Abstract:
:Oral squamous cell carcinoma is the most common head and neck malignancy, characterised by high invasive capacity, lymph node metastasis, and high recurrence rate. Among the morphological features of oral cancer, the tumour-associated tissue eosinophilia has gained growing interest in the last years. Eosinophils are a minor subpopulation of leukocytes, representing 1-3% of all circulating white blood cells. The presence of high levels of eosinophils is associated with several diseases, but their role in cancer pathophysiology is controversial. In particular, an uncertain and contradictory relationship exists between the exact role of tumour-associated tissue eosinophilia and oral cancer development. Many studies have shown that tumour-associated tissue eosinophilia increases both in the progression of oral potentially malignant disorders as well as in the grade and stage progression of oral cancer. Despite this, both negative and positive prognostic outcomes have been associated with eosinophil infiltration. The heterogeneous results may be partially due both to several methodological inconsistencies and to an incorrect interpretation of the physiological role of eosinophils. Therefore, further studies to elucidate the contribution of eosinophil infiltration are needed, focusing on the existence of eosinophil subpopulations regulated by the cancer immune microenvironment. Furthermore, the correct reporting of prognostic marker research is encouraged, in order to ensure the reproducibility and the comparability of the results from different studies.
journal_name
Histol Histopatholjournal_title
Histology and histopathologyauthors
Mascitti M,Togni L,Rubini C,Troiano G,Lo Muzio L,Santarelli Adoi
10.14670/HH-18-250subject
Has Abstractpub_date
2020-09-28 00:00:00pages
18250eissn
0213-3911issn
1699-5848pii
HH-18-250pub_type
杂志文章abstract::Neutrophil extracellular traps (NETs) are innate immune systems against invading pathogens. NETs are characterized as released DNA mixed with cytoplasmic antimicrobial proteins such as myeloperoxidase, proteinase3 and neutrophil elastase. While NETs are thought to have an important role in host defense, recent work ha...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-11-816
更新日期:2017-03-01 00:00:00
abstract::TNFalpha exerts apoptosis throughout an intracellular transduction pathway that involves the kinase proteins TRAF-2 (integration point of apoptotic and survival signals), ASK1 (pro-apoptotic protein), MEK-4 (p38 activator and metastasis suppressor gene), JNK (stress mitogen activated protein kinase) and the transcript...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-23.1279
更新日期:2008-10-01 00:00:00
abstract::To investigate the matrix metalloproteinase (MMP)-9, (MMP)-13, E-Cadherin and Ki-67 expressions in road pavers' skin chronically exposed to bitumen products in order to contribute to a better understanding of the earlier tissue alteration. Skin punch biopsies from 16 daily exposed workers and a control group were stud...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-18-116
更新日期:2019-10-01 00:00:00
abstract::Since endometriosis is a proliferative disease we evaluated the presence of anti-apoptotic factor (Bcl-2) and pro-apoptotic factor (Bax) in deep pelvic endometriosis. A Cross-sectional observational study was performed at Santa Casa de Misericórdia de São Paulo, São Paulo, Brazil. Forty women aged 26 to 46 years with ...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-29.1129
更新日期:2014-09-01 00:00:00
abstract::The matrix metalloproteinases (MMPs) are a family of proteolytic zinc-containing enzymes, which are responsible for the breakdown of the extracellular matrix components in pathological and physiological conditions. They are involved in basement membrane disruption, stroma and blood vessel penetration, metastasis and m...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-21.603
更新日期:2006-06-01 00:00:00
abstract::Pax genes play a pivotal role in development of the vertebrate visual system. Pax6 is the master control gene for eye development: ectopic expression of Pax6 in Xenopus laevis and Drosphila melanogaster leads to the formation of differentiated eyes on the legs or wings. Pax6 is involved in formation of ganglion cells ...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-16.239
更新日期:2001-01-01 00:00:00
abstract::The liver represents a site of expression of neurotrophins and their receptors. We have characterized the expression and intracellular localization of the nerve growth factor (NGF) receptor, Trk-A, in liver cells in vivo and in vitro. In both normal and fibrotic liver tissue, Trk-A immunostaining was present in differ...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-23.327
更新日期:2008-03-01 00:00:00
abstract::Nitric oxide (NO) has opened a new and vigorous field of biological and clinical experimentation as evidenced presently by about one hundred original publications every week. Being a biological signal under physiological conditions, NO may be
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:
更新日期:1997-01-01 00:00:00
abstract::mTOR is a member of the PI3K/Akt/mTOR signaling pathway that participates in cell growth, proliferation, protein synthesis, transcription, angiogenesis, apoptosis and autophagy. mTOR and MAPK pahways are two important key signal pathways which are related to each other. We investigated the role of mTOR and other signa...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-18-258
更新日期:2020-11-01 00:00:00
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journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-13.575
更新日期:1998-04-01 00:00:00
abstract::The three-dimensional structure of the pancreatic ductular system (from the intercalated duct to the intercellular secretory canaliculus) is controversial and unclear. The aim of this study is to reveal the three-dimensional structure of the pancreatic ductular sysytem at the onset of pancreatitis. One day following r...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-17.107
更新日期:2002-01-01 00:00:00
abstract::Much effort has been made by researchers to elucidate the complex biology of breast cancer stem cells (BCSCs), a small subset of breast tumor cells that display stem cell properties, drive tumor initiation, and growth. In recent years, it has been suggested that BCSCs could be responsible for the process of metastasis...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-11-718
更新日期:2016-06-01 00:00:00
abstract::The effects of the administration of cyclophosphamide to male rats at doses of 400 mg/m2 for a period of 5 days and of 200 mg/m2 over two five-day cycles interrupted by a 21-day break reveal differences in the ultrastructural morphology of gonadotrophic cells between treated animals and normal controls. The ultrastruc...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1990-04-01 00:00:00
abstract::The view of how astrocytes, a type of glial cells, contribute to the functioning of the central nervous system (CNS) has changed greatly in the last decade. Although glial cells outnumber neurons in the mammalian brain, it was considered for over a century that they played a subservient role to neurons. This view chan...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-26.277
更新日期:2011-02-01 00:00:00
abstract:BACKGROUND:Synaptotagmin 7 (SYT7) is a component of the synaptotagmin family, which is essential in many physiological and pathological processes. In this study, we aimed to investigate the role of SYT7 in osteosarcoma. METHODS:We defined the expression levels of SYT7 in osteosarcoma tissues and para-sarcoma tissues b...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-18-174
更新日期:2020-03-01 00:00:00
abstract::Aurora A and Aurora B are serine-threonine kinase proteins which have both been implicated in human carcinogenesis through development of aneuploidy and chromosomal instability. The aim of the study is to assess the correlation of both markers with clinical and pathological parameters in patients with bladder cancer o...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-25.1371
更新日期:2010-11-01 00:00:00
abstract::The proto-oncogene, ets-1, is a transcription factor known to control the expression of a number of genes and has been postulated to play a role in cell growth, differentiation and tumour invasion. We examined 137 cases of breast carcinoma by immunohistochemistry and compared the degree of Ets-1 expression among the d...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-20.119
更新日期:2005-01-01 00:00:00
abstract::Previous studies have demonstrated a role for the beta-adrenergic system in the maturation of the fetal alveolar epithelium. Chronic blockade of beta-adrenergic binding sites has been shown to adversely effect physiologic and biochemical indices of fetal lung maturation. In the present study timed-pregnant female Spra...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-17.365
更新日期:2002-04-01 00:00:00
abstract::The FHIT gene encompassing the most active common human fragile region, FRA3B, has been proposed as a tumour suppressor gene for important common human carcinomas. The mechanism in which Fhit protein exerts its tumour suppressor activity is still obscure. To further understand the Fhit function associated with its int...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-21.915
更新日期:2006-09-01 00:00:00
abstract::Primordial germ cells (PGCs) are the founder cells of all gametes. PGCs differentiate from pluripotent epiblasts cells by mesodermal induction signals during gastrulation. Although PGCs are unipotent cells that eventually differentiate into only sperm or oocytes, they dedifferentitate to pluripotent stem cells known a...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-26.643
更新日期:2011-05-01 00:00:00
abstract::STAT and SMAD often exert opposite biological effects on diverse cellular functions. Recent studies have shown that STAT can interface with SMAD at molecular level and that some novel molecules, such as SOCS (also called CIS) and APRO6 (also called TOB), modulate this signaling. A cofactor p300/CBP might act as a brid...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-17.887
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVE:Describe the morphological changes that take place in the lung parenchyma and in the airways during the respiratory cycle with a view to establishing a relationship between them. SUBJECTS:Adult Wistar rats. INTERVENTIONS:The lungs were fixed at seven different points in the respiratory cycle: Inflation, 10 ...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-22.43
更新日期:2007-01-01 00:00:00
abstract::Thrombospondin-1 (TSP-1) is a matrix protein implicated in mechanisms of wound healing. TSP-1 contains the sequence cysteine-serine-valine-threonine-cysteine-glycine (CSVTCG) that has been shown to function primarily as a cell adhesion domain. Our laboratory has isolated a novel receptor specific for the CSVTCG adhesi...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-13.967
更新日期:1998-10-01 00:00:00
abstract::The effects induced by different concentrations (50, 75, 100 microM) of the cytostatic drug cisplatin (cDDP) in NIH/3T3 cells were analyzed. Sub-confluent cultures of this mouse fibroblast line, obtained after serum deprivation, showed the presence of aneuploid/polyploid cells with ploidy values ranging from 4c to 24c...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-23.717
更新日期:2008-06-01 00:00:00
abstract::Current data on the influence of neuropeptides on the growth, structure and function of cells comprising the hypothalamo-pituitary-adrenal axis were presented and discussed. The action of vasopressin, oxytocin, neurotensin, bombesin, neuropeptide Y, substance P and VIP have been evaluated. The hypothesis has been intr...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:
更新日期:1993-01-01 00:00:00
abstract::Differentiating nonspecific interstitial pneumonia (NSIP) from usual interstitial pneumonia (UIP) is important for the determination of both treatment and prognosis. Using two-dimensional fluorescence difference gel electrophoresis (2D-DIGE), we examined 8 UIPs, 8 NSIPs, and 30 normal lung tissues. Comparisons with co...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-29.377
更新日期:2014-03-01 00:00:00
abstract::An inadequate balance between oxidant species and antioxidant mechanisms may constitute the primary mechanisms of a number of pathologies. The liver plays a central role in this balance: parenchymal hepatic cells contain and export especially high levels of the antioxidant glutathione and activated Kupffer cells relea...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:10.14670/HH-22.399
更新日期:2007-04-01 00:00:00
abstract::Having identified glycans of cellular glycoconjugates as versatile molecular messages, their recognition by sugar receptors (lectins) is a fundamental mechanism within the flow of biological information. This type of molecular interplay is increasingly revealed to be involved in a wide range of (patho)physiological pr...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:10.14670/HH-18-199
更新日期:2020-06-01 00:00:00
abstract::The importance of molybdenum-containing enzymes in the pathophysiology of a number of clinical disorders necessitates a comprehensive understanding of their histological localization and expression. The objectives of this review are to cover such enzymes so far reported and their enzyme- and immunohistochemical locali...
journal_title:Histology and histopathology
pub_type: 杂志文章,评审
doi:
更新日期:1997-04-01 00:00:00
abstract::The bronchial-associated lymphoid tissue (BALT) is a lymphoepithelial organ, related to the immune defence of the lung and to alveolar clearance, which changes size in certain states of disease. Changes in the size of BALT were quantified and compared, and Spearman's test was used to test the relation with the bronchi...
journal_title:Histology and histopathology
pub_type: 杂志文章
doi:
更新日期:1992-07-01 00:00:00