Nigral degeneration correlates with persistent activation of cerebellar Purkinje cells in MPTP-treated monkeys.

Abstract:

:In the present work we analyze the cerebellum of chronic parkinsonian monkeys in order to clarify whether chronic mesencephalic depletion is associated with long term activation of the cerebellar neurons in chronic Parkinsonism. In our study, we observed a persistent activation of Purkinje cells in the cerebellum of chronic parkinsonian macaques, characterized by the expression of c-Fos, which correlated with dopaminergic degeneration. These results are compatible with the results observed in fMRI in Parkinson's disease patients, and may contribute to the understanding of additional alterations in the brain circuitry in Parkinsonism.

journal_name

Histol Histopathol

authors

Heman P,Barcia C,Gómez A,Ros CM,Ros-Bernal F,Yuste JE,de Pablos V,Fernandez-Villalba E,Toledo-Cárdenas MR,Herrero MT

doi

10.14670/HH-27.89

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

89-94

issue

1

eissn

0213-3911

issn

1699-5848

journal_volume

27

pub_type

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