Abstract:
:The FHIT gene encompassing the most active common human fragile region, FRA3B, has been proposed as a tumour suppressor gene for important common human carcinomas. The mechanism in which Fhit protein exerts its tumour suppressor activity is still obscure. To further understand the Fhit function associated with its intracellular localization we have investigated its cellular localization and distribution in human normal and cancerous tissues. Data of 1500 samples from immunohistochemistry showed that Fhit protein was preferentially and stably expressed in the nucleus of monocyte-derived or histiocytic lineage cells including monocytes of the circulating blood cells, macrophages of the connective tissue, Kupffer cells of the liver, alveolar macrophages or dust cells of the lung, osteoclasts of bone, microglia of the brain, epithelioid cells under chronic inflammatory conditions, foreign-body giant cells, Langerhans cells of the epidermis and dendritic cells of various kinds of human tissue, although the protein could also be infrequently observed in the nucleus of some quiescent epithelial cells. In active cells other than histiocytes, Fhit protein was detected either in cytoplasm or was negative. Neurons expressed Fhit strongly and neuroglial cells did so moderately but only in the cytoplasm. There was no Fhit protein detected in the neutrophils, lymphocytes, plasma cells and lipocytes. The present data showes that the stable nuclear localization of Fhit is not only a special marker for histiocytes with various morphologies but also may suggest the other function concerning Fhit as a signaling molecule related to anti-proliferation function. The detailed biological function related to nuclear localization of Fhit protein in the histiocytes remains to be further studied.
journal_name
Histol Histopatholjournal_title
Histology and histopathologyauthors
Zhao P,Hou N,Lu Ydoi
10.14670/HH-21.915subject
Has Abstractpub_date
2006-09-01 00:00:00pages
915-23issue
9eissn
0213-3911issn
1699-5848journal_volume
21pub_type
杂志文章abstract::Detailed characterization of the subdermal model is a significant tool for better understanding of calcification mechanisms occurring in heart valves. In previous ultrastructural investigation on six-week-implantated aortic valve leaflets, modified pre-embedding glutaraldehyde-cuprolinic-blue reactions (GA-CB) enabled...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-22.261
更新日期:2007-03-01 00:00:00
abstract::Using histopathological analysis of semi-thin sections stained with toluidine blue, we observed profound pathological changes in the islets of Langerhans of hamsters infected with the scrapie agent (strain 139H). These included cytoplasmic vesicles, nuclear swelling, and vacuolization in the islet cells. Two types of ...
journal_title:Histology and histopathology
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doi:
更新日期:1996-01-01 00:00:00
abstract::Neural stem cells are defined as clonogenic cells with self-renewal capacity and the ability to generate all neural lineages (multipotentiality). Cells with these characteristics have been isolated from the embryonic and adult central nervous system. Under specific conditions, these cells can differentiate into neuron...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-19.1261
更新日期:2004-10-01 00:00:00
abstract::Voltage-activated Ca2+ channels play an important role in synaptic transmission, signal processing and development. The immunohistochemical localization of Cav1.2 (alpha1C) and Cav2.3 (alpha1E) Ca2+ channels was studied in the developing and adult mouse organ of Corti using subunit-specific antibodies and fluorescent ...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-18.1115
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abstract::Melanopsin-expressing retinal ganglion cells (mRGCs) constitute a system in the mammalian retina used for irradiance detection, regulating non-image forming functions, such as photoentrainment of circadian rhythms, control of the pupillary light reflex, masking response, light-regulated melatonin secretion, and modula...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
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journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-27.157
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journal_title:Histology and histopathology
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doi:10.14670/HH-26.87
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-13.109
更新日期:1998-01-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-27.1315
更新日期:2012-10-01 00:00:00
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journal_title:Histology and histopathology
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更新日期:1986-07-01 00:00:00
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journal_title:Histology and histopathology
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更新日期:2007-04-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-19.1175
更新日期:2004-10-01 00:00:00
abstract::We have studied the occurrence and specific features of liver cell dysplasia (LCD) in Chinese patients showing liver cirrhosis with or without hepatocellular carcinoma (HCC). Three types of LCD (SLCD, LLCDo, LLCDe) were morphologically defined, and these types were further analyzed using karyometry, estimation of nucl...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
abstract::The study investigated the link between the potentially nephrotoxic levels of aluminium ingested in the natural diet of eucalypt leaves by koalas in the Adelaide Hills, South Australia, and the high incidence of renal failure in koalas within this habitat. Routine histology of kidney specimens revealed no pathologies ...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-19.777
更新日期:2004-07-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-19.629
更新日期:2004-04-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-15.313
更新日期:2000-01-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-18.19
更新日期:2003-01-01 00:00:00
abstract::Ultrastructural changes of the parathyroid glands of pinealectomized golden hamsters were investigated. The main changes in the parathyroid glands 1 hour and 1 day after pinealectomy compared with the control and sham-operated groups were an increase of the Golgi complexes, cisternae of the granular endoplasmic reticu...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1990-10-01 00:00:00
abstract::Cell shape is mainly determined by biophysical constraints, interacting according to non-linear dynamics upon the basic units provided by the genome. In turn, the specific configuration a cell acquires plays a fundamental, permissive role in modulating gene expression and many other complex biological functions. Cell ...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-28.155
更新日期:2013-02-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-25.1481
更新日期:2010-11-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-22.43
更新日期:2007-01-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-14.805
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journal_title:Histology and histopathology
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doi:10.14670/HH-24.13
更新日期:2009-01-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1989-04-01 00:00:00
abstract::Circadian and seasonal variations were observed in the karyometric index of pinealocytes in the cortical and medullary regions of the distal pineal body. The study involved 70 Wistar rats over a 24-hour interval (0:6, 10:00, 14:00, 18:00, 22:00, 02:00, 06:00 h) during two natural photoluminous periods, i.e. late summe...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1992-10-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract::Renal oncocytosis is a recently established disease entity characterized by numerous oncocytic tumors and diffuse involvement of oncocytic changes in renal parenchymal epithelia. In this article, we review this disease with a focus on its clinical and pathobiological aspects. Clinically, renal oncocytosis may occur in...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-27.1407
更新日期:2012-11-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1996-01-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-11-976
更新日期:2018-09-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1990-07-01 00:00:00