Effects of bombesin on the morphology and function of the rat adrenal cortex: comparison of the acute and chronic responses.

Abstract:

:The acute and chronic effects of bombesin (BM) on the structure and function of rat adrenal cortex were investigated by morphometric and radioimmunological techniques. An intraperitoneal bolus injection of 2 micrograms/rat BM markedly raised plasma corticosterone (B) concentration (PBC). The intraperitoneal BM infusion (1 microgram/rat.h-1) for 1, 2 or 4 days evoked a notable increase in the number of adrenocortical cells, without inducing apparent changes in either PBC or B output by adrenal quarters. Since proliferation and expression of specialized functions are mutually exclusive states of cells, our findings suggest that the conspicuous stimulation of adrenocortical-cell proliferation evoked by BM infusion may be responsible for the apparent lack of effect of this treatment on B secretion.

journal_name

Histol Histopathol

authors

Malendowicz LK,Nussdorfer GG,Miskowiak B,Majchrzak M

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

11-5

issue

1

eissn

0213-3911

issn

1699-5848

journal_volume

10

pub_type

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