Abstract:
:The pancreatic-duct system was observed during the initial stage of type 1 diabetes in C57BL/6J mice rendered diabetic with low doses of streptozocin. Light microscopy revealed that the ducts located in close proximity to islets (islet ducts) were involved in the infiltrating process: inflammatory cells extended from the islets to these ducts. However, ducts that were located far from islets (non-islet ducts) were generally free from infiltration. Immunocytochemistry revealed that both islet ducts and non-islet ducts express MHC class II and ICAM-1 molecules: this positivity seems to be mainly expressed by elements infiltrating the connective layer or by endothelial of vessels surrounding ducts. Strong ICAM-1 positivity demonstrates that adhesiveness is widely represented in early diabetes in this animal model. At the ultrastructural level only a few endocrine elements were observed scattered within the epithelial layer and single infiltrating elements were rarely encountered within the connective layer of ducts. The existence of other sites of "activation" other than the islets of Langerhans, in this as well as in other animal models of types 1 diabetes, is consistent with the hypothesis of an initially more widespread and less specific process that later undergoes restriction.
journal_name
Histol Histopatholjournal_title
Histology and histopathologyauthors
Papaccio G,Strate C,Linn Tsubject
Has Abstractpub_date
1994-07-01 00:00:00pages
529-34issue
3eissn
0213-3911issn
1699-5848journal_volume
9pub_type
杂志文章abstract::Versican, a large extracellular matrix proteoglycan accumulates in tumor stroma and plays a key role in both malignant transformation and tumor progression. Increased versican expression has been observed in a wide range of malignant tumors, and has been associated with both cancer relapse and poor patient outcomes in...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-28.701
更新日期:2013-06-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-20.1173
更新日期:2005-10-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-26.471
更新日期:2011-04-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
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更新日期:1997-10-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
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更新日期:2001-10-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
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更新日期:2012-03-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
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更新日期:1999-10-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-16.443
更新日期:2001-04-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章,评审
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更新日期:2007-09-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-18-205
更新日期:2020-08-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-29.1017
更新日期:2014-08-01 00:00:00
abstract::Src, a 60 kDa non-receptor tyrosine kinase, is the product of normal c-src of the human genome and member of the Src protein tyrosine kinases family (SFK). As described by Martin and Rous, a genetic recombination between c-src and the RSV oncogene of Rous sarcoma virus results in a modified Src protein, with increased...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
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更新日期:2012-06-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-16.239
更新日期:2001-01-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-11-777
更新日期:2016-10-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-14.257
更新日期:1999-01-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-28.277
更新日期:2013-02-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
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更新日期:2008-05-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
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更新日期:2015-07-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-14.719
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journal_title:Histology and histopathology
pub_type: 杂志文章,评审
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-15.7
更新日期:2000-01-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-11-872
更新日期:2017-11-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章,评审
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更新日期:2000-01-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1991-07-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1987-01-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1994-04-01 00:00:00
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journal_title:Histology and histopathology
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更新日期:1999-04-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-22.1129
更新日期:2007-10-01 00:00:00