Studies on the involvement of endogenous neuropeptides in the control of thymocyte proliferation in the rat.

abstract：:Gp96 is the endoplasmic reticulum (ER)-resident molecular chaperone, which is involved in the correction of unfolded proteins, in the activation of proteasome-dependent ER-associated degradation of the misfolded proteins, and in activation of the protein translation that modulates polypeptide traffic into the ER. Furt...

journal_title：Histology and histopathology

authors： Jakovac H,Grebic D,Barac-Latas V,Mrakovcic I,Radosevic-Stasic B

更新日期：2013-01-01 00:00:00

abstract：:In the present study we examined prognostic value of immunohistochemical estimation of topoisomerase 1A (TOP 1A) and HER-2/neu expression in ovarian cancers treated with platinum-based drugs but not with topotecan and the relation between expression of these proteins on the one hand and intensity of proliferation (Ki6...

journal_title：Histology and histopathology

authors： Surowiak P,Materna V,Kaplenko I,Spaczynski M,Dietel M,Lage H,Zabel M

更新日期：2006-07-01 00:00:00

abstract：:The endocrine cells in the gastrointestinal tract of the musk shrew were studied immunohistochemically. Eleven kinds of endocrine cells, immunoreactive for serotonin, somatostatin, gastrin, cholecistokinin, gastric inhibitory polypeptide, motilin, secretin, neurotensin, pancreatic glucagon, enteroglucagon and bovine p...

journal_title：Histology and histopathology

authors： Kitamura N,Yamada J,Watanabe T,Yamashita T

更新日期：1990-01-01 00:00:00

abstract：:Immunocytochemical demonstration of metallothionein (MT) has been reported as a useful prognostic tool in human breast cancer. The aim of this study was to determine the immunohistochemical location of MT in canine mammary tumours and its possible correlation with the morphologic characteristics of these tumours. Surg...

journal_title：Histology and histopathology

authors： Fuentealba IC,Mullins JE

更新日期：1999-01-01 00:00:00

abstract：:25 neuronal tumours with a panel of antibodies were studied and it was found that vimentin was present in 15 tumours. It was also found in a few cells within rosettes. PGP 9.5 showed a somatic pattern of staining with nuclear and perinuclear positivity in 23. Neurofilament reactivity was found in 14. Retinal S-antigen...

journal_title：Histology and histopathology

authors： Cruz-Sánchez FF,Rossi ML,Rodríguez-Prados S,Cusi V,Coakham HB

更新日期：1991-10-01 00:00:00

abstract：:The renin-angiotensin system (RAS) and tubuloglomerular feedback (TGF) are central to the maintenance of blood pressure and body fluid composition. Renin, NO synthase-1 (NOS-1), and cyclooxygenase-2 (COX-2) are key regulators of the RAS and TGF. In the present study, to investigate species-specific differences in the ...

journal_title：Histology and histopathology

authors： Ichii O,Yabuki A,Ojima T,Matsumoto M,Taniguchi K,Suzuki S

更新日期：2008-02-01 00:00:00

abstract：:A rat IgG2a monoclonal antibody against a stage-specific fetal glycoprotein with a molecular mass of 68 kDa (FGP68) was produced and applied to paraffin sections. This monoclonal antibody was used to compare the expression of FGP68 with that of both alpha-fetoprotein (AFP) and carcinoembryonic antigen (CEA) in 75 hepa...

journal_title：Histology and histopathology

authors： Kato M,Shinozawa T,Kato S,Terada T

更新日期：2004-07-01 00:00:00

abstract：:Compliance with current regulations for the development of innovative medicines require the testing of candidate therapies in relevant translational animal models prior to human use. This poses a great challenge when the drug is composed of cells, not only because of the living nature of the active ingredient but also...

journal_title：Histology and histopathology

authors： Ramallo M,Carreras-Sánchez I,López-Fernández A,Vélez R,Aguirre M,Feldman S,Vives J

更新日期：2020-09-11 00:00:00

abstract：:GLI-similar (Glis) 1-3 proteins constitute a subfamily of the Krüppel-like zinc finger transcription factors that are closely related to the Gli family. Glis1-3 play critical roles in the regulation of a number of physiological processes and have been implicated in several pathologies. Mutations in GLIS2 have been lin...

journal_title：Histology and histopathology

authors： Kang HS,ZeRuth G,Lichti-Kaiser K,Vasanth S,Yin Z,Kim YS,Jetten AM

更新日期：2010-11-01 00:00:00

abstract：:Close contacts between endocrine insular cells and exocrine acinar, centroacinar and ductular cells occur frequently in the rat pancreas as seen by both light and electron microscopy. Islets of Langerhans are surrounded incompletely by a thin connective tissue capsule or mantle but numerous exocrine-endocrine cell con...

journal_title：Histology and histopathology

authors： Leeson TS,Leeson R

更新日期：1986-01-01 00:00:00

abstract：:The effects of cadmium exposure on the protein secretory functions of cultured neonatal rat hepatocytes were analyzed by both two-dimensional polyacrylamide gel electrophoresis (2D-PAGE) and electron microscopy. [35S]Methionine-labelled protein secretion was significantly depressed by cadmium exposure in a dose-depend...

journal_title：Histology and histopathology

authors： Hirano T,Ueda H,Kawahara A,Fujimoto S

更新日期：1991-01-01 00:00:00

abstract：:Tumor angiogenesis plays important roles in the pathogenesis and prognosis of lung cancer. Both vascular endothelial growth factor (VEGF) and Dll4/Notch pathways are critical for angiogenesis, whereas their relationship under hypoxia in lung cancer remains unknown. Thus, in the present study, we evaluated the expressi...

journal_title：Histology and histopathology

authors： Yu S,Sun J,Zhang J,Xu X,Li H,Shan B,Tian T,Wang H,Ma D,Ji C

更新日期：2013-02-01 00:00:00

abstract：:Voltage-activated Ca2+ channels play an important role in synaptic transmission, signal processing and development. The immunohistochemical localization of Cav1.2 (alpha1C) and Cav2.3 (alpha1E) Ca2+ channels was studied in the developing and adult mouse organ of Corti using subunit-specific antibodies and fluorescent ...

journal_title：Histology and histopathology

authors： Waka N,Knipper M,Engel J

更新日期：2003-10-01 00:00:00

abstract：:The present study describes the use of a microwave processing protocol for the rapid histopathological and immunohistochemical diagnosis of bovine rabies. Immunohistochemistry has been used for rabies diagnosis in formalin-fixed tissue with satisfactory results, although the time to diagnosis is considerably longer th...

journal_title：Histology and histopathology

authors： Abreu CC,Nakayama PA,Nogueira CI,Mesquita LP,Lopes PF,Varaschin MS,Seixas Jdo N,Ferreira E,Bezerra PS Jr

更新日期：2012-09-01 00:00:00

abstract：:Angiogenesis and bone formation are coupled during skeletal development and fracture healing. This relationship, although known for some time, has not been properly explored. Advances in the discovery of how angiogenesis is regulated in physiological processes like embryogenesis, endometrial regeneration and wound hea...

journal_title：Histology and histopathology

authors： Portal-Núñez S,Lozano D,Esbrit P

更新日期：2012-05-01 00:00:00

abstract：:Spermatogenesis is under the control of a complex endocrine and paracrine system, including estrogen receptor (ER) signaling. In many target cells, ER promotes the transcription of c-fos and other proto-oncogenes to regulate cell growth and differentiation. Thus, in this study we evaluated the expression of the proto-...

journal_title：Histology and histopathology

authors： Araújo FC,Oliveira CA,Reis AB,Del Puerto HL,Martins AS,Reis FM

更新日期：2009-12-01 00:00:00

abstract：:Recent data challenge the relevance of the RB pathway to cancer based on RB inactivation, at least in breast tumors. To obtain information on the actual role of the components of the RB pathway in tumor progression we decided to investigate whether their quantitative changes were associated with variations in the leve...

journal_title：Histology and histopathology

authors： Montanaro L,Vici M,Donati G,Ceccarelli C,Santini D,Treré D,Derenzini M

更新日期：2007-07-01 00:00:00

abstract：:The ultrastructure of the atrial myocardium in the monkey (Macaca fascicularis) was studied after bilateral cervical vagotomy and survival times of 100, 175 and 367 days. Changes were observed in the nucleus and the cytoplasm of the myocyte. Sequestered within the nuclei of the affected myocytes were cytoplasmic organ...

journal_title：Histology and histopathology

authors： Wong WC,Yick TY,Ling EA

更新日期：1989-07-01 00:00:00

abstract：:Aluminium (Al) is a neurotoxic metal and Al exposure may be a factor in the aetiology of various neurodegenerative diseases such as Alzheimer's disease (AD). The major pathohistological findings in the AD brain are the presence of neuritic plaques containing beta-amyloid (Abeta) which may interfere with neuronal commu...

journal_title：Histology and histopathology

authors： Rodella LF,Ricci F,Borsani E,Stacchiotti A,Foglio E,Favero G,Rezzani R,Mariani C,Bianchi R

更新日期：2008-04-01 00:00:00

abstract：:Thyroid hormones (TH) stimulate oxidative metabolism in many tissues in the body, but testis is not one of them. Therefore, in this sense, testis is not considered as a target organ for TH. However, recent findings clearly show that TH have significant functions on the testis in general, and Leydig cells in particular...

journal_title：Histology and histopathology

authors： Mendis-Handagama SM,Ariyaratne HB

更新日期：2004-07-01 00:00:00

abstract：:Sample preparation of dental tissues for quantitative electron microprobe analysis has not been critically examined because of the highly mineralized nature of these structures. The present study was designed to establish the most suitable method for the electron probe quantitative determination of calcium in human pe...

journal_title：Histology and histopathology

authors： Sánchez-Quevedo MC,Nieto-Albano OH,García JM,Gómez de Ferraris ME,Campos A

更新日期：1998-01-01 00:00:00

abstract：:In the lungs, neuronal M2 muscarinic receptors limit the release of acetylcholine from postganglionic cholinergic nerves. However, these receptors are not functional under certain circumstances in animal models of hyperreactivity such as occurs after exposure of sensitised animals to an allergen or during a respirator...

journal_title：Histology and histopathology

authors： Costello RW,Jacoby DB,Gleich GJ,Fryer AD

更新日期：2000-07-01 00:00:00

abstract：:The matrix metalloproteinases (MMPs) are a family of proteolytic zinc-containing enzymes, which are responsible for the breakdown of the extracellular matrix components in pathological and physiological conditions. They are involved in basement membrane disruption, stroma and blood vessel penetration, metastasis and m...

journal_title：Histology and histopathology

authors： Peschos D,Damala C,Stefanou D,Tsanou E,Assimakopoulos D,Vougiouklakis T,Charalabopoulos K,Agnantis NJ

更新日期：2006-06-01 00:00:00

abstract：:The coexistence of serotonin and cholecystokinin was studied in foetal sheep lungs at pseudoglandular stage of development by light microscopic immunohistochemistry. The coexistence was examined by staining consecutive sections with the different antibodies. Serotonin and cholecystokinin immunoreactivity was found wit...

journal_title：Histology and histopathology

authors： Balaguer L,Romano J,Ruiz-Pesini P

更新日期：1994-01-01 00:00:00

abstract：:Detailed characterization of the subdermal model is a significant tool for better understanding of calcification mechanisms occurring in heart valves. In previous ultrastructural investigation on six-week-implantated aortic valve leaflets, modified pre-embedding glutaraldehyde-cuprolinic-blue reactions (GA-CB) enabled...

journal_title：Histology and histopathology

authors： Ortolani F,Bonetti A,Tubaro F,Petrelli L,Contin M,Nori SL,Spina M,Marchini M

更新日期：2007-03-01 00:00:00

abstract：:The FHIT gene encompassing the most active common human fragile region, FRA3B, has been proposed as a tumour suppressor gene for important common human carcinomas. The mechanism in which Fhit protein exerts its tumour suppressor activity is still obscure. To further understand the Fhit function associated with its int...

journal_title：Histology and histopathology

authors： Zhao P,Hou N,Lu Y

更新日期：2006-09-01 00:00:00

abstract：:Treatment of neurodegenerative diseases by classical pharmacotherapy is restricted by blood-brain barrier which prevents access to the brain of potentially therapeutic molecules. Recent progress in the knowledge of pathophysiological molecular processes, and in the development of molecular biotechnology have opened th...

journal_title：Histology and histopathology

authors： Giménez y Ribotta M

更新日期：2001-07-01 00:00:00

abstract：:Huntington's disease (HD) is a tremendously debilitating disorder that strikes relatively young individuals and progresses rapidly over the next ten to fifteen years inducing a loss of cognitive and motor skills and eventually death occurs. The primary locus of the disorder is a polyglutamine expansion of the protein ...

journal_title：Histology and histopathology

authors： Martin B,Golden E,Keselman A,Stone M,Mattson MP,Egan JM,Maudsley S

更新日期：2008-02-01 00:00:00

abstract：:Cancer is the subject of intense research around the world, but many questions about how the disease works remain unanswered. How exactly does cancer start and how do tumours grow? In fact, at present there are ten times more anticancer drugs being tested in clinical trials than there were 15 years ago. However, many ...

journal_title：Histology and histopathology

authors： Romero-Camarero I,Barajas-Diego M,Castellanos-Martín A,García-Martín Á,Varela G,Abad M,Ludeña MD,Pérez-Losada J,Sánchez-García I

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:Synaptotagmin 7 (SYT7) is a component of the synaptotagmin family, which is essential in many physiological and pathological processes. In this study, we aimed to investigate the role of SYT7 in osteosarcoma. METHODS:We defined the expression levels of SYT7 in osteosarcoma tissues and para-sarcoma tissues b...

journal_title：Histology and histopathology

authors： Wu Z,Sun Z,Huang R,Zang D,Wang C,Yan X,Yan W

更新日期：2020-03-01 00:00:00