Extensive alteration in the expression profiles of TGFB pathway signaling components and TP53 is observed along the gastric dysplasia-carcinoma sequence.

Abstract:

AIMS:The expression patterns of TGFB signaling proteins, such as TGFB1/2, TGFBR1(ALK5), TGFBR2, SMAD1/2/3, SMAD2/3, SMAD4, SMAD7, and of downstream targets of TGFB signaling, CDKN1A (p21CIP1), CDKN1B (p27KIP1), MYC, CDC25A, TP53, and RELA (p65NF-kB) were investigated in gastric carcinomas and other gastric lesions. METHODS AND RESULTS:A total of 112 gastric carcinomas, 37 dysplasias, 54 intestinal metaplasias, 29 chronic atrophic gastritis and 54 normal gastric epithelium were analyzed by tissue microarray-based immunohistochemical analysis. Extensive changes in expression profiles of these proteins were observed. Three types of expression patterns were observed along the normal epithelium-atrophic gastritis-dysplasia-carcinoma sequence. (1) Expression of TGFB1/2, TGFBR1, MYC, and TP53 continually increased along this sequence. (2) Expression of SMAD4, CDKN1A, SMAD1/2/3, SMAD2/3, and CDKN1B was enhanced in dysplasia but decreased in carcinoma. (3) Expression of TGFBR2, SMAD7, RELA, and CDC25A was enhanced in dysplasia and the enhanced level was maintained in carcinoma. In addition, we also evaluated the clinical significance of the expression of TGFB signaling proteins in gastric carcinoma. TGFB and MYC were positively correlated with advanced stages, whereas SMAD1/2/3 and SMAD4 were strongly associated with earlier stages. CONCLUSIONS:The extensive change in expression of TGFB signaling components is implicated during tumorigenesis of gastric neoplasias.

journal_name

Histol Histopathol

authors

Kim SH,Lee SH,Choi YL,Wang LH,Park CK,Shin YK

doi

10.14670/HH-23.1439

subject

Has Abstract

pub_date

2008-12-01 00:00:00

pages

1439-52

issue

12

eissn

0213-3911

issn

1699-5848

journal_volume

23

pub_type

杂志文章
  • Unexpected presence of the neurotrophins NGF and BDNF and the neurotrophin receptor p75 in the tendon cells of the human Achilles tendon.

    abstract::Neurotrophins are substances that have been shown to be important in growth and remodelling phases in different types of tissue. There is no information concerning the possible occurrences of neurotrophins and their receptors in tendons. In this study, sections of both chronic painful (tendinosis) and pain-free (non-t...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-24.839

    authors: Bagge J,Lorentzon R,Alfredson H,Forsgren S

    更新日期:2009-07-01 00:00:00

  • C-reactive protein levels are associated with the progression of atherosclerotic lesions in rabbits.

    abstract::Elevated plasma levels of C-reactive protein (CRP) are associated with increased risk of cardiovascular disease. CRP immunoreactive protein is also detected in the lesions of atherosclerosis. However, it is not known whether the CRP contents of atherosclerotic lesions are associated with the initiation and progression...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-27.529

    authors: Yu Q,Li Y,Wang Y,Zhao S,Yang P,Chen Y,Fan J,Liu E

    更新日期:2012-04-01 00:00:00

  • M1- and M2-macrophage polarization in thioacetamide (TAA)-induced rat liver lesions; a possible analysis for hepato-pathology.

    abstract::"Classically activated macrophages (M1)" and "alternatively activated macrophages (M2)", which appear in injured tissues, control either inflammation or remodeling. The mechanism remains unclear. To clarify the M1-/M2-macrophage polarization in acute liver injury, M1- and M2-related factors were analysed in F344 rats ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-29.10.497

    authors: Wijesundera KK,Izawa T,Murakami H,Tennakoon AH,Golbar HM,Kato-Ichikawa C,Tanaka M,Kuwamura M,Yamate J

    更新日期:2014-04-01 00:00:00

  • Targeting WNT, protein kinase B, and mitochondrial membrane integrity to foster cellular survival in the nervous system.

    abstract::Targeting essential cellular pathways that determine neuronal and vascular survival can foster a successful therapeutic platform for the treatment of a wide variety of degenerative disorders in the central nervous system. In particular, oxidative cellular injury can precipitate several nervous system disorders that ma...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-19.495

    authors: Chong ZZ,Maiese K

    更新日期:2004-04-01 00:00:00

  • Histological approach to Bacillus subtilis colony-biofilm: evolving internal architecture and sporulation dynamics.

    abstract::Bacillus subtilis has been used as a classic model to study biofilm formation and sporulation process. Colonies of wild-type strains usually have a complex external morphology, but the details of their internal architecture are still undisclosed. Since bacterial biofilms fulfill the criteria to be considered tissues, ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-28.1351

    authors: Gómez-Aguado F,Corcuera MT,Gómez-Lus ML,de la Parte MA,Ramos C,García-Rey C,Alonso MJ,Prieto J

    更新日期:2013-10-01 00:00:00

  • Chronic retinal effects by ultraviolet irradiation, with special reference to superoxide dismutases.

    abstract::Recently ultraviolet light (UV) reaching the Earth's surface has been gradually increasing in amounts by the destruction of the ozone layers. Large parts of UV are absorbed in the cornea and lens, and only a few amounts reached the retina; however, the effect on the retina is not fully elucidated. 38 rats were irradia...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Oguni M,Tamura H,Kato K,Setogawa T

    更新日期:1996-07-01 00:00:00

  • Multilocular cystic renal cell carcinoma with focus on clinical and pathobiological aspects.

    abstract::Multilocular cystic renal cell carcinoma (MCRCC) accounts for approximately 1 to 2% of all renal tumors. This tumor is currently classified as a subtype of clear cell RCC. Clinically, the majority of these tumors are incidentally found. Macroscopically, the tumor is well demarcated and consists of various-sized cysts....

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-27.969

    authors: Kuroda N,Ohe C,Mikami S,Inoue K,Nagashima Y,Cohen RJ,Pan CC,Michal M,Hes O

    更新日期:2012-08-01 00:00:00

  • Molecular and cellular mechanisms of heterotopic ossification.

    abstract::Heterotopic ossification (HO) is a debilitating condition in which cartilage and bone forms in soft tissues such as muscle, tendon, and ligament causing immobility. This process is induced by inflammation associated with traumatic injury. In an extremely rare genetic disorder called fibrodysplasia ossificans progessiv...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-29.1281

    authors: Ramirez DM,Ramirez MR,Reginato AM,Medici D

    更新日期:2014-10-01 00:00:00

  • Serotonin-producing pancreatic endocrine tumour. Histological, ultrastructural and immunohistochemical study of a case.

    abstract::Serotonin-producing pancreatic endocrine tumours are rare neoplasms which in most cases exhibit malignant biological behaviour. These tumours, in the majority of the well-documented cases, are composed of argyrophil- and argentaffin-positive cells which contain large pleomorphic neurosecretory granules. In contrast, a...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Kanavaros P,Hoang C,Le Bodic MF,Polivka M,Hautefeuille P

    更新日期:1990-07-01 00:00:00

  • The deep-sea teleost cornea: a comparative study of gadiform fishes.

    abstract::The corneal structure of three deep-sea species of teleosts (Gadiformes, Teleostei) from different depths (250-4000 m) and photic zones are examined at the level of the light and electron microscopes. Each species shows a similar but complex arrangement of layers with a cornea split into dermal and scleral components....

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-13.325

    authors: Collin SP,Collin HB

    更新日期:1998-04-01 00:00:00

  • Histopathological changes in the eyes in systemic lupus erythematosus: an electron microscope and immunohistochemical study.

    abstract::This paper reports the histopathological findings in the eyes of a 26-year-old female patient diagnosed with systemic lupus erythematosus (SLE) with peripheral neuropathy. The patient had no significant ocular problems. She died of pneumonia after two years of suffering. The eyeballs were procured at autopsy and the r...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-20.373

    authors: Nag TC,Wadhwa S

    更新日期:2005-04-01 00:00:00

  • Morphological and functional changes in experimental ocular hypertension and role of neuroprotective drugs.

    abstract::Glaucoma is a neurodegenerative disease characterized by progressive loss of retinal ganglion cell axons and their cell bodies in the retina. Elevated intraocular pressure (IOP) is considered to be the major risk factor associated with the development of this neuropathy. Randomized controlled clinical trials have demo...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-22.1399

    authors: García-Campos J,Villena A,Díaz F,Vidal L,Moreno M,Pérez de Vargas I

    更新日期:2007-12-01 00:00:00

  • Enhanced CD24 expression in endometrial carcinoma and its expression pattern in normal and hyperplastic endometrium.

    abstract::CD24 is known to be an important diagnostic and prognostic marker of several major cancers affecting females. We aimed to determine CD24 expression in normal, hyperplastic, and carcinomatous endometrium and its correlation with estrogen and progesterone receptor expression. A total of 271 cases including 62 normal/atr...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-24.309

    authors: Kim KH,Choi JS,Kim JM,Choi YL,Shin YK,Lee HC,Seong IO,Kim BK,Chae SW,Kim SH

    更新日期:2009-03-01 00:00:00

  • Cyclosporin A-induced changes of the thymic microenvironment. A review of morphological studies.

    abstract::Cyclosporin A is an immunosuppressive drug, which disrupts the activation of peripheral T-lymphocyte pool and blocks the maturation of thymocytes within the thymus. Normally, thymic nonlymphoid cells provide the optimal inductive microenvironment for development of T-lymphocytes. After application of cyclosporin A the...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-13.1183

    authors: Milićević NM,Milićević Z

    更新日期:1998-10-01 00:00:00

  • Therapeutic perspectives for the treatment of Huntington's disease: treating the whole body.

    abstract::Huntington's disease (HD) is a tremendously debilitating disorder that strikes relatively young individuals and progresses rapidly over the next ten to fifteen years inducing a loss of cognitive and motor skills and eventually death occurs. The primary locus of the disorder is a polyglutamine expansion of the protein ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-23.237

    authors: Martin B,Golden E,Keselman A,Stone M,Mattson MP,Egan JM,Maudsley S

    更新日期:2008-02-01 00:00:00

  • Collagen-platelet interaction: platelet non-integrin receptors.

    abstract::Platelet-collagen interaction is a complex event that involves ligand-receptor interaction. There are many adhesive non-integrin receptors for platelets to interact with various types of collagens. These non-integrin receptors also serve as signal transducers both from the outside of platelets to the inside and possib...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-14.579

    authors: Chiang TM

    更新日期:1999-04-01 00:00:00

  • Cadmium toxicity on cultured neonatal rat hepatocytes: biochemical and ultrastructural analyses.

    abstract::The effects of cadmium exposure on the protein secretory functions of cultured neonatal rat hepatocytes were analyzed by both two-dimensional polyacrylamide gel electrophoresis (2D-PAGE) and electron microscopy. [35S]Methionine-labelled protein secretion was significantly depressed by cadmium exposure in a dose-depend...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Hirano T,Ueda H,Kawahara A,Fujimoto S

    更新日期:1991-01-01 00:00:00

  • Immunohistochemical localization of renin, NO synthase-1, and cyclooxygenase-2 in rodent kidney.

    abstract::The renin-angiotensin system (RAS) and tubuloglomerular feedback (TGF) are central to the maintenance of blood pressure and body fluid composition. Renin, NO synthase-1 (NOS-1), and cyclooxygenase-2 (COX-2) are key regulators of the RAS and TGF. In the present study, to investigate species-specific differences in the ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-23.143

    authors: Ichii O,Yabuki A,Ojima T,Matsumoto M,Taniguchi K,Suzuki S

    更新日期:2008-02-01 00:00:00

  • Intraepidermal free nerve fiber endings in the hairless skin of the rat as revealed by the zinc iodide-osmium tetroxide technique.

    abstract::The nerve fiber distribution in the epidermis of the hairless rat skin was studied light microscopically by means of zinc iodide-osmium tetroxide staining. Two different morphological types of free nerve fiber endings could be detected: clusters of relatively thick nerve fibers stretched up through the spinous layer u...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-15.493

    authors: Müller T

    更新日期:2000-04-01 00:00:00

  • Cerebrovascular pathophysiology of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage.

    abstract::Aneurysmal subarachnoid hemorrhage (SAH) remains a serious cerebrovascular disease. Even if SAH patients survive the initial insults, delayed cerebral ischemia (DCI) may occur at 4 days or later post-SAH. DCI is characteristics of SAH, and is considered to develop by blood breakdown products and inflammatory reactions...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-18-253

    authors: Suzuki H,Kanamaru H,Kawakita F,Asada R,Fujimoto M,Shiba M

    更新日期:2020-09-30 00:00:00

  • Pathological findings in a cat with cryptococcosis and feline immunodeficiency virus infection.

    abstract::This report describes the gross, histopathological, immunocytochemical and electron microscopic findings in a cat with systemic cryptococcosis and feline immunodeficiency virus (FIV) infection. Lymphadenopathy and cloudiness of leptomeninges were the major gross findings. Numerous cryptococcal yeasts were found in lym...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Ramos-Vara JA,Ferrer L,Visa J

    更新日期:1994-04-01 00:00:00

  • Morphological hysteresis of the small airways.

    abstract::The resistance to airflow that develops in most obstructive processes takes place in the small airways. The aim of the present paper is to describe bronchial hysteresis morphometrically in a respiratory cycle model. As a working hypothesis, it is proposed that the changes that take place in the respiratory tract durin...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-18.19

    authors: Escolar JD,Escolar MA,Guzmán J,Roqués M

    更新日期:2003-01-01 00:00:00

  • Fhit protein is preferentially expressed in the nucleus of monocyte-derived cells and its possible biological significance.

    abstract::The FHIT gene encompassing the most active common human fragile region, FRA3B, has been proposed as a tumour suppressor gene for important common human carcinomas. The mechanism in which Fhit protein exerts its tumour suppressor activity is still obscure. To further understand the Fhit function associated with its int...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-21.915

    authors: Zhao P,Hou N,Lu Y

    更新日期:2006-09-01 00:00:00

  • Pathophysiology of stem cells in restenosis.

    abstract::Recent evidence has shown that vascular function depends not only on cells within the vessels, but is also significantly modulated by circulating cells derived from the bone marrow. A number of studies indicate that an early reendothelialization by circulating endothelial precursors after vascular injury prevents exce...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-22.547

    authors: Forte A,Cipollaro M,Cascino A,Galderisi U

    更新日期:2007-05-01 00:00:00

  • In vitro and in vivo characterization of neural stem cells.

    abstract::Neural stem cells are defined as clonogenic cells with self-renewal capacity and the ability to generate all neural lineages (multipotentiality). Cells with these characteristics have been isolated from the embryonic and adult central nervous system. Under specific conditions, these cells can differentiate into neuron...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-19.1261

    authors: Bazán E,Alonso FJ,Redondo C,López-Toledano MA,Alfaro JM,Reimers D,Herranz AS,Paíno CL,Serrano AB,Cobacho N,Caso E,Lobo MV

    更新日期:2004-10-01 00:00:00

  • Mad2 and spindle assembly checkpoint function during meiosis I in mammalian oocytes.

    abstract::During mammalian mitosis, a proofreading network called the spindle assembly checkpoint (SAC) is indispensable for ensuring the fidelity of chromosome segregation. An inhibitory SAC signal is deputed to inhibits mitotic cell-cycle progression in response to misaligned chromosomes until such imperfections are rectified...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-21.873

    authors: Homer HA

    更新日期:2006-08-01 00:00:00

  • Perspectives of SLIT/ROBO signaling in placental angiogenesis.

    abstract::A novel family of evolutionally conserved neuronal guidance cues, including ligands (i.e., Slit, netrin, epherin, and semaphorin) and their corresponding receptors (i.e., Robo, DCC/Unc5, Eph and plexin/ neuropilin), has been identified to play a crucial role in axon pathfinding and branching as well as neuronal cell m...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-25.1181

    authors: Liao WX,Wing DA,Geng JG,Chen DB

    更新日期:2010-09-01 00:00:00

  • Pax genes in development and maturation of the vertebrate visual system: implications for optic nerve regeneration.

    abstract::Pax genes play a pivotal role in development of the vertebrate visual system. Pax6 is the master control gene for eye development: ectopic expression of Pax6 in Xenopus laevis and Drosphila melanogaster leads to the formation of differentiated eyes on the legs or wings. Pax6 is involved in formation of ganglion cells ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-16.239

    authors: Ziman MR,Rodger J,Chen P,Papadimitriou JM,Dunlop SA,Beazley LD

    更新日期:2001-01-01 00:00:00

  • Ultrastructural studies on myofibrillogenesis and neogenesis of skeletal muscles after prolonged traction in rabbits.

    abstract::Little is known about the morphological response of muscle after long term traction. The purpose of this study was to investigate the morphological changes of skeletal muscle during limb lengthening. After application of mini-extraskeletal fixator, the hindlimb of New Zealand white rabbit was osteotomized and then slo...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Sun JS,Hou SM,Hang YS,Liu TK,Lu KS

    更新日期:1996-04-01 00:00:00

  • Histochemical aspects of the yolk-sac and digestive tract of larvae of the Senegal sole, Solea senegalensis (Kaup, 1858).

    abstract::Histochemical distribution of glycoproteins, carbohydrates and proteins rich in different amino acids were studied using histological and histochemical procedures, in Senegal sole, Solea senegalensis (Kaup, 1858) larvae from hatching until day 15. Glycogen, proteins and glycoproteins were detected in the yolk-sac of t...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Sarasquete C,González de Canales ML,Arellano JM,Muñoz-Cueto JA,Ribeiro L,Dinis MT

    更新日期:1996-10-01 00:00:00