Vacuolar-type proton pump ATPases: roles of subunit isoforms in physiology and pathology.

Abstract:

:The vacuolar-type H(+)-ATPases (V-ATPases) are a family of multi-subunit ATP-dependent proton pumps involved in diverse cellular processes, including acid/base homeostasis, receptor-mediated endocytosis, processing of proteins and signaling molecules, targeting of lysosomal enzymes, and activation of various degradation enzymes. These fundamental cellular activities are naturally related to higher order physiological functions in multicellular organisms. V-ATPases are involved in several physiological processes, including renal acidification, bone resorption, and neurotransmitter accumulation. Both forward- and reverse-genetic approaches have revealed that V-ATPase malfunction causes diseases and/or pathophysiological states, demonstrating its diverse roles in normal physiology. Here, we focus on the recent insights into the function of mammalian V-ATPase in highly differentiated cells and tissues.

journal_name

Histol Histopathol

authors

Sun-Wada GH,Wada Y

doi

10.14670/HH-25.1611

subject

Has Abstract

pub_date

2010-12-01 00:00:00

pages

1611-20

issue

12

eissn

0213-3911

issn

1699-5848

journal_volume

25

pub_type

杂志文章,评审
  • New models towards assessing anti-cancer therapeutics.

    abstract::Cancer is the subject of intense research around the world, but many questions about how the disease works remain unanswered. How exactly does cancer start and how do tumours grow? In fact, at present there are ten times more anticancer drugs being tested in clinical trials than there were 15 years ago. However, many ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-27.157

    authors: Romero-Camarero I,Barajas-Diego M,Castellanos-Martín A,García-Martín Á,Varela G,Abad M,Ludeña MD,Pérez-Losada J,Sánchez-García I

    更新日期:2012-02-01 00:00:00

  • New insights into the cytoplasmic function of PML.

    abstract::PML is a tumour suppressor inactivated in Acute Promyelocytic Leukaemia (APL). PML is the essential component of a subnuclear structure called the PML nuclear body (PML-NB), which is disrupted in APL. By targeting different cellular proteins to this structure, PML can either hamper or potentiate their functions. The P...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-22.937

    authors: Salomoni P,Bellodi C

    更新日期:2007-08-01 00:00:00

  • Epidemiology and molecular biology of gastrointestinal stromal tumors (GISTs): a population-based study in the South of Switzerland, 1999-2005.

    abstract::Introduction. Gastrointestinal stromal tumors (GISTs) are characterized at the molecular level by c-kit or PDGFRA oncogene mutations. Although GISTs raised major interest in past decades, population-based studies are still rare. Materials and Methods. All GISTs diagnosed in Southern Switzerland (1999-2005) were identi...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-23.1379

    authors: Mazzola P,Spitale A,Banfi S,Mazzucchelli L,Frattini M,Bordoni A

    更新日期:2008-11-01 00:00:00

  • Microvascular changes in relation to inflammation and epidermal hyperplasia in chronic cutaneous lesions of psoriasis vulgaris.

    abstract::Epidermal proliferation, inflammatory changes and microvascular augmentation are prominent features of chronic cutaneous psoriatic lesions. The objective of this study was the investigation of blood and lymphatic microvascular changes in relation to epidermal changes and inflammatory infiltration in dermis. Immunohist...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-11-811

    authors: Výbohová D,Adamicová K,Mellová Y,Hešková G

    更新日期:2017-05-01 00:00:00

  • Primordial germ cell specification: the importance of being 'blimped'.

    abstract::In mouse embryos, the expression of Blimp1 has recently revealed a population of allocated primordial germ cell precursors 24 hours earlier than previously thought. Those 'blimped' precursors have been shown to give rise, by mitotic division, to germ cells only and no other cell lineages. Here, we try to understand th...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-23.1553

    authors: Chuva de Sousa Lopes SM,Roelen BA

    更新日期:2008-12-01 00:00:00

  • Effects of chronic administration of either ethanol or pentanol on rat duodenum morphology.

    abstract::The morphology of the rat duodenum after chronic treatment with 15% (v/v) ethanol and 4% (v/v) pentanol was studied. Male Wistar rats of experimental groups were given ethanol and pentanol for 15 weeks with food and fluid freely available. Ethanol-15% and 4% pentanol-fed rats showed a significantly reduced fluid and f...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-17.199

    authors: Vaquera J,Vaquera A,Girbes T

    更新日期:2002-01-01 00:00:00

  • A potential ex vivo infection model of human induced pluripotent stem cell-3D organoids beyond coronavirus disease 2019.

    abstract::The novel coronavirus disease 2019 (COVID-19) outbreak began in the city of Wuhan, whereupon it rapidly spread throughout China and subsequently across the world. Rapid transmission of COVID-19 has caused wide-spread panic. Many established medications have been used to treat the disease symptoms; however, no specific...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-18-223

    authors: Zhou H,Liu LP,Fang M,Li YM,Zheng YW

    更新日期:2020-10-01 00:00:00

  • Primary perivascular epithelioid cell tumor of the liver not related to hepatic ligaments: hepatic PEComa as an emerging entity.

    abstract::Primary perivascular epithelioid cell tumor (PEComa) of the liver is a very rare example of an emerging family of hepatic PEC tumors. Only few cases have been described so far. We report the case of a large but benign hepatic PEComa in a 53-year-old man without signs of tuberous sclerosis. In contrast to recently desc...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-23.1185

    authors: Zimmermann A,von der Brelie C,Berger B,Kappeler A,Candinas D

    更新日期:2008-10-01 00:00:00

  • Nigral degeneration correlates with persistent activation of cerebellar Purkinje cells in MPTP-treated monkeys.

    abstract::In the present work we analyze the cerebellum of chronic parkinsonian monkeys in order to clarify whether chronic mesencephalic depletion is associated with long term activation of the cerebellar neurons in chronic Parkinsonism. In our study, we observed a persistent activation of Purkinje cells in the cerebellum of c...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-27.89

    authors: Heman P,Barcia C,Gómez A,Ros CM,Ros-Bernal F,Yuste JE,de Pablos V,Fernandez-Villalba E,Toledo-Cárdenas MR,Herrero MT

    更新日期:2012-01-01 00:00:00

  • Overexpression of YES1 is associated with favorable prognosis and increased platinum-sensitivity in patients with epithelial ovarian cancer.

    abstract:AIMS:The prognostic application of YES1 in epithelial ovarian cancer (EOC) is currently unclear. We aimed to investigate the expression of YES1 and its correlation with survival outcome in patients with EOC. METHODS:A retrospective study of patients diagnosed with EOC at the Cancer Center, Sun Yat-Sen University, Guan...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-18-203

    authors: Zhou Y,Chen P,Huang Q,Wan T,Jiang Y,Jiang S,Yan S,Zheng M

    更新日期:2020-07-01 00:00:00

  • Comparison of the dysadherin and E-cadherin expression in primary lung cancer and metastatic sites.

    abstract::Dysadherin, a cancer associated cell membrane glycoprotein, has been reported to downregulate E-cadherin. Aberrant expression of E-cadherin has been associated with the development of metastases in patients with cancer. Even though the expression of dysadherin and E-cadherin has been studied in primary non-small cell ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-25.1257

    authors: Mitselou A,Batistatou A,Nakanishi Y,Hirohashi S,Vougiouklakis T,Charalabopoulos K

    更新日期:2010-10-01 00:00:00

  • GADD153 is an independent prognostic factor in melanoma: immunohistochemical and molecular genetic analysis.

    abstract::The main role of growth arrest and DNA damage-inducible (GADD) genes is to block proliferation at G1 and G2 checkpoints in response to DNA damage. The goal of this study was to examine the expression of GADD genes in primary melanomas with respect to prognosis. GADD34 was found in 73% of the primary melanomas investig...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-17.805

    authors: Korabiowska M,Cordon-Cardo C,Betke H,Schlott T,Kotthaus M,Stachura J,Brinck U

    更新日期:2002-01-01 00:00:00

  • Cyclosporin A-induced changes of the thymic microenvironment. A review of morphological studies.

    abstract::Cyclosporin A is an immunosuppressive drug, which disrupts the activation of peripheral T-lymphocyte pool and blocks the maturation of thymocytes within the thymus. Normally, thymic nonlymphoid cells provide the optimal inductive microenvironment for development of T-lymphocytes. After application of cyclosporin A the...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-13.1183

    authors: Milićević NM,Milićević Z

    更新日期:1998-10-01 00:00:00

  • Novel PD-L1 mAb HC16 reveals upregulation of PD-L1 in BAC subtype.

    abstract::Programmed death-ligand 1 (PD-L1) is an inhibitory transmembrane protein that can prevent autoimmune response. Upregulated PD-L1 serves as a predictive biomarker for patients who may respond well to immune checkpoint therapies. However, variable associations of PD-L1 level with prognoses have been reported. In this st...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-18-272

    authors: Su BC,Ting CH,Lee KY,Wu SM,Feng PH,Chan YF,Chen JY

    更新日期:2020-10-28 00:00:00

  • Histopathological changes in the eyes in systemic lupus erythematosus: an electron microscope and immunohistochemical study.

    abstract::This paper reports the histopathological findings in the eyes of a 26-year-old female patient diagnosed with systemic lupus erythematosus (SLE) with peripheral neuropathy. The patient had no significant ocular problems. She died of pneumonia after two years of suffering. The eyeballs were procured at autopsy and the r...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-20.373

    authors: Nag TC,Wadhwa S

    更新日期:2005-04-01 00:00:00

  • Mononuclear cell subpopulations and infiltrating lymphocytes in erythema dyschromicum perstans and vitiligo.

    abstract::Erythema dyschromicum perstans (EDP) and vitiligo are two cutaneous pigmentary dermatoses of unknown etiology. In the present study, the leukocyte infiltrates in the affected skin of EDP and vitiligo patients were studied using the avidin-biotin (ABC) immunoperoxidase technique and monoclonal antibodies which recognis...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Gross A,Tapia FJ,Mosca W,Perez RM,Briceño L,Henriquez JJ,Convit J

    更新日期:1987-07-01 00:00:00

  • Anti-platelet agents reduce morphological changes of chronic hypoxic pulmonary hypertension.

    abstract::The pathophysiologic mechanism by which chronic hypoxia causes pulmonary hypertension is unknown. If anti-platelet agents, or other pharmacologic interventions, altered the pulmonary vascular changes induced by hypoxia, information concerning the pathogenesis of the pulmonary hypertension or the potential therapeutic ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Keith IM,Will JA,Huxtable RJ,Weir K

    更新日期:1987-04-01 00:00:00

  • Monocarboxylate transporters: past, present, and future.

    abstract::We review here the 14 members of the Monocarboxylate transporter family (MCTs), their relationship based on sequence homology. The range of substrates transported by different members of this family extends from the standard monocarboxylate metabolites, lactic and pyruvic acids, to aromatic amino acids and thyroid hor...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-24.243

    authors: Merezhinskaya N,Fishbein WN

    更新日期:2009-02-01 00:00:00

  • Markers of squamocolumnar junction cells in normal tonsils and oropharyngeal cancer with and without HPV infection.

    abstract::HPV infection has been identified recently as the causative agent of a subset of squamous cell carcinomas arising in oropharyngeal tonsils. Factors influencing the susceptibility of tonsillar epithelium to HPV-induced oncogenesis are far from being elucidated. A 5-protein signature including cytokeratin (CK)7, anterio...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-11-590

    authors: Morbini P,Capello GL,Alberizzi P,Benazzo M,Paglino C,Comoli P,Pedrazzoli P

    更新日期:2015-07-01 00:00:00

  • Coexistence of serotonin and cholecystokinin in paraneurons of the foetal sheep lung.

    abstract::The coexistence of serotonin and cholecystokinin was studied in foetal sheep lungs at pseudoglandular stage of development by light microscopic immunohistochemistry. The coexistence was examined by staining consecutive sections with the different antibodies. Serotonin and cholecystokinin immunoreactivity was found wit...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Balaguer L,Romano J,Ruiz-Pesini P

    更新日期:1994-01-01 00:00:00

  • Potential therapeutic effect of SO₂ on fibrosis.

    abstract::Fibrosis is a pathological feature of most chronic diseases and leads to the dysfunction of various organs. However, there is currently no effective method for treating fibrosis. In recent years, a small gas, sulfur dioxide (SO₂), which can be generated endogenously in mammals, has been found to have vasorelaxation ac...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-18-169

    authors: Wang XB,Cui H,Du JB

    更新日期:2019-12-01 00:00:00

  • Comparison of histological characteristics and expression of CD3 and CD79a among the hemal nodes, lymph nodes and spleens of yaks (Bos grunniens).

    abstract::This experiment compared the histological characteristics and distribution of CD3 and CD79a among yak lymph nodes, hemal nodes and spleen. The three organs from ten clinically healthy newborn and adult yaks were studied using histology and immunohistochemistry. The yak hemal nodes, which consisted of blood sinuses, ly...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-18-030

    authors: Huang Y,Cui Y,Yu S,He J,He Y,Zhang Q,Liu P,Pu Y,Sun J,Kang X

    更新日期:2019-03-01 00:00:00

  • Immune complex-mediated glomerulopathy in Barbus graellsi infected with Myxobolus spp.

    abstract::Membranous glomerulonephritis caused in Barbus graellsi by myxosporidian infections have been studied by electron microscopy and immunoelectron microscopy techniques. This study indicates that Myxosporidian infection produces a chronic severe aggression. Spores reach the spleen, the kidney and the liver, where they ar...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Peribañez MA,del Cacho E,Castillo JA,Arnal MC

    更新日期:1993-10-01 00:00:00

  • Selective immunolabeling of early gestational cytotrophoblast and its neoplastic counterpart by the monoclonal antibody Ber-EP4.

    abstract::This report presents preliminary observations on the distribution of an epithelial surface antigen in human trophoblastic cells studied with the monoclonal antibody Ber-EP4 by means of an immunoperoxidase technique. Three cases of gestational choriocarcinoma and 20 cases of both villous and extravillous trophoblast, i...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Babury RA,Moscovic EA

    更新日期:1993-04-01 00:00:00

  • Use of a fibroblastic matrix improves the results of mesothelial-cell seeding on vascular prostheses of polytetrafluoroethylene.

    abstract::Mesothelial cells (MC) obtained from the human omentum are a good alternative to the use of endothelial cells (EC) as a covering for vascular prostheses of polytetrafluoroethylene (PTFE), given the antithrombogenic properties and good behavior in vitro of mesothelial cells. We studied the behaviour of mesothelial cell...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Buján J,García-Honduvilla N,Hernando A,Bellón JM

    更新日期:1995-10-01 00:00:00

  • Immunocytohistochemical characterization of pituitary cells of the bluefin tuna, Thunnus thynnus L.

    abstract::In this paper we report the first complete mapping of the pituitary in a tuna species. The various different adenohypophysis cell types of the bluefin tuna, Thunnus thynnus L. have been identified and located using different antisera against mammalian and piscine hormones and various histochemical techniques: PAS, Alc...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-16.443

    authors: Rodríguez-Gómez FJ,Rendón-Unceta MC,Piñuela C,Muñoz-Cueto JA,Jiménez-Tenorio N,Sarasquete C

    更新日期:2001-04-01 00:00:00

  • Ultrastructural evidence in vitro of osteoclast-induced degradation of calcium phosphate ceramic by simultaneous resorption and phagocytosis mechanisms.

    abstract::Osteoclasts are physiological polykaryons specialized in the resorption of calcified tissue. In the context of the clinical use of calcium-phosphate (CaP) ceramics as bone substitutes, this study used transmission electron microscopy to investigate the in vitro mechanisms of CaP ceramic degradation by osteoclastic cel...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-16.37

    authors: Heymann D,Guicheux J,Rousselle AV

    更新日期:2001-01-01 00:00:00

  • Hydroxy group requirement for halofuginone-dependent inhibition of muscle fibrosis and improvement of histopathology in the mdx mouse model for Duchenne muscular dystrophy.

    abstract::In Duchenne muscular dystrophy (DMD), the progressive loss of muscle and its ability to function is associated with significant fibrosis, representing the major disease complication in patients. Halofuginone, a halogenated analog of the naturally occurring febrifugine, has been shown to prevent fibrosis in various ani...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-18-083

    authors: Wellner G,Mordechay S,Evans P,Genin O,Pines M,Halevy O

    更新日期:2019-07-01 00:00:00

  • Antioxidant enzymes in renal cell carcinoma.

    abstract::The aim of the study was to estimate the significance of oxidative/nitrosative damage and expression of antioxidant enzymes in renal cell carcinomas (RCC). For this we investigated immunohistochemically six antioxidant enzymes (AOEs) including MnSOD, ECSOD, thioredoxin, thioredoxin reductase, and gammaglutamyl cystein...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-21.157

    authors: Soini Y,Kallio JP,Hirvikoski P,Helin H,Kellokumpu-Lehtinen P,Tammela TL,Peltoniemi M,Martikainen PM,Kinnula LV

    更新日期:2006-02-01 00:00:00

  • Thermotherapy for Harding-Passey melanoma: light and electron microscopic study.

    abstract::The changes of implanted Harding-Passey melanoma in C57Bl/6J mice following treatment with wholebody hyperthermia were studied. The treated tumours showed a progressive growth delay, cellular and architectural irregularities as well as cell injury characteristics. The presence of distended and irregular blood vessels,...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Vicente V,Gómez M,Gómez S,Calderon F,Canteras M,Cremades A

    更新日期:1987-10-01 00:00:00