Fhit protein is preferentially expressed in the nucleus of monocyte-derived cells and its possible biological significance.


:The FHIT gene encompassing the most active common human fragile region, FRA3B, has been proposed as a tumour suppressor gene for important common human carcinomas. The mechanism in which Fhit protein exerts its tumour suppressor activity is still obscure. To further understand the Fhit function associated with its intracellular localization we have investigated its cellular localization and distribution in human normal and cancerous tissues. Data of 1500 samples from immunohistochemistry showed that Fhit protein was preferentially and stably expressed in the nucleus of monocyte-derived or histiocytic lineage cells including monocytes of the circulating blood cells, macrophages of the connective tissue, Kupffer cells of the liver, alveolar macrophages or dust cells of the lung, osteoclasts of bone, microglia of the brain, epithelioid cells under chronic inflammatory conditions, foreign-body giant cells, Langerhans cells of the epidermis and dendritic cells of various kinds of human tissue, although the protein could also be infrequently observed in the nucleus of some quiescent epithelial cells. In active cells other than histiocytes, Fhit protein was detected either in cytoplasm or was negative. Neurons expressed Fhit strongly and neuroglial cells did so moderately but only in the cytoplasm. There was no Fhit protein detected in the neutrophils, lymphocytes, plasma cells and lipocytes. The present data showes that the stable nuclear localization of Fhit is not only a special marker for histiocytes with various morphologies but also may suggest the other function concerning Fhit as a signaling molecule related to anti-proliferation function. The detailed biological function related to nuclear localization of Fhit protein in the histiocytes remains to be further studied.


Histol Histopathol


Zhao P,Hou N,Lu Y




Has Abstract


2006-09-01 00:00:00












  • Nuclear localization of TRK-A in liver cells.

    abstract::The liver represents a site of expression of neurotrophins and their receptors. We have characterized the expression and intracellular localization of the nerve growth factor (NGF) receptor, Trk-A, in liver cells in vivo and in vitro. In both normal and fibrotic liver tissue, Trk-A immunostaining was present in differ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Bonacchi A,Taddei ML,Petrai I,Efsen E,Defranco R,Nosi D,Torcia M,Rosini P,Formigli L,Rombouts K,Zecchi S,Milani S,Pinzani M,Laffi G,Marra F

    更新日期:2008-03-01 00:00:00

  • Immunohistochemical distribution of cocaine- and amphetamine-regulated transcript peptide - like immunoreactive (CART-LI) nerve fibers and various degree of co-localization with other neuronal factors in the circular muscle layer of human descending colon

    abstract::Cocaine- and amphetamine-regulated transcript peptide (CART) is a neuromediator and/or neuromodulator in nerve structures within the gastrointestinal tract, but knowledge about its distribution, functions and co-localisation with other neuronal factors, especially in humans, is very scarce. During the present investig...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Gonkowski S,Kamińska B,Landowski P,Całka J

    更新日期:2013-07-01 00:00:00

  • Regeneration of the periodontium for preservation of the damaged tooth.

    abstract::The population of the world grows every year, and life expectancy tends to increase. Thus, long-term preservation of teeth in aged individuals is an urgent issue. The main causes of tooth loss are well known to be periodontitis, caries, fractures, and orthodontic conditions. Although implant placement is a widely acce...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Maeda H,Tomokiyo A,Wada N,Koori K,Kawachi G,Akamine A

    更新日期:2014-10-01 00:00:00

  • Physiopathologic dynamics of vesicle traffic in astrocytes.

    abstract::The view of how astrocytes, a type of glial cells, contribute to the functioning of the central nervous system (CNS) has changed greatly in the last decade. Although glial cells outnumber neurons in the mammalian brain, it was considered for over a century that they played a subservient role to neurons. This view chan...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Potokar M,Stenovec M,Kreft M,Gabrijel M,Zorec R

    更新日期:2011-02-01 00:00:00

  • Immunohistochemistry of connexin43 and zonula occludens-1 in the myocardium as markers of early ischemia in autopsy material.

    abstract::Immunohistochemistry of the terminal complement complex (C5b-9) and fibronectin (FN) is useful to detect myocardial ischemia preceding necrosis in the postmortem diagnosis of sudden cardiac death. The present immunohistochemical study examined connexin43 (Cx43) and zonula occludens-1 (ZO-1) as markers of early myocard...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Kawamoto O,Michiue T,Ishikawa T,Maeda H

    更新日期:2014-06-01 00:00:00

  • Control of the cell cycle by neurotrophins: lessons from the p75 neurotrophin receptor.

    abstract::Although traditionally little attention has been paid to the interplay between neurotrophins and the cell cycle, a number of recent findings suggest an important role for these growth factors in the regulation of this aspect of the cellular physiology. In this article, we review the evidence from a number of studies t...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: López-Sánchez N,Frade JM

    更新日期:2002-10-01 00:00:00

  • The role of TET family proteins and 5-hydroxymethylcytosine in human tumors.

    abstract::Tumorigenesis correlates with hypermethylation of tumor suppressors and hypomethylation of oncogenes. DNA methyltransferases (DNMTs) catalyze DNA methylation, and mutations and aberrant expression in DNMT genes are found in multiple human tumors. The discovery of the DNA demethylation function of TET proteins has open...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Wu YC,Ling ZQ

    更新日期:2014-08-01 00:00:00

  • Histopathological changes in the islets of Langerhans in hamsters infected with the 139H strain of scrapie: semi-thin section study.

    abstract::Using histopathological analysis of semi-thin sections stained with toluidine blue, we observed profound pathological changes in the islets of Langerhans of hamsters infected with the scrapie agent (strain 139H). These included cytoplasmic vesicles, nuclear swelling, and vacuolization in the islet cells. Two types of ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Ye X,Carp RI

    更新日期:1996-01-01 00:00:00

  • High prevalence of human papillomavirus 16 in penile carcinoma.

    abstract::In order to analyze the incidence and prevalence of Human Papillomavirus (HPV) in penile carcinoma, we studied 49 patients with penile carcinoma. Formalin-fixed, paraffin-embedded tissue samples were collected from 64 samples of penile carcinoma from the Hospital General Universitario (Albacete, Spain). Cases were his...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Pascual A,Pariente M,Godínez JM,Sánchez-Prieto R,Atienzar M,Segura M,Poblet E

    更新日期:2007-02-01 00:00:00

  • Expression of cell-cycle regulatory proteins BUBR1, MAD2, Aurora A, cyclin A and cyclin E in invasive ductal breast carcinomas.

    abstract::Cyclin A, cyclin E, BUBR1, MAD2 and Aurora A are all cell-cycle regulatory proteins and have been proven to play crucial roles in carcinogenesis. However, their expression patterns in invasive ductal breast carcinoma (IDBC) are controversial and unclear. In this study, we examined the expression status of these candid...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Du J,Du Q,Zhang Y,Sajdik C,Ruan Y,Tian XX,Fang WG

    更新日期:2011-06-01 00:00:00

  • Histology and ultrastructure of the pineal organ in the domestic goose.

    abstract::The pineal organs of 14-week-old domestic geese were investigated with light and electron microscopy. The pineals consisted of a wide distal part and a narrow middle-proximal one. The glands were attached to the intercommissural region via the choroid plexus. The pineal parenchyma was formed by round or elongated foll...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Prusik M,Lewczuk B,Nowicki M,Przybylska-Gornowicz B

    更新日期:2006-10-01 00:00:00

  • Targeting WNT, protein kinase B, and mitochondrial membrane integrity to foster cellular survival in the nervous system.

    abstract::Targeting essential cellular pathways that determine neuronal and vascular survival can foster a successful therapeutic platform for the treatment of a wide variety of degenerative disorders in the central nervous system. In particular, oxidative cellular injury can precipitate several nervous system disorders that ma...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Chong ZZ,Maiese K

    更新日期:2004-04-01 00:00:00

  • Comparative in vivo and in vitro models to approach the cellular basis of endotoxic shock. The role of sinusoidal liver cells.

    abstract::During endotoxic shock, the liver exerts a lipopolysaccharide (LPS) clearance function with the participation of both parenchymal and sinusoidal cells. Liver damage could be caused by LPS direct action, hypoxia and/or inflammatory mediators released by Kupffer cells. The aim of this study is to establish an experiment...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Pagani R,Portolés MT,Arahuetes R,Ainaga MJ,Machín C,Rua C

    更新日期:1996-07-01 00:00:00

  • Morphology, differentiation and matrix production of liver cells in organoid cultures (high density cultures) of fetal rat livers.

    abstract::The aim of this study was to demonstrate the morphology and matrix synthesis of embryonic rat liver cells (day 18 of gestation) in organoid cultures (high density cultures) with electron microscopic and immunomorphological techniques. For this purpose the cells of embryonic rat livers were isolated enzymatically and g...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Elkasaby A,Xu D,Schröter-Kermani C,Merker HJ

    更新日期:1991-04-01 00:00:00

  • Histological villous maturation in placentas of complicated pregnancies.

    abstract::Chorioamnionitis and preeclampsia account for the majority of preterm births worldwide. Thus far, adequate methods for early detection or prevention of these diseases are lacking. In preeclampsia, accelerated villous maturation is believed to compensate placental insufficiency. However, little is known about the effec...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Vangrieken P,Vanterpool SF,van Schooten FJ,Al-Nasiry S,Andriessen P,Degreef E,Alfer J,Kramer BW,von Rango U

    更新日期:2020-08-01 00:00:00

  • Molecular biology of glioma tumorigenesis.

    abstract::Gliomas are the most common intracranial malignant tumors in humans, and high-grade gliomas in particular pose a unique challenge due to their propensity for proliferation and tissue invasion. Our understanding of glioma oncogenesis, proliferation, and invasion has been greatly advanced in the past 10 years as researc...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Ware ML,Berger MS,Binder DK

    更新日期:2003-01-01 00:00:00

  • Oncocytic adenoma of the nasal cavity. A case report.

    abstract::The authors present a case of benign oncocytoma (oxyphil cell adenoma) of the nasal cavity in a young woman. This is the fifth case reported in that region. Immunohistochemical stains revealed positivity only for cytokeratin. ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Miracco C,Sensini I,Vessio G,Luzi P

    更新日期:1986-01-01 00:00:00

  • Oxidative damage in age-related macular degeneration.

    abstract::Epidemiologic studies have suggested that elderly patients who consumed diets rich in antioxidants throughout their lives are less likely to be afflicted with age-related macular degeneration (AMD). This led to the Age-Related Eye Disease Study, which showed that supplements containing antioxidant vitamins and zinc re...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Shen JK,Dong A,Hackett SF,Bell WR,Green WR,Campochiaro PA

    更新日期:2007-12-01 00:00:00

  • Distribution and pathophysiologic role of molybdenum-containing enzymes.

    abstract::The importance of molybdenum-containing enzymes in the pathophysiology of a number of clinical disorders necessitates a comprehensive understanding of their histological localization and expression. The objectives of this review are to cover such enzymes so far reported and their enzyme- and immunohistochemical locali...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Moriwaki Y,Yamamoto T,Higashino K

    更新日期:1997-04-01 00:00:00

  • Telocytes form networks in normal cardiac tissues.

    abstract::Telocytes (TC) are a class of interstitial cells present in heart. Their characteristic feature is the presence of extremely long and thin prolongations (called telopodes). Therefore, we were interested to see whether or not TCs form networks in normal cardiac tissues, as previously suggested. Autopsy samples of card...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Rusu MC,Pop F,Hostiuc S,Curca GC,Jianu AM,Paduraru D

    更新日期:2012-06-01 00:00:00

  • Ocular surface injuries in autoimmune dry eye. The severity of microscopical disturbances goes parallel with the severity of symptoms of dryness.

    abstract::Autoimmune dry eye (Sjögren's syndrome, SS) is a chronic systemic disease characterized by salivary and lacrimal gland inflammation and tissue damage leading to keratoconjunctivitis sicca and xerostomia. In this review attention has been devoted to the cause of the development of oxidative injuries of the ocular surfa...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Cejková J,Ardan T,Cejka C,Malec J,Jirsová K,Filipec M,Ruzicková E,Dotrelová D,Brunová B

    更新日期:2009-10-01 00:00:00

  • An immunohistochemical study on the distribution of endocrine cells in the gastrointestinal tract of the musk shrew, Suncus murinus.

    abstract::The endocrine cells in the gastrointestinal tract of the musk shrew were studied immunohistochemically. Eleven kinds of endocrine cells, immunoreactive for serotonin, somatostatin, gastrin, cholecistokinin, gastric inhibitory polypeptide, motilin, secretin, neurotensin, pancreatic glucagon, enteroglucagon and bovine p...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Kitamura N,Yamada J,Watanabe T,Yamashita T

    更新日期:1990-01-01 00:00:00

  • Immunolocalization of interleukin-1 receptor antagonist in healthy and infarcted myocardium.

    abstract::Ischemic heart disease is a widespread cause of death. During infarction, myocardial injury is mediated by release of several pro-inflammatory cytokines including multifunctional interleukin-1 (IL-1). In various tissues, IL-1-mediated deleterious effects are known to be attenuated via the over-expression of natural an...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Bonetti A,Marchini M,Ortolani F

    更新日期:2008-09-01 00:00:00

  • Dendritic cells: sentinels against pathogens.

    abstract::Dendritic cells (DCs) are the most potent antigen-presenting cells, and are regarded as "natural adjuvants" for the induction of primary T or T-dependent immunity. DCs in the peripheral sites capture and process antigens. Encounter of exogenous or endogenous stimuli mature the function of DCs, and they thus acquire T-...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Chung NP,Chen Y,Chan VS,Tam PK,Lin CL

    更新日期:2004-01-01 00:00:00

  • Fine reconstruction of the pancreatic ductular system at the onset of pancreatitis.

    abstract::The three-dimensional structure of the pancreatic ductular system (from the intercalated duct to the intercellular secretory canaliculus) is controversial and unclear. The aim of this study is to reveal the three-dimensional structure of the pancreatic ductular sysytem at the onset of pancreatitis. One day following r...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Endo H,Ashizawa N,Niigaki M,Hamamoto N,Niigaki M,Kaji T,Katsube T,Watanabe M,Naora H,Otani H,Kinoshita Y

    更新日期:2002-01-01 00:00:00

  • Morphological characteristics and peptidergic innervation in the carotid body of spontaneously hypertensive rats.

    abstract::We examined morphological characteristics of the carotid body of spontaneously hypertensive rats (SHR), those of age-matched normotensive Wistar rats (NWR), and age-matched genetically comparable Wistar Kyoto rats (WKY). We examined the distribution and abundance of four different regulatory neuropeptides: substance P...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Takahashi M,Matsuda H,Hayashida Y,Yamamoto Y,Tsukuda M,Kusakabe T

    更新日期:2011-03-01 00:00:00

  • Ecophysiological responses of the seminal vesicle of Libyan jird (Meriones libycus) to the Saharan conditions: histological, morphometric and immunohistochemical analysis.

    abstract::The Libyan jird (Meriones libycus) is a nocturnal Saharan Rodent submitted to a seasonal cycle of reproduction characterized by a short active period during spring and beginning of summer, and a long phase of sexual quiescence from the end of summer until the end of winter. During this cycle, the male reproductive org...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Belhocine M,Gernigon-Spychalowicz T,Robert AM,Schoevaert D,Bennazzoug Y,Exbrayat JM

    更新日期:2007-06-01 00:00:00

  • Cape Town solution in prolonged myocardial preservation: structural and ultrastructural study.

    abstract::This study deals with myocardial preservation after 24 hours of continuous, hypothermic and oxygenated perfusion with Cape Town (CT) solution, focusing on the morphological changes produced by preservation and reperfusion, and their possible relationship to the composition of the solution and the immediate hemodynamic...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: García-Poblete E,Alvarez L,Fernández H,Escudero C,Torralba A

    更新日期:1998-01-01 00:00:00

  • Bacillary angiomatosis. A "new" disease with a broadening clinicopathologic spectrum.

    abstract::Bacillary angiomatosis (BA) is a reactive vasoproliferative lesion occurring almost exclusively in immunocompromised individuals in response to infection by a bacillus closely related to Rochalimaea quintana. The commonest site of involvement is the skin, in the form of multiple erythematous nodules, but bacillary ang...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Tsang WY,Chan JK

    更新日期:1992-01-01 00:00:00

  • The low density lipoprotein receptor-related protein (LRP) 1 and its function in lung diseases.

    abstract::The low density lipoprotein receptor-related protein (LRP) 1 is a ubiquitously expressed, versatile cell surface transmembrane receptor involved in embryonic development and adult tissue homeostasis. LRP1 binds and endocytoses a broad spectrum of over 40 ligands identified thus far, including lipoproteins, extracellul...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Wujak L,Markart P,Wygrecka M

    更新日期:2016-07-01 00:00:00