Physiological and pathological significance of the molecular cross-talk between autophagy and apoptosis.

abstract：:We examined the relationship between the incidence of ultrastructural changes in the alveolar septum and the extravascular lung water content. Pulmonary edema was induced in 18 mongrel dogs by either dextran (n = 12) or alloxan (n = 6) administration. Six other dogs served as controls. Extravascular lung water content...

journal_title：Histology and histopathology

authors： Oda H,Arakawa M,Kambara K,Nakahara K,Segawa T,Ando F,Kawada T,Hirakawa S,Shoumura S,Isono H

更新日期：1993-01-01 00:00:00

abstract：:Nitric oxide (NO) has opened a new and vigorous field of biological and clinical experimentation as evidenced presently by about one hundred original publications every week. Being a biological signal under physiological conditions, NO may be to pathologically affected tissues. Major insights into the ...

journal_title：Histology and histopathology

authors： Wolf G

更新日期：1997-01-01 00:00:00

abstract：:Introduction. Gastrointestinal stromal tumors (GISTs) are characterized at the molecular level by c-kit or PDGFRA oncogene mutations. Although GISTs raised major interest in past decades, population-based studies are still rare. Materials and Methods. All GISTs diagnosed in Southern Switzerland (1999-2005) were identi...

journal_title：Histology and histopathology

authors： Mazzola P,Spitale A,Banfi S,Mazzucchelli L,Frattini M,Bordoni A

更新日期：2008-11-01 00:00:00

abstract：:HtrA1 is a secreted protein which behaves as a molecular chaperone at low temperatures and as a serine protease at high temperatures. When the placenta escapes the normal growth control mechanisms, which are present during normal pregnancy, it may develop trophoblastic diseases, such as hydatidiform mole and choriocar...

journal_title：Histology and histopathology

authors： Marzioni D,Quaranta A,Lorenzi T,Morroni M,Crescimanno C,De Nictolis M,Toti P,Muzzonigro G,Baldi A,De Luca A,Castellucci M

更新日期：2009-10-01 00:00:00

abstract：:Targeting essential cellular pathways that determine neuronal and vascular survival can foster a successful therapeutic platform for the treatment of a wide variety of degenerative disorders in the central nervous system. In particular, oxidative cellular injury can precipitate several nervous system disorders that ma...

journal_title：Histology and histopathology

authors： Chong ZZ,Maiese K

更新日期：2004-04-01 00:00:00

abstract：:Earlier we reported that atherosclerotic lesions of apoE-deficient mice contained cells which stained positively with anti-S-100 antibody and that cells exhibiting the ultrastructural features of dendritic cells were present in the aortic lesions. These observations suggested that dendritic cells might be involved in ...

journal_title：Histology and histopathology

authors： Bobryshev YV,Taksir T,Lord RS,Freeman MW

更新日期：2001-07-01 00:00:00

abstract：:Our previous study on human skeletal muscle undergoing ischemia and reperfusion has revealed that granulocytes, which infiltrate the muscle tissue in large numbers, play an important role in mediating fibre injuries by producing superoxide anion (O2-) which is responsible for membrane lipid peroxidation. In the curren...

journal_title：Histology and histopathology

authors： Adembri C,Domenici LL,Formigli L,Brunelleschi S,Ferrari E,Novelli GP

更新日期：1994-10-01 00:00:00

abstract：:Neonatal hypoxic ischemia (HI) results in different extents of brain damage, and immature brain tissue is particularly sensitive to the stimulation of HI. Hypoxic-ischemic brain damage (HIBD) is a common and serious nervous system disease in neonates, for both full-term infants and preterm infants, and is one of the m...

journal_title：Histology and histopathology

authors： Yang L,Zhao H,Cui H

更新日期：2020-09-01 00:00:00

abstract：:This study concerns the results of penile biopsies in 50 patients aged 27 to 80, with secondary impotence removed with a biopty gun or during penile surgery. The biopty gun specimens were equally representative as the open biopsy ones. The cause and the degree of erectile dysfunction were determined by clinical and la...

journal_title：Histology and histopathology

authors： Malovrouvas D,Petraki C,Constantinidis E,Petraki K,Antoniadis G,Constantinidis C,Kranidis A

更新日期：1994-07-01 00:00:00

abstract：:The vacuolar-type H(+)-ATPases (V-ATPases) are a family of multi-subunit ATP-dependent proton pumps involved in diverse cellular processes, including acid/base homeostasis, receptor-mediated endocytosis, processing of proteins and signaling molecules, targeting of lysosomal enzymes, and activation of various degradati...

journal_title：Histology and histopathology

authors： Sun-Wada GH,Wada Y

更新日期：2010-12-01 00:00:00

abstract：:The bronchial-associated lymphoid tissue (BALT) is a lymphoepithelial organ, related to the immune defence of the lung and to alveolar clearance, which changes size in certain states of disease. Changes in the size of BALT were quantified and compared, and Spearman's test was used to test the relation with the bronchi...

journal_title：Histology and histopathology

authors： Escolar Castellón JD,Escolar Castellón A,Roche Roche PA,Miñana Amada C

更新日期：1992-07-01 00:00:00

abstract：:Glucose uptake and metabolism are essential for proliferation and survival of cells, and are supposed to be enhanced in actively proliferating cell systems such as embryonic and cancer tissues. Glucose uptake is usually carried out through glucose transporters. In the developing fetal lung, metabolism of glucose is th...

journal_title：Histology and histopathology

authors： Ito T,Noguchi Y,Udaka N,Kitamura H,Satoh S

更新日期：1999-07-01 00:00:00

abstract：:Calcium/calmodulin-dependent protein kinase II (CaMKII) is considered one of the key intracellular signaling proteins for development of neuropathy. We analyzed the expression of total CaMKII (tCaMKII) and its alpha, beta, gamma and delta isoforms in dorsal root ganglia (DRG) in a rat model of Diabetes mellitus type I...

journal_title：Histology and histopathology

authors： Ferhatovic L,Jelicic Kadic A,Boric M,Puljak L

更新日期：2014-05-01 00:00:00

abstract：:Morphological and biochemical alterations have been described in neurons of the aged human brain. However, the cell death process associated with neuronal senescence remains to be elucidated. Apoptosis and autophagic degeneration, two modes of programmed cell death described in embryogenesis and tissue renewal in adul...

journal_title：Histology and histopathology

authors： Anglade P,Vyas S,Hirsch EC,Agid Y

更新日期：1997-07-01 00:00:00

abstract：:The coexistence of serotonin and cholecystokinin was studied in foetal sheep lungs at pseudoglandular stage of development by light microscopic immunohistochemistry. The coexistence was examined by staining consecutive sections with the different antibodies. Serotonin and cholecystokinin immunoreactivity was found wit...

journal_title：Histology and histopathology

authors： Balaguer L,Romano J,Ruiz-Pesini P

更新日期：1994-01-01 00:00:00

abstract：:The aim of our study was to evaluate corneal cell proliferation and apoptosis in cases of granular, macular and lattice dystrophy, and to provide evidence which may help to clarify whether apoptosis is a pathogenic factor in any of these dystrophies. The study group comprised 39 eyes (from 33 patients) which had under...

journal_title：Histology and histopathology

authors： Szentmáry N,Takács L,Berta A,Szende B,Süveges I,Módis L

更新日期：2007-08-01 00:00:00

abstract：:Bone marrow features in stable-phase chronic myelogenous leukemia (CML) are characterized by a striking heterogeneity which is determinable by appropriate means including representative pre-treatment trephine biopsies, immunohistochemistry and morphometry. Cell lineages involved to a variable extent consist not only o...

journal_title：Histology and histopathology

authors： Thiele J,Kvasnicka HM,Fischer R

更新日期：1999-10-01 00:00:00

abstract：BACKGROUND:Gelatinases include matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9). The abnormal expressions of gelatinases are implicated in the pathogenesis of extracellular matrix (ECM) accumulation. Apolipo-protein E (apoE) is an important plasma protein in cholesterol homeostasis and plays a ...

journal_title：Histology and histopathology

authors： Zhou TB,Qin YH,Lei FY,Su LN,Zhao YJ,Huang WF

更新日期：2012-02-01 00:00:00

abstract：:Current data on the influence of neuropeptides on the growth, structure and function of cells comprising the hypothalamo-pituitary-adrenal axis were presented and discussed. The action of vasopressin, oxytocin, neurotensin, bombesin, neuropeptide Y, substance P and VIP have been evaluated. The hypothesis has been intr...

journal_title：Histology and histopathology

authors： Malendowicz LK

更新日期：1993-01-01 00:00:00

abstract：:Thyroid hormones (TH) stimulate oxidative metabolism in many tissues in the body, but testis is not one of them. Therefore, in this sense, testis is not considered as a target organ for TH. However, recent findings clearly show that TH have significant functions on the testis in general, and Leydig cells in particular...

journal_title：Histology and histopathology

authors： Mendis-Handagama SM,Ariyaratne HB

更新日期：2004-07-01 00:00:00

abstract：:Much effort has been made by researchers to elucidate the complex biology of breast cancer stem cells (BCSCs), a small subset of breast tumor cells that display stem cell properties, drive tumor initiation, and growth. In recent years, it has been suggested that BCSCs could be responsible for the process of metastasis...

journal_title：Histology and histopathology

authors： Schwarz-Cruz Y Celis A,Espinosa M,Maldonado V,Melendez-Zajgla J

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Protein tyrosine kinase 7 (PTK7) is a member of receptor protein tyrosine kinase-like molecules, which is involved in tumorigenesis. However, the association between PTK7 expression and its pathological significance in survival prognosis remains under investigation. The purpose of this meta-analysis is to cl...

journal_title：Histology and histopathology

authors： Chen G,Qi S,Yang X,Chen W

更新日期：2018-04-01 00:00:00

abstract：:We review the morphofunctional characteristics of CD34+ stromal fibroblastic/fibrocytic cells (CD34+ SFCs) and report our observations. We consider the following aspects of CD34+ SFCs: A) The confusing terms applied to this cell type, often combining the prefix CD34 with numerous names, including fibroblasts, fibrocyt...

journal_title：Histology and histopathology

authors： Díaz-Flores L,Gutiérrez R,García MP,Sáez FJ,Díaz-Flores L Jr,Valladares F,Madrid JF

更新日期：2014-07-01 00:00:00

abstract：:In the present work we analyze the cerebellum of chronic parkinsonian monkeys in order to clarify whether chronic mesencephalic depletion is associated with long term activation of the cerebellar neurons in chronic Parkinsonism. In our study, we observed a persistent activation of Purkinje cells in the cerebellum of c...

journal_title：Histology and histopathology

authors： Heman P,Barcia C,Gómez A,Ros CM,Ros-Bernal F,Yuste JE,de Pablos V,Fernandez-Villalba E,Toledo-Cárdenas MR,Herrero MT

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Gastric Cardiac Cancer (GCC) has high incidence and poor prognosis requiring early screening of high-risk populations. Minichromosome maintenance (MCM) proteins are used as diagnostic-biomarkers in many cancers but not validated for GCC. We evaluate MCM protein 2 (MCM2), comparing it with the validated marke...

journal_title：Histology and histopathology

authors： Liu M,Li JS,Tian DP,Huang B,Rosqvist S,Su M

更新日期：2013-04-01 00:00:00

abstract：:Aurora A and Aurora B are serine-threonine kinase proteins which have both been implicated in human carcinogenesis through development of aneuploidy and chromosomal instability. The aim of the study is to assess the correlation of both markers with clinical and pathological parameters in patients with bladder cancer o...

journal_title：Histology and histopathology

authors： Bufo P,Sanguedolce F,Tortorella S,Cormio L,Carrieri G,Pannone G

更新日期：2010-11-01 00:00:00

abstract：:Prion diseases are characterized by the accumulation of PrPSc, an altered isoform of a normal cellular protein, PrPc. The prion hypothesis holds that the process of conformational change from PrPc to PrPSc under the influence of PrPSc constitutes the basic infectious mechanism in prion diseases. It is still unknown wh...

journal_title：Histology and histopathology

authors： Brown DR,Kretzschmar HA

更新日期：1997-07-01 00:00:00

abstract：:Chronic lung allograft dysfunction (CLAD) still remains a major drawback in the outcome following lung transplantation (LTx). New therapeutic strategies are warranted. Growth factors and their receptors like platelet-derived growth factor-receptor (PDGFR) and vascular endothelial growth factor-receptor (VEGFR), may pl...

journal_title：Histology and histopathology

authors： Keil L,Schaub AL,Hirt SW,Schmid C,Lehle K,von Suesskind-Schwendi M

更新日期：2019-07-01 00:00:00

abstract：:The pathophysiologic mechanism by which chronic hypoxia causes pulmonary hypertension is unknown. If anti-platelet agents, or other pharmacologic interventions, altered the pulmonary vascular changes induced by hypoxia, information concerning the pathogenesis of the pulmonary hypertension or the potential therapeutic ...

journal_title：Histology and histopathology

authors： Keith IM,Will JA,Huxtable RJ,Weir K

更新日期：1987-04-01 00:00:00

abstract：:The effects of the administration of cyclophosphamide to male rats at doses of 400 mg/m2 for a period of 5 days and of 200 mg/m2 over two five-day cycles interrupted by a 21-day break reveal differences in the ultrastructural morphology of gonadotrophic cells between treated animals and normal controls. The ultrastruc...

journal_title：Histology and histopathology

authors： Poblador MS,Rojas C,Raya A,Casares JA,Aparicio J,Lancho Alonso JL

更新日期：1990-04-01 00:00:00