In vitro and in vivo characterization of neural stem cells.

Abstract:

:Neural stem cells are defined as clonogenic cells with self-renewal capacity and the ability to generate all neural lineages (multipotentiality). Cells with these characteristics have been isolated from the embryonic and adult central nervous system. Under specific conditions, these cells can differentiate into neurons, glia, and non-neural cell types, or proliferate in long-term cultures as cell clusters termed "neurospheres". These cultures represent a useful model for neurodevelopmental studies and a potential cell source for cell replacement therapy. Because no specific markers are available to unequivocally identify neural stem cells, their functional characteristics (self-renewal and multipotentiality) provide the main features for their identification. Here, we review the experimental and ultrastructural studies aimed at identifying the morphological characteristics and the antigenic markers of neural stem cells for their in vitro and in vivo identification.

journal_name

Histol Histopathol

authors

Bazán E,Alonso FJ,Redondo C,López-Toledano MA,Alfaro JM,Reimers D,Herranz AS,Paíno CL,Serrano AB,Cobacho N,Caso E,Lobo MV

doi

10.14670/HH-19.1261

subject

Has Abstract

pub_date

2004-10-01 00:00:00

pages

1261-75

issue

4

eissn

0213-3911

issn

1699-5848

journal_volume

19

pub_type

杂志文章,评审
  • Markers of squamocolumnar junction cells in normal tonsils and oropharyngeal cancer with and without HPV infection.

    abstract::HPV infection has been identified recently as the causative agent of a subset of squamous cell carcinomas arising in oropharyngeal tonsils. Factors influencing the susceptibility of tonsillar epithelium to HPV-induced oncogenesis are far from being elucidated. A 5-protein signature including cytokeratin (CK)7, anterio...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-11-590

    authors: Morbini P,Capello GL,Alberizzi P,Benazzo M,Paglino C,Comoli P,Pedrazzoli P

    更新日期:2015-07-01 00:00:00

  • New insights into the cytoplasmic function of PML.

    abstract::PML is a tumour suppressor inactivated in Acute Promyelocytic Leukaemia (APL). PML is the essential component of a subnuclear structure called the PML nuclear body (PML-NB), which is disrupted in APL. By targeting different cellular proteins to this structure, PML can either hamper or potentiate their functions. The P...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-22.937

    authors: Salomoni P,Bellodi C

    更新日期:2007-08-01 00:00:00

  • Morphological, immunohistochemical and ultrastructural changes in dimethylnitrosamine [correction of dimenthylnitrosamine] induced liver injury. Effect of malotilate.

    abstract::Dimethylnitrosamine (DMN) induced liver injury in rats with cell necrosis, inflammation, hemorrhages, increased collagen type III synthesis and basement membrane component laminin and collagen IV localization in perisinusoidal sites. Malotilate ingestion during DMN treatment abolished inflammation and decreased inters...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Stenbäck F,Ala-Kokko L,Ryhänen L

    更新日期:1989-01-01 00:00:00

  • Synaptophysin immunoreactivity in the cat cochlear nuclei.

    abstract::The presence of synaptophysin, a presynaptic Ca2+ binding glycoprotein, has been analyzed in the cochlear nucleus complex of the adult cat using an antisynaptophysin monoclonal antibody. Synaptophysin immunoreactivity was differently distributed between regions of cochlear nuclei. Terminal boutons contacting directly ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-13.415

    authors: Gil-Loyzaga P,Bartolomé MV,Ibáñez A

    更新日期:1998-04-01 00:00:00

  • Histopathological changes in the islets of Langerhans in hamsters infected with the 139H strain of scrapie: semi-thin section study.

    abstract::Using histopathological analysis of semi-thin sections stained with toluidine blue, we observed profound pathological changes in the islets of Langerhans of hamsters infected with the scrapie agent (strain 139H). These included cytoplasmic vesicles, nuclear swelling, and vacuolization in the islet cells. Two types of ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Ye X,Carp RI

    更新日期:1996-01-01 00:00:00

  • Ductular hepatocytes.

    abstract::Ductular hepatocytes are observed in the livers of both experimental animals and man under various conditions of severe toxin-, carcinogen- or viral-induced hepatic injury with prominent loss of parenchymal hepatocytes. These unique hepatic epithelial cells are characterized by phenotypic traits that are intermediate ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:

    authors: Sirica AE

    更新日期:1995-04-01 00:00:00

  • Telocytes form networks in normal cardiac tissues.

    abstract::Telocytes (TC) are a class of interstitial cells present in heart. Their characteristic feature is the presence of extremely long and thin prolongations (called telopodes). Therefore, we were interested to see whether or not TCs form networks in normal cardiac tissues, as previously suggested. Autopsy samples of card...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-27.807

    authors: Rusu MC,Pop F,Hostiuc S,Curca GC,Jianu AM,Paduraru D

    更新日期:2012-06-01 00:00:00

  • Three types of liver cell dysplasia (LCD) in small cirrhotic nodules are distinguishable by karyometry and PCNA labelling, and their features resemble distinct grades of hepatocellular carcinoma.

    abstract::We have studied the occurrence and specific features of liver cell dysplasia (LCD) in Chinese patients showing liver cirrhosis with or without hepatocellular carcinoma (HCC). Three types of LCD (SLCD, LLCDo, LLCDe) were morphologically defined, and these types were further analyzed using karyometry, estimation of nucl...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Zhao M,Zhang NX,Du ZY,Laissue JA,Zimmermann A

    更新日期:1994-01-01 00:00:00

  • Analysis of wt1a reporter line expression levels during proepicardium formation in the zebrafish.

    abstract::The epicardium is the outer mesothelial layer of the heart. It covers the myocardium and plays important roles in both heart development and regeneration. It is derived from the proepicardium (PE), groups of cells that emerges at early developmental stages from the dorsal pericardial layer (DP) close to the atrio-vent...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-18-238

    authors: Andrés-Delgado L,Galardi-Castilla M,Mercader N,Santamaría L

    更新日期:2020-09-01 00:00:00

  • MMP-2 and TIMP-2 in the prostates of male and female mongolian gerbils: effects of hormonal manipulation.

    abstract::TIMPs in the prostates of male and female gerbils and evaluated the effects of testosterone on the expression of these enzymes. Ventral prostates from male gerbils that were either intact or had been castrated for 7 or 21 days, along with prostates from female gerbils that were either intact or had been treated with t...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-26.1423

    authors: Rochel-Maia SS,Santos FC,Vilamaior PS,Justulin LA Jr,Felisbino SL,Góes RM,Taboga SR

    更新日期:2011-11-01 00:00:00

  • Immunohistological signposts in central nervous system tumours with neuronal differentiation.

    abstract::25 neuronal tumours with a panel of antibodies were studied and it was found that vimentin was present in 15 tumours. It was also found in a few cells within rosettes. PGP 9.5 showed a somatic pattern of staining with nuclear and perinuclear positivity in 23. Neurofilament reactivity was found in 14. Retinal S-antigen...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Cruz-Sánchez FF,Rossi ML,Rodríguez-Prados S,Cusi V,Coakham HB

    更新日期:1991-10-01 00:00:00

  • Regional differences in cell surface patterns in normal human sulcular epithelium.

    abstract::Studies with scanning electron microscopy in the normal human sulcular epithelium are scarce, and no precise information exists about cell surface patterns along the epithelium, the frequencies of these patterns, or possible regional differences within the mouth. In five periodontal biopsy specimens each from the ante...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Sánchez-Quevedo MC,Moreu G,Campos A,García JM,González-Jaranay M

    更新日期:1994-01-01 00:00:00

  • Localization of sex steroid receptors in human skin.

    abstract::Sex steroid hormones are involved in regulation of skin development and functions as well as in some skin pathological events. To determine the sites of action of estrogens, androgens and progestins, studies have been performed during the recent years to accurately localize receptors for each steroid hormone in human ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-19.629

    authors: Pelletier G,Ren L

    更新日期:2004-04-01 00:00:00

  • Prognostic significance of PTK7 in human malignancies.

    abstract:BACKGROUND:Protein tyrosine kinase 7 (PTK7) is a member of receptor protein tyrosine kinase-like molecules, which is involved in tumorigenesis. However, the association between PTK7 expression and its pathological significance in survival prognosis remains under investigation. The purpose of this meta-analysis is to cl...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,meta分析

    doi:10.14670/HH-11-933

    authors: Chen G,Qi S,Yang X,Chen W

    更新日期:2018-04-01 00:00:00

  • Bone marrow stromal cells for spinal cord repair: a challenge for contemporary neurobiology.

    abstract::In the last years, it has been reported that bone marrow stromal cells (BMSC) are able to differentiate towards a neuronal phenotype, in vitro as well as in vivo, and consequently, the possible use of these cells for the treatment of neurological diseases has acquired enormous importance. The objective of this review ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-24.107

    authors: Vaquero J,Zurita M

    更新日期:2009-01-01 00:00:00

  • Age-related quantitative changes in the organelles of rat neocerebellar Purkinje cells.

    abstract::A quantitative study regarding the age-related changes occurring in the somatic organelles of the neocerebellar Purkinje cell is carried out, using female rats aged 2 to 24 months. Standard manual morphometric techniques are used to calculate the following parameters: somatic volume, volumetric fractions and absolute ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Monteiro RA

    更新日期:1991-01-01 00:00:00

  • Ewing sarcoma and the new emerging Ewing-like sarcomas: (CIC and BCOR-rearranged-sarcomas). A systematic review.

    abstract::Ewing-like sarcomas (ELS) are a heterogenous group of tumors that frequently affect pediatric and young adult patients. Accurate classification and distinction from the Ewing sarcoma family of tumor (ESFT) is decisive in patient management. ELS share a significant morphologic, immunohistochemical and clinical overlap ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-11-792

    authors: Machado I,Navarro S,Llombart-Bosch A

    更新日期:2016-11-01 00:00:00

  • Expression of the ets-1 proto-oncogene in human breast carcinoma: differential expression with histological grading and growth pattern.

    abstract::The proto-oncogene, ets-1, is a transcription factor known to control the expression of a number of genes and has been postulated to play a role in cell growth, differentiation and tumour invasion. We examined 137 cases of breast carcinoma by immunohistochemistry and compared the degree of Ets-1 expression among the d...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-20.119

    authors: Katayama S,Nakayama T,Ito M,Naito S,Sekine I

    更新日期:2005-01-01 00:00:00

  • Estimation and comparison of the contents of blood group B antigens in selected human tissues by microphotometric quantification of Griffonia simplicifolia agglutinin I-B4 staining with or without prior alpha-galactosidase digestion.

    abstract::Griffonia simplicifolia agglutinin I-B4 (GSAI-B4) has broader specificity for B antigen variants and can recognize the antigens in a wide variety of human tissues. Thus, the concentration range of GSAI-B4 required for staining and the susceptibility of staining to alpha-galactosidase digestion is presumed to correlate...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Ito N,Nagaike C,Morimura Y,Hatake H

    更新日期:1997-04-01 00:00:00

  • Time-dependent effects of maternal continuous propranolol on fetal lung development in rats.

    abstract::Previous studies have demonstrated a role for the beta-adrenergic system in the maturation of the fetal alveolar epithelium. Chronic blockade of beta-adrenergic binding sites has been shown to adversely effect physiologic and biochemical indices of fetal lung maturation. In the present study timed-pregnant female Spra...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-17.365

    authors: Smith DM,Sommers SS

    更新日期:2002-04-01 00:00:00

  • Morphological hysteresis of the small airways.

    abstract::The resistance to airflow that develops in most obstructive processes takes place in the small airways. The aim of the present paper is to describe bronchial hysteresis morphometrically in a respiratory cycle model. As a working hypothesis, it is proposed that the changes that take place in the respiratory tract durin...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-18.19

    authors: Escolar JD,Escolar MA,Guzmán J,Roqués M

    更新日期:2003-01-01 00:00:00

  • The role of apoptosis in pulmonary fibrosis.

    abstract::Pulmonary fibrosis is a common response to various injuries to the lung. The resolution of a fibroproliferative response after lung injury is key to survival. Although there are various initiating factors or causes, the terminal stages are characterized by proliferation and progressive accumulation of connective tissu...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-19.867

    authors: Kuwano K,Hagimoto N,Nakanishi Y

    更新日期:2004-07-01 00:00:00

  • Multilocular cystic renal cell carcinoma with focus on clinical and pathobiological aspects.

    abstract::Multilocular cystic renal cell carcinoma (MCRCC) accounts for approximately 1 to 2% of all renal tumors. This tumor is currently classified as a subtype of clear cell RCC. Clinically, the majority of these tumors are incidentally found. Macroscopically, the tumor is well demarcated and consists of various-sized cysts....

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-27.969

    authors: Kuroda N,Ohe C,Mikami S,Inoue K,Nagashima Y,Cohen RJ,Pan CC,Michal M,Hes O

    更新日期:2012-08-01 00:00:00

  • Muscle fiber types in tetrapods. A comparative histochemical and morphometric study.

    abstract::A comparative histochemical and morphometric study in two groups of homologous muscles from different tetrapods (rat, pigeon, lizard and frog) was performed. On the basis of their fiber diameters and oxidative enzyme activities, an initial correlation between fiber types of all animals is observed, although in the liz...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Burgos Bretones JJ,Razquin Peralta B,Aguirre Urizar J,Rivera Pomar JM

    更新日期:1987-01-01 00:00:00

  • Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease.

    abstract::Parkinson's disease (PD) is a neurodegenerative disorder characterized by progressive cell loss confined mostly to dopaminergic neurons of the substantia nigra. Several factors, including oxidative stress, and decreased activity of complex I mitochondrial respiratory chain, are involved in the degenerative process. Ye...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Anglade P,Vyas S,Javoy-Agid F,Herrero MT,Michel PP,Marquez J,Mouatt-Prigent A,Ruberg M,Hirsch EC,Agid Y

    更新日期:1997-01-01 00:00:00

  • An ultrastructural and immunohistochemical study of extracellular matrix in meningiomas.

    abstract::Extracellular matrix of meningiomas was studied by light and electron microscopy with the aid of immunohistochemical techniques. Special attention was paid to the distribution of type I, III, IV, V collagens and laminin with a comparison between meningothelial and fibroblastic types. Connective tissue fibers and basem...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:

    authors: Nitta H,Yamashima T,Yamashita J,Kubota T

    更新日期:1990-07-01 00:00:00

  • Ecophysiological responses of the seminal vesicle of Libyan jird (Meriones libycus) to the Saharan conditions: histological, morphometric and immunohistochemical analysis.

    abstract::The Libyan jird (Meriones libycus) is a nocturnal Saharan Rodent submitted to a seasonal cycle of reproduction characterized by a short active period during spring and beginning of summer, and a long phase of sexual quiescence from the end of summer until the end of winter. During this cycle, the male reproductive org...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-22.603

    authors: Belhocine M,Gernigon-Spychalowicz T,Robert AM,Schoevaert D,Bennazzoug Y,Exbrayat JM

    更新日期:2007-06-01 00:00:00

  • Adhesion-dependent signalling and the initiation of haemostasis and thrombosis.

    abstract::Cell-cell and cell-extracellular matrix adhesion are critical aspects of platelet function, regulating interactions between circulating platelets in the bloodstream with the blood vessel wall. In haemostasis, platelets adhere to the subendothelial matrix of a damaged vessel, spread over the surface and recruit additio...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-13.837

    authors: Andrews RK,Berndt MC

    更新日期:1998-07-01 00:00:00

  • Molecular and cellular mechanisms of heterotopic ossification.

    abstract::Heterotopic ossification (HO) is a debilitating condition in which cartilage and bone forms in soft tissues such as muscle, tendon, and ligament causing immobility. This process is induced by inflammation associated with traumatic injury. In an extremely rare genetic disorder called fibrodysplasia ossificans progessiv...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审

    doi:10.14670/HH-29.1281

    authors: Ramirez DM,Ramirez MR,Reginato AM,Medici D

    更新日期:2014-10-01 00:00:00

  • Elastin variations implicating in vascular smooth muscle cells phenotype in human tortuous arteries.

    abstract::The aim of the present work was to study the morphological implications between the elastin and the phenotypic expression of the vascular smooth muscle cells. For this purpose, sixty human tortuous arteries from different territories have been studied. We have measured the morphometric indexes Intimal Thickening Index...

    journal_title:Histology and histopathology

    pub_type: 杂志文章

    doi:10.14670/HH-15.95

    authors: Ortiz PP,Sarrat R,Daret D,Whyte J,Torres A,Lamazière JM

    更新日期:2000-01-01 00:00:00