Abstract：
:Dysadherin, a cancer associated cell membrane glycoprotein, has been reported to downregulate E-cadherin. Aberrant expression of E-cadherin has been associated with the development of metastases in patients with cancer. Even though the expression of dysadherin and E-cadherin has been studied in primary non-small cell lung carcinoma, little is known about its expression at the distant metastases sites. We investigate by immunohistochemistry the relationship between E-cadherin and dysadherin in 111 cases of primary lung carcinomas (53 squamous cell carcinomas, 21 adenocarcinomas, 13 large cell carcinomas, and 24 small cell carcinomas), and their distant metastases. The intensity, the expression pattern and the percentage of neoplastic cell staining were recorded and the results were correlated with clinicopathological findings of the subjects. Dysadherin immunostain was expressed in 61 (54.95%) of the cases, and increased dysadherin expression was significantly correlated with tumour size (p=0.003), distant metastases (p=0.0034), and metastasis size (p=0.0008). Reduced E-cadherin expression was noted in 46 (41.45%) of the cases, and was correlated with high-grade tumour (p=0.02), infiltrative growth pattern (p=0.042), and advanced stage (p=0.032). Although the correlation between the expression of dysadherin and E-cadherin was not significant, a group of patients showed reduced E-cadherin expression with dysadherin overexpression. In lung carcinomas dysadherin expression seems to reflect tumour aggressiveness and may be considered a positive marker of poor prognosis when considered alone or/and in combination with down-regulation of E-cadherin.
journal_name
Histol Histopatholjournal_title
Histology and histopathologyauthors
Mitselou A,Batistatou A,Nakanishi Y,Hirohashi S,Vougiouklakis T,Charalabopoulos Kdoi
10.14670/HH-25.1257subject
Has Abstractpub_date
2010-10-01 00:00:00pages
1257-67issue
10eissn
0213-3911issn
1699-5848journal_volume
25pub_type
杂志文章abstract：:The aim of this study was to examine the effects of timolol in an experimental model of elevated intraocular pressure (IOP). Three episcleral veins of rats with normal IOP were cauterized. Three months later we examined the effects on anterograde axonal transport from the retinal ganglion cells (RGCs) to the superior ...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-20.1077
更新日期：2005-10-01 00:00:00
abstract：:Thyroid glands from 7 marmosets (Callithrix jacchus) of different age groups (newborn, 2 weeks, 2, 7, 8 and 11 months, and 8 years) were grown as organ culture according to Trowell at the medium/air interphase for 3 to 30 days. The morphology of thyroid tissue was well preserved until the end of the culture period. Ne...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1995-10-01 00:00:00
abstract：:Ebulin f is a ribosome-inactivating protein (RIP) present in green fruits of the dwarf elder (Sambucus ebulus L). Since dwarf elder fruits are used for food and as a medicine, we assessed the study of toxicological effects and safety of ebulin f in elderly mice, comparing these results with those reported in young ani...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-11-992
更新日期：2018-09-01 00:00:00
abstract：:Cancer is the subject of intense research around the world, but many questions about how the disease works remain unanswered. How exactly does cancer start and how do tumours grow? In fact, at present there are ten times more anticancer drugs being tested in clinical trials than there were 15 years ago. However, many ...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-27.157
更新日期：2012-02-01 00:00:00
abstract：:The need for an immunophenotypical referential framework relative to lymphoid follicle has led us to apply a panel of monoclonal and polyclonal antibodies, by means of a sensitive immunostaining method. Lymphoid follicle is an immunophenotypically complex structure made up of three lymphoid populations (B, being its b...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：:Fibrosis is a pathological feature of most chronic diseases and leads to the dysfunction of various organs. However, there is currently no effective method for treating fibrosis. In recent years, a small gas, sulfur dioxide (SO₂), which can be generated endogenously in mammals, has been found to have vasorelaxation ac...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-18-169
更新日期：2019-12-01 00:00:00
abstract：:In mouse embryos, the expression of Blimp1 has recently revealed a population of allocated primordial germ cell precursors 24 hours earlier than previously thought. Those 'blimped' precursors have been shown to give rise, by mitotic division, to germ cells only and no other cell lineages. Here, we try to understand th...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-23.1553
更新日期：2008-12-01 00:00:00
abstract：:Gp96 is the endoplasmic reticulum (ER)-resident molecular chaperone, which is involved in the correction of unfolded proteins, in the activation of proteasome-dependent ER-associated degradation of the misfolded proteins, and in activation of the protein translation that modulates polypeptide traffic into the ER. Furt...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-28.61
更新日期：2013-01-01 00:00:00
abstract：:Early observations that cultured mesenchymal stem cells (MSCs) could be induced to exhibit certain characteristics of osteocytes and chondrocytes led to the proposal that they could be transplanted for tissue repair through cellular differentiation. Therefore, many subsequent preclinical studies with transplanted MSCs...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-28.1109
更新日期：2013-09-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1988-07-01 00:00:00
abstract：:The photoreceptors of the barred owl (Strix varia) consist of rods, single cones and unequal double cones present in a ratio of about 35:1:3. In the light-adapted condition the rods are of uniform diameter along their entire length and are therefore not felt to undergo photomechanical changes. The rod outer segment co...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：:Various microscopic methods have been used to analyze the morphology and molecular distribution of cells and tissues. Using conventional procedures, however, ischemic or anoxic artifacts are inevitably caused by tissue-resection or perfusion-fixation. The in vivo cryotechnique (IVCT) was developed to overcome these pr...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-22.1281
更新日期：2007-11-01 00:00:00
abstract：:Systematic studies on hepatic stellate cells and myofibroblasts have so far mainly focused on cells located in the perisinusoidal space of Disse, the so-called littoral compartment. Here, these cells play a key role for intralobular fibrogenesis and sinusoidal capillarization. However, advanced hepatic fibrosis and ci...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-14.719
更新日期：1999-07-01 00:00:00
abstract：:An inadequate balance between oxidant species and antioxidant mechanisms may constitute the primary mechanisms of a number of pathologies. The liver plays a central role in this balance: parenchymal hepatic cells contain and export especially high levels of the antioxidant glutathione and activated Kupffer cells relea...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-22.399
更新日期：2007-04-01 00:00:00
abstract：:Most patients with ovarian cancers relapse, and treatment failure has often been attributed to chemoresistance in tumor cells. Emerging evidence indicates that tumor heterogeneity may play an equally important role. Although the idea of tumor heterogeneity is not new, little attention has been focused on applying it t...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-30.173
更新日期：2015-02-01 00:00:00
abstract：:TNFalpha exerts apoptosis throughout an intracellular transduction pathway that involves the kinase proteins TRAF-2 (integration point of apoptotic and survival signals), ASK1 (pro-apoptotic protein), MEK-4 (p38 activator and metastasis suppressor gene), JNK (stress mitogen activated protein kinase) and the transcript...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-23.1279
更新日期：2008-10-01 00:00:00
abstract：:The morphology of the rat duodenum after chronic treatment with 15% (v/v) ethanol and 4% (v/v) pentanol was studied. Male Wistar rats of experimental groups were given ethanol and pentanol for 15 weeks with food and fluid freely available. Ethanol-15% and 4% pentanol-fed rats showed a significantly reduced fluid and f...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-17.199
更新日期：2002-01-01 00:00:00
abstract：:Mitochondrial transcription factor A (mtTFA) plays a crucial role in both the transcription and maintenance of mitochondrial DNA. A high expression of mtTFA has been demonstrated in several solid tumors, and is closely associated with cancer cell survival/apoptosis and growth. However, its expression pattern in pancre...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-30.193
更新日期：2015-02-01 00:00:00
abstract：:The salamanderfish, Lepidogalaxias salamandroides (Galaxiidae, Teleostei) is endemic to southwestern Australia and inhabits shallow, freshwater pools which evaporate during the hot summer months. Burrowing into the substrate in response to falling water levels allows these fish to aestivate for extended periods of tim...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-13.1037
更新日期：1998-10-01 00:00:00
abstract：:A current concern about the biological effects of electromagnetic fields (EMF) is increasing with the wide spread use of X-band microwaves (MW, 8-10 GHz range). Gigahertz transverse electromagnetic (GTEM) field flat transmission lines are currently being used for experimental exposure of biological samples to high fre...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-26.1187
更新日期：2011-09-01 00:00:00
abstract：:The present review examines various aspects of the developmental expression of neuropeptides and of their receptors in mammalian retinas, emphasizing their possible roles in retinal maturation. Different peptidergic systems have been investigated with some detail during retinal development, including substance P (SP),...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-18.1219
更新日期：2003-10-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1986-01-01 00:00:00
abstract：:Elevated plasma levels of C-reactive protein (CRP) are associated with increased risk of cardiovascular disease. CRP immunoreactive protein is also detected in the lesions of atherosclerosis. However, it is not known whether the CRP contents of atherosclerotic lesions are associated with the initiation and progression...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-27.529
更新日期：2012-04-01 00:00:00
abstract：:Prion diseases are characterized by the accumulation of PrPSc, an altered isoform of a normal cellular protein, PrPc. The prion hypothesis holds that the process of conformational change from PrPc to PrPSc under the influence of PrPSc constitutes the basic infectious mechanism in prion diseases. It is still unknown wh...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：
更新日期：1997-07-01 00:00:00
abstract：:We have examined the ontogeny of somatostatin-, Glucagon-, Vasoactive Intestinal Polypeptide-, Substance P-, Neuropeptide Y, and Calcitonin gene-related peptide-Iike structures in the chicken retina by immunocytochemistry. Neuroblastic cells containing Substance P-Iike immunoreactivity (IR) first appeared at embryonic...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-18.1013
更新日期：2003-10-01 00:00:00
abstract：:Little is known about the morphological response of muscle after long term traction. The purpose of this study was to investigate the morphological changes of skeletal muscle during limb lengthening. After application of mini-extraskeletal fixator, the hindlimb of New Zealand white rabbit was osteotomized and then slo...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1996-04-01 00:00:00
abstract：:Targeting essential cellular pathways that determine neuronal and vascular survival can foster a successful therapeutic platform for the treatment of a wide variety of degenerative disorders in the central nervous system. In particular, oxidative cellular injury can precipitate several nervous system disorders that ma...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-19.495
更新日期：2004-04-01 00:00:00
abstract：:In recent years, the different mechanisms of epithelial cell loss which occur in mammalian and avian small intestine have been re-investigated. Information is now available for a variety of mammalian types and mechanisms can be divided into two major classes: [i] those preserving epithelial integrity by maintaining in...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-14.257
更新日期：1999-01-01 00:00:00
abstract：:Experimental Doxorubicin-exposure in utero is correlated with foetal oesophageal atresia, tracheo-oesophageal fistula, axial alterations. While gastrointestinal and respiratory defects have been largely investigated, only sporadic data have been published to date on notochordal and vertebral defects. The aim of this w...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-17.31
更新日期：2002-01-01 00:00:00
abstract：:The adrenal glands of lower vertebrates display a notable intermingling between steroidogenic and chromaffin tissues, which increases from Pisces to Aves. As in mammals, adrenal chromaffin cells contain and release, in addition to catecholamines, serotonin and several peptides, which may affect the secretory activity ...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-13.209
更新日期：1998-01-01 00:00:00
