Abstract：
:A novel family of evolutionally conserved neuronal guidance cues, including ligands (i.e., Slit, netrin, epherin, and semaphorin) and their corresponding receptors (i.e., Robo, DCC/Unc5, Eph and plexin/ neuropilin), has been identified to play a crucial role in axon pathfinding and branching as well as neuronal cell migration. The presence of commonalities in both neural and vascular developments has led to some exciting discoveries recently, which have extended the functions of these systems to vascular formation (vasculogenesis) and development (angiogenesis). Some of these ligands and receptors have been found to be expressed in the vasculature and surrounding tissues in physiological and pathological conditions. It is postulated that they regulate the formation and integrity of blood vessels. In particular, it has been shown that the Slit/Robo pair plays a novel role in angiogenesis during tumorigenesis and vascular formation during embryogenesis. Herein we summarize briefly the characteristics of this family of neuronal guidance molecules and discuss the extra-neural expression and function of the Slit/Robo pair in angiogenesis in physiological and pathological settings. We report expression of Robo1 protein in capillary endothelium and co-expression of Slit2 and Robo1 proteins in syncytiotrophoblast in healthy term human placental villi. These cellular expression patterns implicate that the Slit/Robo signaling plays an autocrine and/or paracrine role in angiogenesis and trophoblast functions. We also speculate a possible role of this system in pathophysiological placental angiogenesis.
journal_name
Histol Histopatholjournal_title
Histology and histopathologyauthors
Liao WX,Wing DA,Geng JG,Chen DBdoi
10.14670/HH-25.1181subject
Has Abstractpub_date
2010-09-01 00:00:00pages
1181-90issue
9eissn
0213-3911issn
1699-5848journal_volume
25pub_type
杂志文章,评审abstract：:Griffonia simplicifolia agglutinin I-B4 (GSAI-B4) has broader specificity for B antigen variants and can recognize the antigens in a wide variety of human tissues. Thus, the concentration range of GSAI-B4 required for staining and the susceptibility of staining to alpha-galactosidase digestion is presumed to correlate...
journal_title：Histology and histopathology
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doi：
更新日期：1997-04-01 00:00:00
abstract：:A number of tumor suppressor and tumor-related genes exhibit promoter hypermethylation with resulting gene silencing in human cancers. In addition, several gene promoters have also been shown to become hypermethylated in non-neoplastic cells during aging. To assess the physiological consequence and clinical significan...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-19.221
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journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-21.503
更新日期：2006-05-01 00:00:00
abstract：:The repair of articular cartilage defects is increasingly moving into the focus of experimental and clinical investigations. Histological analysis is the gold standard for a valid and objective evaluation of cartilaginous repair tissue and predominantly relies on the use of established scoring systems. In the past thr...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-11-620
更新日期：2015-08-01 00:00:00
abstract：:A proportion of anaplastic large cell tumours is difficult to classify on sections of routinely processed, paraffin-embedded tissue. Differentiation into large cell lymphoma, carcinoma, melanoma or sarcoma is important in order to assess prognosis and proper treatment. Although the use of immunohistochemistry has been...
journal_title：Histology and histopathology
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更新日期：1987-04-01 00:00:00
abstract：:The purpose of this investigation was to clarify the mechanisms of amyloid fibril formation in human lymph nodes. In our present study, amyloid deposition was observed diffusely in all compartments of the lymph nodes. The deposition form showed extremely characteristic findings in its morphological features. Namely, a...
journal_title：Histology and histopathology
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更新日期：1986-07-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-23.77
更新日期：2008-01-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-24.1213
更新日期：2009-10-01 00:00:00
abstract：:Nitric oxide (NO) has opened a new and vigorous field of biological and clinical experimentation as evidenced presently by about one hundred original publications every week. Being a biological signal under physiological conditions, NO may be
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：
更新日期：1997-01-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-29.831
更新日期：2014-07-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1989-04-01 00:00:00
abstract：:The Farnesoid X Receptor (FXR) is a member of the nuclear receptor superfamily of ligand-activated transcription factors, which plays crucial role in bile acid, cholesterol, lipid and glucose metabolism, as well as in the development of atherosclerosis, intestinal bacterial growth and liver regeneration. FXR is also i...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-27.835
更新日期：2012-07-01 00:00:00
abstract：:This study explores the possibility of a regulatory role for cytokine IL-10 in platelet aggregation as an active vascular repair mechanism. Endothelial cells from human umbilical cord vein were cultured in the presence of different IL-10 concentrations (0-100 ng/ml). Platelet-rich plasma was then added to these cultur...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-18.695
更新日期：2003-07-01 00:00:00
abstract：:The mandible has a mixed embryological origin, and its growth is associated with the secondary cartilage of the condyle process (CP). In this area, growth depends on an array of intrinsic and extrinsic factors that influence protein metabolism. In the present study, we used an adolescent rat model to evaluate the grow...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-25.45
更新日期：2010-01-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-20.719
更新日期：2005-07-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-11-776
更新日期：2016-12-01 00:00:00
abstract：:The view of how astrocytes, a type of glial cells, contribute to the functioning of the central nervous system (CNS) has changed greatly in the last decade. Although glial cells outnumber neurons in the mammalian brain, it was considered for over a century that they played a subservient role to neurons. This view chan...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-26.277
更新日期：2011-02-01 00:00:00
abstract：:Ductular hepatocytes are observed in the livers of both experimental animals and man under various conditions of severe toxin-, carcinogen- or viral-induced hepatic injury with prominent loss of parenchymal hepatocytes. These unique hepatic epithelial cells are characterized by phenotypic traits that are intermediate ...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：
更新日期：1995-04-01 00:00:00
abstract：:High mobility group box 1 protein (HMGB1) is a non-histone chromosomal protein which is highly conserved, ubiquitous, and widely distributed. HMGB1 has multiple functions in the nucleus, including the maintenance of nucleosome structure, the regulation of gene transcription, and involvement in DNA recombination. HMBG1...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-29.235
更新日期：2014-02-01 00:00:00
abstract：:The present study describes the use of a microwave processing protocol for the rapid histopathological and immunohistochemical diagnosis of bovine rabies. Immunohistochemistry has been used for rabies diagnosis in formalin-fixed tissue with satisfactory results, although the time to diagnosis is considerably longer th...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-27.1227
更新日期：2012-09-01 00:00:00
abstract：:The presence of synaptophysin, a presynaptic Ca2+ binding glycoprotein, has been analyzed in the cochlear nucleus complex of the adult cat using an antisynaptophysin monoclonal antibody. Synaptophysin immunoreactivity was differently distributed between regions of cochlear nuclei. Terminal boutons contacting directly ...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-13.415
更新日期：1998-04-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:In the present work a morphopathological study is carried out of the glomerular filtration barrier in 20 Large-White pigs weighing 20 kg, subjected to experimental intravenous inoculations of endotoxin from Salmonella enteritidis. The study is completed with the determination of protein plasmatic levels, through urine...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1989-10-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1991-10-01 00:00:00
abstract：:Osteoclasts are physiological polykaryons specialized in the resorption of calcified tissue. In the context of the clinical use of calcium-phosphate (CaP) ceramics as bone substitutes, this study used transmission electron microscopy to investigate the in vitro mechanisms of CaP ceramic degradation by osteoclastic cel...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-16.37
更新日期：2001-01-01 00:00:00
abstract：:Fatty acid binding proteins (FABPs) are 15-kDa proteins responsible for the transport of fatty acids both intracellularly and extracellularly. Consisting of 12 different isoforms, some of the proteins have been found to be released in the serum and to be correlated with various diseases including cancer. Differential ...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-18-014
更新日期：2019-01-01 00:00:00
abstract：:Voltage-activated Ca2+ channels play an important role in synaptic transmission, signal processing and development. The immunohistochemical localization of Cav1.2 (alpha1C) and Cav2.3 (alpha1E) Ca2+ channels was studied in the developing and adult mouse organ of Corti using subunit-specific antibodies and fluorescent ...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-18.1115
更新日期：2003-10-01 00:00:00
abstract：AIMS:Gastric hyperplastic polyps (GHPs) are the most common polypoid lesion of the stomach, and their malignant potential has been demonstrated. In the present study, we evaluated the mucin phenotypes of GHPs and investigated the relationships among mucin phenotypes and clinical-pathological factors, proliferative acti...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-29.343
更新日期：2014-03-01 00:00:00
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journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1986-01-01 00:00:00
abstract：:The vacuolar-type H(+)-ATPases (V-ATPases) are a family of multi-subunit ATP-dependent proton pumps involved in diverse cellular processes, including acid/base homeostasis, receptor-mediated endocytosis, processing of proteins and signaling molecules, targeting of lysosomal enzymes, and activation of various degradati...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-25.1611
更新日期：2010-12-01 00:00:00
