Abstract：
:TNFalpha exerts apoptosis throughout an intracellular transduction pathway that involves the kinase proteins TRAF-2 (integration point of apoptotic and survival signals), ASK1 (pro-apoptotic protein), MEK-4 (p38 activator and metastasis suppressor gene), JNK (stress mitogen activated protein kinase) and the transcription factor AP-1. TNFalpha also exerts proliferation by p38 activation, or when TRAF-2 simultaneously induces the transcription factor NF-kappaB by NIK. NIK and p38 may also be activated by IL-1. P38 activated several transcription factors such as Elk-1, ATF-2 and NF-kappaB. NIK also may activate NF-kappaB. The aim of the present article was to evaluate the different components of this TNFalpha/IL-1 transduction pathway in human prostate carcinoma (PC) in comparison with normal human prostate. In prostate cancer, pro-apoptotic TNFalpha/AP-1 pathway is probably inactivated by different factors such as p21 (at ASK-1 level) and bcl-2 (at JNK level), or diverted towards p38 or NIK activation. IL-1alpha enhances proliferation through IL-1RI that activates either NIK or p38 transduction pathway. P38 and NIK activate different transcription factors related with cell proliferation and survival such as ATF-2, Elk-1 or NF-kappaB. In order to search a possible target to cancer prostate treatment we proposed that inhibition of several proinflamatory cytokines such as IL-1 and TNFalpha might be a possible target for PC treatment, because decrease the activity of all transduction pathway members that activate transcription factors as NF-kappaB, Elk-1 or ATF-2.
journal_name
Histol Histopatholjournal_title
Histology and histopathologyauthors
Royuela M,Rodríguez-Berriguete G,Fraile B,Paniagua Rdoi
10.14670/HH-23.1279subject
Has Abstractpub_date
2008-10-01 00:00:00pages
1279-90issue
10eissn
0213-3911issn
1699-5848journal_volume
23pub_type
杂志文章,评审abstract：:Neurotrophins are substances that have been shown to be important in growth and remodelling phases in different types of tissue. There is no information concerning the possible occurrences of neurotrophins and their receptors in tendons. In this study, sections of both chronic painful (tendinosis) and pain-free (non-t...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-24.839
更新日期：2009-07-01 00:00:00
abstract：:We have studied the occurrence and specific features of liver cell dysplasia (LCD) in Chinese patients showing liver cirrhosis with or without hepatocellular carcinoma (HCC). Three types of LCD (SLCD, LLCDo, LLCDe) were morphologically defined, and these types were further analyzed using karyometry, estimation of nucl...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：:The acute and chronic effects of bombesin (BM) on the structure and function of rat adrenal cortex were investigated by morphometric and radioimmunological techniques. An intraperitoneal bolus injection of 2 micrograms/rat BM markedly raised plasma corticosterone (B) concentration (PBC). The intraperitoneal BM infusio...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
abstract：:This experiment compared the histological characteristics and distribution of CD3 and CD79a among yak lymph nodes, hemal nodes and spleen. The three organs from ten clinically healthy newborn and adult yaks were studied using histology and immunohistochemistry. The yak hemal nodes, which consisted of blood sinuses, ly...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-18-030
更新日期：2019-03-01 00:00:00
abstract：:We describe a new technique, decalcification by perfusion, for the softening of bony tissue. The blood circulatory system was perfused in 16 rats via a cannula through the left heart ventricle with a fixative followed by New Decalc (an acidic demineralizer) for 30-240 minutes. Perfusion decalcification for 120 minutes...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1991-07-01 00:00:00
abstract：:Glucocorticoids play a major role in attenuation of the inflammatory response and they are useful in the primary combination chemotherapy of breast cancer, since in vitro studies have demonstrated an antiproliferative effect in human breast cancer cells. In contrast, it was recently shown that glucocorticoids protect ...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-23.77
更新日期：2008-01-01 00:00:00
abstract：:Brain-derived neurotrophic factor (BDNF) and its receptor, TrkB, are broadly expressed in the developing and adult mammalian brain. BDNF/TrkB-stimulated intracellular signaling is critical for neuronal survival, morphogenesis, and plasticity. It is well known that binding of BDNF to TrkB elicits various intracellular ...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-25.237
更新日期：2010-02-01 00:00:00
abstract：:Nitric oxide (NO) is a biological messenger molecule produced by one of the essential amino acids L-arginine by the catalytic action of the enzyme NO synthase (NOS). The dual role of NO as a protective or toxic molecule is due to several factors, such as; the isoform of NOS involved, concentration of NO and the type o...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-21.445
更新日期：2006-04-01 00:00:00
abstract：:Dysadherin, a cancer associated cell membrane glycoprotein, has been reported to downregulate E-cadherin. Aberrant expression of E-cadherin has been associated with the development of metastases in patients with cancer. Even though the expression of dysadherin and E-cadherin has been studied in primary non-small cell ...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-25.1257
更新日期：2010-10-01 00:00:00
abstract：:Pneumadin (PNM) is a biologically active decapeptide, which has previously been found to enhanced rat adrenal growth; the mechanism is indirect and probably involves the stimulation of both arginine-vasopressin (AVP) and ACTH release. The effects of 2- and 6-day PNM administration on the atrophic adrenal cortices of r...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1997-07-01 00:00:00
abstract：:A comparative histochemical and morphometric study in two groups of homologous muscles from different tetrapods (rat, pigeon, lizard and frog) was performed. On the basis of their fiber diameters and oxidative enzyme activities, an initial correlation between fiber types of all animals is observed, although in the liz...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
abstract：:Although testicular germ cell tumors (TGCTs) are relatively uncommon, they are particularly important, as they tend to affect children and young men, the most common tumor being in males aged from 20 to 40 years, and the incidence has been increasing in the last years. TGCTs comprise two major histologic groups: semin...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-29.999
更新日期：2014-08-01 00:00:00
abstract：:A battery of horseradish peroxidase-conjugated lectins (Con A, WGA and DBA), as well as conventional histochemical techniques (PAS, saponification, Alcian Blue pH 0.1, 1, 2.5, chlorhydric hydrolisis, neuraminidase, Bromophenol blue, Tioglycollate reduction and Ferric-ferricyanide-FeIII) were used to study the content ...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-13.727
更新日期：1998-07-01 00:00:00
abstract：:Using histopathological analysis of semi-thin sections stained with toluidine blue, we observed profound pathological changes in the islets of Langerhans of hamsters infected with the scrapie agent (strain 139H). These included cytoplasmic vesicles, nuclear swelling, and vacuolization in the islet cells. Two types of ...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：:Transforming growth factor-betas (TGF-betas) are multifunctional cytokines that exist in 3 isoforms in mammals. The TGF-betas are ubiquitously expressed and all isoforms are secreted as biologically inactive precursors called latent TGF-beta (L-TGF-beta). L-TGF-betas are generally not effective molecules because they ...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-16.541
更新日期：2001-04-01 00:00:00
abstract：:The corneas of nine pipefish, Corythoichthyes paxtoni (Syngnathidae, Teleostei), five freshly fixed and four museum specimens, were examined using light and electron microscopy. In transverse section, the surface of the corneal epithelium is covered by a complex series of ridges or microplicae which extends over the c...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1995-04-01 00:00:00
abstract：:Studies in a canine bronchogenic carcinoma model indicate that alveolar type II cells may differentiate from carcinogen-exposed epithelium of larger bronchi and generate adenocarcinomas with bronchioloalveolar and other growth patterns. In this study, we investigated whether type II cells are one of the major prolifer...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1997-04-01 00:00:00
abstract：:Spectrins are members of the superfamily of F-actin cross linking proteins that are important as scaffolding proteins for protein sorting, cell adhesion, and migration. In addition, spectrins have been implicated in TGF-beta signaling. The aim of the present study was to analyze the expression and localization of beta...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-25.1497
更新日期：2010-12-01 00:00:00
abstract：:We used antisera to pure atrial natriuretic peptide to localise this peptide by immunocytochemistry in rat and human tissue. We showed that both rat and human atrial cardiocytes gave a positive reaction while ventricular cardiocytes were consistently negative. Peripheral islet cells in rat but not in human pancreas al...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1986-04-01 00:00:00
abstract：:The population of the world grows every year, and life expectancy tends to increase. Thus, long-term preservation of teeth in aged individuals is an urgent issue. The main causes of tooth loss are well known to be periodontitis, caries, fractures, and orthodontic conditions. Although implant placement is a widely acce...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-29.1249
更新日期：2014-10-01 00:00:00
abstract：:The adrenal glands of lower vertebrates display a notable intermingling between steroidogenic and chromaffin tissues, which increases from Pisces to Aves. As in mammals, adrenal chromaffin cells contain and release, in addition to catecholamines, serotonin and several peptides, which may affect the secretory activity ...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-13.209
更新日期：1998-01-01 00:00:00
abstract：:To clarify the role of REG IV, a new member of the regenerating gene (REG) family, in tumorigenesis and progression of colorectal carcinoma (CRC), 320 CRC specimens, 123 corresponding adjacent non-cancerous mucosa (ANCMs), 46 corresponding non-adjacent non-cancerous mucosa (NANCMs) and 86 adenomas were investigated im...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-25.473
更新日期：2010-04-01 00:00:00
abstract：:The aim of our study was to document whether relationships existed among bone morphogenetic proteins (BMPs), peripheral nerve and neoplastic lesions of nerve sheath tumors. The mRNA transcriptions of BMP-2, 3, 4 and 5 in 10 cases of schwannoma, three cases of malignant schwannoma and two cases of trigeminal neuralgia ...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-16.1013
更新日期：2001-10-01 00:00:00
abstract：:Neonatal hypoxic ischemia (HI) results in different extents of brain damage, and immature brain tissue is particularly sensitive to the stimulation of HI. Hypoxic-ischemic brain damage (HIBD) is a common and serious nervous system disease in neonates, for both full-term infants and preterm infants, and is one of the m...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-18-214
更新日期：2020-09-01 00:00:00
abstract：:Aurora A and Aurora B are serine-threonine kinase proteins which have both been implicated in human carcinogenesis through development of aneuploidy and chromosomal instability. The aim of the study is to assess the correlation of both markers with clinical and pathological parameters in patients with bladder cancer o...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-25.1371
更新日期：2010-11-01 00:00:00
abstract：:Dramatical development of molecular genetics has been disclosing the molecular mechanism of Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD). DMD gene product, dystrophin, is a submembranous cytoskeletal protein and many dystrophin-associated proteins (DAPs) have been identified, such as utrophin,...
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：10.14670/HH-15.753
更新日期：2000-07-01 00:00:00
abstract：:Serotonin-producing pancreatic endocrine tumours are rare neoplasms which in most cases exhibit malignant biological behaviour. These tumours, in the majority of the well-documented cases, are composed of argyrophil- and argentaffin-positive cells which contain large pleomorphic neurosecretory granules. In contrast, a...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：
更新日期：1990-07-01 00:00:00
abstract：:The anabolic androgenic steroid nandrolone decanoate has minimal androgenic effects and, thus, is widely used to induce muscle hypertrophy in both patients and athletes. Although increases in satellite cell numbers and satellite cells giving rise to new myonuclei are associated with hypertrophy in many experimental mo...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-25.133
更新日期：2010-02-01 00:00:00
abstract：:Chronic lung allograft dysfunction (CLAD) still remains a major drawback in the outcome following lung transplantation (LTx). New therapeutic strategies are warranted. Growth factors and their receptors like platelet-derived growth factor-receptor (PDGFR) and vascular endothelial growth factor-receptor (VEGFR), may pl...
journal_title：Histology and histopathology
pub_type： 杂志文章
doi：10.14670/HH-18-088
更新日期：2019-07-01 00:00:00
abstract：:Nitric oxide (NO) has opened a new and vigorous field of biological and clinical experimentation as evidenced presently by about one hundred original publications every week. Being a biological signal under physiological conditions, NO may be
journal_title：Histology and histopathology
pub_type： 杂志文章,评审
doi：
更新日期：1997-01-01 00:00:00
