The effects of cyclophosphamide on the gonadotrophic cells of the normal rat.

Abstract:

:The effects of the administration of cyclophosphamide to male rats at doses of 400 mg/m2 for a period of 5 days and of 200 mg/m2 over two five-day cycles interrupted by a 21-day break reveal differences in the ultrastructural morphology of gonadotrophic cells between treated animals and normal controls. The ultrastructural data obtained coincide with the results obtained from the measurement of serum FSH and LH levels, indicating hypofunction. A significant fall was also recorded in blood testosterone levels. The two types of treatment did not give rise to morphological or functional differences.

journal_name

Histol Histopathol

authors

Poblador MS,Rojas C,Raya A,Casares JA,Aparicio J,Lancho Alonso JL

subject

Has Abstract

pub_date

1990-04-01 00:00:00

pages

173-80

issue

2

eissn

0213-3911

issn

1699-5848

journal_volume

5

pub_type

杂志文章
  • Molecular and morphological characterization of neural tube defects in embryos of diabetic Swiss Albino mice.

    abstract:BACKGROUND AND RESULTS:Embryos from diabetic mice exhibit several forms of neural tube defects, including non-closure of the neural tube. In the present study, embryos collected at embryonic day 11.5 from diabetic pregnancies displayed open neural tube with architectural disruption of the surrounding tissues. The perce...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-26.965

    authors: Loh WT,Dheen ST,Jiang B,Kumar SD,Tay SS

    更新日期:2011-08-01 00:00:00

  • Somatostatinoma: collision with neurofibroma and ultrastructural features.

    abstract::The clinical presentation, histopathology and immunoelectron microscopic features of two cases of duodenal somatostatinoma are described, one of which is a hitherto unreported example of a collision tumour with a neurofibroma. Ultrastructural morphometric immunoelectron microscopy studies revealed the presence of four...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-21.1171

    authors: Varikatt W,Yong JL,Killingsworth MC

    更新日期:2006-11-01 00:00:00

  • Primordial germ cell specification: the importance of being 'blimped'.

    abstract::In mouse embryos, the expression of Blimp1 has recently revealed a population of allocated primordial germ cell precursors 24 hours earlier than previously thought. Those 'blimped' precursors have been shown to give rise, by mitotic division, to germ cells only and no other cell lineages. Here, we try to understand th...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-23.1553

    authors: Chuva de Sousa Lopes SM,Roelen BA

    更新日期:2008-12-01 00:00:00

  • Role of angiogenesis on bone formation.

    abstract::Angiogenesis and bone formation are coupled during skeletal development and fracture healing. This relationship, although known for some time, has not been properly explored. Advances in the discovery of how angiogenesis is regulated in physiological processes like embryogenesis, endometrial regeneration and wound hea...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-27.559

    authors: Portal-Núñez S,Lozano D,Esbrit P

    更新日期:2012-05-01 00:00:00

  • Down-regulation of TSG101 by small interfering RNA inhibits the proliferation of breast cancer cells through the MAPK/ERK signal pathway.

    abstract::We designed to investigate the effects of down-regulating the tumor susceptibility gene 101 (TSG101) on the proliferation and apoptosis of the human breast cancer MCF-7 cell line, and the role of the MAPK/ERK signal pathway in this process. The siRNA against TSG101 was transfected into the breast cancer MCF-7 cell lin...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-26.87

    authors: Zhang Y,Song M,Cui ZS,Li CY,Xue XX,Yu M,Lu Y,Zhang SY,Wang EH,Wen YY

    更新日期:2011-01-01 00:00:00

  • Cell proliferation and apoptosis in stromal corneal dystrophies.

    abstract::The aim of our study was to evaluate corneal cell proliferation and apoptosis in cases of granular, macular and lattice dystrophy, and to provide evidence which may help to clarify whether apoptosis is a pathogenic factor in any of these dystrophies. The study group comprised 39 eyes (from 33 patients) which had under...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,多中心研究

    doi:10.14670/HH-22.837

    authors: Szentmáry N,Takács L,Berta A,Szende B,Süveges I,Módis L

    更新日期:2007-08-01 00:00:00

  • Understanding the role of the cytoskeleton in the complex regulation of the endothelial repair.

    abstract::Actin microfilaments and microtubules are important cytoskeletal proteins that regulate endothelial repair through alterations in cell shape and through regulation of cell migration following wounding of the endothelium. Upstream pathways have been identified in the regulation of actin and microtubule organization, es...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-18.879

    authors: Lee JS,Gotlieb AI

    更新日期:2003-07-01 00:00:00

  • Transcriptional mRNA of BMP-2, 3, 4 and 5 in trigeminal nerve, benign and malignant peripheral nerve sheath tumors.

    abstract::The aim of our study was to document whether relationships existed among bone morphogenetic proteins (BMPs), peripheral nerve and neoplastic lesions of nerve sheath tumors. The mRNA transcriptions of BMP-2, 3, 4 and 5 in 10 cases of schwannoma, three cases of malignant schwannoma and two cases of trigeminal neuralgia ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-16.1013

    authors: Jin Y,Lu HB,Liong E,Lau TY,Tipoe GL

    更新日期:2001-10-01 00:00:00

  • The dynamic stem cell microenvironment is orchestrated by microvesicle-mediated transfer of genetic information.

    abstract::It has been commonly supposed that adult stem cells co-localize with supporting cells within specific regions or specialized microenvironment in each tissue/organ, called stem cell niche. This concept was based on the assumption that stem cells are intrinsically hierarchical in nature. However, recent data indicate th...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-25.397

    authors: Deregibus MC,Tetta C,Camussi G

    更新日期:2010-03-01 00:00:00

  • Expression of mitotic kinases phospho-aurora A and aurora B correlates with clinical and pathological parameters in bladder neoplasms.

    abstract::Aurora A and Aurora B are serine-threonine kinase proteins which have both been implicated in human carcinogenesis through development of aneuploidy and chromosomal instability. The aim of the study is to assess the correlation of both markers with clinical and pathological parameters in patients with bladder cancer o...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-25.1371

    authors: Bufo P,Sanguedolce F,Tortorella S,Cormio L,Carrieri G,Pannone G

    更新日期:2010-11-01 00:00:00

  • Fluoxetine may worsen hyperoxia-induced lung damage in neonatal rats.

    abstract::Fluoxetine shows controversial lung effects as it prevents pulmonary hypertension in adult rats but exposure during gestation causes pulmonary hypertension in neonatal rats. In the present study, we tested the null hypothesis that the antidepressant drug fluoxetine does not modify the development of bronchopulmonary d...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-27.1599

    authors: Porzionato A,Zaramella P,Macchi V,Grisafi D,Salmaso R,Baraldi M,Fornaro E,Tassone E,Masola V,Onisto M,Chiandetti L,De Caro R

    更新日期:2012-12-01 00:00:00

  • Molecules of cell adhesion and extracellular matrix proteolysis in oral squamous cell carcinoma.

    abstract::Oral squamous cell carcinoma (OSCC) is the most common malignancy of the oral cavity with a poor 5-year survival rate, due in large part to the presence of metastatic disease at initial diagnosis. In recent years, a number of studies have examined the oral tumor microenvironment to asses the potential dynamic balance ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-25.917

    authors: Shi Z,Stack MS

    更新日期:2010-07-01 00:00:00

  • MMP-2 and TIMP-2 in the prostates of male and female mongolian gerbils: effects of hormonal manipulation.

    abstract::TIMPs in the prostates of male and female gerbils and evaluated the effects of testosterone on the expression of these enzymes. Ventral prostates from male gerbils that were either intact or had been castrated for 7 or 21 days, along with prostates from female gerbils that were either intact or had been treated with t...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-26.1423

    authors: Rochel-Maia SS,Santos FC,Vilamaior PS,Justulin LA Jr,Felisbino SL,Góes RM,Taboga SR

    更新日期:2011-11-01 00:00:00

  • Enhanced CD24 expression in endometrial carcinoma and its expression pattern in normal and hyperplastic endometrium.

    abstract::CD24 is known to be an important diagnostic and prognostic marker of several major cancers affecting females. We aimed to determine CD24 expression in normal, hyperplastic, and carcinomatous endometrium and its correlation with estrogen and progesterone receptor expression. A total of 271 cases including 62 normal/atr...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-24.309

    authors: Kim KH,Choi JS,Kim JM,Choi YL,Shin YK,Lee HC,Seong IO,Kim BK,Chae SW,Kim SH

    更新日期:2009-03-01 00:00:00

  • Studies on the involvement of endogenous neuropeptides in the control of thymocyte proliferation in the rat.

    abstract::The possible involvement of endogenous vasoactive intestinal peptide (VIP), cholecystokinin (CCK) and neurotensin (NT) in the control of thymocyte proliferation has been investigated in vivo in the immature rat. For this task, we have studied the effects of the administration of selective antagonists of the receptors ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-16.155

    authors: Trejter M,Warchol JB,de Caro R,Brelinska R,Nussdorfer GG,Malendowicz LK

    更新日期:2001-01-01 00:00:00

  • Sulfur dioxide: foe or friend for life?

    abstract::Sulfur dioxide (SO₂) is a toxic gas and air pollutant. The toxic effects of SO₂ have been extensively studied. Oxidative damage due to SO₂ can occur in multiple organs. Inhaled SO₂ can also cause chromosomal aberrations, DNA damage and gene mutations in mammals. However, SO₂ can also be generated from the sulfur-conta...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-11-904

    authors: Wang XB,Cui H,Liu X,Du JB

    更新日期:2017-12-01 00:00:00

  • Atrial natriuretic peptide in the heart and pancreas.

    abstract::We used antisera to pure atrial natriuretic peptide to localise this peptide by immunocytochemistry in rat and human tissue. We showed that both rat and human atrial cardiocytes gave a positive reaction while ventricular cardiocytes were consistently negative. Peripheral islet cells in rat but not in human pancreas al...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Lindop GB,Mallon EA,MacIntyre G

    更新日期:1986-04-01 00:00:00

  • An immunohistochemical study on the distribution of endocrine cells in the gastrointestinal tract of the musk shrew, Suncus murinus.

    abstract::The endocrine cells in the gastrointestinal tract of the musk shrew were studied immunohistochemically. Eleven kinds of endocrine cells, immunoreactive for serotonin, somatostatin, gastrin, cholecistokinin, gastric inhibitory polypeptide, motilin, secretin, neurotensin, pancreatic glucagon, enteroglucagon and bovine p...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Kitamura N,Yamada J,Watanabe T,Yamashita T

    更新日期:1990-01-01 00:00:00

  • Immune complex-mediated glomerulopathy in Barbus graellsi infected with Myxobolus spp.

    abstract::Membranous glomerulonephritis caused in Barbus graellsi by myxosporidian infections have been studied by electron microscopy and immunoelectron microscopy techniques. This study indicates that Myxosporidian infection produces a chronic severe aggression. Spores reach the spleen, the kidney and the liver, where they ar...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Peribañez MA,del Cacho E,Castillo JA,Arnal MC

    更新日期:1993-10-01 00:00:00

  • Multilocular cystic renal cell carcinoma with focus on clinical and pathobiological aspects.

    abstract::Multilocular cystic renal cell carcinoma (MCRCC) accounts for approximately 1 to 2% of all renal tumors. This tumor is currently classified as a subtype of clear cell RCC. Clinically, the majority of these tumors are incidentally found. Macroscopically, the tumor is well demarcated and consists of various-sized cysts....

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-27.969

    authors: Kuroda N,Ohe C,Mikami S,Inoue K,Nagashima Y,Cohen RJ,Pan CC,Michal M,Hes O

    更新日期:2012-08-01 00:00:00

  • Three types of liver cell dysplasia (LCD) in small cirrhotic nodules are distinguishable by karyometry and PCNA labelling, and their features resemble distinct grades of hepatocellular carcinoma.

    abstract::We have studied the occurrence and specific features of liver cell dysplasia (LCD) in Chinese patients showing liver cirrhosis with or without hepatocellular carcinoma (HCC). Three types of LCD (SLCD, LLCDo, LLCDe) were morphologically defined, and these types were further analyzed using karyometry, estimation of nucl...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Zhao M,Zhang NX,Du ZY,Laissue JA,Zimmermann A

    更新日期:1994-01-01 00:00:00

  • Eosinophils and airway nerves in asthma.

    abstract::In the lungs, neuronal M2 muscarinic receptors limit the release of acetylcholine from postganglionic cholinergic nerves. However, these receptors are not functional under certain circumstances in animal models of hyperreactivity such as occurs after exposure of sensitised animals to an allergen or during a respirator...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-15.861

    authors: Costello RW,Jacoby DB,Gleich GJ,Fryer AD

    更新日期:2000-07-01 00:00:00

  • MYC and BCL-2 adjusted-International Prognostic Index (A-IPI) is a better predictor of outcome than the standard IPI for patients with diffuse large B-cell lymphoma treated with R-CHOP.

    abstract::The International Prognostic Index (IPI) has been the basis for determining prognosis in patients with diffuse large B-cell lymphoma (DLBCL) for the past 20 years. The utility of the IPI must be reassessed in the era of immunochemotherapy. Seven risk factors at diagnosis were identified, and a maximum of 7 points were...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-11-673

    authors: Wang J,Zhou M,Xu JY,Yang YG,Zhang QG,Zhou RF,Chen B,Ouyang J,Li C

    更新日期:2016-03-01 00:00:00

  • Abnormal distribution of CD45 isoforms expressed by CD4+ and CD8+ T cells in rheumatoid arthritis.

    abstract::CD45RO+ T cells are referred to as memory or helper-inducer while CD45RA+ T cells are regarded as naive or suppressor-inducer T cells. The former population predominates in the peripheral blood and even more in the synovial fluid of patients with rheumatoid arthritis, to the expense of the latter population. Within th...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-15.587

    authors: Mamoune A,Durand V,Le Goff P,Pennec YL,Youinou P,Le Corre R

    更新日期:2000-04-01 00:00:00

  • Apocrine secretory mechanism: recent findings and unresolved problems.

    abstract::Cell secretion is an important physiological process that ensures smooth metabolic activities, tissue repair and growth and immunological functions in the body. It occurs when the intracellular secretory materials are released to the exterior; these may be in the form of lipids, protein or mucous and may travel throug...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-18.597

    authors: Gesase AP,Satoh Y

    更新日期:2003-04-01 00:00:00

  • Hormonal receptors, cell proliferation fraction (Ki-67) and c-erbB-2 amplification in breast cancer. Relationship between differentiation degree and axillary lymph node metastases.

    abstract::In view of the limitations of conventional prognostic factors such as differentiation degree, metastatic lymph nodes, hormonal receptors and others, especially when early lesions are found, additional new markers have been studied, such as gene amplification and cell proliferation index, in order to choose the appropr...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Sirvent JJ,Santafé M,Salvadó MT,Alvaro T,Raventós A,Palacios J

    更新日期:1994-07-01 00:00:00

  • Review of mucinous tubular and spindle-cell carcinoma of the kidney with a focus on clinical and pathobiological aspects.

    abstract::Recently, the characterization of mucinous tubular and spindle-cell carcinoma (MTSCC) has been established. MTSCC predominantly occurs in females. This tumor is histologically characterized by eosinophilic cytoplasm, elongated and anastomosing tubules, myxomatous stroma and low-grade nuclear cytology. Proliferation of...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-20.221

    authors: Kuroda N,Toi M,Hiroi M,Shuin T,Enzan H

    更新日期:2005-01-01 00:00:00

  • Telocytes form networks in normal cardiac tissues.

    abstract::Telocytes (TC) are a class of interstitial cells present in heart. Their characteristic feature is the presence of extremely long and thin prolongations (called telopodes). Therefore, we were interested to see whether or not TCs form networks in normal cardiac tissues, as previously suggested. Autopsy samples of card...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-27.807

    authors: Rusu MC,Pop F,Hostiuc S,Curca GC,Jianu AM,Paduraru D

    更新日期:2012-06-01 00:00:00

  • Immunocytohistochemical characterization of pituitary cells of the bluefin tuna, Thunnus thynnus L.

    abstract::In this paper we report the first complete mapping of the pituitary in a tuna species. The various different adenohypophysis cell types of the bluefin tuna, Thunnus thynnus L. have been identified and located using different antisera against mammalian and piscine hormones and various histochemical techniques: PAS, Alc...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-16.443

    authors: Rodríguez-Gómez FJ,Rendón-Unceta MC,Piñuela C,Muñoz-Cueto JA,Jiménez-Tenorio N,Sarasquete C

    更新日期:2001-04-01 00:00:00

  • Potential therapeutic effect of SO₂ on fibrosis.

    abstract::Fibrosis is a pathological feature of most chronic diseases and leads to the dysfunction of various organs. However, there is currently no effective method for treating fibrosis. In recent years, a small gas, sulfur dioxide (SO₂), which can be generated endogenously in mammals, has been found to have vasorelaxation ac...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-18-169

    authors: Wang XB,Cui H,Du JB

    更新日期:2019-12-01 00:00:00