The effects of cyclophosphamide on the gonadotrophic cells of the normal rat.


:The effects of the administration of cyclophosphamide to male rats at doses of 400 mg/m2 for a period of 5 days and of 200 mg/m2 over two five-day cycles interrupted by a 21-day break reveal differences in the ultrastructural morphology of gonadotrophic cells between treated animals and normal controls. The ultrastructural data obtained coincide with the results obtained from the measurement of serum FSH and LH levels, indicating hypofunction. A significant fall was also recorded in blood testosterone levels. The two types of treatment did not give rise to morphological or functional differences.


Histol Histopathol


Poblador MS,Rojas C,Raya A,Casares JA,Aparicio J,Lancho Alonso JL


Has Abstract


1990-04-01 00:00:00












  • Muscular hypertrophy and atrophy in normal rats provoked by the administration of normal and denervated muscle extracts.

    abstract::This study was conducted to determine the effects of extracts obtained from both normal and denervated muscles on different muscle types. Wistar rats were used and were divided into a control group and four experimental groups. Each experimental group was treated intraperitoneally during 10 consecutive days with a dif...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Agüera E,Castilla S,Luque E,Jimena I,Leiva-Cepas F,Ruz-Caracuel I,Peña J

    更新日期:2016-12-01 00:00:00

  • Changes of calcium/calmodulin-dependent protein kinase II expression in dorsal root ganglia during maturation in long-term diabetes.

    abstract::Calcium/calmodulin-dependent protein kinase II (CaMKII) is considered one of the key intracellular signaling proteins for development of neuropathy. We analyzed the expression of total CaMKII (tCaMKII) and its alpha, beta, gamma and delta isoforms in dorsal root ganglia (DRG) in a rat model of Diabetes mellitus type I...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Ferhatovic L,Jelicic Kadic A,Boric M,Puljak L

    更新日期:2014-05-01 00:00:00

  • Synergism of imatinib, vatalanib and everolimus in the prevention of chronic lung allograft rejection after lung transplantation (LTx) in rats.

    abstract::Chronic lung allograft dysfunction (CLAD) still remains a major drawback in the outcome following lung transplantation (LTx). New therapeutic strategies are warranted. Growth factors and their receptors like platelet-derived growth factor-receptor (PDGFR) and vascular endothelial growth factor-receptor (VEGFR), may pl...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Keil L,Schaub AL,Hirt SW,Schmid C,Lehle K,von Suesskind-Schwendi M

    更新日期:2019-07-01 00:00:00

  • Presence and distribution of 5HT-, VIP-, NPY-, and SP-immunoreactive structures in adult mouse lung.

    abstract::A large number of biologically active substances have been identified and characterised in the respiratory tract of several mammals. These substances (amines and peptides) exert important regulatory influences on respiratory functions, and they act as neurotransmitters/neuromodulators, both being released from nerve t...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Verástegui C,Fernández-Vivero J,Prada A,Rodríguez F,Romero A,González-Moreno M,de Castro JM

    更新日期:1997-10-01 00:00:00

  • Regional differences in cell surface patterns in normal human sulcular epithelium.

    abstract::Studies with scanning electron microscopy in the normal human sulcular epithelium are scarce, and no precise information exists about cell surface patterns along the epithelium, the frequencies of these patterns, or possible regional differences within the mouth. In five periodontal biopsy specimens each from the ante...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Sánchez-Quevedo MC,Moreu G,Campos A,García JM,González-Jaranay M

    更新日期:1994-01-01 00:00:00

  • Histochemical study of skin and gills of Senegal sole, Solea senegalensis larvae and adults.

    abstract::A battery of horseradish peroxidase-conjugated lectins (Con A, WGA and DBA), as well as conventional histochemical techniques (PAS, saponification, Alcian Blue pH 0.1, 1, 2.5, chlorhydric hydrolisis, neuraminidase, Bromophenol blue, Tioglycollate reduction and Ferric-ferricyanide-FeIII) were used to study the content ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Sarasquete C,González de Canales ML,Arellano J,Muñoz Cueto JA,Ribeiro L,Dinis MT

    更新日期:1998-07-01 00:00:00

  • Adipose-derived stem cells in articular cartilage regeneration: current concepts and optimization strategies.

    abstract::Knee osteoarthritis (KOA) is the most common progressive joint disorder associated with disability in the world. As a chronic disease, KOA has multifactorial etiology. However, the poor self-healing ability of the articular cartilage due to its intrinsic tissue hypovascularity and hypocellularity seems to be directly ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Gu X,Li C,Yin F,Yang G

    更新日期:2018-07-01 00:00:00

  • Structure and function of melanocytes: microscopic morphology and cell biology of mouse melanocytes in the epidermis and hair follicle.

    abstract::Melanocytes characterized by their tyrosinase activity, melanosomes and dendrites locate in the basal layer of epidermis and hair bulb in the skin of mice. Melanocytes differentiate from undifferentiated melanoblasts derived from embryonic neural crest. Melanocyte-stimulating hormone plays an important role in the reg...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Hirobe T

    更新日期:1995-01-01 00:00:00

  • Efficient uptake of mannosylated proteins by a human Schwann cell line.

    abstract::Complex carbohydrate structures are essential molecules of infectious microbes and host cells, and are involved in cell signaling associated with inflammatory and immune responses. The uptake of mannose-tailed glycans is usually carried out by macrophages, dendritic cells (DCs), and other professional phagocytes to tr...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Baetas-da-Cruz W,Alves L,Guimarães EV,Santos-Silva A,Pessolani MC,Barbosa HS,Corte-Real S,Cavalcante LA

    更新日期:2009-08-01 00:00:00

  • Primordial germ cell specification: the importance of being 'blimped'.

    abstract::In mouse embryos, the expression of Blimp1 has recently revealed a population of allocated primordial germ cell precursors 24 hours earlier than previously thought. Those 'blimped' precursors have been shown to give rise, by mitotic division, to germ cells only and no other cell lineages. Here, we try to understand th...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Chuva de Sousa Lopes SM,Roelen BA

    更新日期:2008-12-01 00:00:00

  • The low density lipoprotein receptor-related protein (LRP) 1 and its function in lung diseases.

    abstract::The low density lipoprotein receptor-related protein (LRP) 1 is a ubiquitously expressed, versatile cell surface transmembrane receptor involved in embryonic development and adult tissue homeostasis. LRP1 binds and endocytoses a broad spectrum of over 40 ligands identified thus far, including lipoproteins, extracellul...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Wujak L,Markart P,Wygrecka M

    更新日期:2016-07-01 00:00:00

  • Ultrastructure and organisation of the cornea, lens and iris in the pipefish, Corythoichthyes paxtoni (Syngnathidae, Teleostei).

    abstract::The corneas of nine pipefish, Corythoichthyes paxtoni (Syngnathidae, Teleostei), five freshly fixed and four museum specimens, were examined using light and electron microscopy. In transverse section, the surface of the corneal epithelium is covered by a complex series of ridges or microplicae which extends over the c...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Collin HB,Collin SP

    更新日期:1995-04-01 00:00:00

  • Oxidative damage in age-related macular degeneration.

    abstract::Epidemiologic studies have suggested that elderly patients who consumed diets rich in antioxidants throughout their lives are less likely to be afflicted with age-related macular degeneration (AMD). This led to the Age-Related Eye Disease Study, which showed that supplements containing antioxidant vitamins and zinc re...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Shen JK,Dong A,Hackett SF,Bell WR,Green WR,Campochiaro PA

    更新日期:2007-12-01 00:00:00

  • Hepatic response to chronic hypoxia in experimental rat model through HIF-1 alpha, activator protein-1 and NF-kappa B.

    abstract::Chronic liver diseases are commonly associated with tissue hypoxia that may cause inflammation, oxidative stress, liver cell injury and increased nuclear transcriptional regulation. The hepatic response to chronic hypoxia at the molecular level has not yet been clearly understood until now. The aim of this study is to...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Lau TY,Xiao J,Liong EC,Liao L,Leung TM,Nanji AA,Fung ML,Tipoe GL

    更新日期:2013-04-01 00:00:00

  • Paracrine control of steroid hormone secretion by chromaffin cells in the adrenal gland of lower vertebrates.

    abstract::The adrenal glands of lower vertebrates display a notable intermingling between steroidogenic and chromaffin tissues, which increases from Pisces to Aves. As in mammals, adrenal chromaffin cells contain and release, in addition to catecholamines, serotonin and several peptides, which may affect the secretory activity ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Mazzocchi G,Gottardo G,Nussdorfer GG

    更新日期:1998-01-01 00:00:00

  • Muscle-derived stem cells in tissue engineering: defining cell properties suitable for construct design.

    abstract::The terms construct or tissue equivalent refer to neotissue produced by tissue engineering techniques. The elements forming the construct are scaffolds on which cells are "recreated" to form an engineered-tissue sensitive to certain cell signals. The ability of the cells to expand and differentiate on the scaffold is ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Buján J,Pascual G,Corrales C,Gómez-Gil V,Rodríguez M,Bellón JM

    更新日期:2005-07-01 00:00:00

  • Alterations induced by E-cadherin and beta-catenin antibodies during the development of Bufo arenarum (Anura-Bufonidae).

    abstract::E(epithelial)-cadherin is a member of a calcium-dependent family of cell surface glycoproteins involved in cell-cell adhesion and morphogenesis. Catenins are a large family of proteins that connect the cadherins to the cytoskeleton. They are important for cadherin function and for transducing signals involved in speci...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Izaguirre MF,Adur JF,Soler AP,Casco VH

    更新日期:2001-10-01 00:00:00

  • Down-regulation of TSG101 by small interfering RNA inhibits the proliferation of breast cancer cells through the MAPK/ERK signal pathway.

    abstract::We designed to investigate the effects of down-regulating the tumor susceptibility gene 101 (TSG101) on the proliferation and apoptosis of the human breast cancer MCF-7 cell line, and the role of the MAPK/ERK signal pathway in this process. The siRNA against TSG101 was transfected into the breast cancer MCF-7 cell lin...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Zhang Y,Song M,Cui ZS,Li CY,Xue XX,Yu M,Lu Y,Zhang SY,Wang EH,Wen YY

    更新日期:2011-01-01 00:00:00

  • The thyroid gland of Callithrix jacchus in organ culture.

    abstract::Thyroid glands from 7 marmosets (Callithrix jacchus) of different age groups (newborn, 2 weeks, 2, 7, 8 and 11 months, and 8 years) were grown as organ culture according to Trowell at the medium/air interphase for 3 to 30 days. The morphology of thyroid tissue was well preserved until the end of the culture period. Ne...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Maile S,Merker HJ

    更新日期:1995-10-01 00:00:00

  • Selective immunolabeling of early gestational cytotrophoblast and its neoplastic counterpart by the monoclonal antibody Ber-EP4.

    abstract::This report presents preliminary observations on the distribution of an epithelial surface antigen in human trophoblastic cells studied with the monoclonal antibody Ber-EP4 by means of an immunoperoxidase technique. Three cases of gestational choriocarcinoma and 20 cases of both villous and extravillous trophoblast, i...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Babury RA,Moscovic EA

    更新日期:1993-04-01 00:00:00

  • Implications of androgen receptor and FUS expression on tumor progression in urothelial carcinoma.

    abstract::Androgen receptor (AR) interact with many pathways involved in bladder cancer development and progression. FUS (fused in liposarcoma), a multifunctional protein essential for different cellular processes, has been demonstrated as a key link between androgen receptor signaling and cell-cycle progression in prostate can...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Abd Raboh NM,Hakim SA,Abd El Atti RM

    更新日期:2020-12-23 00:00:00

  • Sulfur dioxide: foe or friend for life?

    abstract::Sulfur dioxide (SO₂) is a toxic gas and air pollutant. The toxic effects of SO₂ have been extensively studied. Oxidative damage due to SO₂ can occur in multiple organs. Inhaled SO₂ can also cause chromosomal aberrations, DNA damage and gene mutations in mammals. However, SO₂ can also be generated from the sulfur-conta...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Wang XB,Cui H,Liu X,Du JB

    更新日期:2017-12-01 00:00:00

  • Somatostatinoma: collision with neurofibroma and ultrastructural features.

    abstract::The clinical presentation, histopathology and immunoelectron microscopic features of two cases of duodenal somatostatinoma are described, one of which is a hitherto unreported example of a collision tumour with a neurofibroma. Ultrastructural morphometric immunoelectron microscopy studies revealed the presence of four...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Varikatt W,Yong JL,Killingsworth MC

    更新日期:2006-11-01 00:00:00

  • Expression of the proto-oncogene c-fos and the immunolocalization of c-fos, phosphorylated c-fos and estrogen receptor beta in the human testis.

    abstract::Spermatogenesis is under the control of a complex endocrine and paracrine system, including estrogen receptor (ER) signaling. In many target cells, ER promotes the transcription of c-fos and other proto-oncogenes to regulate cell growth and differentiation. Thus, in this study we evaluated the expression of the proto-...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Araújo FC,Oliveira CA,Reis AB,Del Puerto HL,Martins AS,Reis FM

    更新日期:2009-12-01 00:00:00

  • Neutrophil extracellular traps in tissue pathology.

    abstract::Neutrophil extracellular traps (NETs) are innate immune systems against invading pathogens. NETs are characterized as released DNA mixed with cytoplasmic antimicrobial proteins such as myeloperoxidase, proteinase3 and neutrophil elastase. While NETs are thought to have an important role in host defense, recent work ha...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Nakazawa D,Kumar S,Desai J,Anders HJ

    更新日期:2017-03-01 00:00:00

  • The combined effect of honey and olive oil against methotrexate mediated hepatotoxicity in rats: A biochemical, histological and immunohistological study.

    abstract:BACKGROUND:Honey and olive oil are natural products that have high nutritional values, and therapeutic properties. Cytotoxic drugs, like methotrexate (MTX) are used to treat malignancies in tumour cells; however, these drugs also have serious side effects that could threaten the patient's life. AIM:To evaluate the pot...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Alturkistani HA,Abuzinadah OAH,Kelany AM,Abd El-Aziz GS,Alrafiah AR

    更新日期:2019-12-01 00:00:00

  • Induction system of neural and muscle lineage cells from bone marrow stromal cells; a new strategy for tissue reconstruction in degenerative diseases.

    abstract::Since bone marrow stromal cells (MSCs) are easily accessible both from healthy donors and patients, and can be expanded on a therapeutic scale, they have attracted attention for cell-based therapy. MSCs contribute to the protection of host tissue after transplantation by Immune modulation and trophic effect. They also...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Kitada M,Dezawa M

    更新日期:2009-05-01 00:00:00

  • Might the Masson trichrome stain be considered a useful method for categorizing experimental tendon lesions?

    abstract::Strain injuries of tendons are the most common orthopedic injuries in athletic subjects, be they equine or human. When the tendon is suddenly damaged, an acute inflammatory phase occurs whereas its repetitive overloading may cause chronic injuries. Currently the criteria used for grading injuries are general and subje...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Martinello T,Pascoli F,Caporale G,Perazzi A,Iacopetti I,Patruno M

    更新日期:2015-08-01 00:00:00

  • Effects of Helicobacter pylori on biological characteristics of gastric epithelial cells.

    abstract::Infection with Helicobacter pylori (H. pylori) strains is linked to an increased risk of inflammation and gastric cancer. To investigate the effects of H. pylori on biological characteristics of gastric epithelial cells SGC-7901, derived from human adenocarcinoma, morphological appearances of both the pathogen and the...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Wang P,Mei J,Tao J,Zhang N,Tian H,Fu GH

    更新日期:2012-08-01 00:00:00

  • Structural and ultrastructural hepatic changes in experimental canine leishmaniasis.

    abstract::Six 4 month-old beagles were inoculated with Leishmania donovani infantum, three of them intraperitoneally (Group A) and the other three intravenously (Group B). The animals from Group A were killed 109, 433 and 592 days after inoculation and animals from Group B 109, 171 and 334 after inoculation. The liver of each o...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: González JL,Rollán E,Novoa C,Castaño M

    更新日期:1988-10-01 00:00:00