An up-date on newly discovered immunohistochemical biomarkers for the diagnosis of human testicular germ cell tumors.


:Although testicular germ cell tumors (TGCTs) are relatively uncommon, they are particularly important, as they tend to affect children and young men, the most common tumor being in males aged from 20 to 40 years, and the incidence has been increasing in the last years. TGCTs comprise two major histologic groups: seminomas and non-seminomas germ cell tumors (NSGCTs). NSGCTs can be further divided into embryonal, carcinoma, Teratoma, yolk sac tumor, and choriocarcinoma. Seminomas and NSGCTs present significant differences in clinical features, therapy, and prognosis, and both show characteristics of the Primordial Germ Cells (PGCs). For proper diagnosis of the different histological subgroups, immunohistochemistry is required using different molecular markers, such as Aurora B, GPR30, Nek2, HMGA1, HMGA2, and others, and they could represent useful novel molecular targets for antineoplastic strategies. More insight into the pathogenesis of TGCTs is likely to contribute not only to better treatment of these tumors but also to a better understanding of stem cells and oncogenesis.


Histol Histopathol


Chieffi P,Chieffi S




Has Abstract


2014-08-01 00:00:00














  • C-reactive protein levels are associated with the progression of atherosclerotic lesions in rabbits.

    abstract::Elevated plasma levels of C-reactive protein (CRP) are associated with increased risk of cardiovascular disease. CRP immunoreactive protein is also detected in the lesions of atherosclerosis. However, it is not known whether the CRP contents of atherosclerotic lesions are associated with the initiation and progression...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Yu Q,Li Y,Wang Y,Zhao S,Yang P,Chen Y,Fan J,Liu E

    更新日期:2012-04-01 00:00:00

  • Immunocytohistochemical characterization of pituitary cells of the bluefin tuna, Thunnus thynnus L.

    abstract::In this paper we report the first complete mapping of the pituitary in a tuna species. The various different adenohypophysis cell types of the bluefin tuna, Thunnus thynnus L. have been identified and located using different antisera against mammalian and piscine hormones and various histochemical techniques: PAS, Alc...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Rodríguez-Gómez FJ,Rendón-Unceta MC,Piñuela C,Muñoz-Cueto JA,Jiménez-Tenorio N,Sarasquete C

    更新日期:2001-04-01 00:00:00

  • Studies with the Golgi method in central gangliogliomas and dysplastic gangliocytoma of the cerebellum (Lhermitte-Duclos disease).

    abstract::The rapid Golgi method, combined with current optical and electronmicroscopical techniques, was used in three central gangliogliomas and in one dysplastic gangliocytoma of the cerebellum to study the morphology of ganglionic cells. Gangliogliomas were composed of bipolar, fusiform and radiate cells with dense core and...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Ferrer I,Martí E,Guionnet N,Bella R,Serrano T,Towse J,Conesa G,Isamat F

    更新日期:1990-07-01 00:00:00

  • Enhanced CD24 expression in endometrial carcinoma and its expression pattern in normal and hyperplastic endometrium.

    abstract::CD24 is known to be an important diagnostic and prognostic marker of several major cancers affecting females. We aimed to determine CD24 expression in normal, hyperplastic, and carcinomatous endometrium and its correlation with estrogen and progesterone receptor expression. A total of 271 cases including 62 normal/atr...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Kim KH,Choi JS,Kim JM,Choi YL,Shin YK,Lee HC,Seong IO,Kim BK,Chae SW,Kim SH

    更新日期:2009-03-01 00:00:00

  • Differential severity of LPS-induced lung injury in CD26/DPP4 positive and deficient F344 rats.

    abstract:BACKGROUND:Lipopolysaccharide (LPS) induced inflammation often leads to lung injury, in which pulmonary recruitment of neutrophils plays a pivotal role. Inflammatory processes are influenced by CD26/DPP4, highly expressed in lungs. Asthma induced CD26/DPP4 deficient (CD26/DPP4⁻) Fischer (F) 344 rats suffering from a tr...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Zientara A,Stephan M,von Hörsten S,Schmiedl A

    更新日期:2019-10-01 00:00:00

  • Distribution of bile acid receptor TGR5 in the gastrointestinal tract of dogs.

    abstract::Takeda-G-protein-receptor-5 (TGR5) is a receptor for bile acids and its expression has been described in a variety of tissues and species. Characterization of TGR5 distribution and function has been investigated in drug discovery for the treatment of metabolic diseases in humans. Because dogs are one of the species us...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Giaretta PR,Suchodolski JS,Blick AK,Steiner JM,Lidbury JA,Rech RR

    更新日期:2019-01-01 00:00:00

  • Immunolocalization of serum proteins in xenografted mouse model of human tumor cells by various cryotechniques.

    abstract::The transport mechanism of soluble molecules throughout the interstitial matrix is closely associated with human tumor behavior in vivo. However, the examination of soluble components in histological architectures has been hampered by artifacts caused during conventional tissue preparation. In this study, the immunodi...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Bai Y,Ohno N,Terada N,Saitoh S,Nakazawa T,Nakamura N,Katoh R,Ohno S

    更新日期:2009-06-01 00:00:00

  • Expression of cell-cycle regulatory proteins BUBR1, MAD2, Aurora A, cyclin A and cyclin E in invasive ductal breast carcinomas.

    abstract::Cyclin A, cyclin E, BUBR1, MAD2 and Aurora A are all cell-cycle regulatory proteins and have been proven to play crucial roles in carcinogenesis. However, their expression patterns in invasive ductal breast carcinoma (IDBC) are controversial and unclear. In this study, we examined the expression status of these candid...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Du J,Du Q,Zhang Y,Sajdik C,Ruan Y,Tian XX,Fang WG

    更新日期:2011-06-01 00:00:00

  • Immunohistochemical distribution of cocaine- and amphetamine-regulated transcript peptide - like immunoreactive (CART-LI) nerve fibers and various degree of co-localization with other neuronal factors in the circular muscle layer of human descending colon

    abstract::Cocaine- and amphetamine-regulated transcript peptide (CART) is a neuromediator and/or neuromodulator in nerve structures within the gastrointestinal tract, but knowledge about its distribution, functions and co-localisation with other neuronal factors, especially in humans, is very scarce. During the present investig...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Gonkowski S,Kamińska B,Landowski P,Całka J

    更新日期:2013-07-01 00:00:00

  • Efficient uptake of mannosylated proteins by a human Schwann cell line.

    abstract::Complex carbohydrate structures are essential molecules of infectious microbes and host cells, and are involved in cell signaling associated with inflammatory and immune responses. The uptake of mannose-tailed glycans is usually carried out by macrophages, dendritic cells (DCs), and other professional phagocytes to tr...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Baetas-da-Cruz W,Alves L,Guimarães EV,Santos-Silva A,Pessolani MC,Barbosa HS,Corte-Real S,Cavalcante LA

    更新日期:2009-08-01 00:00:00

  • Silencing of synaptotagmin 7 regulates osteosarcoma cell proliferation, apoptosis, and migration.

    abstract:BACKGROUND:Synaptotagmin 7 (SYT7) is a component of the synaptotagmin family, which is essential in many physiological and pathological processes. In this study, we aimed to investigate the role of SYT7 in osteosarcoma. METHODS:We defined the expression levels of SYT7 in osteosarcoma tissues and para-sarcoma tissues b...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Wu Z,Sun Z,Huang R,Zang D,Wang C,Yan X,Yan W

    更新日期:2020-03-01 00:00:00

  • Review of mucinous tubular and spindle-cell carcinoma of the kidney with a focus on clinical and pathobiological aspects.

    abstract::Recently, the characterization of mucinous tubular and spindle-cell carcinoma (MTSCC) has been established. MTSCC predominantly occurs in females. This tumor is histologically characterized by eosinophilic cytoplasm, elongated and anastomosing tubules, myxomatous stroma and low-grade nuclear cytology. Proliferation of...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Kuroda N,Toi M,Hiroi M,Shuin T,Enzan H

    更新日期:2005-01-01 00:00:00

  • CD34+ stromal cells/fibroblasts/fibrocytes/telocytes as a tissue reserve and a principal source of mesenchymal cells. Location, morphology, function and role in pathology.

    abstract::We review the morphofunctional characteristics of CD34+ stromal fibroblastic/fibrocytic cells (CD34+ SFCs) and report our observations. We consider the following aspects of CD34+ SFCs: A) The confusing terms applied to this cell type, often combining the prefix CD34 with numerous names, including fibroblasts, fibrocyt...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Díaz-Flores L,Gutiérrez R,García MP,Sáez FJ,Díaz-Flores L Jr,Valladares F,Madrid JF

    更新日期:2014-07-01 00:00:00

  • Review of papillary renal cell carcinoma with focus on clinical and pathobiological aspects.

    abstract::Recent studies have shown that papillary renal cell carcinoma (RCC) is clinically and genotypically a distinct entity. Papillary RCCs account for about 10-15% of renal parenchymal neoplasms. Macroscopically, the cut surface is yellow or brown in color and large tumors frequently show cystic change. Hemorrhage and necr...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Kuroda N,Toi M,Hiroi M,Enzan H

    更新日期:2003-04-01 00:00:00

  • Ultrastructure of the chronically vagotomised atrial myocardium in the monkey (Macaca fascicularis).

    abstract::The ultrastructure of the atrial myocardium in the monkey (Macaca fascicularis) was studied after bilateral cervical vagotomy and survival times of 100, 175 and 367 days. Changes were observed in the nucleus and the cytoplasm of the myocyte. Sequestered within the nuclei of the affected myocytes were cytoplasmic organ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Wong WC,Yick TY,Ling EA

    更新日期:1989-07-01 00:00:00

  • Comparative histopathological characteristics of highly pathogenic avian influenza (HPAI) in chickens and domestic ducks in 2008 Korea.

    abstract::We compared characteristic lesions occurring in chickens and domestic ducks naturally infected with H5N1 HPAI virus in April and May 2008. Infected chickens generally exhibited pale-green, watery diarrhoea, depression, neurological signs and cyanosis of wattles and combs, and infected ducks generally exhibited neurolo...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Woo GH,Kim HY,Bae YC,Jean YH,Bak EJ,Kim MJ,Hwang EK,Joo YS

    更新日期:2011-02-01 00:00:00

  • Antigen retrieval on epoxy sections based on tissue infiltration with a moderately increased amount of accelerator to detect immune complex deposits in glomerular tissue.

    abstract::We wanted to examine the effect of antigen retrieval on epoxy sections where the tissue had been infiltrated by resin containing moderately increased amounts of accelerator. The concentration of accelerator DMP-30 (Tri(Dimethyl Amino Methyl) Phenol) was varied in the range of 0% to 4% in the infiltration step of the t...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Brorson SH,Andersen T,Haug S,Kristiansen I,Risstubben A,Tchou H,Ulstein J

    更新日期:1999-01-01 00:00:00

  • Expression of the ets-1 proto-oncogene in human breast carcinoma: differential expression with histological grading and growth pattern.

    abstract::The proto-oncogene, ets-1, is a transcription factor known to control the expression of a number of genes and has been postulated to play a role in cell growth, differentiation and tumour invasion. We examined 137 cases of breast carcinoma by immunohistochemistry and compared the degree of Ets-1 expression among the d...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Katayama S,Nakayama T,Ito M,Naito S,Sekine I

    更新日期:2005-01-01 00:00:00

  • Expression of the Shwachman-Bodian-Diamond syndrome (SBDS) protein in human pancreatic cancer and chronic pancreatitis.

    abstract:BACKGROUND:The Shwachman-Bodian-Diamond syndrome (SBDS) protein is a member of a highly conserved family which influences RNA activation and is associated with pancreatic, skeletal and bone marrow deficiencies, as well as hematological malignancies. METHODS:In this study, the expression and localization of SBDS were i...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Kayed H,Bekasi S,Keleg S,Welsch T,Esposito I,Shimamura A,Michalski CW,Friess H,Kleeff J

    更新日期:2008-07-01 00:00:00

  • Expression of mitotic kinases phospho-aurora A and aurora B correlates with clinical and pathological parameters in bladder neoplasms.

    abstract::Aurora A and Aurora B are serine-threonine kinase proteins which have both been implicated in human carcinogenesis through development of aneuploidy and chromosomal instability. The aim of the study is to assess the correlation of both markers with clinical and pathological parameters in patients with bladder cancer o...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Bufo P,Sanguedolce F,Tortorella S,Cormio L,Carrieri G,Pannone G

    更新日期:2010-11-01 00:00:00

  • Neutrophil extracellular traps in tissue pathology.

    abstract::Neutrophil extracellular traps (NETs) are innate immune systems against invading pathogens. NETs are characterized as released DNA mixed with cytoplasmic antimicrobial proteins such as myeloperoxidase, proteinase3 and neutrophil elastase. While NETs are thought to have an important role in host defense, recent work ha...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Nakazawa D,Kumar S,Desai J,Anders HJ

    更新日期:2017-03-01 00:00:00

  • Treatment and new progress of neonatal hypoxic-ischemic brain damage.

    abstract::Neonatal hypoxic ischemia (HI) results in different extents of brain damage, and immature brain tissue is particularly sensitive to the stimulation of HI. Hypoxic-ischemic brain damage (HIBD) is a common and serious nervous system disease in neonates, for both full-term infants and preterm infants, and is one of the m...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Yang L,Zhao H,Cui H

    更新日期:2020-09-01 00:00:00

  • Molecular and morphological characterization of neural tube defects in embryos of diabetic Swiss Albino mice.

    abstract:BACKGROUND AND RESULTS:Embryos from diabetic mice exhibit several forms of neural tube defects, including non-closure of the neural tube. In the present study, embryos collected at embryonic day 11.5 from diabetic pregnancies displayed open neural tube with architectural disruption of the surrounding tissues. The perce...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Loh WT,Dheen ST,Jiang B,Kumar SD,Tay SS

    更新日期:2011-08-01 00:00:00

  • Telocytes form networks in normal cardiac tissues.

    abstract::Telocytes (TC) are a class of interstitial cells present in heart. Their characteristic feature is the presence of extremely long and thin prolongations (called telopodes). Therefore, we were interested to see whether or not TCs form networks in normal cardiac tissues, as previously suggested. Autopsy samples of card...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Rusu MC,Pop F,Hostiuc S,Curca GC,Jianu AM,Paduraru D

    更新日期:2012-06-01 00:00:00

  • Effects of sex steroids on the Syrian hamster liver.

    abstract::The primary objective of this research project was to study the role of sex steroids in the pathogenesis of cholelithiasis using the Syrian hamster as a model. In addition to the morphological examination of the gallbladder epithelium, we thought it imperative to observe the changes induced in the biliary tract in res...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Karkare S,Adamiec-Beyga E,Gilloteaux J

    更新日期:1995-07-01 00:00:00

  • MMP-2 and TIMP-2 in the prostates of male and female mongolian gerbils: effects of hormonal manipulation.

    abstract::TIMPs in the prostates of male and female gerbils and evaluated the effects of testosterone on the expression of these enzymes. Ventral prostates from male gerbils that were either intact or had been castrated for 7 or 21 days, along with prostates from female gerbils that were either intact or had been treated with t...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Rochel-Maia SS,Santos FC,Vilamaior PS,Justulin LA Jr,Felisbino SL,Góes RM,Taboga SR

    更新日期:2011-11-01 00:00:00

  • Complex and elementary histological scoring systems for articular cartilage repair.

    abstract::The repair of articular cartilage defects is increasingly moving into the focus of experimental and clinical investigations. Histological analysis is the gold standard for a valid and objective evaluation of cartilaginous repair tissue and predominantly relies on the use of established scoring systems. In the past thr...

    journal_title:Histology and histopathology

    pub_type: 杂志文章,评审


    authors: Orth P,Madry H

    更新日期:2015-08-01 00:00:00

  • Structural and ultrastructural hepatic changes in experimental canine leishmaniasis.

    abstract::Six 4 month-old beagles were inoculated with Leishmania donovani infantum, three of them intraperitoneally (Group A) and the other three intravenously (Group B). The animals from Group A were killed 109, 433 and 592 days after inoculation and animals from Group B 109, 171 and 334 after inoculation. The liver of each o...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: González JL,Rollán E,Novoa C,Castaño M

    更新日期:1988-10-01 00:00:00

  • The effect of somatostatin analog octreotide on diethylstilbestrol-induced prolactin secretion, cell proliferation and vascular changes in the rat anterior pituitary gland.

    abstract::The effects of diethylstilbestrol (DES) and of long-acting somatostatin analog, octreotide (SMS) on the rat anterior pituitary microvasculature have been studied by means of computer-assisted image analysis. Additionally, the effects of DES and SMS on prolactin secretion and anterior pituitary cell proliferation have ...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Pawlikowski M,Kunert-Radek J,Grochal M,Zieliński K,Kulig A

    更新日期:1997-10-01 00:00:00

  • Renal clear-cell carcinoma: an ultrastructural study on the junctional complexes.

    abstract::Junctional complexes such as tight junctions, adherens junctions, and desmosomes play crucial roles in the structure and function of epithelial cells. These junctions are involved in increasing cell-cell contact and as well serve as signaling centers regulating multiple functions in epithelial cells. Carcinoma cell li...

    journal_title:Histology and histopathology

    pub_type: 杂志文章


    authors: Kim G,Rajasekaran SA,Thomas G,Rosen EA,Landaw EM,Shintaku P,Lassman C,Said J,Rajasekaran AK

    更新日期:2005-01-01 00:00:00