Abstract：
:Cancer is the subject of intense research around the world, but many questions about how the disease works remain unanswered. How exactly does cancer start and how do tumours grow? In fact, at present there are ten times more anticancer drugs being tested in clinical trials than there were 15 years ago. However, many of the new anticancer agents are predicted to show clinical benefit in only small subpopulations of patients. The cancer stem cell model could explain not only how some cancers work but also why patients suffer relapses, providing a good opportunity to gain insight into the reasons why agents work or, more commonly, don't work, before going into a clinical trial.
journal_name
Histol Histopatholjournal_title
Histology and histopathologyauthors
Romero-Camarero I,Barajas-Diego M,Castellanos-Martín A,García-Martín Á,Varela G,Abad M,Ludeña MD,Pérez-Losada J,Sánchez-García Idoi
10.14670/HH-27.157subject
Has Abstractpub_date
2012-02-01 00:00:00pages
157-70issue
2eissn
0213-3911issn
1699-5848journal_volume
27pub_type
杂志文章,评审abstract：:Prion diseases are characterized by the accumulation of PrPSc, an altered isoform of a normal cellular protein, PrPc. The prion hypothesis holds that the process of conformational change from PrPc to PrPSc under the influence of PrPSc constitutes the basic infectious mechanism in prion diseases. It is still unknown wh...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：
更新日期：1997-07-01 00:00:00
abstract：:Glomerular alterations of experimental diabetes mellitus are observed in animals submitted to a reduction in renal mass, suggesting that some mechanisms responsible for the progression of renal disease are common. The aim of this study was to investigate the effect of nephrectomy on the renal function and morphology o...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-19.1085
更新日期：2004-10-01 00:00:00
abstract：:Macrophages play important roles in host defense mechanisms. In the brain, besides microglial cells, meningeal macrophages are present. However, the pathobiological characteristics of meningeal macrophages in rats remain to be investigated. In normal meninx, immunohistochemically, macrophages reacting to CD163 (macrop...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-24.13
更新日期：2009-01-01 00:00:00
abstract：:The purpose of our study was to elucidate pathways of genetically programmed cell death (apoptosis) in corneas with macular dystrophy. 10 corneal buttons (10 patients) with macular dystrophy and 8 buttons (8 patients) from enucleated eyes with chorioideal melanoma (controls) were analysed histologically. Immunohistoch...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-25.287
更新日期：2010-03-01 00:00:00
abstract：:Compliance with current regulations for the development of innovative medicines require the testing of candidate therapies in relevant translational animal models prior to human use. This poses a great challenge when the drug is composed of cells, not only because of the living nature of the active ingredient but also...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-18-249
更新日期：2020-09-11 00:00:00
abstract：:Our study aimed to investigate the association of Pyruvate Kinase isozyme type M2 (PKM2) with radiation resistance in locally advanced cervical squamous cell carcinoma (LACSCC). We retrospectively reviewed 132 female patients who received primary radiation therapy to treat LACSCC at Federation Internationale of Gyneco...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-11-627
更新日期：2015-11-01 00:00:00
abstract：:Studies in a canine bronchogenic carcinoma model indicate that alveolar type II cells may differentiate from carcinogen-exposed epithelium of larger bronchi and generate adenocarcinomas with bronchioloalveolar and other growth patterns. In this study, we investigated whether type II cells are one of the major prolifer...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1997-04-01 00:00:00
abstract：:Glucocorticoids play a major role in attenuation of the inflammatory response and they are useful in the primary combination chemotherapy of breast cancer, since in vitro studies have demonstrated an antiproliferative effect in human breast cancer cells. In contrast, it was recently shown that glucocorticoids protect ...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-23.77
更新日期：2008-01-01 00:00:00
abstract：:PML is a tumour suppressor inactivated in Acute Promyelocytic Leukaemia (APL). PML is the essential component of a subnuclear structure called the PML nuclear body (PML-NB), which is disrupted in APL. By targeting different cellular proteins to this structure, PML can either hamper or potentiate their functions. The P...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-22.937
更新日期：2007-08-01 00:00:00
abstract：:Thrombospondin-1 (TSP-1) is a matrix protein implicated in mechanisms of wound healing. TSP-1 contains the sequence cysteine-serine-valine-threonine-cysteine-glycine (CSVTCG) that has been shown to function primarily as a cell adhesion domain. Our laboratory has isolated a novel receptor specific for the CSVTCG adhesi...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-13.967
更新日期：1998-10-01 00:00:00
abstract：:Platelet-collagen interaction is a complex event that involves ligand-receptor interaction. There are many adhesive non-integrin receptors for platelets to interact with various types of collagens. These non-integrin receptors also serve as signal transducers both from the outside of platelets to the inside and possib...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-14.579
更新日期：1999-04-01 00:00:00
abstract：:Histochemical distribution of glycoproteins, carbohydrates and proteins rich in different amino acids were studied using histological and histochemical procedures, in Senegal sole, Solea senegalensis (Kaup, 1858) larvae from hatching until day 15. Glycogen, proteins and glycoproteins were detected in the yolk-sac of t...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1996-10-01 00:00:00
abstract：:HPV infection has been identified recently as the causative agent of a subset of squamous cell carcinomas arising in oropharyngeal tonsils. Factors influencing the susceptibility of tonsillar epithelium to HPV-induced oncogenesis are far from being elucidated. A 5-protein signature including cytokeratin (CK)7, anterio...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-11-590
更新日期：2015-07-01 00:00:00
abstract：:The Farnesoid X Receptor (FXR) is a member of the nuclear receptor superfamily of ligand-activated transcription factors, which plays crucial role in bile acid, cholesterol, lipid and glucose metabolism, as well as in the development of atherosclerosis, intestinal bacterial growth and liver regeneration. FXR is also i...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-27.835
更新日期：2012-07-01 00:00:00
abstract：:The study was carried out on the distribution of neurons and fibres which contain the Corticotropin releasing factor-like (CRF) immunoreactivity in the encephalon of two species of teleosts, Gambusia affinis and Salmo trutta. The peroxidase-antiperoxidase (PAP) immunocytochemical technique was employed. The present st...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1994-04-01 00:00:00
abstract：:Pax genes play a pivotal role in development of the vertebrate visual system. Pax6 is the master control gene for eye development: ectopic expression of Pax6 in Xenopus laevis and Drosphila melanogaster leads to the formation of differentiated eyes on the legs or wings. Pax6 is involved in formation of ganglion cells ...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-16.239
更新日期：2001-01-01 00:00:00
abstract：:The FHIT gene encompassing the most active common human fragile region, FRA3B, has been proposed as a tumour suppressor gene for important common human carcinomas. The mechanism in which Fhit protein exerts its tumour suppressor activity is still obscure. To further understand the Fhit function associated with its int...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-21.915
更新日期：2006-09-01 00:00:00
abstract：:A number of tumor suppressor and tumor-related genes exhibit promoter hypermethylation with resulting gene silencing in human cancers. In addition, several gene promoters have also been shown to become hypermethylated in non-neoplastic cells during aging. To assess the physiological consequence and clinical significan...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-19.221
更新日期：2004-01-01 00:00:00
abstract：:In the present work we analyze the cerebellum of chronic parkinsonian monkeys in order to clarify whether chronic mesencephalic depletion is associated with long term activation of the cerebellar neurons in chronic Parkinsonism. In our study, we observed a persistent activation of Purkinje cells in the cerebellum of c...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-27.89
更新日期：2012-01-01 00:00:00
abstract：:The effects of diethylstilbestrol (DES) and of long-acting somatostatin analog, octreotide (SMS) on the rat anterior pituitary microvasculature have been studied by means of computer-assisted image analysis. Additionally, the effects of DES and SMS on prolactin secretion and anterior pituitary cell proliferation have ...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1997-10-01 00:00:00
abstract：:The histological and ultrastructural features, as well as the immunoreactivity of one case of uncommon primary papillary and psammomatous adenocarcinoma of the umbilicus are studied in the present work. The observations have been undertaken in a nine-year follow-up, and have included the primitive tumour, two local re...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1993-10-01 00:00:00
abstract：:Morphological, histochemical and ultrastructural investigations on epiphyseal apparatus of Rana Esculenta were made. The most important findings were the following: 1) metaphyseal cartilage is localized inside proximal diaphyseal compact bone as a plug; 2) metaphyseal cartilage do not reduce in thickness during ageing...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1992-04-01 00:00:00
abstract：:Dysadherin, a cancer associated cell membrane glycoprotein, has been reported to downregulate E-cadherin. Aberrant expression of E-cadherin has been associated with the development of metastases in patients with cancer. Even though the expression of dysadherin and E-cadherin has been studied in primary non-small cell ...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-25.1257
更新日期：2010-10-01 00:00:00
abstract：:Melanocytes characterized by their tyrosinase activity, melanosomes and dendrites locate in the basal layer of epidermis and hair bulb in the skin of mice. Melanocytes differentiate from undifferentiated melanoblasts derived from embryonic neural crest. Melanocyte-stimulating hormone plays an important role in the reg...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：
更新日期：1995-01-01 00:00:00
abstract：BACKGROUND:Gastric Cardiac Cancer (GCC) has high incidence and poor prognosis requiring early screening of high-risk populations. Minichromosome maintenance (MCM) proteins are used as diagnostic-biomarkers in many cancers but not validated for GCC. We evaluate MCM protein 2 (MCM2), comparing it with the validated marke...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-28.481
更新日期：2013-04-01 00:00:00
abstract：UNLABELLED:The aim of this work was to evaluate the effect of magnesium sulphate (MgSO4) administration on blood-brain barrier (BBB) permeabilization after cerebral hypoxia-ischemia (HI) induced by partial occlusion of the umbilical cord of premature fetal lambs. We also characterized BBB dysfunction in terms of the le...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-24.1129
更新日期：2009-09-01 00:00:00
abstract：AIMS:The expression patterns of TGFB signaling proteins, such as TGFB1/2, TGFBR1(ALK5), TGFBR2, SMAD1/2/3, SMAD2/3, SMAD4, SMAD7, and of downstream targets of TGFB signaling, CDKN1A (p21CIP1), CDKN1B (p27KIP1), MYC, CDC25A, TP53, and RELA (p65NF-kB) were investigated in gastric carcinomas and other gastric lesions. ME...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-23.1439
更新日期：2008-12-01 00:00:00
abstract：:A variety of studies have shown that incubation of different tumour cell lines with mistletoe lectins (MLs) in vitro has a marked cytotoxic effect. In the concentration range of low cytotoxicity cell death induced by ML-I is quantitatively due to apoptotic processes. The first events observed being membrane perforatio...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-21.285
更新日期：2006-03-01 00:00:00
abstract：:Sample preparation of dental tissues for quantitative electron microprobe analysis has not been critically examined because of the highly mineralized nature of these structures. The present study was designed to establish the most suitable method for the electron probe quantitative determination of calcium in human pe...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-13.109
更新日期：1998-01-01 00:00:00
abstract：:Chronic liver diseases are commonly associated with tissue hypoxia that may cause inflammation, oxidative stress, liver cell injury and increased nuclear transcriptional regulation. The hepatic response to chronic hypoxia at the molecular level has not yet been clearly understood until now. The aim of this study is to...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：2013-04-01 00:00:00
