Abstract:
:The acute and chronic effects of bombesin (BM) on the structure and function of rat adrenal cortex were investigated by morphometric and radioimmunological techniques. An intraperitoneal bolus injection of 2 micrograms/rat BM markedly raised plasma corticosterone (B) concentration (PBC). The intraperitoneal BM infusion (1 microgram/rat.h-1) for 1, 2 or 4 days evoked a notable increase in the number of adrenocortical cells, without inducing apparent changes in either PBC or B output by adrenal quarters. Since proliferation and expression of specialized functions are mutually exclusive states of cells, our findings suggest that the conspicuous stimulation of adrenocortical-cell proliferation evoked by BM infusion may be responsible for the apparent lack of effect of this treatment on B secretion.
journal_name
Histol Histopatholjournal_title
Histology and histopathologyauthors
Malendowicz LK,Nussdorfer GG,Miskowiak B,Majchrzak Msubject
Has Abstractpub_date
1995-01-01 00:00:00pages
11-5issue
1eissn
0213-3911issn
1699-5848journal_volume
10pub_type
杂志文章abstract::The immunohistochemical distribution of 15 blood coagulation factors in the germinal centers (GCs) of human Peyer's patches (PPs) was studied. Although factor VIII, active alpha-thrombin, and fibrinogen were hardly evident in the GCs, the majority of coagulation factors, such as kallikrein, high-molecular-weight kinin...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1992-04-01 00:00:00
abstract::This paper reports the histopathological findings in the eyes of a 26-year-old female patient diagnosed with systemic lupus erythematosus (SLE) with peripheral neuropathy. The patient had no significant ocular problems. She died of pneumonia after two years of suffering. The eyeballs were procured at autopsy and the r...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-20.373
更新日期:2005-04-01 00:00:00
abstract::TIMPs in the prostates of male and female gerbils and evaluated the effects of testosterone on the expression of these enzymes. Ventral prostates from male gerbils that were either intact or had been castrated for 7 or 21 days, along with prostates from female gerbils that were either intact or had been treated with t...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-26.1423
更新日期:2011-11-01 00:00:00
abstract::Dendritic cells (DCs) are the most potent antigen-presenting cells, and are regarded as "natural adjuvants" for the induction of primary T or T-dependent immunity. DCs in the peripheral sites capture and process antigens. Encounter of exogenous or endogenous stimuli mature the function of DCs, and they thus acquire T-...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-19.317
更新日期:2004-01-01 00:00:00
abstract::Ischemic heart disease is a widespread cause of death. During infarction, myocardial injury is mediated by release of several pro-inflammatory cytokines including multifunctional interleukin-1 (IL-1). In various tissues, IL-1-mediated deleterious effects are known to be attenuated via the over-expression of natural an...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-23.1093
更新日期:2008-09-01 00:00:00
abstract::To date, no detailed knowledge from animal experiments is available on the kind and extent of osseous and mineral metabolic disorders in genetically determined, insulin-dependent Type I diabetes. The purpose of this study was to examine the influence of the diabetic metabolic state in spontaneously diabetic BB/O(ttawa...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-18.111
更新日期:2003-01-01 00:00:00
abstract::Primary perivascular epithelioid cell tumor (PEComa) of the liver is a very rare example of an emerging family of hepatic PEC tumors. Only few cases have been described so far. We report the case of a large but benign hepatic PEComa in a 53-year-old man without signs of tuberous sclerosis. In contrast to recently desc...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-23.1185
更新日期:2008-10-01 00:00:00
abstract::The study investigated the link between the potentially nephrotoxic levels of aluminium ingested in the natural diet of eucalypt leaves by koalas in the Adelaide Hills, South Australia, and the high incidence of renal failure in koalas within this habitat. Routine histology of kidney specimens revealed no pathologies ...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-19.777
更新日期:2004-07-01 00:00:00
abstract::Gp96 is the endoplasmic reticulum (ER)-resident molecular chaperone, which is involved in the correction of unfolded proteins, in the activation of proteasome-dependent ER-associated degradation of the misfolded proteins, and in activation of the protein translation that modulates polypeptide traffic into the ER. Furt...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-28.61
更新日期:2013-01-01 00:00:00
abstract::The aim of the present work was to study the morphological implications between the elastin and the phenotypic expression of the vascular smooth muscle cells. For this purpose, sixty human tortuous arteries from different territories have been studied. We have measured the morphometric indexes Intimal Thickening Index...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-15.95
更新日期:2000-01-01 00:00:00
abstract::Discrimination of follicular cell-derived benign and malignant tumors of the thyroid is one of the major problems encountered in surgical pathology. In the present study, we evaluated the immunohistochemical expression of NGAL, an iron-binding protein involved in the infiltrative potential of cancer cells, in a cohort...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-27.329
更新日期:2012-03-01 00:00:00
abstract::Dimethylnitrosamine (DMN) induced liver injury in rats with cell necrosis, inflammation, hemorrhages, increased collagen type III synthesis and basement membrane component laminin and collagen IV localization in perisinusoidal sites. Malotilate ingestion during DMN treatment abolished inflammation and decreased inters...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract::The effects of diethylstilbestrol (DES) and of long-acting somatostatin analog, octreotide (SMS) on the rat anterior pituitary microvasculature have been studied by means of computer-assisted image analysis. Additionally, the effects of DES and SMS on prolactin secretion and anterior pituitary cell proliferation have ...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1997-10-01 00:00:00
abstract::Pax genes play a pivotal role in development of the vertebrate visual system. Pax6 is the master control gene for eye development: ectopic expression of Pax6 in Xenopus laevis and Drosphila melanogaster leads to the formation of differentiated eyes on the legs or wings. Pax6 is involved in formation of ganglion cells ...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-16.239
更新日期:2001-01-01 00:00:00
abstract::Light and electron microscopy were used to analyze the epithelial lining of odontogenic cysts excised from edentulous regions of the jaws. Clinically, three cases were identified as keratocysts, and 21 cases as cysts other than keratocysts ("non-keratocysts"). The epithelium of the former was found to achieve keratini...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1996-04-01 00:00:00
abstract::In recent years, the different mechanisms of epithelial cell loss which occur in mammalian and avian small intestine have been re-investigated. Information is now available for a variety of mammalian types and mechanisms can be divided into two major classes: [i] those preserving epithelial integrity by maintaining in...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-14.257
更新日期:1999-01-01 00:00:00
abstract::Monoclonal antibody against histiocytosis X cells (HXCs) was established. The antigen was the cell membrane of HXCs from the submandibular lesion of a 63-year-old man who had been diagnosed as an adult type of histiocytosis X (HX) and whose HXCs had numerous Birbeck granules (BGs). The obtained monoclonal antibody, na...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1992-07-01 00:00:00
abstract::Erythema dyschromicum perstans (EDP) and vitiligo are two cutaneous pigmentary dermatoses of unknown etiology. In the present study, the leukocyte infiltrates in the affected skin of EDP and vitiligo patients were studied using the avidin-biotin (ABC) immunoperoxidase technique and monoclonal antibodies which recognis...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1987-07-01 00:00:00
abstract::Osteoarthritis (OA) is characterized by cartilage attrition, subchondral bone remodeling, osteophyte formation and synovial inflammation. Perturbed homeostasis caused by inflammation, oxidative stress, mitochondrial dysfunction and proapoptotic/antiapoptotic dysregulation is known to impair chondrocyte survival in joi...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-26.1265
更新日期:2011-10-01 00:00:00
abstract::TNFalpha exerts apoptosis throughout an intracellular transduction pathway that involves the kinase proteins TRAF-2 (integration point of apoptotic and survival signals), ASK1 (pro-apoptotic protein), MEK-4 (p38 activator and metastasis suppressor gene), JNK (stress mitogen activated protein kinase) and the transcript...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-23.1279
更新日期:2008-10-01 00:00:00
abstract::Dysadherin, a cancer associated cell membrane glycoprotein, has been reported to downregulate E-cadherin. Aberrant expression of E-cadherin has been associated with the development of metastases in patients with cancer. Even though the expression of dysadherin and E-cadherin has been studied in primary non-small cell ...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-25.1257
更新日期:2010-10-01 00:00:00
abstract::There is now evidence that estrogens and androgens are exerting their effects in different tissues throughout the body. In order to determine the sites of action of these steroids, studies have been performed to identify at the cellular level the localization of androgen receptor (AR) and the two estrogen receptor (ER...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-15.1261
更新日期:2000-10-01 00:00:00
abstract::Six 4 month-old beagles were inoculated with Leishmania donovani infantum, three of them intraperitoneally (Group A) and the other three intravenously (Group B). The animals from Group A were killed 109, 433 and 592 days after inoculation and animals from Group B 109, 171 and 334 after inoculation. The liver of each o...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1988-10-01 00:00:00
abstract::The purpose of our study was to elucidate pathways of genetically programmed cell death (apoptosis) in corneas with macular dystrophy. 10 corneal buttons (10 patients) with macular dystrophy and 8 buttons (8 patients) from enucleated eyes with chorioideal melanoma (controls) were analysed histologically. Immunohistoch...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-25.287
更新日期:2010-03-01 00:00:00
abstract::25 neuronal tumours with a panel of antibodies were studied and it was found that vimentin was present in 15 tumours. It was also found in a few cells within rosettes. PGP 9.5 showed a somatic pattern of staining with nuclear and perinuclear positivity in 23. Neurofilament reactivity was found in 14. Retinal S-antigen...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1991-10-01 00:00:00
abstract::The nerve fiber distribution in the epidermis of the hairless rat skin was studied light microscopically by means of zinc iodide-osmium tetroxide staining. Two different morphological types of free nerve fiber endings could be detected: clusters of relatively thick nerve fibers stretched up through the spinous layer u...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-15.493
更新日期:2000-04-01 00:00:00
abstract::Neural stem cells are defined as clonogenic cells with self-renewal capacity and the ability to generate all neural lineages (multipotentiality). Cells with these characteristics have been isolated from the embryonic and adult central nervous system. Under specific conditions, these cells can differentiate into neuron...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-19.1261
更新日期:2004-10-01 00:00:00
abstract::The repair of articular cartilage defects is increasingly moving into the focus of experimental and clinical investigations. Histological analysis is the gold standard for a valid and objective evaluation of cartilaginous repair tissue and predominantly relies on the use of established scoring systems. In the past thr...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-11-620
更新日期:2015-08-01 00:00:00
abstract::Ductular hepatocytes are observed in the livers of both experimental animals and man under various conditions of severe toxin-, carcinogen- or viral-induced hepatic injury with prominent loss of parenchymal hepatocytes. These unique hepatic epithelial cells are characterized by phenotypic traits that are intermediate ...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:
更新日期:1995-04-01 00:00:00
abstract::Sulfur dioxide (SO₂) is a toxic gas and air pollutant. The toxic effects of SO₂ have been extensively studied. Oxidative damage due to SO₂ can occur in multiple organs. Inhaled SO₂ can also cause chromosomal aberrations, DNA damage and gene mutations in mammals. However, SO₂ can also be generated from the sulfur-conta...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-11-904
更新日期:2017-12-01 00:00:00