The relative effects of severe burn injury and pre- and post-natal protein deprivation on mandibular condyle morphology.

Abstract:

:The mandible has a mixed embryological origin, and its growth is associated with the secondary cartilage of the condyle process (CP). In this area, growth depends on an array of intrinsic and extrinsic factors that influence protein metabolism. In the present study, we used an adolescent rat model to evaluate the growth and development of the CP under conditions of pre- and postnatal protein deficiency, combined with or without the stress of severe burn injury (BI). We found that protein deficiency severely undermined the growth of the CP, by altering the thickness of its constituent layers. BI is also capable of affecting CP growth, although the effect is less severe than protein deficiency. Interestingly, the summed effect of protein deficiency and BI on the CP is less severe than protein deficiency alone. A possible explanation is that the increased carbohydrates in a hypoproteic diet stimulate the production of endogenous insulin and protein synthesis, which partially compensates for the loss of lean body mass caused by BI.

journal_name

Histol Histopathol

authors

de Oliveira BC,de Oliveira F,Martini DT,Prisco CR,da Silva Riguetti MM,Liberti EA,de Campos Boldrini S

doi

10.14670/HH-25.45

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

45-54

issue

1

eissn

0213-3911

issn

1699-5848

journal_volume

25

pub_type

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