Abstract：
:We examined the relationship between the incidence of ultrastructural changes in the alveolar septum and the extravascular lung water content. Pulmonary edema was induced in 18 mongrel dogs by either dextran (n = 12) or alloxan (n = 6) administration. Six other dogs served as controls. Extravascular lung water content was measured by the thermal-dye double indicator dilution method. Specimens of lung tissue were examined with an electron microscope, and the incidence of 13 types of pathological changes in the alveolar septum was studied. For each type of pathological change, the incidence was correlated with the magnitude of lung water content. The following results were obtained. The incidence of edematous changes in the alveolar interstitium (widening of the interstitial space, and dispersion and disarray of collagen fibres in the interstitial space) was well correlated with lung water content (r = 0.78, p < 0.01, and r = 0.84, p < 0.01, respectively). The correlation was not significant in the remaining types of changes. We conclude that the incidence of the pathological changes in the alveolar septum is increased along with the increase in the content of lung water in both dextran- and alloxan-induced experimental pulmonary edema in dogs.
journal_name
Histol Histopatholjournal_title
Histology and histopathologyauthors
Oda H,Arakawa M,Kambara K,Nakahara K,Segawa T,Ando F,Kawada T,Hirakawa S,Shoumura S,Isono Hsubject
Has Abstractpub_date
1993-01-01 00:00:00pages
73-82issue
1eissn
0213-3911issn
1699-5848journal_volume
8pub_type
杂志文章abstract：BACKGROUND:Expression of hypoxia-related tissue factors in 1p-aberrant oligodendroglial neoplasms diminishes patient outcome. Differentiated embryo-chondrocyte expressed gene 1 (DEC1) has been described as novel hypoxia-related tissue factor. In our study, we assessed the expression of DEC1 in 1p aberrant oligodendrogl...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-20.1173
更新日期：2005-10-01 00:00:00
abstract：:Oligodendrocytes are the myelinating cells of the central nervous system. Since many studies of demyelinating diseases focus their research on this cell type, there is growing interest for obtaining reliable markers that can specifically recognize oligodendroglia. Established markers are the myelin-associated neurite ...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-11-640
更新日期：2015-12-01 00:00:00
abstract：:The International Prognostic Index (IPI) has been the basis for determining prognosis in patients with diffuse large B-cell lymphoma (DLBCL) for the past 20 years. The utility of the IPI must be reassessed in the era of immunochemotherapy. Seven risk factors at diagnosis were identified, and a maximum of 7 points were...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-11-673
更新日期：2016-03-01 00:00:00
abstract：:Spectrins are members of the superfamily of F-actin cross linking proteins that are important as scaffolding proteins for protein sorting, cell adhesion, and migration. In addition, spectrins have been implicated in TGF-beta signaling. The aim of the present study was to analyze the expression and localization of beta...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-25.1497
更新日期：2010-12-01 00:00:00
abstract：:The mandible has a mixed embryological origin, and its growth is associated with the secondary cartilage of the condyle process (CP). In this area, growth depends on an array of intrinsic and extrinsic factors that influence protein metabolism. In the present study, we used an adolescent rat model to evaluate the grow...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-25.45
更新日期：2010-01-01 00:00:00
abstract：:Since endometriosis is a proliferative disease we evaluated the presence of anti-apoptotic factor (Bcl-2) and pro-apoptotic factor (Bax) in deep pelvic endometriosis. A Cross-sectional observational study was performed at Santa Casa de Misericórdia de São Paulo, São Paulo, Brazil. Forty women aged 26 to 46 years with ...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-29.1129
更新日期：2014-09-01 00:00:00
abstract：:Studies with scanning electron microscopy in the normal human sulcular epithelium are scarce, and no precise information exists about cell surface patterns along the epithelium, the frequencies of these patterns, or possible regional differences within the mouth. In five periodontal biopsy specimens each from the ante...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：:Primordial germ cells (PGCs) are the founder cells of all gametes. PGCs differentiate from pluripotent epiblasts cells by mesodermal induction signals during gastrulation. Although PGCs are unipotent cells that eventually differentiate into only sperm or oocytes, they dedifferentitate to pluripotent stem cells known a...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-26.643
更新日期：2011-05-01 00:00:00
abstract：:In view of the limitations of conventional prognostic factors such as differentiation degree, metastatic lymph nodes, hormonal receptors and others, especially when early lesions are found, additional new markers have been studied, such as gene amplification and cell proliferation index, in order to choose the appropr...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1994-07-01 00:00:00
abstract：:Despite years of research into its pathobiology and continuing clinical trials for novel therapies, the prognosis for patients with glioblastoma (GBM) remains dismal. An important obstacle against treatment efficacy may be a high degree of intra- and inter-tumoral heterogeneity within GBMs, which may be caused by the ...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-11-695
更新日期：2016-03-01 00:00:00
abstract：:The aim of this study was to examine the effects of timolol in an experimental model of elevated intraocular pressure (IOP). Three episcleral veins of rats with normal IOP were cauterized. Three months later we examined the effects on anterograde axonal transport from the retinal ganglion cells (RGCs) to the superior ...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-20.1077
更新日期：2005-10-01 00:00:00
abstract：:Emperipolesis has recently been described as a constant feature of "biphasic squamoid" papillary renal cell carcinoma (BPRCC). We also noticed this in some high-grade (HG) RCC, which promoted the present study to estimate the incidence of emperipolesis in RCCs and to describe them in further detail. 14 cases of HGRCC ...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-11-925
更新日期：2018-03-01 00:00:00
abstract：:In this article we review immunocytochemical localization studies using a monoclonal antibody raised against the 31 kD subunit of bovine H(+)-ATPase, and indirect immunofluorescent staining. In the proximal tubules there is intense H(+)-ATPase staining along the brush borders of S1 and S2, and linear subvillar invagin...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：
更新日期：1997-07-01 00:00:00
abstract：AIMS:The prognostic application of YES1 in epithelial ovarian cancer (EOC) is currently unclear. We aimed to investigate the expression of YES1 and its correlation with survival outcome in patients with EOC. METHODS:A retrospective study of patients diagnosed with EOC at the Cancer Center, Sun Yat-Sen University, Guan...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-18-203
更新日期：2020-07-01 00:00:00
abstract：:The effects of cadmium exposure on the protein secretory functions of cultured neonatal rat hepatocytes were analyzed by both two-dimensional polyacrylamide gel electrophoresis (2D-PAGE) and electron microscopy. [35S]Methionine-labelled protein secretion was significantly depressed by cadmium exposure in a dose-depend...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:Nitric oxide (NO) is a biological messenger molecule produced by one of the essential amino acids L-arginine by the catalytic action of the enzyme NO synthase (NOS). The dual role of NO as a protective or toxic molecule is due to several factors, such as; the isoform of NOS involved, concentration of NO and the type o...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-21.445
更新日期：2006-04-01 00:00:00
abstract：:Detailed characterization of the subdermal model is a significant tool for better understanding of calcification mechanisms occurring in heart valves. In previous ultrastructural investigation on six-week-implantated aortic valve leaflets, modified pre-embedding glutaraldehyde-cuprolinic-blue reactions (GA-CB) enabled...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-22.261
更新日期：2007-03-01 00:00:00
abstract：:Previous studies have demonstrated a role for the beta-adrenergic system in the maturation of the fetal alveolar epithelium. Chronic blockade of beta-adrenergic binding sites has been shown to adversely effect physiologic and biochemical indices of fetal lung maturation. In the present study timed-pregnant female Spra...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-17.365
更新日期：2002-04-01 00:00:00
abstract：:Morphological and biochemical alterations have been described in neurons of the aged human brain. However, the cell death process associated with neuronal senescence remains to be elucidated. Apoptosis and autophagic degeneration, two modes of programmed cell death described in embryogenesis and tissue renewal in adul...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1997-07-01 00:00:00
abstract：:Transforming growth factor-beta1 (TGF-1beta) has been shown to modulate both cell proliferation and the synthesis of extracellular matrix by vascular cells. This study was aimed to establish the temporal correlation between TGF-beta1 expression, the expression of the extracellular matrix protein fibronectin, and plaqu...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-15.421
更新日期：2000-04-01 00:00:00
abstract：:In the present work a morphopathological study is carried out of the glomerular filtration barrier in 20 Large-White pigs weighing 20 kg, subjected to experimental intravenous inoculations of endotoxin from Salmonella enteritidis. The study is completed with the determination of protein plasmatic levels, through urine...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1989-10-01 00:00:00
abstract：:Primary perivascular epithelioid cell tumor (PEComa) of the liver is a very rare example of an emerging family of hepatic PEC tumors. Only few cases have been described so far. We report the case of a large but benign hepatic PEComa in a 53-year-old man without signs of tuberous sclerosis. In contrast to recently desc...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-23.1185
更新日期：2008-10-01 00:00:00
abstract：:Sex steroid hormones are involved in regulation of skin development and functions as well as in some skin pathological events. To determine the sites of action of estrogens, androgens and progestins, studies have been performed during the recent years to accurately localize receptors for each steroid hormone in human ...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-19.629
更新日期：2004-04-01 00:00:00
abstract：:An inadequate balance between oxidant species and antioxidant mechanisms may constitute the primary mechanisms of a number of pathologies. The liver plays a central role in this balance: parenchymal hepatic cells contain and export especially high levels of the antioxidant glutathione and activated Kupffer cells relea...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-22.399
更新日期：2007-04-01 00:00:00
abstract：:Thyroid hormones (TH) stimulate oxidative metabolism in many tissues in the body, but testis is not one of them. Therefore, in this sense, testis is not considered as a target organ for TH. However, recent findings clearly show that TH have significant functions on the testis in general, and Leydig cells in particular...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-19.985
更新日期：2004-07-01 00:00:00
abstract：:Leukemias, a heterogeneous group of hematological disorders, are characterized by ineffective hematopoiesis and morphologic abnormalities of hematopoietic cells. Thrombocytopenia is a common problem among leukemia types that can lead to hemorrhagic complications in patients. The purpose of this review article is to id...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-11-976
更新日期：2018-09-01 00:00:00
abstract：:The aim of this study was to demonstrate the morphology and matrix synthesis of embryonic rat liver cells (day 18 of gestation) in organoid cultures (high density cultures) with electron microscopic and immunomorphological techniques. For this purpose the cells of embryonic rat livers were isolated enzymatically and g...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1991-04-01 00:00:00
abstract：BACKGROUND:Lipopolysaccharide (LPS) induced inflammation often leads to lung injury, in which pulmonary recruitment of neutrophils plays a pivotal role. Inflammatory processes are influenced by CD26/DPP4, highly expressed in lungs. Asthma induced CD26/DPP4 deficient (CD26/DPP4⁻) Fischer (F) 344 rats suffering from a tr...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-18-117
更新日期：2019-10-01 00:00:00
abstract：:The techniques for light and electron microscopic radioautography developed in our laboratory are described. The outlines of the applications to various tissues and organs are also briefly summarized. First, the techniques are explained in detail. These techniques can be divided into two categories, i.e., chemical fix...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：
更新日期：1997-10-01 00:00:00
abstract：BACKGROUND:Honey and olive oil are natural products that have high nutritional values, and therapeutic properties. Cytotoxic drugs, like methotrexate (MTX) are used to treat malignancies in tumour cells; however, these drugs also have serious side effects that could threaten the patient's life. AIM:To evaluate the pot...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-18-126
更新日期：2019-12-01 00:00:00
