Abstract:
BACKGROUND:Protein tyrosine kinase 7 (PTK7) is a member of receptor protein tyrosine kinase-like molecules, which is involved in tumorigenesis. However, the association between PTK7 expression and its pathological significance in survival prognosis remains under investigation. The purpose of this meta-analysis is to clarify the prognostic value of PTK7 expression in human malignancies. METHODS:A comprehensive literature search was performed in databases of PubMed, Embase and Cochrane Library. The statistical procedures were conducted by Stata 14.0 and the effect size was displayed by model of relative risk. Subgroup analyses were additionally implemented to disclose the potential confounding elements. Sensitivity analysis was used for evaluating the outcome stability, both Begg's test and Egger's test were utilized to detect the publication bias across the included studies. RESULTS:We identified 11 studies published with a total sample-size of 2431 participants. Patients with higher PTK7 expression were significantly associated with cancer risk (RR =2.995, 95% CI: 1.048-8.56, p=0.041, random model), and histological grade (RR = 0.696, 95% CI: 0.499-0.972, p=0.033, random model). PTK7 was also found to be an unfavorable prognostic marker for overall survival (HR = 2.621 95% CI: 1.980-3.468, p=0.000, fixed model) and shorter disease free survival (HR =2.242, 95% CI: 1.112-4.521, p=0.024, random model). CONCLUSIONS:Higher expression of PTK7 significantly indicates worse prognosis in human malignancies.
journal_name
Histol Histopatholjournal_title
Histology and histopathologyauthors
Chen G,Qi S,Yang X,Chen Wdoi
10.14670/HH-11-933subject
Has Abstractpub_date
2018-04-01 00:00:00pages
379-388issue
4eissn
0213-3911issn
1699-5848pii
HH-11-933journal_volume
33pub_type
杂志文章,meta分析abstract::The techniques for light and electron microscopic radioautography developed in our laboratory are described. The outlines of the applications to various tissues and organs are also briefly summarized. First, the techniques are explained in detail. These techniques can be divided into two categories, i.e., chemical fix...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:
更新日期:1997-10-01 00:00:00
abstract::The histological and ultrastructural features, as well as the immunoreactivity of one case of uncommon primary papillary and psammomatous adenocarcinoma of the umbilicus are studied in the present work. The observations have been undertaken in a nine-year follow-up, and have included the primitive tumour, two local re...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1993-10-01 00:00:00
abstract::Chaperone-mediated autophagy (CMA), a selective form of autophagy, where cellular proteins with KFERQ-like motif are targeted to the lysosome for degradation, is necessary to maintain cellular homeostasis. The role of CMA in neurodegenerative diseases has been extensively studied in the past decades, with defects in t...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-18-202
更新日期:2020-07-01 00:00:00
abstract::Diabetic nephropathy (DN) is a major cause of end-stage renal disease (ESRD), however, specific treatment for DN has not yet been elucidated. Therefore, it is critically important to understand the molecular mechanism underlying DN to develop cause-related therapeutic strategy. To date, various factors such as hemodyn...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-11-777
更新日期:2016-10-01 00:00:00
abstract::Recent evidence has shown that vascular function depends not only on cells within the vessels, but is also significantly modulated by circulating cells derived from the bone marrow. A number of studies indicate that an early reendothelialization by circulating endothelial precursors after vascular injury prevents exce...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-22.547
更新日期:2007-05-01 00:00:00
abstract::To clarify the role of REG IV, a new member of the regenerating gene (REG) family, in tumorigenesis and progression of colorectal carcinoma (CRC), 320 CRC specimens, 123 corresponding adjacent non-cancerous mucosa (ANCMs), 46 corresponding non-adjacent non-cancerous mucosa (NANCMs) and 86 adenomas were investigated im...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-25.473
更新日期:2010-04-01 00:00:00
abstract::Recently, the characterization of mucinous tubular and spindle-cell carcinoma (MTSCC) has been established. MTSCC predominantly occurs in females. This tumor is histologically characterized by eosinophilic cytoplasm, elongated and anastomosing tubules, myxomatous stroma and low-grade nuclear cytology. Proliferation of...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-20.221
更新日期:2005-01-01 00:00:00
abstract::This study concerns the results of penile biopsies in 50 patients aged 27 to 80, with secondary impotence removed with a biopty gun or during penile surgery. The biopty gun specimens were equally representative as the open biopsy ones. The cause and the degree of erectile dysfunction were determined by clinical and la...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1994-07-01 00:00:00
abstract::The main objective of this ultrastructural study was to gain a better understanding of the involvement of brain vasculature in clearance of proteins from edematous fluid. For this purpose, both native and modified (cationized, glucosylated, and mannosylated) bovine serum albumin-gold complexes (BSA-G, catBSA-G, glucBS...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-13.647
更新日期:1998-07-01 00:00:00
abstract::The possible involvement of endogenous vasoactive intestinal peptide (VIP), cholecystokinin (CCK) and neurotensin (NT) in the control of thymocyte proliferation has been investigated in vivo in the immature rat. For this task, we have studied the effects of the administration of selective antagonists of the receptors ...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-16.155
更新日期:2001-01-01 00:00:00
abstract::Histochemical distribution of glycoproteins, carbohydrates and proteins rich in different amino acids were studied using histological and histochemical procedures, in Senegal sole, Solea senegalensis (Kaup, 1858) larvae from hatching until day 15. Glycogen, proteins and glycoproteins were detected in the yolk-sac of t...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1996-10-01 00:00:00
abstract::Laminin (LAM) and fibronectin (FI) are regarded as major components of the glomerular extracellular matrix. The aim of this study was to define the distribution of LAM and FI in primary glomerulonephritis (GN) and GN of systemic lupus erythematosus (SLE) and to correlate the type of glomerular disorders with possible ...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1993-07-01 00:00:00
abstract::Telocytes (TC) are a class of interstitial cells present in heart. Their characteristic feature is the presence of extremely long and thin prolongations (called telopodes). Therefore, we were interested to see whether or not TCs form networks in normal cardiac tissues, as previously suggested. Autopsy samples of card...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-27.807
更新日期:2012-06-01 00:00:00
abstract::Takeda-G-protein-receptor-5 (TGR5) is a receptor for bile acids and its expression has been described in a variety of tissues and species. Characterization of TGR5 distribution and function has been investigated in drug discovery for the treatment of metabolic diseases in humans. Because dogs are one of the species us...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-18-025
更新日期:2019-01-01 00:00:00
abstract::Huntington's disease (HD) is a tremendously debilitating disorder that strikes relatively young individuals and progresses rapidly over the next ten to fifteen years inducing a loss of cognitive and motor skills and eventually death occurs. The primary locus of the disorder is a polyglutamine expansion of the protein ...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-23.237
更新日期:2008-02-01 00:00:00
abstract::Differentiating nonspecific interstitial pneumonia (NSIP) from usual interstitial pneumonia (UIP) is important for the determination of both treatment and prognosis. Using two-dimensional fluorescence difference gel electrophoresis (2D-DIGE), we examined 8 UIPs, 8 NSIPs, and 30 normal lung tissues. Comparisons with co...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-29.377
更新日期:2014-03-01 00:00:00
abstract::Factor H (FH) is the predominant soluble inhibitor of the complement system. With a concentration of 200-800 microg/ml in human and rat plasma it acts as a cofactor for the soluble factor I (FI)-mediated cleavage of the component C3b to iC3b. Furthermore it competes with factor B for binding to C3b and C3(H2O) and pro...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-21.93
更新日期:2006-01-01 00:00:00
abstract::The acute and chronic effects of bombesin (BM) on the structure and function of rat adrenal cortex were investigated by morphometric and radioimmunological techniques. An intraperitoneal bolus injection of 2 micrograms/rat BM markedly raised plasma corticosterone (B) concentration (PBC). The intraperitoneal BM infusio...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
abstract::Sulfur dioxide (SO₂) is a toxic gas and air pollutant. The toxic effects of SO₂ have been extensively studied. Oxidative damage due to SO₂ can occur in multiple organs. Inhaled SO₂ can also cause chromosomal aberrations, DNA damage and gene mutations in mammals. However, SO₂ can also be generated from the sulfur-conta...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-11-904
更新日期:2017-12-01 00:00:00
abstract::Light and electron microscopy were used to analyze the epithelial lining of odontogenic cysts excised from edentulous regions of the jaws. Clinically, three cases were identified as keratocysts, and 21 cases as cysts other than keratocysts ("non-keratocysts"). The epithelium of the former was found to achieve keratini...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1996-04-01 00:00:00
abstract::Morphological, histochemical and ultrastructural investigations on epiphyseal apparatus of Rana Esculenta were made. The most important findings were the following: 1) metaphyseal cartilage is localized inside proximal diaphyseal compact bone as a plug; 2) metaphyseal cartilage do not reduce in thickness during ageing...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1992-04-01 00:00:00
abstract::Monoclonal antibody against histiocytosis X cells (HXCs) was established. The antigen was the cell membrane of HXCs from the submandibular lesion of a 63-year-old man who had been diagnosed as an adult type of histiocytosis X (HX) and whose HXCs had numerous Birbeck granules (BGs). The obtained monoclonal antibody, na...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1992-07-01 00:00:00
abstract::This study deals with myocardial preservation after 24 hours of continuous, hypothermic and oxygenated perfusion with Cape Town (CT) solution, focusing on the morphological changes produced by preservation and reperfusion, and their possible relationship to the composition of the solution and the immediate hemodynamic...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-13.21
更新日期:1998-01-01 00:00:00
abstract::Within the last few years, advances have been made regarding perivascular nerves and the endothelium of the vascular system, both potentially important in the understanding of the mechanisms of local control of blood flow. Endothelin-1 (ET-1) has been identified in rat cerebrovascular nerves, neuropeptide Y (NPY) has ...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-17.591
更新日期:2002-04-01 00:00:00
abstract::To determine the appropriate time for bone reconstruction after irradiation, the healing process after autogenous iliac bone transplantation in the irradiated parietal bone was examined by scanning electron microscopy and light microscopy. Bone transplantation was carried out at the second and the fourth weeks after C...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-15.7
更新日期:2000-01-01 00:00:00
abstract::Neurotrophins are substances that have been shown to be important in growth and remodelling phases in different types of tissue. There is no information concerning the possible occurrences of neurotrophins and their receptors in tendons. In this study, sections of both chronic painful (tendinosis) and pain-free (non-t...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-24.839
更新日期:2009-07-01 00:00:00
abstract::Detailed histomorphometric analysis of human conjunctival biopsy specimens has convincingly demonstrated that tissue remodeling of the extracellular matrix (ECM) is an essential and dynamic process associated with conjunctival scarring in ocular cicatricial pemphigoid (OCP). The conjunctival scarring often eventually ...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-16.1203
更新日期:2001-10-01 00:00:00
abstract::Cell secretion is an important physiological process that ensures smooth metabolic activities, tissue repair and growth and immunological functions in the body. It occurs when the intracellular secretory materials are released to the exterior; these may be in the form of lipids, protein or mucous and may travel throug...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-18.597
更新日期:2003-04-01 00:00:00
abstract::The response of the SON to various forms of stress is well documented. However, the effect of operative stress, which is a common and important clinical event requiring the mediation of vasopressin, has largely escaped attention. The present report describes the ultrastructural changes in the neurons of the caudal (re...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1988-04-01 00:00:00
abstract::The primary objective of this research project was to study the role of sex steroids in the pathogenesis of cholelithiasis using the Syrian hamster as a model. In addition to the morphological examination of the gallbladder epithelium, we thought it imperative to observe the changes induced in the biliary tract in res...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1995-07-01 00:00:00