Abstract:
:Thyroid hormones (TH) stimulate oxidative metabolism in many tissues in the body, but testis is not one of them. Therefore, in this sense, testis is not considered as a target organ for TH. However, recent findings clearly show that TH have significant functions on the testis in general, and Leydig cells in particular; this begins from the onset of their differentiation through aging. Some of these functions include triggering the Leydig stem cells to differentiate, producing increased numbers of Leydig cells during differentiation by causing proliferation of Leydig stem cells and progenitors, stimulation of the Leydig cell steroidogenic function and cellular maintenance. The mechanism of action of TH on Leydig cell differentiation is still not clear and needs to be determined in future studies. However, some information on the mechanisms of TH action on Leydig cell steroidogenesis is available. TH acutely stimulate testosterone production by the Leydig cells in vitro via stimulating the production of steroidogenic acute regulatory protein (StAR) and StAR mRNA in Leydig cells; StAR is associated with intracellular trafficking of cholesterol into the mitochondria during steroid hormone synthesis. However, the presence and/or the types of TH receptors in Leydig cells and other cell types of the Leydig cell lineage is still to be resolved. Additionally, it has been shown that thyrotropin-releasing hormone (TRH), TRH receptor and TRH mRNA in the testis in many mammalian species are seen exclusively in Leydig cells. Although the significance of the latter observations are yet to be determined, these findings prompt whether hypothalamo-pituitary-thyroid axis and hypothalamo-pituitary-testis axis are short-looped through Leydig cells.
journal_name
Histol Histopatholjournal_title
Histology and histopathologyauthors
Mendis-Handagama SM,Ariyaratne HBdoi
10.14670/HH-19.985subject
Has Abstractpub_date
2004-07-01 00:00:00pages
985-97issue
3eissn
0213-3911issn
1699-5848journal_volume
19pub_type
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journal_title:Histology and histopathology
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journal_title:Histology and histopathology
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更新日期:1998-04-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1994-04-01 00:00:00
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journal_title:Histology and histopathology
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更新日期:1987-04-01 00:00:00
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journal_title:Histology and histopathology
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更新日期:2001-04-01 00:00:00
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journal_title:Histology and histopathology
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更新日期:1988-04-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章,评审
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更新日期:1998-01-01 00:00:00
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journal_title:Histology and histopathology
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doi:
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journal_title:Histology and histopathology
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doi:
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