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-17.199
更新日期:2002-01-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-15.95
更新日期:2000-01-01 00:00:00
abstract::Telocytes (TCs) represent a new distinct type of interstitial cells found in many organs, including lungs. TCs are mainly defined by a small cellular body from which arise very long (hundreds of micrometers) extensions named telopodes. During the last years, TCs were characterized in respect with their microRNA profil...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-11-807
更新日期:2016-12-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:
更新日期:1992-01-01 00:00:00