The low density lipoprotein receptor-related protein (LRP) 1 and its function in lung diseases.

Abstract:

:The low density lipoprotein receptor-related protein (LRP) 1 is a ubiquitously expressed, versatile cell surface transmembrane receptor involved in embryonic development and adult tissue homeostasis. LRP1 binds and endocytoses a broad spectrum of over 40 ligands identified thus far, including lipoproteins, extracellular matrix proteins, proteases and protease/inhibitor complexes and growth factors. Interactions with other membrane receptors and intracellular adaptors/scaffolding proteins allow LRP1 to modulate cell migration, survival, proliferation and (trans) differentiation. Because LRP1 displays a wide-range of interactions and activities, its expression and function is temporally and spatially tightly controlled. It is not, therefore, surprising that deregulation of LRP1 production and/or activity is observed in several diseases. In this review, we will systematically examine the evidence for the role of LRP1 in human pathologies placing special emphasis on LRP1-mediated pathogenesis of the lung.

journal_name

Histol Histopathol

authors

Wujak L,Markart P,Wygrecka M

doi

10.14670/HH-11-746

subject

Has Abstract

pub_date

2016-07-01 00:00:00

pages

733-45

issue

7

eissn

0213-3911

issn

1699-5848

pii

HH-11-746

journal_volume

31

pub_type

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