Abstract:
:A quantitative study regarding the age-related changes occurring in the somatic organelles of the neocerebellar Purkinje cell is carried out, using female rats aged 2 to 24 months. Standard manual morphometric techniques are used to calculate the following parameters: somatic volume, volumetric fractions and absolute volumes of the intracellular structures as well as the membrane profile concentration, the membrane surface concentration and the mean surface of the rough endoplasmic reticulum cisternae per cell (RER-S). From a statistical point of view, all the cell components significantly modify their volumetric fractions (except the multivesicular bodies and nucleolus; the latter in relation to the nucleus) and their absolute volumes (except the mitochondria and the multivesicular bodies); the parameters regarding the reticulum are also modified during ageing. There is a linear trend between the age and either the somatic volume of the RER-S or the absolute volumes of the following structures: mitochondria, dense bodies, ground substance and total cytoplasm. A linear correlation is also observed between the cell volume and either the RER-S or the absolute volume of intracellular structures (the Golgi apparatus, the multivesicular bodies and nucleolus being excluded). Anatomophysiological considerations about the findings are discussed. The role of the ground substance as the major modulator of the volumetric plasticity of the Purkinje cell during ageing, is emphasized as a conclusion.
journal_name
Histol Histopatholjournal_title
Histology and histopathologyauthors
Monteiro RAsubject
Has Abstractpub_date
1991-01-01 00:00:00pages
9-20issue
1eissn
0213-3911issn
1699-5848journal_volume
6pub_type
杂志文章abstract::Versican, a large extracellular matrix proteoglycan accumulates in tumor stroma and plays a key role in both malignant transformation and tumor progression. Increased versican expression has been observed in a wide range of malignant tumors, and has been associated with both cancer relapse and poor patient outcomes in...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-28.701
更新日期:2013-06-01 00:00:00
abstract::The three-dimensional structure of the pancreatic ductular system (from the intercalated duct to the intercellular secretory canaliculus) is controversial and unclear. The aim of this study is to reveal the three-dimensional structure of the pancreatic ductular sysytem at the onset of pancreatitis. One day following r...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-17.107
更新日期:2002-01-01 00:00:00
abstract::Platelet-collagen interaction is a complex event that involves ligand-receptor interaction. There are many adhesive non-integrin receptors for platelets to interact with various types of collagens. These non-integrin receptors also serve as signal transducers both from the outside of platelets to the inside and possib...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-14.579
更新日期:1999-04-01 00:00:00
abstract::In the present work a morphopathological study is carried out of the glomerular filtration barrier in 20 Large-White pigs weighing 20 kg, subjected to experimental intravenous inoculations of endotoxin from Salmonella enteritidis. The study is completed with the determination of protein plasmatic levels, through urine...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1989-10-01 00:00:00
abstract::The purpose of our study was to elucidate pathways of genetically programmed cell death (apoptosis) in corneas with macular dystrophy. 10 corneal buttons (10 patients) with macular dystrophy and 8 buttons (8 patients) from enucleated eyes with chorioideal melanoma (controls) were analysed histologically. Immunohistoch...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-25.287
更新日期:2010-03-01 00:00:00
abstract::A rat IgG2a monoclonal antibody against a stage-specific fetal glycoprotein with a molecular mass of 68 kDa (FGP68) was produced and applied to paraffin sections. This monoclonal antibody was used to compare the expression of FGP68 with that of both alpha-fetoprotein (AFP) and carcinoembryonic antigen (CEA) in 75 hepa...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-19.701
更新日期:2004-07-01 00:00:00
abstract::Spinal cord injury (SCI) is one of the most destructive traumatic diseases in human beings. The balance of inflammation in the microenvironment is crucial to the repair process of spinal cord injury. Inflammatory cytokines are direct mediators of local lesion inflammation and affect the prognosis of spinal cord injury...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-18-262
更新日期:2020-10-01 00:00:00
abstract::E(epithelial)-cadherin is a member of a calcium-dependent family of cell surface glycoproteins involved in cell-cell adhesion and morphogenesis. Catenins are a large family of proteins that connect the cadherins to the cytoskeleton. They are important for cadherin function and for transducing signals involved in speci...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-16.1097
更新日期:2001-10-01 00:00:00
abstract::Chorioamnionitis and preeclampsia account for the majority of preterm births worldwide. Thus far, adequate methods for early detection or prevention of these diseases are lacking. In preeclampsia, accelerated villous maturation is believed to compensate placental insufficiency. However, little is known about the effec...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-18-205
更新日期:2020-08-01 00:00:00
abstract::Bacillus subtilis has been used as a classic model to study biofilm formation and sporulation process. Colonies of wild-type strains usually have a complex external morphology, but the details of their internal architecture are still undisclosed. Since bacterial biofilms fulfill the criteria to be considered tissues, ...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-28.1351
更新日期:2013-10-01 00:00:00
abstract::Recently, the characterization of mucinous tubular and spindle-cell carcinoma (MTSCC) has been established. MTSCC predominantly occurs in females. This tumor is histologically characterized by eosinophilic cytoplasm, elongated and anastomosing tubules, myxomatous stroma and low-grade nuclear cytology. Proliferation of...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-20.221
更新日期:2005-01-01 00:00:00
abstract::This paper reports the histopathological findings in the eyes of a 26-year-old female patient diagnosed with systemic lupus erythematosus (SLE) with peripheral neuropathy. The patient had no significant ocular problems. She died of pneumonia after two years of suffering. The eyeballs were procured at autopsy and the r...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-20.373
更新日期:2005-04-01 00:00:00
abstract::TNFalpha exerts apoptosis throughout an intracellular transduction pathway that involves the kinase proteins TRAF-2 (integration point of apoptotic and survival signals), ASK1 (pro-apoptotic protein), MEK-4 (p38 activator and metastasis suppressor gene), JNK (stress mitogen activated protein kinase) and the transcript...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-23.1279
更新日期:2008-10-01 00:00:00
abstract::The pancreatic-duct system was observed during the initial stage of type 1 diabetes in C57BL/6J mice rendered diabetic with low doses of streptozocin. Light microscopy revealed that the ducts located in close proximity to islets (islet ducts) were involved in the infiltrating process: inflammatory cells extended from ...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1994-07-01 00:00:00
abstract::Immunohistochemistry of the terminal complement complex (C5b-9) and fibronectin (FN) is useful to detect myocardial ischemia preceding necrosis in the postmortem diagnosis of sudden cardiac death. The present immunohistochemical study examined connexin43 (Cx43) and zonula occludens-1 (ZO-1) as markers of early myocard...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-29.767
更新日期:2014-06-01 00:00:00
abstract::Androgen receptor (AR) interact with many pathways involved in bladder cancer development and progression. FUS (fused in liposarcoma), a multifunctional protein essential for different cellular processes, has been demonstrated as a key link between androgen receptor signaling and cell-cycle progression in prostate can...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-18-295
更新日期:2020-12-23 00:00:00
abstract:BACKGROUND:Protein tyrosine kinase 7 (PTK7) is a member of receptor protein tyrosine kinase-like molecules, which is involved in tumorigenesis. However, the association between PTK7 expression and its pathological significance in survival prognosis remains under investigation. The purpose of this meta-analysis is to cl...
journal_title:Histology and histopathology
pub_type: 杂志文章,meta分析
doi:10.14670/HH-11-933
更新日期:2018-04-01 00:00:00
abstract::Since bone marrow stromal cells (MSCs) are easily accessible both from healthy donors and patients, and can be expanded on a therapeutic scale, they have attracted attention for cell-based therapy. MSCs contribute to the protection of host tissue after transplantation by Immune modulation and trophic effect. They also...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-24.631
更新日期:2009-05-01 00:00:00
abstract::Factor H (FH) is the predominant soluble inhibitor of the complement system. With a concentration of 200-800 microg/ml in human and rat plasma it acts as a cofactor for the soluble factor I (FI)-mediated cleavage of the component C3b to iC3b. Furthermore it competes with factor B for binding to C3b and C3(H2O) and pro...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-21.93
更新日期:2006-01-01 00:00:00
abstract::The aims of the present study were to apply the AMG technique for localization of mercury at the light and electron microscopic level in the ovary of crucian carp after exposure to mercuric chloride and to find out if this heavy metal induces expression of caspase-3. Depending on the stage of ovarian follicle developm...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-24.141
更新日期:2009-02-01 00:00:00
abstract::Neurons of the substantia nigra show severe morphological changes in Parkinson's disease. Pathological alterations of cell bodies have been described, whereas those of neuronal processes have hardly been investigated. Golgi impregnation has been the chosen method for demonstrating neuronal processes and dendritic and ...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1991-07-01 00:00:00
abstract::Epidemiologic studies have suggested that elderly patients who consumed diets rich in antioxidants throughout their lives are less likely to be afflicted with age-related macular degeneration (AMD). This led to the Age-Related Eye Disease Study, which showed that supplements containing antioxidant vitamins and zinc re...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-22.1301
更新日期:2007-12-01 00:00:00
abstract::Many surgical techniques are employed in the treatment of severe obesity. A main consequence of these techniques is the improvement of type 2 Diabetes mellitus. Ghrelin is a gut hormone released in the gastric fundus and corpus, which has been related to diabetic improvement as mentioned in these papers. Sleeve gastre...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-18-200
更新日期:2020-08-01 00:00:00
abstract::We examined the relationship between the incidence of ultrastructural changes in the alveolar septum and the extravascular lung water content. Pulmonary edema was induced in 18 mongrel dogs by either dextran (n = 12) or alloxan (n = 6) administration. Six other dogs served as controls. Extravascular lung water content...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract::Orexins A and B are two hypothalamic peptides, involved in the central regulation of feeding, which act through two receptor subtypes, named OX1R and OX2R. OX1R is selective for orexin-A, and OX2R binds both orexins. We have investigated the effects of three subcutaneous injections of 10 nmol/kg body weight of orexins...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-16.713
更新日期:2001-07-01 00:00:00
abstract::The study was carried out on the distribution of neurons and fibres which contain the Corticotropin releasing factor-like (CRF) immunoreactivity in the encephalon of two species of teleosts, Gambusia affinis and Salmo trutta. The peroxidase-antiperoxidase (PAP) immunocytochemical technique was employed. The present st...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1994-04-01 00:00:00
abstract::The response of the SON to various forms of stress is well documented. However, the effect of operative stress, which is a common and important clinical event requiring the mediation of vasopressin, has largely escaped attention. The present report describes the ultrastructural changes in the neurons of the caudal (re...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1988-04-01 00:00:00
abstract::Beta-catenin expression in small cell lung carcinomas (SCLC) was investigated by immunohistochemical method using antibodies against beta-catenin. 50 pre-treatment biopsies were examined and the relationship between beta-catenin expression and the patients' relevant clinical characteristics, response to chemotherapy, ...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-16.353
更新日期:2001-04-01 00:00:00
abstract::Melanopsin-expressing retinal ganglion cells (mRGCs) constitute a system in the mammalian retina used for irradiance detection, regulating non-image forming functions, such as photoentrainment of circadian rhythms, control of the pupillary light reflex, masking response, light-regulated melatonin secretion, and modula...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-18-138
更新日期:2019-12-01 00:00:00
abstract::Actin microfilaments and microtubules are important cytoskeletal proteins that regulate endothelial repair through alterations in cell shape and through regulation of cell migration following wounding of the endothelium. Upstream pathways have been identified in the regulation of actin and microtubule organization, es...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-18.879
更新日期:2003-07-01 00:00:00