Abstract：
:Recent evidence has shown that vascular function depends not only on cells within the vessels, but is also significantly modulated by circulating cells derived from the bone marrow. A number of studies indicate that an early reendothelialization by circulating endothelial precursors after vascular injury prevents excessive cell proliferation and restenosis. Conversely, other studies concluded that the homing of other cell fractions, consisting mainly of smooth muscle precursors, cause pathological remodelling. Different cell types have been identified and characterized so far as circulating precursors able to participate in vascular repair by homing and differentiating towards endothelial cells or smooth muscle cells. Among these, endothelial precursor cells, smooth muscle progenitor cells, mesenchymal stem cells and others have been described. The origins, the hierarchy, the role and the markers of these different cell populations are still controversial. Nevertheless, different strategies have been developed so far in animal models to induce the mobilization and the recruitment of stem cells to the injury site, based on physical training, hormone injection and application of stem cell-capturing coated stents. It should also be mentioned that the limited data currently available derived from clinical trials provide contrasting results about the effective role of vascular cell precursors in restenosis prevention, thus indicating that conclusions derived from studies in animal models cannot always be directly applied to humans and that caution should be used in the manipulation of circulating progenitor cells for therapeutic strategies.
journal_name
Histol Histopatholjournal_title
Histology and histopathologyauthors
Forte A,Cipollaro M,Cascino A,Galderisi Udoi
10.14670/HH-22.547subject
Has Abstractpub_date
2007-05-01 00:00:00pages
547-57issue
5eissn
0213-3911issn
1699-5848journal_volume
22pub_type
杂志文章,评审abstract：:"Classically activated macrophages (M1)" and "alternatively activated macrophages (M2)", which appear in injured tissues, control either inflammation or remodeling. The mechanism remains unclear. To clarify the M1-/M2-macrophage polarization in acute liver injury, M1- and M2-related factors were analysed in F344 rats ...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-29.10.497
更新日期：2014-04-01 00:00:00
abstract：:Glaucoma is a neurodegenerative disease characterized by progressive loss of retinal ganglion cell axons and their cell bodies in the retina. Elevated intraocular pressure (IOP) is considered to be the major risk factor associated with the development of this neuropathy. Randomized controlled clinical trials have demo...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-22.1399
更新日期：2007-12-01 00:00:00
abstract：:Actin microfilaments and microtubules are important cytoskeletal proteins that regulate endothelial repair through alterations in cell shape and through regulation of cell migration following wounding of the endothelium. Upstream pathways have been identified in the regulation of actin and microtubule organization, es...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-18.879
更新日期：2003-07-01 00:00:00
abstract：:Ebulin f is a ribosome-inactivating protein (RIP) present in green fruits of the dwarf elder (Sambucus ebulus L). Since dwarf elder fruits are used for food and as a medicine, we assessed the study of toxicological effects and safety of ebulin f in elderly mice, comparing these results with those reported in young ani...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-11-992
更新日期：2018-09-01 00:00:00
abstract：:Three-dimensional characteristics of the epithelial cell layer and connective tissue interface of the tongue were studied using scanning electron microscopy. In this study, the fragments of tongue were fixed in modified Karnovsky's fixative solution. Subsequently, the specimens were treated with 10% NaOH solution for ...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-17.455
更新日期：2002-04-01 00:00:00
abstract：:The coexistence of serotonin and cholecystokinin was studied in foetal sheep lungs at pseudoglandular stage of development by light microscopic immunohistochemistry. The coexistence was examined by staining consecutive sections with the different antibodies. Serotonin and cholecystokinin immunoreactivity was found wit...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：:A current concern about the biological effects of electromagnetic fields (EMF) is increasing with the wide spread use of X-band microwaves (MW, 8-10 GHz range). Gigahertz transverse electromagnetic (GTEM) field flat transmission lines are currently being used for experimental exposure of biological samples to high fre...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-26.1187
更新日期：2011-09-01 00:00:00
abstract：:Studies in a canine bronchogenic carcinoma model indicate that alveolar type II cells may differentiate from carcinogen-exposed epithelium of larger bronchi and generate adenocarcinomas with bronchioloalveolar and other growth patterns. In this study, we investigated whether type II cells are one of the major prolifer...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1997-04-01 00:00:00
abstract：:A quantitative study regarding the age-related changes occurring in the somatic organelles of the neocerebellar Purkinje cell is carried out, using female rats aged 2 to 24 months. Standard manual morphometric techniques are used to calculate the following parameters: somatic volume, volumetric fractions and absolute ...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:Identification of robust diagnostic and therapeutic target molecules for human malignancy is still an important issue. If we identify novel proteins which play a stem-line role for cellular transformation or aggravation of malignancy, it could give us a clue to diagnose a tumor in an earlier stage and to develop more ...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-20.999
更新日期：2005-07-01 00:00:00
abstract：:Dimethylnitrosamine (DMN) induced liver injury in rats with cell necrosis, inflammation, hemorrhages, increased collagen type III synthesis and basement membrane component laminin and collagen IV localization in perisinusoidal sites. Malotilate ingestion during DMN treatment abolished inflammation and decreased inters...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:The growth of a transplantable murine non-Hodgkin lymphoma tumour, developing either intraperitoneally as an ascites tumour or subcutaneously as a solid tumour, has been shown to be markedly diminished by including phytohaemagglutinin (PHA), a lectin present in raw kidney bean (Phaseolus vulgaris) in the diet. In NMRI...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-13.575
更新日期：1998-04-01 00:00:00
abstract：:Spectrins are members of the superfamily of F-actin cross linking proteins that are important as scaffolding proteins for protein sorting, cell adhesion, and migration. In addition, spectrins have been implicated in TGF-beta signaling. The aim of the present study was to analyze the expression and localization of beta...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-25.1497
更新日期：2010-12-01 00:00:00
abstract：:The clinical presentation, histopathology and immunoelectron microscopic features of two cases of duodenal somatostatinoma are described, one of which is a hitherto unreported example of a collision tumour with a neurofibroma. Ultrastructural morphometric immunoelectron microscopy studies revealed the presence of four...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-21.1171
更新日期：2006-11-01 00:00:00
abstract：BACKGROUND:Synaptotagmin 7 (SYT7) is a component of the synaptotagmin family, which is essential in many physiological and pathological processes. In this study, we aimed to investigate the role of SYT7 in osteosarcoma. METHODS:We defined the expression levels of SYT7 in osteosarcoma tissues and para-sarcoma tissues b...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-18-174
更新日期：2020-03-01 00:00:00
abstract：:The ultrastructure of the atrial myocardium in the monkey (Macaca fascicularis) was studied after bilateral cervical vagotomy and survival times of 100, 175 and 367 days. Changes were observed in the nucleus and the cytoplasm of the myocyte. Sequestered within the nuclei of the affected myocytes were cytoplasmic organ...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1989-07-01 00:00:00
abstract：:A proportion of anaplastic large cell tumours is difficult to classify on sections of routinely processed, paraffin-embedded tissue. Differentiation into large cell lymphoma, carcinoma, melanoma or sarcoma is important in order to assess prognosis and proper treatment. Although the use of immunohistochemistry has been...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1987-04-01 00:00:00
abstract：:To understand the role of microtubules and microfilaments in regulating endothelial monolayer integrity and repair, and since microtubules and microfilaments show some co-alignment in endothelial cells, we tested the hypothesis that microtubules organize microfilament distribution. Disruption of microtubules with colc...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-20.455
更新日期：2005-04-01 00:00:00
abstract：:The ultrastructure of four aldosterone secreting adenomas and of the adjacent zona glomerulosa has been described by the use of stereological techniques. Adenomatous cells (about 2800 microns 3 in volume) invariably displayed a striking abundance of lipid droplets, which occupied about 30% of the cytoplasm. Mitochondr...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1988-07-01 00:00:00
abstract：:The integrity of the thymus during early life is necessary for a proper maturation of the neuroendocrine system, including the adrenal axis. The thymic metallopeptide thymulin seems to be a central physiologic mediator of thymus-pituitary communication. Furthermore, neonatal thymulin gene therapy has been shown to pre...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-26.471
更新日期：2011-04-01 00:00:00
abstract：:Leukemias, a heterogeneous group of hematological disorders, are characterized by ineffective hematopoiesis and morphologic abnormalities of hematopoietic cells. Thrombocytopenia is a common problem among leukemia types that can lead to hemorrhagic complications in patients. The purpose of this review article is to id...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-11-976
更新日期：2018-09-01 00:00:00
abstract：:The sarcolemmal domain of rat duodenal smooth muscle cells includes caveolae and associated cytoskeletal or filamentous elements. We have used the quick-freezing, deep-etching method to examine the three dimensional relationships between these components. Replica membranes for separated strips of rat duodenal muscle l...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-15.1059
更新日期：2000-10-01 00:00:00
abstract：:The effect of chronic alcoholism on the human hippocampus was studied in 21 patients, divided in 4 groups: Group A under 45 years, group B 46-59 years, group C 60-69, and Group D over 70 years; and compared with age-matched control patients who died without neurological complications. The gyrus dentatus and the ammoni...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1990-07-01 00:00:00
abstract：:Autoimmune dry eye (Sjögren's syndrome, SS) is a chronic systemic disease characterized by salivary and lacrimal gland inflammation and tissue damage leading to keratoconjunctivitis sicca and xerostomia. In this review attention has been devoted to the cause of the development of oxidative injuries of the ocular surfa...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-24.1357
更新日期：2009-10-01 00:00:00
abstract：:Primary cultured human salivary gland cells were transfected with ori-defective mutant DNA of SV40. Following 2-3 weeks of transfection, slowly expanding colonies consisting of small compact cells emerged, while mock-transfected cells did not grow any more and eventually entered crisis, followed by cell death. Using l...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：
更新日期：1994-10-01 00:00:00
abstract：:The International Prognostic Index (IPI) has been the basis for determining prognosis in patients with diffuse large B-cell lymphoma (DLBCL) for the past 20 years. The utility of the IPI must be reassessed in the era of immunochemotherapy. Seven risk factors at diagnosis were identified, and a maximum of 7 points were...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-11-673
更新日期：2016-03-01 00:00:00
abstract：:Androgen receptor (AR) interact with many pathways involved in bladder cancer development and progression. FUS (fused in liposarcoma), a multifunctional protein essential for different cellular processes, has been demonstrated as a key link between androgen receptor signaling and cell-cycle progression in prostate can...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-18-295
更新日期：2020-12-23 00:00:00
abstract：:β-lapachone is a quinone of lapachol extracted from the bark of lapacho tree. Recent findings demonstrated that punched skin wounds of mice healed faster with β-lapachone treatment. The present study investigates the effects of β-lapachone on burn-wound skin of C57BL/6 mice injured by a 100 °C iron stick. Our results ...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-26.905
更新日期：2011-07-01 00:00:00
abstract：:Brain-derived neurotrophic factor (BDNF) and its receptor, TrkB, are broadly expressed in the developing and adult mammalian brain. BDNF/TrkB-stimulated intracellular signaling is critical for neuronal survival, morphogenesis, and plasticity. It is well known that binding of BDNF to TrkB elicits various intracellular ...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-25.237
更新日期：2010-02-01 00:00:00
abstract：:Bacillus subtilis has been used as a classic model to study biofilm formation and sporulation process. Colonies of wild-type strains usually have a complex external morphology, but the details of their internal architecture are still undisclosed. Since bacterial biofilms fulfill the criteria to be considered tissues, ...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-28.1351
更新日期：2013-10-01 00:00:00
