The effects of cyclophosphamide on the gonadotrophic cells of the normal rat.

Abstract:

:The effects of the administration of cyclophosphamide to male rats at doses of 400 mg/m2 for a period of 5 days and of 200 mg/m2 over two five-day cycles interrupted by a 21-day break reveal differences in the ultrastructural morphology of gonadotrophic cells between treated animals and normal controls. The ultrastructural data obtained coincide with the results obtained from the measurement of serum FSH and LH levels, indicating hypofunction. A significant fall was also recorded in blood testosterone levels. The two types of treatment did not give rise to morphological or functional differences.

journal_name

Histol Histopathol

authors

Poblador MS,Rojas C,Raya A,Casares JA,Aparicio J,Lancho Alonso JL

subject

Has Abstract

pub_date

1990-04-01 00:00:00

pages

173-80

issue

2

eissn

0213-3911

issn

1699-5848

journal_volume

5

pub_type

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